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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 20
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Original Articles

Preparation of Aryl Cyclobutenes Under Mild and Neutral Conditions

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Pages 3795-3805 | Received 22 Apr 1998, Published online: 23 Aug 2006

REFERENCES

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  • The possibility of traces amount of acid was eliminated by the addition of sodium bicarbonate in the reaction mixture. This reaction gave the desired cyclobutene in high yield (>90%)
  • No reaction was observed under 3 M concentration and below
  • Purification of cyclobutenes by standard flash chromatography on silica gel proved to be troublesome due to some decomposition
  • Grieco , P. A.D. , Bay , W. J. and Todd , L. J. 1996 . Tetrahedron Lett. , 37 : 8707 – 8710 .
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