References
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- General experimental procedure : To a stirred suspension of Wang resin (300mg, 1 mmol/g) in CH2CI2 (10 mL), diethyl phosphonoacetic acid (1 64 μmL, 0.4 mmol), DCC (104 mg, 0.5 mmol), HOBt (13.5 mg, 0.1 mmol) and triethylamine (63 μmL, 0.45 mmol) at room temperature, followed by stirring for 10 h. The resin 2 was washed (Et2O and EtOAc), dried. The loaded resin 2 (100 mg) was suspended in toluene (2 mL) and MgCk (10.7 mg, 0.11 mmol), triethylamine(42 μmL. 0.3 mmol) and carboxylic acid chloride (0.2 mmol) were added and stirred for 12 h at room temperature. The resin 3 was washed (CH2Cl2 and EtOAc), resuspended in 2 mL of TFA/ CH2Cl2 (1:1) for 30 min. The filtrate was pooled with resin washing (CH2Cl2 and EtOAc), concentrated, and chromatographed to give β-keto phosphonate 4