Synthesis of N-Alkyl-3-Azetidinol Ethers

References

• For reviews on azetidines see
   Google Scholar
• Cromwell , N. H. and Phillips , B. 1979 . Chem Rev. , 79 : 331
   Web of Science ®Google Scholar
• Vaughan , W. R. , Klonowski , R. S. , McElhinney , R. S. and Millward , B. B. 1961 . J. Org. Chem. , 26 : 138
   Google Scholar
• For a review of β-blockers, see
   Google Scholar
• Roberts , S. M. and Price , B. J. 1988 . Medicinal Chemistry , pp 69 – 92 . London : Academic .
   Google Scholar
• Wright , J. , Crooks , C. R. , Callery , P. S. and Moreton , J. E. 1979 . J. Med. Chem. , 22 : 210
   PubMedGoogle Scholar
• Gaertner , V. R. 1966 . Tetrahedron Lett. , 22 : 4691
   Google Scholar
• Gaertner , V. R. 1967 . J. Org. Chem. , 22 : 2972
   Google Scholar
• Gaj , B. J. and Moore , D. R. 1967 . Tetrahedron Lett. , 23 : 2155
   Google Scholar
• Jenkins , H. and Cale , A. D.-Jr. 1970 . Robins, A. H., Co., Inc , 72 : 100478s Ger. Offen. 1,932,219 (Cl. C 07d), 05 Mar 1970, US Appl. 27 Jun 1968 as reported in CA
   Google Scholar
• Chong , J. M. and Sokoll , K. K. 1992 . Tetrahedron Lett. , 33 : 879
   Google Scholar
• These reactions do proceed with 1.1 equivalents of amine and 2 equivalents of pyridine serving as solvent and base; however the yields of azetidine are poor (19–23%) with substantial quantities of starting material recovered
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