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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 29, 1999 - Issue 23
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Original Articles

A Facile and Practical Synthesis of Capsazepine, a Vanilloid Receptor Antagonist

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Pages 4127-4140 | Received 16 Feb 1999, Published online: 17 Sep 2007

References

  • Walpole , C. S. J. and Wrigglesworth , R. 1993 . Capsaicin in the Study of Pain , Edited by: Wood , J. N. 63 – 81 . San Diego, CA : Harcourt Brace .
  • 1998 . Alexis Biochemicals , 550 – 145 . San Diego, , USA : Catalog .
  • Walpole , C. S. J. , Bevan , S. , Bovermann , G. , Boelsterli , J. J. , Breckenridge , R. , Davies , J. W. , Hughes , G. A. , James , I. , Oberer , L. , Winter , J. and Wrigglesworth , R. 1994 . J. Med. Chem. , 37 : 1942
  • Trost , B. M. and Fleming , I. , eds. 1991 . Comprehensive Organic Synthesis , 1007 – 1046 . Oxford : Pergamon .
  • Among the conditions of the intramolecular Mannich reaction investigated, the reaction of 1 with paraformaldehyde (1.0 eq) in formic acid at 90 °C for 40 h gave the best yield (10%) of 2 along with 3 (24%).
  • Kim , S. and Yi , K. Y. 1986 . J. Org. Chem. , 57 : 2613

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