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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 22
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Original Articles

Straightforward and Scalable Synthesis of Diethyl Fluoro-(phenylsulfonyl)methylphosphonate

Pages 3583-3587 | Received 11 Apr 1995, Published online: 23 Sep 2006

References

  • McCarthy , J. R. , Matthews , D. P. and Paolini , J. P. 1993 . Org. Syn. , 72 : 209
  • McCarthy , J. R. , Matthews , D. P. , Edwards , M. L. , Stemerick , D. M. and Jarvi , E. T. 1990 . Tetrahedron Lett. , 31 : 5449
  • McCarthy , J. R. , Matthews , D. P. , Stemerick , D. M. , Huber , E. W. , Bey , P. , Lippert , B. J. , Snyder , R. D. and Sunkara , P. S. 1991 . J. Amer. Chem. Soc. , 113 : 7439
  • Matthews , D. P. , Persichetti , R. A. , Sabol , J. S. , Stewart , K. T. and McCarthy , J. R. 1993 . Nucleosides & Nucleotides , 12 : 115
  • Koizumi , T. , Hagi , T. , Horie , Y. and Takeuchi , Y. 1987 . Chem. Pharm Bull. , 35 : 3959
  • Lal , G. S. 1993 . J. Org. Chem. , 58 : 2791
  • Matthews Persichetti , D. P. and McCarthy , J. R. 1994 . Org. Prep. Proc. Int. , 26 : 605
  • 1993 . Diethyl chlorophosphate is a highly toxic and potent acetylcholinesterase inhibitor and should be handled with great care , The Aldrich Chemical Co. . Material Safety Data Sheet
  • Excess butyllithium and diethyl chlorophosphate only gave more butyl diethylphosphonate, the product of attack of butyllithium on diethyl chlorophosphate
  • Phosphonate 1 is unstable to hydroxide and it is suspected that most or all of the fluoromethyl phenyl sulfone remaining in the reaction was formed during the quenching procedure with aqueous ammonium chloride

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