Are you thinking what I’m thinking? Defining what we mean by “polysubstance use.”

References

• Gladden RM, O’Donnell J, Mattson CL, Seth P. Changes in opioid-involved overdose deaths by opioid type and presence of benzodiazepines, cocaine, and methamphetamine — 25 States, July–December 2017 to January–June 2018. MMWR Morb Mortal Wkly Rep [Internet]. 2019;68:737–44. doi:10.15585/mmwr.mm6834a2.
   PubMed Web of Science ®Google Scholar
• Liu S, O’Donnell J, Gladden RM, McGlone L, Chowdhury F. Trends in Nonfatal and fatal overdoses involving benzodiazepines — 38 States and the District of Columbia, 2019–2020. MMWR Morb Mortal Wkly Rep [Internet]. 2021;70:1136–41. doi:10.15585/mmwr.mm7034a2.
   PubMed Web of Science ®Google Scholar
• Liu S, Scholl L, Hoots B, Seth P. Nonfatal drug and polydrug overdoses treated in emergency departments — 29 States, 2018–2019. MMWR Morb Mortal Wkly Rep [Internet]. 2020;69:1149–55. doi:10.15585/mmwr.mm6934a1.
   PubMed Web of Science ®Google Scholar
• Bunting AM, Oser C, Staton M, Knudsen H. Polysubstance use patterns among justice-involved individuals who use opioids. Subst Use Misuse. 2020;55:2165–74. doi:10.1080/10826084.2020.1795683.
   PubMed Web of Science ®Google Scholar
• Karamouzian M, Pilarinos A, Hayashi K, Buxton JA, Kerr T. Latent patterns of polysubstance use among people who use opioids: a systematic review. Int J Drug Policy. 2022;102:103584. doi:10.1016/j.drugpo.2022.103584.
   PubMed Web of Science ®Google Scholar
• Palis H, Gan W, Xavier C, Desai R, Scow M, Sedgemore KO, Greiner L, Nicholls T, Slaunwhite A. Association of opioid and stimulant use disorder diagnoses with fatal and nonfatal overdose among people with a history of incarceration. JAMA Netw Open. 2022 5:e2243653. doi:10.1001/jamanetworkopen.2022.43653.
   PubMed Web of Science ®Google Scholar
• Winkelman TNA, Chang VW, Binswanger IA. Health, polysubstance use, and criminal justice involvement among adults with varying levels of opioid use. JAMA Netw Open. 2018 1:e180558–e180558. doi:10.1001/jamanetworkopen.2018.0558.
   PubMed Web of Science ®Google Scholar
• Shearer RD, Howell BA, Bart G, Winkelman TNA. Substance use patterns and health profiles among US adults who use opioids, methamphetamine, or both, 2015-2018. Drug Alcohol Depend. 2020 214:108162. doi:10.1016/j.drugalcdep.2020.108162.
   PubMed Web of Science ®Google Scholar
• McCabe SE, Arterberry BJ, Dickinson K, Evans-Polce RJ, Ford JA, Ryan JE, Schepis TS. Assessment of changes in alcohol and marijuana abstinence, co-use, and use disorders among US young adults from 2002 to 2018. JAMA Pediatr. 2021 175:64–72. doi:10.1001/jamapediatrics.2020.3352.
   PubMed Web of Science ®Google Scholar
• Terry-McElrath YM, Patrick ME. Simultaneous Alcohol and marijuana use among young adult drinkers: age-specific changes in prevalence from 1977 to 2016. Alcohol Clin Exp Res. 2018 Nov;42:2224–33. doi:10.1111/acer.13879.
   PubMed Web of Science ®Google Scholar
• Linden-Carmichael AN, Van Doren N, Masters LD, Lanza ST. Simultaneous alcohol and marijuana use in daily life: implications for level of use, subjective intoxication, and positive and negative consequences. Psychol Addict Behav J Soc Psychol Addict Behav. 2020 May;34:447–53. doi:10.1037/adb0000556.
   PubMed Web of Science ®Google Scholar
• Lipperman-Kreda S, Gruenewald PJ, Grube JW, Bersamin M. Adolescents, alcohol, and marijuana: context characteristics and problems associated with simultaneous use. Drug Alcohol Depend. 2017 179:55–60. doi:10.1016/j.drugalcdep.2017.06.023.
   PubMed Web of Science ®Google Scholar
• Lee CM, Calhoun BH, Abdallah DA, Blayney JA, Schultz NR, Brunner M, Patrick ME. Simultaneous alcohol and marijuana use among young adults: a scoping review of prevalence, patterns, psychosocial correlates, and consequences. Alcohol Res Curr Rev. 2022;42:08. doi:10.35946/arcr.v42.1.08
   Web of Science ®Google Scholar
• RFA-DA-23-015. Transformative research on the basic mechanisms of polysubstance use in addiction (R01 - clinical trial not allowed) [Internet]. [accessed 2023 Feb 15]. https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-23-015.html.
   Google Scholar
• RFA-DA-22-048. HEAL Initiative: pilot and feasibility trials to improve prevention and treatment service delivery for polysubstance use (R34 clinical trial optional) [Internet]. [accessed 2023 Feb 15]. https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-22-048.html.
   Google Scholar
• Gunn R, Jackson K, Borsari B, Metrik J. A longitudinal examination of daily patterns of cannabis and alcohol co-use among medicinal and recreational veteran cannabis users. Drug Alcohol Depend. 2019 205:107661. doi:10.1016/j.drugalcdep.2019.107661.
   PubMed Web of Science ®Google Scholar
• Linden-Carmichael AN, Allen HK, Masters LD, Ansell EB, Lanza ST. Age-varying trends in alcohol and cannabis co-occurring use: implications for prescription drug misuse. Am J Drug Alcohol Abuse. 2021;47:209–19. doi:10.1080/00952990.2020.1831003.
   PubMed Web of Science ®Google Scholar
• Linden-Carmichael AN, Stamates AL, Lau-Barraco C. Simultaneous use of alcohol and marijuana: patterns and individual differences. Subst Use Misuse. 2019 54:2156–66. doi:10.1080/10826084.2019.1638407.
   PubMed Web of Science ®Google Scholar
• Subbaraman MS, Kerr WC. Simultaneous versus concurrent use of alcohol and cannabis in the national alcohol survey. Alcohol Clin Exp Res. 2015;39:872–79. doi:10.1111/acer.12698.
   PubMed Web of Science ®Google Scholar
• Warfield SC, Bharat C, Bossarte RM, DePhilippis D, Farrell M, Hoover M, Larney S, Marshalek P, McKetin R, Degenhardt L. Trends in comorbid opioid and stimulant use disorders among veterans receiving care from the veterans health administration, 2005–2019. Drug Alcohol Depend. 2022 232:109310. doi:10.1016/j.drugalcdep.2022.109310.
   PubMed Web of Science ®Google Scholar
• Lorvick J, Browne EN, Lambdin BH, Comfort M. Polydrug use patterns, risk behavior and unmet healthcare need in a community-based sample of women who use cocaine, heroin or methamphetamine. Addict Behav. 2018 85:94–99. doi:10.1016/j.addbeh.2018.05.013.
   PubMed Web of Science ®Google Scholar
• Stockwell T. A cross-cutting research agenda on alcohol, tobacco and other drugs: where to start? Addiction. 2007;102:1191–92.
   PubMed Web of Science ®Google Scholar
• John WS, Zhu H, Mannelli P, Subramaniam GA, Schwartz RP, McNeely J, Wu L-T. Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco. Drug Alcohol Depend. 2019 194:468–75. doi:10.1016/j.drugalcdep.2018.11.011.
   PubMed Web of Science ®Google Scholar
• McCabe SE, West BT, Veliz P, Boyd CJ. E-cigarette use, cigarette smoking, dual use, and problem behaviors among U.S. adolescents: results from a national survey. J Adolesc Health. 2017 61:155–62. doi:10.1016/j.jadohealth.2017.02.004.
   PubMed Web of Science ®Google Scholar
• Schauer GL, Rosenberry ZR, Peters EN. Marijuana and tobacco co-administration in blunts, spliffs, and mulled cigarettes: a systematic literature review. Addict Behav. 2017 64:200–11. doi:10.1016/j.addbeh.2016.09.001.
   PubMed Web of Science ®Google Scholar
• Key substance use and mental health indicators in the United States: results from the 2020 national survey on drug use and health. 2021.
   Google Scholar
• Treatment Episode Data Set (TEDS): 2019. Admissions to and discharges from publicly funded substance use treatment. Rockville (MD): Substance Abuse and Mental Health Services Administration; 2021.
   Google Scholar
• Bhalla IP, Stefanovics EA, Rosenheck RA. Clinical epidemiology of single versus multiple substance use disorders: polysubstance use disorder. Med Care. 2017 Sep;55:S24. doi:10.1097/MLR.0000000000000731.
   PubMed Web of Science ®Google Scholar
• Fitzgerald ND, Liu Y, Wang A, Striley CW, Setlow B, Knackstedt L, Cottler LB. Test-retest reliability of a new assessment to detect detailed temporal patterns of polysubstance use. Int J Methods Psychiatr Res. 2022 Sep;31:e1912. doi:10.1002/mpr.1912.
   PubMed Web of Science ®Google Scholar
• Pan Y, Feaster DJ, Odom G, Brandt L, Hu MC, Weiss RD, Rotrosen J, Saxon AJ, Luo SX, Balise RR. Specific polysubstance use patterns predict relapse among patients entering opioid use disorder treatment. Drug Alcohol Depend Rep. 2022 5:100128. doi:10.1016/j.dadr.2022.100128.
   PubMedGoogle Scholar
• Korthuis PT, Cook RR, Foot CA, Leichtling G, Tsui JI, Stopka TJ, Leahy J, Jenkins WD, Baker R, Chan B, et al. Association of methamphetamine and opioid use with nonfatal overdose in rural communities. JAMA Netw Open. 2022;5:e2226544. doi:10.1001/jamanetworkopen.2022.26544
   PubMed Web of Science ®Google Scholar
• Jarlenski M, Barry CL, Gollust S, Graves AJ, Kennedy-Hendricks A, Kozhimannil K. Polysubstance use among US women of reproductive age who use opioids for nonmedical reasons. Am J Public Health. 2017 107:1308–10. doi:10.2105/AJPH.2017.303825.
   PubMed Web of Science ®Google Scholar
• Meacham MC, Rudolph AE, Strathdee SA, Rusch ML, Brouwer KC, Patterson TL, Vera A, Rangel G, Roesch SC. Polydrug use and HIV risk among people who Inject heroin in Tijuana, Mexico: a latent class analysis. Subst Use Misuse. 2015;50:1351–59. doi:10.3109/10826084.2015.1013132.
   PubMed Web of Science ®Google Scholar
• Kuo I, Golin CE, Wang J, Haley DF, Hughes J, Mannheimer S, Justman J, Rompalo A, Frew PM, Adimora AA, Soto-Torres L. Substance use patterns and factors associated with changes over time in a cohort of heterosexual women at risk for HIV acquisition in the United States. Drug Alcohol Depend. 2014 139:93–99. doi:10.1016/j.drugalcdep.2014.03.007.
   PubMed Web of Science ®Google Scholar
• McCabe SE, Engstrom CW, Kcomt L, Evans-Polce R, West BT. Trends in binge drinking, marijuana use, illicit drug use, and polysubstance use by sexual identity in the United States (2006-2017). Subst Abuse. 2022;43:194–203. doi:10.1080/08897077.2021.1913696.
   PubMed Web of Science ®Google Scholar
• Bobashev G, Tebbe K, Peiper N, Hoffer L. Polydrug use among heroin users in Cleveland, OH. Drug Alcohol Depend. 2018 192:80–87. doi:10.1016/j.drugalcdep.2018.06.039.
   PubMed Web of Science ®Google Scholar
• Mccabe SE, Cranford JA, Morales M, Young A. Simultaneous and concurrent polydrug use of alcohol and prescription drugs: prevalence, correlates, and consequences. J Stud Alcohol. 2006 Jul;67:529–37. doi:10.15288/jsa.2006.67.529.
   PubMed Web of Science ®Google Scholar
• Midanik LT, Tam TW, Weisner C. Concurrent and simultaneous drug and alcohol use: results of the 2000 national alcohol survey. Drug Alcohol Depend. 2007 90:72–80. doi:10.1016/j.drugalcdep.2007.02.024.
   PubMed Web of Science ®Google Scholar
• Martin CS, Clifford PR, Maisto SA, Earleywine M, Kirisci L, Longabaugh R. Polydrug use in an inpatient treatment sample of problem drinkers. Alcohol Clin Exp Res. 1996;20:413–17. doi:10.1111/j.1530-0277.1996.tb01067.x.
   PubMed Web of Science ®Google Scholar
• Boileau-Falardeau M, Contreas G, Gariepy G, Laprise C Patterns and motivations of polysubstance use: a rapid review of the qualitative evidence. HPCDP Journal [Internet]. 2022 Feb 16 [accessed 2022 Mar 8]. https://www.canada.ca/en/public-health/services/reports-publications/health-promotion-chronic-disease-prevention-canada-research-policy-practice/vol-42-no-2-2022/patterns-motivations-polysubstance-use-rapid-review-qualitative-evidence.html.
   Google Scholar
• Cooper ML, Kuntsche E, Levitt A, Barber LL, Wolf S. Motivational models of substance use: a review of theory and research on motives for using alcohol, marijuana, and tobacco. In: Sher K, editor. The Oxford Handbook of substance use and substance use disorders: volume 1 [Internet]. Oxford University Press; 2016 [accessed 2022 Dec 2]. doi:10.1093/oxfordhb/9780199381678.013.017.
   Google Scholar
• Ciccarone D. The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis. Curr Opin Psychiatry. 2021 Jul;34:344–50. doi:10.1097/YCO.0000000000000717.
   PubMed Web of Science ®Google Scholar
• Palamar JJ, Ciccarone D, Rutherford C, Keyes KM, Carr TH, Cottler LB. Trends in seizures of powders and pills containing illicit fentanyl in the United States, 2018 through 2021. Drug Alcohol Depend. 2022 234:109398. doi:10.1016/j.drugalcdep.2022.109398.
   PubMed Web of Science ®Google Scholar
• O’Donnell J, Tanz LJ, Gladden RM, Davis NL, Bitting J. Trends in and characteristics of drug overdose deaths involving illicitly manufactured fentanyls — United States, 2019–2020. MMWR Morb Mortal Wkly Rep. 2021;70:1740–46. doi:10.15585/mmwr.mm7050e3.
   PubMed Web of Science ®Google Scholar
• Arya S, Nagappala S, Krawczyk N, Gu Y, Meacham MC, Bunting AM. Fentanyl in pressed oxycodone pills: a qualitative analysis of online community experiences with an emerging drug trend. Subst Use Misuse. 2022 Nov 10;57:1940–45. doi:10.1080/10826084.2022.2120365.
   PubMed Web of Science ®Google Scholar
• Duhart Clarke SE, Kral AH, Zibbell JE. Consuming illicit opioids during a drug overdose epidemic: illicit fentanyls, drug discernment, and the radical transformation of the illicit opioid market. Int J Drug Policy. 2022 Jan;99:103467. doi:10.1016/j.drugpo.2021.103467.
   PubMed Web of Science ®Google Scholar
• Brar R, Grant C, DeBeck K, Milloy MJ, Fairbairn N, Wood E, Kerr T, Hayashi K. Changes in drug use behaviors coinciding with the emergence of illicit fentanyl among people who use drugs in Vancouver, Canada. Am J Drug Alcohol Abuse. 2020 46:625–31. doi:10.1080/00952990.2020.1771721.
   PubMed Web of Science ®Google Scholar
• Maghsoudi N, Tanguay J, Scarfone K, Rammohan I, Ziegler C, Werb D, Scheim AI. Drug checking services for people who use drugs: a systematic review. Addict Abingdon Engl. 2022 Mar;117:532–44. doi:10.1111/add.15734.
   PubMed Web of Science ®Google Scholar
• Park JN, Urquhart G, Morris M, Dahal R, Rouhani S, Sherman SG. Discordance between self-reported and biologically tested exposure to fentanyl among people at risk of opioid overdose. J Addict Med. 2022;16:722–24. doi:10.1097/ADM.0000000000000969.
   PubMed Web of Science ®Google Scholar
• Daniulaityte R, Carlson RR, Juhascik MP, Strayer KE, Sizemore IE. Street fentanyl use: experiences, preferences, and concordance between self-reports and urine toxicology. Int J Drug Policy. 2019 Sep;71:3–9. doi:10.1016/j.drugpo.2019.05.020.
   PubMed Web of Science ®Google Scholar
• Sobell LC, MB S. Timeline follow-back: a technique for assessing self-reported alcohol consumption In: .Litten RZ, and JP Allen, editors. Measuring alcohol consumption: psychosocial and biological methods. Towota (NJ): Humana Press; 1992. p. 41–72. doi:10.1007/978-1-4612-0357-5_3.
   Google Scholar
• Shiffman S. Ecological Momentary Assessment (EMA) in studies of substance use. Psychol Assess. 2009 Dec;21:486–97. doi:10.1037/a0017074.
   PubMed Web of Science ®Google Scholar
• Hopper JW, Su Z, Looby AR, Ryan ET, Penetar DM, Palmer CM, Lukas SE. Incidence and patterns of polydrug use and craving for ecstasy in regular ecstasy users: an ecological momentary assessment study. Drug Alcohol Depend. 2006 Dec 1;85:221–35. doi:10.1016/j.drugalcdep.2006.04.012.
   PubMed Web of Science ®Google Scholar
• Sokolovsky AW, Gunn RL, Micalizzi L, White HR, Jackson KM. Alcohol and marijuana co-use: consequences, subjective intoxication, and the operationalization of simultaneous use. Drug Alcohol Depend. 2020 212:107986. doi:10.1016/j.drugalcdep.2020.107986.
   PubMed Web of Science ®Google Scholar
• Collins LM, Lanza ST. Latent class and latent transition analysis: with applications in the social, behavioral, and health sciences. John Wiley & Sons; 2009. 330 p. doi:10.1002/9780470567333.
   Google Scholar
• Quek LH, Chan GCK, White A, Connor JP, Baker PJ, Saunders JB, Kelly AB. Concurrent and Simultaneous Polydrug use: latent class analysis of an Australian nationally representative sample of young adults. Front Public Health [Internet]. 2013 Nov 28;1. [accessed 2018 Dec 13].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860005/
   PubMedGoogle Scholar
• Lanza ST, Sokolovsky AW, Linden-Carmichael AN, White HR, Jackson KM. Understanding heterogeneity among simultaneous alcohol and marijuana users: latent classes derived from daily diary data. J Stud Alcohol Drugs. 2022 May;83:358–63. doi:10.15288/jsad.2022.83.358.
   PubMed Web of Science ®Google Scholar
• Linden-Carmichael AN, Van Doren N, Bray BC, Jackson KM, Lanza ST. Stress and Affect as daily risk factors for substance use patterns: an application of latent class analysis for daily diary data. Prev Sci [Internet]. 2021 23:598–607. doi:10.1007/s11121-021-01305-9.
   PubMed Web of Science ®Google Scholar