Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 54, 2024 - Issue 3
138
Views
0
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model

, , , , &
Pages 107-115 | Received 24 Nov 2023, Accepted 08 Jan 2024, Published online: 17 Jan 2024

References

  • Abdel-Rahman SM, Marcucci K, Boge T, Gotschall RR, Kearns GL, Leeder JS. 1999. Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine. Drug Metab Dispos. 27(7):770–775.
  • Balwani M, Burrow TA, Charrow J, Goker-Alpan O, Kaplan P, Kishnani PS, Mistry P, Ruskin J, Weinreb N. 2016. Recommendations for the use of eliglustat in the treatment of adults with Gaucher disease type 1 in the United States. Mol Genet Metab. 117(2):95–103. doi: 10.1016/j.ymgme.2015.09.002.
  • Chiba K, Kato M, Ito T, Suwa T, Sugiyama Y. 2012. Inter-individual variability of in vivo CYP2D6 activity in different genotypes. Drug Metab Pharmacokinet. 27(4):405–413. doi: 10.2133/dmpk.dmpk-11-rg-078.
  • Dehbozorghi S, Bagheri S, Moradi K, Shokraee K, Mohammadi MR, Akhondzadeh S. 2019. Efficacy and safety of tipepidine as adjunctive therapy in children with attention-deficit/hyperactivity disorder: randomized, double-blind, placebo-controlled clinical trial. Psychiatry Clin Neurosci. 73(11):690–696. doi: 10.1111/pcn.12913.
  • Ebisawa A, Hiratsuka M, Sakuyama K, Konno Y, Sasaki T, Mizugaki M. 2005. Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals. Drug Metab Pharmacokinet. 20(4):294–299. doi: 10.2133/dmpk.20.294.
  • Frederiksen T, Areberg J, Schmidt E, Bjerregaard Stage T, Brøsen K. 2021. Quantification of in vivo metabolic activity of CYP2D6 genotypes and alleles through population pharmacokinetic analysis of vortioxetine. Clin Pharmacol Ther. 109(1):150–159. doi: 10.1002/cpt.1972.
  • Hayashi S, Kawaguchi H, Watanabe T, Miyawaki I, Fukami T, Nakajima M. 2023. Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver. Xenobiotica. 53(4):241–247. doi: 10.1080/00498254.2023.2224863.
  • Honda S, Kawaura K, Soeda F, Shirasaki T, Takahama K. 2011. The potent inhibitory effect of tipepidine on marble-burying behavior in mice. Behav Brain Res. 216(1):308–312. doi: 10.1016/j.bbr.2010.08.010.
  • Hoobehfekr S, Moghaddam HS, Shalbafan M, Hashemi MG, Pirmoradi MM, Sakenian A, Poopak A, Kashefinejad S, Yarahmadi M, Akhondzadeh S. 2021. Efficacy and safety of tipepidine as adjunctive therapy in major depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. Psychiatry Clin Neurosci. 75(2):57–62. doi: 10.1111/pcn.13180.
  • Hosea NA, Collard WT, Cole S, Maurer TS, Fang RX, Jones H, Kakar SM, Nakai Y, Smith BJ, Webster R, et al. 2009. Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches. J Clin Pharmacol. 49(5):513–533. doi: 10.1177/0091270009333209.
  • Imai Y, Ishii W, Endo A, Arakawa C, Kohira R, Fujita Y, Fuchigami T, Mugishima H. 2011. Tipepidine hibenzate intoxication. Pediatr Int. 53(5):779–781. doi: 10.1111/j.1442-200X.2010.03297.x.
  • Kawaura K, Ogata Y, Inoue M, Honda S, Soeda F, Shirasaki T, Takahama K. 2009. The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats. Behav Brain Res. 205(1):315–318. doi: 10.1016/j.bbr.2009.07.004.
  • Lobell M, Sivarajah V. 2003. In silico prediction of aqueous solubility, human plasma protein binding and volume of distribution of compounds from calculated pKa and AlogP98 values. Mol Divers. 7(1):69–87. doi: 10.1023/b:modi.0000006562.93049.36.
  • Lu C, Berg C, Prakash SR, Lee FW, Balani SK. 2008. Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation with fluconazole. Drug Metab Dispos. 36(7):1261–1266. doi: 10.1124/dmd.107.019000.
  • Maldonado R. 2013. Comparison of the pharmacokinetics and clinical efficacy of new extended-release formulations of methylphenidate. Expert Opin Drug Metab Toxicol. 9(8):1001–1014. doi: 10.1517/17425255.2013.786041.
  • Mao J, Mohutsky MA, Harrelson JP, Wrighton SA, Hall SD. 2012. Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions. Drug Metab Dispos. 40(4):706–716. doi: 10.1124/dmd.111.043158.
  • Miki R, Honda I, Hamasaki R, Kawahara R, Soeda F, Shirasaki T, Misumi S, Takahama K. 2019. Effects of tipepidine on MK-801-induced cognitive impairment in mice. Brain Res. 1710:230–236. doi: 10.1016/j.brainres.2018.12.032.
  • Nakamura T, Toshimoto K, Lee W, Imamura CK, Tanigawara Y, Sugiyama Y. 2018. Application of PBPK modeling and virtual clinical study approaches to predict the outcomes of CYP2D6 genotype-guided dosing of tamoxifen. CPT Pharmacometrics Syst Pharmacol. 7(7):474–482. doi: 10.1002/psp4.12307.
  • PMDA 2023. Asverin interview form https://www.info.pmda.go.jp/go/interview/2/430920_2249003B1037_2_010_1F.pdf.
  • Pope LE, Khalil MH, Berg JE, Stiles M, Yakatan GJ, Sellers EM. 2004. Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers. J Clin Pharmacol. 44(10):1132–1142. doi: 10.1177/0091270004269521.
  • Saito T, Yamashita Y, Tomoda A, Okada T, Umeuchi H, Iwamori S, Shinoda S, Mizuno-Yasuhira A, Urano H, Nishino I, et al. 2020. Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder. BMC Psychiatry. 20(1):530. doi: 10.1186/s12888-020-02932-2.
  • Sasaki T, Hashimoto K, Tachibana M, Kurata T, Okawada K, Ishikawa M, Kimura H, Komatsu H, Ishikawa M, Hasegawa T, et al. 2014a. Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study. Neuropsychiatr Dis Treat. 10:147–151. doi: 10.2147/NDT.S58480.
  • Sasaki T, Hashimoto K, Tachibana M, Kurata T, Kimura H, Komatsu H, Ishikawa M, Hasegawa T, Shiina A, Hashimoto T, et al. 2014b. Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study. Neuropsychiatr Dis Treat. 10:719–722. doi: 10.2147/NDT.S63075.
  • Soeda F, Fujieda Y, Kinoshita M, Shirasaki T, Takahama K. 2016. Centrally acting non-narcotic antitussives prevent hyperactivity in mice: involvement of GIRK channels. Pharmacol Biochem Behav. 144:26–32. doi: 10.1016/j.pbb.2016.02.006.
  • Sychterz C, Gardner I, Chiang M, Rachumallu R, Neuhoff S, Perera V, Merali S, Schmidt BJ, Gaohua L. 2022. Performance verification of CYP2C19 enzyme abundance polymorphism settings within the Simcyp Simulator v21. Metabolites. 12(10):1001. doi: 10.3390/metabo12101001.
  • Uchaipichat V, Winner LK, Mackenzie PI, Elliot DJ, Williams JA, Miners JO. 2006. Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation. Br J Clin Pharmacol. 61(4):427–439. doi: 10.1111/j.1365-2125.2006.02588.x.
  • VandenBrink BM, Foti RS, Rock DA, Wienkers LC, Wahlstrom JL. 2012. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 40(1):47–53. doi: 10.1124/dmd.111.041210.
  • Yoon DY, Lee S, Jang IJ, Kim M, Lee H, Kim S, Kim B, Song GS, Rhee SJ. 2021. Prediction of drug-drug interaction potential of tegoprazan using physiologically based pharmacokinetic modeling and simulation. Pharmaceutics. 13(9):1489. doi: 10.3390/pharmaceutics13091489.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.