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Original Article

GxE interaction effects of HCRTR2 single nucleotide polymorphism and adverse childhood experiences on methamphetamine use disorder

, , , &
Pages 84-94 | Received 13 Sep 2023, Accepted 18 Dec 2023, Published online: 31 Jan 2024

References

  • UNODC. Drug market trends of cocain, amphetamine-type stimulants and new pyschoactive substances. Vienna, Austria: United Nations publication; 2022.
  • Paulus MP, Neurobiology SJ. Clinical presentation, and treatment of methamphetamine use disorder: a review. JAMA Psychiarty. 2020;77:959–66. doi:10.1001/jamapsychiatry.2020.0246.
  • Lee W-C, Chang H-M, Huang M-C, Pan C-H, Su S-S, Tsai S-Y, Chen C-C, Kuo C-J. All-cause and suicide mortality among people with methamphetamine use disorder: a nation-wide cohort study in Taiwan. Addiction. 2021;116:3127–38. doi:10.1111/add.15501.
  • Chen Y-H, Chen M-H, Wei H-T, Chen L-Y. Survey of substance use among adolescent drug offenders referred from juvenile courts in Taiwan: clinical epidemiology of single versus multiple illicit substance use. J Formos Med Assoc. 2022;121:2257–64. doi:10.1016/j.jfma.2022.04.009.
  • Lin C-C, Weng T-I, Ng C-J, Shih C-P, Hsu J, Liao Y-C, Yang C-C, Fang C-C. Emergency department visits due to new psychoactive substances and other illicit drugs in Taiwan: preliminary results of the Taiwan emergency department drug abuse surveillance (TEDAS) project. Clinical Toxicology. 2022;60:708–15. doi:10.1080/15563650.2022.2038793.
  • de Lecea L, Kilduff TS, Peyron C, Gao X-B, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett F, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci. 1998;95:322–27. doi:10.1073/pnas.95.1.322.
  • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573–85. doi:10.1016/S0092-8674(00)80949-6.
  • Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 1998;18:9996–10015. doi:10.1523/jneurosci.18-23-09996.1998.
  • Sutcliffe JG, de Lecea L. The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. J Neurosci Res. 2000;62:161–68. doi:10.1002/1097-4547(20001015)62:2<161:AID-JNR1>3.0.CO;2-1.
  • Harris GC, Wimmer M, Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature. 2005;437:556–9. doi:10.1038/nature04071.
  • Aston-Jones G, Smith RJ, Sartor GC, Moorman DE, Massi L, Tahsili-Fahadan P, Richardson KA. Lateral hypothalamic orexin/hypocretin neurons: a role in reward-seeking and addiction. Brain Res. 2010;1314:74–90. doi:10.1016/j.brainres.2009.09.106.
  • Koob GF. A role for brain stress systems in addiction. Neuron. 2008;59:11–34. doi:10.1016/j.neuron.2008.06.012. PubMed PMID: 18614026; PubMed Central PMCID: PMC2748830.
  • Sharf R, Sarhan M, Dileone RJ. Role of orexin/hypocretin in dependence and addiction. Brain Res. 2010;1314:130–8. doi:10.1016/j.brainres.2009.08.028. PubMed PMID: 19699189; PubMed Central PMCID: PMC2819591.
  • Giardino WJ, de Lecea L. Hypocretin (orexin) neuromodulation of stress and reward pathways. Curr Opin Neurobiol. 2014;29:103–8. doi:10.1016/j.conb.2014.07.006.
  • Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield Jr TW, et al. Addiction as a stress surfeit disorder. Neuropharmacology. 2014;76:370–82. doi:10.1016/j.neuropharm.2013.05.024. PubMed PMID: 23747571; PubMed Central PMCID: PMC3830720.
  • Herrera DG, Robertson HA. Activation of c-fos in the brain. Prog Neurobiol. 1996;50:83–107. doi:10.1016/S0301-0082(96)00021-4.
  • Estabrooke IV, McCarthy MT, Ko E, Chou TC, Chemelli RM, Yanagisawa M, Saper CB, Scammell TE. Fos expression in orexin neurons varies with behavioral state. J Neurosci. 2001;21:1656–62. doi:10.1523/jneurosci.21-05-01656.2001. PubMed PMID: 11222656; PubMed Central PMCID: PMC6762959.
  • Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B. The orexin system regulates alcohol-seeking in rats. Br J Pharmacol. 2006;148:752–9. doi:10.1038/sj.bjp.0706789. PubMed PMID: 16751790; PubMed Central PMCID: PMC1617074.
  • Hollander JA, Lu Q, Cameron MD, Kamenecka TM, Kenny PJ. Insular hypocretin transmission regulates nicotine reward. Proc Natl Acad Sci. 2008;105:19480–85. doi:10.1073/pnas.0808023105.
  • Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci. 2005;102:19168–73. doi:10.1073/pnas.0507480102.
  • Zlebnik NE, Holtz NA, Lepak VC, Saykao AT, Zhang Y, Carroll ME. Age-specific treatment effects of orexin/hypocretin-receptor antagonism on methamphetamine-seeking behavior. Drug Alcohol Depen. 2021;224:108719. doi:10.1016/j.drugalcdep.2021.108719.
  • Khosrowabadi E, Karimi-Haghighi S, Jamali S, Haghparast A. Differential roles of intra-accumbal orexin receptors in acquisition and expression of methamphetamine-induced conditioned place preference in the rats. Neurochem Res. 2020;45:2230–41. doi:10.1007/s11064-020-03084-1.
  • Majidinezhad M, Amirteymouri H, Karimi-Haghighi S, Kourosh-Arami M, Haghparast A. Orexin system in the ventral tegmental area is implicated in the rewarding properties of methamphetamine. Eur J Pharmacol. 2022;930:175170. doi:10.1016/j.ejphar.2022.175170.
  • Amirteymori H, Karimi-Haghighi S, Mirmohammadi M, Majidinezhad M, Khosrowabadi E, Haghparast A. Hypocretin/Orexin system in the nucleus accumbens as a promising player in the extinction and reinstatement of methamphetamine-induced CPP. Prog Neuropsychopharmacol Biol Psychiatry. 2023;120:110616. doi:10.1016/j.pnpbp.2022.110616.
  • Amirteymori H, Veisi A, Khaleghzadeh-Ahangar H, Mozafari R, Haghparast A. Involvement of orexin-2 receptors in the CA1 region of the hippocampus in the extinction and reinstatement of methamphetamine-induced conditioned place preference in the rats. Peptides. 2023;160:170926. doi:10.1016/j.peptides.2022.170926.
  • Nazari-Serenjeh F, Azizbeigi R, Rashvand M, Mesgar S, Amirteymori H, Haghparast A. Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats. Life Sci. 2023;312:121262. doi:10.1016/j.lfs.2022.121262.
  • Chen W-Y, Kao C-F, Chen P-Y, Lin S-K, Huang M-C. Orexin-a level elevation in recently abstinent male methamphetamine abusers. Psychiatry Res. 2016;239:9–11. doi:10.1016/j.psychres.2016.02.059.
  • Pulver A, Kiive E, Kanarik M, Harro J. Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender. Brain Res. 2020;1746:147013. doi:10.1016/j.brainres.2020.147013.
  • Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, et al. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Mol Brain. 2015;8:50.
  • Enoch M-A. The influence of gene–environment interactions on the development of alcoholism and drug dependence. Curr Psychiatry Rep. 2012;14:150–8. doi:10.1007/s11920-011-0252-9.
  • Dube SR, Felitti VJ, Dong M, Chapman DP, Giles WH, Anda RF. Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: the adverse childhood experiences study. Pediatrics. 2003;111:564–72. doi:10.1542/peds.111.3.564.
  • Ding Y, Lin H, Zhou L, Yan H, He N. Adverse childhood experiences and interaction with methamphetamine use frequency in the risk of methamphetamine-associated psychosis. Drug Alcohol Depen. 2014;142:295–300. doi:10.1016/j.drugalcdep.2014.06.042.
  • Forster M, Grigsby TJ, Rogers CJ, Benjamin SM. The relationship between family-based adverse childhood experiences and substance use behaviors among a diverse sample of college students. Addict Behav. 2018;76:298–304. doi:10.1016/j.addbeh.2017.08.037.
  • Leza L, Siria S, López-Goñi JJ, Fernández-Montalvo J. Adverse childhood experiences (ACEs) and substance use disorder (SUD): a scoping review. Drug Alcohol Depen. 2021;221:108563. doi:10.1016/j.drugalcdep.2021.108563.
  • Lee W-C, Fang S-C, Chen Y-Y, Liu H-C, Huang M-C, McKetin R. Exploring the mediating role of methamphetamine use in the relationship between adverse childhood experiences and attempted suicide. Addict Behav. 2021;123:107060. doi:10.1016/j.addbeh.2021.107060.
  • Pasman JA, Verweij KJH, Abdellaoui A, Hottenga JJ, Fedko IO, Willemsen G, Boomsma DI, Vink JM. Substance use: interplay between polygenic risk and neighborhood environment. Drug Alcohol Depen. 2020;209:107948.
  • Mishra AA, Marceau K, Christ SL, Schwab Reese LM, Taylor ZE, Knopik VS. Multi-type childhood maltreatment exposure and substance use development from adolescence to early adulthood: a GxE study. Child Abuse Neglect. 2022;126:105508. doi:10.1016/j.chiabu.2022.105508.
  • Hikida T, Morita M, Kuroiwa M, Macpherson T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A. Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neurosci Res. 2020;151:38–45.
  • Chen WJ, Liu SK, Chang C-J, Lien Y-J, Chang Y-H, Hwu H-G. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am J Psychiatry. 1998;155:1214–20. doi:10.1176/ajp.155.9.1214. PubMed PMID: 9734545.
  • Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study. American Journal Of Preventive Medicine. 1998;14:245–58. doi:10.1016/S0749-3797(98)00017-8.
  • Rainero I, Rubino E, Valfrè W, Gallone S, De Martino P, Zampella E, Pinessi L. Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis. J Headache Pain. 2007;8:152–6. doi:10.1007/s10194-007-0383-x.
  • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol. 1995;57:289–300. doi:10.1111/j.2517-6161.1995.tb02031.x.
  • Schürks M, Kurth T, Geissler I, Tessmann G, Diener HC, Rosskopf D. Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. Neurology. 2006;66:1917–19. doi:10.1212/01.wnl.0000215852.35329.34. PubMed PMID: 16554494.
  • Annerbrink K, Westberg L, Olsson M, Andersch S, Sjödin I, Holm G, Allgulander C, Eriksson E. Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene. Psychiatric Genetics. 2011;21:85–89. doi: 10.1097/YPG.0b013e328341a3db. PubMed PMID: 00041444-201104000-00004.
  • Firouzabadi N, Navabzadeh N, Moghimi-Sarani E, Haghnegahdar M. Orexin/Hypocretin type 2 receptor (HCRTR2) gene as a candidate gene in sertraline-associated insomnia in depressed patients. Neuropsychiatr Dis Treat. 2020;16:1121–8. doi:10.2147/ndt.S250141. PubMed PMID: 32440126; PubMed Central PMCID: PMC7210038.
  • Rainero I, Gallone S, Rubino E, Ponzo P, Valfre W, Binello E, Fenoglio P, Gentile S, Anoaica M, Gasparini M, et al. Haplotype analysis confirms the association between the HCRTR2 gene and cluster headache. Headache. 2008;48:1108–14. doi:10.1111/j.1526-4610.2008.01080.x.
  • Briggs EC, Amaya-Jackson L, Putnam KT, Putnam FW. All adverse childhood experiences are not equal: the contribution of synergy to adverse childhood experience scores. Am Psychol. 2021;76:243–52. doi:10.1037/amp0000768. PubMed PMID: 33734792.
  • Huang M-C, Schwandt ML, Ramchandani VA, George DT, Heilig M. Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients. Alcohol. 2012;36:1099–107. doi:10.1111/j.1530-0277.2011.01695.x.
  • Hughes K, Bellis MA, Hardcastle KA, Sethi D, Butchart A, Mikton C, Jones L, Dunne MP. The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. The Lancet Public Health. 2017;2:e356–66. doi:10.1016/S2468-2667(17)30118-4.
  • Tang S, Jones CM, Wisdom A, Lin H-C, Bacon S, Houry D. Adverse childhood experiences and stimulant use disorders among adults in the United States. Psychiatry Res. 2021;299:113870. doi:10.1016/j.psychres.2021.113870.
  • Wang B, You Z-B, Wise RA. Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network. Biol Psychiatry. 2009;65:857–62. doi:10.1016/j.biopsych.2009.01.018.
  • Tung L-W, Lu G-L, Lee Y-H, Yu L, Lee H-J, Leishman E, Bradshaw H, Hwang L-L, Hung M-S, Mackie K, et al. Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. Nat Commun. 2016;7:12199.
  • Nishino S. Chapter 47 - hypothalamus, hypocretins/orexin, and vigilance control. In: Montagna P, and S Chokroverty, editors. Handbook of clinical neurology. Vol. 99. Amsterdam, Netherlands: Elsevier; 2011. p. 765–82.
  • Schmeichel BE, Herman MA, Roberto M, Koob GF. Hypocretin neurotransmission within the central amygdala mediates escalated cocaine self-administration and stress-induced reinstatement in rats. Biol Psychiatry. 2017;81:606–15. doi:10.1016/j.biopsych.2016.06.010.

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