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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 10
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Research Article

Tissue distribution of YM758, a novel If channel inhibitor, in pregnant and lactating rats

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Pages 1274-1288 | Received 31 Mar 2008, Accepted 21 Aug 2008, Published online: 16 Oct 2008

References

  • Behravan J, Piquette-Miller M. Drug transport across the placenta, role of the ABC drug efflux transporters. Expert Opinion on Drug Metabolism and Toxicology 2007; 3: 819–830
  • Bonati M, Bortolus R, Marchetti F, Romero M, Tognoni G. Drug use in pregnancy: An overview of epidemiological (drug utilization) studies. European Journal of Clinical Pharmacology 1990; 38: 325–328
  • Bucchi A, Barbuti A, Baruscotti M, DiFrancesco D. Heart rate reduction via selective ‘funny’ channel blockers. Current Opinion in Pharmacology 2007; 7: 208–213
  • Buckberg GD, Fixler DE, Archie JP, Hoffman JI. Experimental subendocardial ischemia in dogs with normal coronary arteries. Circulation Research 1972; 30: 67–81
  • Grube M, Reuther S, Meyer Zu Schwabedissen H, Köck K, Draber K, Ritter CA, Fusch C, Jedlitschky G, Kroemer HK. Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Drug Metabolism and Disposition 2007; 35: 30–35
  • Heikkinen T, Ekblad U, Kero P, Ekblad S, Laine K. Citalopram in pregnancy and lactation. Clinical Pharmacology and Therapeutics 2002; 72: 184–191
  • Heikkinen T, Ekblad U, Palo P, Laine K. Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation. Clinical Pharmacology and Therapeutics 2003; 73: 330–337
  • Hirohashi T, Suzuki H, Takikawa H, Sugiyama Y. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). Journal of Biological Chemistry 2000; 275: 2905–2910
  • Indolfi C, Guth BD, Miura T, Miyazaki S, Schulz R, Ross J, Jr. Mechanisms of improved ischaemic regional dysfunction by bradycardia. Studies on UL-FS 49 in swine. Circulation 1989; 80: 983–993
  • Jonker JW, Merino G, Musters S, Van Herwaarden AE, Bolscher E, Wagenaar E, Mesman E, Dale TC, Schinkel AH. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nature Medicine 2005; 11: 127–129
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 2001; 120: 525–533
  • Lankas GR, Wise LD, Cartwright ME, Pippert T, Umbenhauer DR. Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. Reproductive Toxicology 1998; 12: 457–463
  • Laurent D, Bolene-Williams C, Williams FL, Katz LN. Effects of heart rate on coronary flow and cardiac oxygen consumption. American Journal of Physiology 1956; 185: 355–364
  • Matt DW, Borezelleca JF. Toxic effects on the female reproductive system during pregnancy, parturition, and lactation. Reproductive toxicology, RJ Witorsch. Raven, New York, NY 1995; 175–196
  • Nagata Y, Kusuhara H, Hirono S, Endou H, Sugiyama Y. Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3. Drug Metabolism and Disposition 2004; 32: 1040–1047
  • Ohta K, Fukasawa Y, Yamaguchi J, Kohno Y, Fukushima K, Suwa T, Awazu S. Retention mechanism of imidazoles in connective tissue. IV. Identification of a nucleophilic imidazolone metabolite in rats. Biological and Pharmaceutical Bulletin 1998; 21: 1334–1337
  • Oitate M, Hirota T, Koyama K, Inoue S, Kawai K, Ikeda T. Covalent binding of radioactivity from [14C]rofecoxib, but not [14C]celecoxib or [14C]CS-706, to the arterial elastin of rats. Drug Metabolism and Disposition 2006; 34: 1417–1422
  • Oitate M, Hirota T, Murai T, Miura S, Ikeda T. Covalent binding of rofecoxib, but not other cyclooxygenase-2 inhibitors, to allysine aldehyde in elastin of human aorta. Drug Metabolism and Disposition 2007a; 35: 1846–1852
  • Oitate M, Hirota T, Takahashi M, Murai T, Miura S, Senoo A, Hosokawa T, Oonishi T, Ikeda T. Mechanism for covalent binding of rofecoxib to elastin of rat aorta. Journal of Pharmacology and Experimental Therapeutics 2007b; 320: 1195–1203
  • Oo CY, Paxton EW, McNamara PJ. Active transport of nitrofurantoin into rat milk. Advances in Experimental Medicine and Biology 2001; 501: 547–552
  • Pavek P, Merino G, Wagenaar E, Bolscher E, Novotna M, Jonker JW, Schinkel AH. Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine. Journal of Pharmacology and Experimental Therapeutics 2005; 312: 144–152
  • Roth W, Bauer E, Heinzel G, Cornelissen PJ, Van Tol RG, Jonkman JH, Zuiderwijk PB. Zatebradine: pharmacokinetics of a novel heart-rate-lowering agent after intravenous infusion and oral administration to healthy subjects. Journal of Pharmaceutical Sciences 1993; 82: 99–106
  • Sastry BV. Placental toxicology: tobacco smoke, abused drugs, multiple chemical interactions, and placental function. Reproduction, Fertility, and Development 1991; 34: 355–372
  • Sonnenblick EH, Ross J, Jr, Braunwald E. Oxygen consumption of the heart. Newer concepts of its multifactoral determination. American Journal of Cardiology 1968; 22: 328–336
  • Umehara KI, Iwai M, Adachi Y, Usui T, Iwatsubo T, Usui T, Kamimura H. Hepatic uptake and excretion of (–)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel if channel inhibitor, in rats and humans. Drug Metabolism and Disposition 2008b; 36: 1030–1038
  • Umehara KI, Iwatsubo T, Noguchi K, Kamimura H. Comparison of kinetic characteristics of inhibitory effects by biguanides and H2-blockers on the organic cation transporters-mediated transport between human (OCT) and rat (oct): Insight into the application to the development of drug candidates. Xenobiotica 2007; 37: 618–634
  • Umehara KI, Seya K, Sonoda T, Nakamura E, Noguchi K, Usui T, Kamimura H. Comparative evaluation of absorption, distribution, and excretion of YM758, a novel If channel inhibitor, between albino and non-albino rats. Xenobiotica 2008a; 38: 527–539
  • Wilson JG. Current status of teratology. Handbook of teratology, JG Wilson, FC Fraster. Plenum, New York, NY 1977; 47
  • Young AM, Allen CE, Audus KL. Efflux transporters of the human placenta. Advanced Drug Delivery Reviews 2003; 55: 125–132

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