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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 5-6
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Original Articles

The Stereoselective Aldol Condensation of α-Fluoroacetates

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Pages 1081-1090 | Received 29 Aug 1988, Published online: 24 Oct 2006

References

  • Welch , J. T. , Seper , K. , Eswarakrishnan , S. and Samartino , J. S. 1984 . J. Org. Chem. , 49 : 4720 – 4721 .
  • Welch , J. T. and Seper , K. 1984 . Tetrahedron Lett. , 25 : 5247 – 5250 .
  • Welch , J. T. and Eswarakrishnan , S. 1985 . J. Org. Chem. , 50 : 5403 – 5405 .
  • Molines , H. , Massoudi , M. H. , Cantacuzene , D. and Wakselman , C. 1983 . Synthesis , : 322 – 324 .
  • Nakai , H. , Hamanaka , N. , Miyake , H. and Hayashi , M. 1979 . Chem. Lett. , : 1499 – 1502 .
  • Heathcock , C. H. , Pirrung , M. C. , Montgomery , S. H. and Lampe , J. 1981 . Tetrahedron , 37 : 4087 – 4095 .
  • Heathcock , C. H. 1984 . Asymmetric Synthesis , Edited by: Morrison , J. Vol 3 , 111 – 212 . Orlando : Academic . D., Part B
  • Still , W. C. , Kahn , M. and Mitra , A. 1978 . J. Org. Chem. , 43 : 2923 – 2925 .
  • Caution: Ethyl fluoroacetate (Fike Chemical, Sigma Chemical Company) is extremely poisonous, causing convulsions and ventricular fibrillation. It was used without purification, and handled by syringe in an efficient fume hood. Sodium fluoroacetate (Sigma Chemical Company) and fluoroacetyl chloride are fatal poisons affecting the central nervous system causing epilectic convulsions. They were also handled with extreme caution in an efficient fume hood.

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