References
- Bermudez , J. , King , F. D. and Sanger , G. J. 1992 . Bioorganic and Medicinal Chemistry Letters , 2 : 1509
- Dittami , J. P. and Ramanathan , H. 1988 . Tetrahedron Letters, ( , 29 : 45
- Pratt , R. N. , Stokes , D. P. , Taylor , G. A. and Brookes , P. C. 1968 . J. Chem. Soc. (C) , : 2086 (in part)
- Narr , B. , Hauel , N. , Noll , K. , Heider , J. , Psiorz , M. , Bomhard , A. , Van Meel , J. and Diederen , W. Ger. Offen. DE 3,639,466 (Chemical Abstracts 109 149533c)
- Coates , I. H. , North , P. C. and Oxford , A. W. Eur. Pat. Appl. , EP 306,323
- Fujimoto Pharmaceutical Co. Ltd., Jpn. Kokai Tokkyo Koho JP 57,212,165 . (Chemical Abstracts 98 160714n)
- Continental Farma Inc., Jpn. Kokai Tokkyo Koho JP 61,176,571 . (Chemical Abstracts 106 119885q)
- Webb , R. L. and Lewis , J. J. 1981 . J. Heterocyclic Chem. , 18 : 1301
- The acetoacetate 3 can be purified by column chromatography and has been characterised by its 1H NMR and mass spectra. It exists in solution as a mixture of keto-enol forms
- The chlorides (and iodides) are prone to decomposition on chromatography and on storage
- The use of 2, X=Cl, R=Bn has also been examined in the alkylation reaction but its poor solubility in THF was a major problem and the required product was not obtained