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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 11-12
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Original Articles

The Synthesis of 1-Aminoxanthones

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Pages 2001-2015 | Received 13 Dec 1989, Published online: 24 Oct 2006

References

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  • Using several different solvent systems a single spot was observed on tlc. The 200 MHz pmr spectrum showed large coupling constants between H and F which is consistent with the H's being ortho to the fluorine.
  • The long reaction time is a reflection of both the intrinsic sluggishness of the reaction (involves nucleophilic aromatic substitution) and the dilute nature of the reaction.
  • The P388 leukemia system is used routinely for initial screening of crude natural products. It is generally considered to be a sensitive system capable of detecting low orders of activity.
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