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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 23, 1993 - Issue 15
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Original Articles

An Effective Method for the Preparation of 21-Chlorosteroids Using the Vilsmeier Reagent

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Pages 2199-2211 | Received 09 Mar 1993, Published online: 23 Sep 2006

References

  • Tirilazad belongs to a group of 21-amino steroids that inhibit iron-dependent lipid peroxidation thus protecting against central nervous system trauma.
  • Jacobsen , E. J. , McCall , J. M. , Ayer , D. E. , VanDoornik , F. J. , Palmer , J. R. , Belonga , K. L. , Braughler , J. M. , Hall , E. D. , Houser , D. J. , Krook , M. A. and Runge , T. A. 1990 . J. Med. Chem. , 33 : 1145
  • Unpublished results of Thomas A Runge, Chemical Research Preparations unit, The Upjohn Company.
  • Sugai , S. , Okazaki , T. and Akaboshi , S. 1982 . Synthesis 1023
  • issued to Taisho Pharmaceutical Co., Ltd, Sept. 12 . US patent4,113,680 . 1978 .
  • Sugai , S. , Akaboshi , S. and Ikegami , S. 1983 . Chem. Pharm Bull, Tokyo , 31 : 12
  • issued to Syntex. . US patent 3,644,340 . 1972 .
  • Available from Aldrich Chemical Co.
  • Hanessian , S. and Plessas , N. R. 1967 . J. Chem. Soc. Chem. Commun. 1152
  • Dods , R. F. and Roth , J. S. 1969 . Tetrahedron Lett. 165
  • Hepburn , D. R. and Hudson , H. R. 1976 . J. Chem. Soc., Perkin Trans 1 , : 754

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