Synthesis of 1,3-Diynes Using Palladium-Copper Catalysis

References

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• Representative procedure: to a solution of 3-hydroxy-1-iodopropyne (0.20 g, 1.1 mmol), phenylacetylene (145 L, 1.32 mmol), (pph3)2PdCl2 (21 mg, 0.03 mmol and Cul14 (6 mg, 0.03 mmol) in THF (8 ml) and under a nitrogen atmosphere was added diisopropylamine (0.3 ml, 2 mmol). After 1.5 hr at room temperature, the mixture was diluted with ether, extracted with dilute acid, water and brine, then dried (MgSO4). Purification using flash chromatography gave a 79% yield of 1-hydroxy-5-phenyl-2,4-pentadiyne
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