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- Using several different solvent systems a single spot was observed on tlc. The 200 MHz pmr spectrum showed large coupling constants between H and F which is consistent with the H's being ortho to the fluorine.
- The long reaction time is a reflection of both the intrinsic sluggishness of the reaction (involves nucleophilic aromatic substitution) and the dilute nature of the reaction.
- The P388 leukemia system is used routinely for initial screening of crude natural products. It is generally considered to be a sensitive system capable of detecting low orders of activity.
- Mancini , M. L. and Honek , J. F. 1986 . Synthetic Communications ( , 16 : 1109