A New Method for the Preparation of β-Hydroxy Nitriles: Transformation of 3-Bromo-2-isoxazolines to β-Hydroxy Nitriles by Treatment of Alkanethiolates

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• 2d: 1H-NMR(CDCl3), δ, 2. 72(d, 2H, J, = 6. 18 Hz, CH2CN), 5. 00(t, 1H, J, = 6. 18 Hz, CHOH), 7. 37 (s, 5H, Ph); IR(neat), 3400, 2250, 1055, 755, 700 cm−1 2f: 1H-NMR(D2O), δ, 2. 72(d, 2H, J, = 6. 42 Hz, CH2CN), 3. 62(d, 2H, J, = 5. 60 Hz, CH2OH), 4. 00(m, 1H, CHOH); IR(neat), 3380, 2250, 1100, 1045 cm−1 2g: 1H-NMR(CDCl3, δ, 2. 71(d, 2H, J, = 6. 15 Hz, CH2, CN), 3. 65(d, 2H, J, = 5. 26 Hz, CH2Cl), 4. 20(m, 1H, CHOH); IR(neat), 3400, 2255, 1090 cm−1 2h: 1H-NMR(CDCl3), δ, 3. 18–3. 49(m, 3H, CHCN, CH2, 5. 27(d, 1H, J, = 5. 15 Hz, CHOH), 7. 33(m, 4H, Ph). IR(neat), 3400, 2245, 1105, 1100, 760 cm−1 2i: 1H-NMR(CDCl3), δ, 4. 03(d, 1H, J, = 5. 76 Hz, CHCN), 4. 97(d, 1H, J, = 5. 45 Hz, CHOH), 7. 29(s, 10H, Ph); IR(neat), 3450, 2245, 1050, 760, 700 cm−1
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