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Review

Hepatic Neutrophil Infiltration in the Pathogenesis of Alcohol-Induced Liver Injury

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Pages 431-440 | Received 10 Mar 2007, Accepted 14 Apr 2007, Published online: 09 Oct 2008

REFERENCES

  • Afford S. C., Fisher N. C., Neil D. A., Fear J., Brun P., Hubscher S. G., Adams D. H. Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis. J Pathol. 1998; 186: 82–89
  • Apte U. M., Banerjee A., McRee R., Wellberg E., Ramaiah S. K. Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis. Toxicol. Appl. Pharmacol. 2005; 207: 25–38
  • Bajt M. L., Farhood A., Jaeschke H. Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature. Am. J. Physiol. Gastrointest. Liver Physiol. 2001; 281: G1188–G1195
  • Banerjee A., Apte U., Smith R., Ramaiah S. Higher neutrophil infiltration mediated by osteopontin is the likely factor for increased susceptibility of females to alcoholic liver disease. J. Pathol. 2006a; 208: 473–485
  • Banerjee A., Burghardt R. C., Johnson G. A., White F. J., Ramaiah S. K. The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: a potential biomarker. Toxicol. Pathol. 2006b; 34: 373–384
  • Bautista A. P. Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver. Hepatology 1997; 25: 335–342
  • Bautista A. P. Impact of alcohol on the ability of Kupffer cells to produce chemokines and its role in alcoholic liver disease. J. Gastroenterol. Hepatol. 2000; 15: 349–356
  • Bautista A. P. Neutrophilic infiltration in alcoholic hepatitis. Alcohol 2002; 27: 17–21
  • Bautista A. P., Spitzer J. J. Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion. Free Radic. Res. Commun. 1992; 17: 195–209
  • Bilzer M., Lauterburg B. H. Effects of hypochlorous acid and chloramines on vascular resistance, cell integrity, and biliary glutathione disulfide in the perfused rat liver: modulation by glutathione. J. Hepatol. 1991; 13: 84–89
  • Bode C., Bode J. C. Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol?. Alcohol Clin. Exp. Res. 2005; 29(Suppl)166S–171S
  • Casey C. A., Nanji A., Cederbaum A. I., Adachi M., Takahashi T. Alcoholic liver disease and apoptosis. Alcohol Clin. Exp. Res. 2001; 25: 49S–53S
  • Chosay J. G., Essani N. A., Dunn C. J., Jaeschke H. Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury. Am. J. Physiol. 1997; 272: G1195–G1200
  • Christensen E., Gluud C. Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables. Gut 1995; 37: 113–118
  • Colletti L. M., Kunkel S. L., Walz A., Burdick M. D., Kunkel R. G., Wilke C. A., Strieter R. M. The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology 1996; 23: 506–514
  • Day C. P., James O. F. Hepatic steatosis: innocent bystander or guilty party?. Hepatology 1998; 27: 1463–1466
  • Denhardt D., Giachelli C. M., Rittling S. R. Role of osteopontin in cellular signaling and toxicant injury. Ann. Rev. Pharmacol. Toxicol. 2001; 41: 723–749
  • Diehl A. M. Liver disease in alcohol abusers: clinical perspective. Alcohol 2002; 27: 7–11
  • Enomoto N., Yamashita S., Kono H., Schemmer P., Rivera C. A., Enomoto A., Nishiura T., Nishimura T., Brenner D. A., Thurman R. G. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Hepatology 1999; 29: 1680–1689
  • Essani N. A., Fisher M. A., Farhood A., Manning A. M., Smith C. W., Jaeschke H. Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role on the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 1995; 21: 1632–1639
  • Essani N. A., Fisher M. A., Simmons C. A., Hoover J. L., Farhood A., Jaeschke H. Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J. Leukoc. Biol. 1998; 63: 288–296
  • Faouzi S., Burckhardt B. E., Hanson J. C., Campe C. B., Schrum L. W., Rippe R. A., Maher J. J. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J. Biol. Chem. 2001; 276: 49077–49082
  • Francki A., Sage E. H. SPARC and the kidney glomerulus: matricellular proteins exhibit diverse functions under normal and pathological conditions. Trends Cardiovasc. Med. 2001; 11: 32–37
  • French S. W. Alcoholic hepatitis: inflammatory cell-mediated hepatocellular injury. Alcohol 2002; 27: 43–46
  • Galambos J. T. Natural history of alcoholic hepatitis. Histological changes. Gastroenterology 1972; 63: 1026–1035
  • Gujral J. S., Farhood A., Bajt M. L., Jaeschke H. Neutrophils aggravate acute liver injury during obstructive choleostasis in bile-duct ligated mice. Hepatology 2003; 38: 355–363
  • Gujral J. S., Hinson J. A., Farhood A., Jaeschke H. NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia. Am. J. Physiol. Gastrointest. Liver Physiol. 2004; 287: G234–G252
  • Hill D. A., Jean P. A., Roth R. A. Bile duct epithelial cells exposed to α-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro. Toxicol. Sci. 1999; 47: 118–125
  • Ho J. S., Buchweitz J. P., Roth R. A., Ganey P. E. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes. J. Leukoc. Biol. 1996; 59: 716–724
  • Horie Y., Kato S., Ohki E., Tamai H., Yamagishi Y., Ishii H. Hepatic microvascular dysfunction in endotoxemic rats after acute ethanol administration. Alcoholism Clin. Exper. Res. 2000; 24: 691–698
  • Iimuro Y., Frankenberg M. V., Arteel G. E., Bradford B. U., Wall C. A., Thurman R. G. Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males. Am. J. Physiol. Gastrointest. Liver Physiol. 1997; 272: G1186–G1194
  • Ito Y., Abril E. R., Bethea N. W., McCuskey M. K., Cover C., Jaeschke H., McCuskey R. S. Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2006; 291: G211–G218
  • Jaeschke H. Cellular adhesion molecules: regulation and functional significance in the pathogenesis of liver diseases. Am. J. Physiol. 1997; 273: G602–G611
  • Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury. J. Gastroenterol. Hepatol. 2000; 15: 718–724
  • Jaeschke H. Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol 2002; 27: 23–27
  • Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am. J. Physiol. Gastrointest. Liver Physiol. 2003; 284: G15–G26
  • Jaeschke H., Farhood A., Bautista A. P., Spolarics Z., Spitzer J. J. Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am. J. Physiol. 1993; 264: G801–G809
  • Jaeschke H., Farhood A., Smith C. W. Neutrophils contribute to ischemia-reperfusion injury in rat liver in vivo. FASEB J. 1990; 4: 3355–3359
  • Jaeschke H., Farhood A., Smith C. W. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am. J. Physiol. 1991; 261: G1051–G1056
  • Jaeschke H., Fisher M. A., Lawson J. A., Simmons C. A., Farhood A., Jones D. A. Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil mediated necrosis in a murine endotoxin shock model. J. Immunol. 1998; 160: 3480–3486
  • Jaeschke H., Hasegawa T. Role of neutrophils in acute inflammatory liver injury. Liver Int. 2006; 26: 912–919
  • Jaeschke H., Ho Y. S., Fisher M. A., Lawson J. A., Farhood A. Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress. Hepatology 1999; 29: 443–450
  • Jaeschke H., Smith C. W. Mechanisms of neutrophil-induced parenchymal cell injury. J. Leukoc. Biol. 1997; 61: 647–653
  • Janeway C. A., Medhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20: 197–216
  • Karaa A., Kamoun W. S., Clemens M. G. Chronic ethanol sensitizes the liver to endotoxin via effects on endothelial nitric oxide synthase regulation. Shock 2005; 24: 447–454
  • Kawashima R., Mochida S., Matsui A., YouLuTuZ Y., Ishikawa K., Toshima K., Yamanobe F., Inao M., Ikeda H., Ohno A., Nagoshi S., Uede T., Fujiwara K. Expression of osteopontin in Kupffer cells and hepatic macrophages and stellate cells in rat liver after carbon tetrachloride intoxication: a possible factor for macrophage migration into hepatic necrotic areas. Bichem. Biophys. Res. Commun. 1999; 256: 527–531
  • Kim T. H., Mars W. M., Stolz D. B., Petersen B. E., Michalopoulos G. K. Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Hepatology 1997; 26: 896–904
  • Kono H., Uesugi T., Froh M., Rusyn I., Blair U., Bradford B. C., Thurman R. G. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knock out mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2001; 280: 1289–1295
  • Kubes P., Payne D., Woodman R. C. Molecular mechanisms of leukocyte recruitment in postischemic liver microcirculation. Am. J. Physiol. Gastrointest. Liver Physiol. 2002; 283: G139–G147
  • Murohisa G., Kobayashi Y., Kawasaki T., Nakamura S., Nakamura H. Involvement of platelet activating factor in hepatic apoptosis and necrosis in chronic ethanol fed rats given endotoxin. Liver 2002; 22: 394–403
  • Lawson J. A., Burns A. R., Farhood A., Bajt M. L., Collins R. G., Smith C. W., Jaeschke H. Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice. Hepatology 2000; 32: 990–998
  • Lawson J. A., Fisher M. A., Simmons C. A., Farhood A., Jaeschke H. Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody induced liver injury. Hepatology 1998; 28: 761–767
  • Lentsch A. B., Yoshidome H., Cheadle W. G., Miller F. N., Edwards M. J. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC. Hepatology 1998; 27: 507–512
  • Lieber C. S. Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy. Crit. Rev. Clin. Lab. Sci. 2000; 37: 551–584
  • Limaye P., Apte U., Shankar K., Bucci T., Warbritton A., Mehendale H. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol. Appl. Pharmacol. 2003; 191: 211–226
  • Limaye P. B., Bhave V. S., Palkar P. S., Apte U. M., Sawant S. P., Yu S., Latendresse J. R., Reddy J. K., Mehendale H. M. Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity. Hepatology 2006; 44: 379–388
  • Linderoth G., Jepsen P., Schonheyder H. C., Johnsen S. P., Sorensen H. T. Short-term prognosis of community-acquired bacteremia in patients with liver cirrhosis or alcoholism: a population-based cohort study. Alcohol Clin. Exp. Res. 2006; 30: 636–641
  • MacSween R. N., Burt A. D. Histological spectrum of alcoholic liver disease. Semin. Liver Dis. 1986; 6: 221–232
  • Maher J. J. Alcoholic steatosis and steatohepatitis. Semin. Gastrointest. Dis. 2002; 13: 31–39
  • Maher J. J., Scott M. K., Saito J. M., Burton M. C. Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis. Hepatology 1997; 25: 624–630
  • Mathurin P., Duchatelle V., Ramond M. J., Degott C., Bedossa P., Erlinger S., Benhamou J. P., Chaput J. C., Rueff B., Poynard T. Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone. Gastroenterology 1996; 110: 1847–1853
  • Mathurin P., Mendenhall C. L., Carithers Jr. R. L., Ramond M. J., Maddrey W. C., Garstide P., Rueff B., Naveau S., Chaput J. C., Poynard T. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J. Hepatol. 2002; 36: 480–487
  • Mehendale H. M., Limaye P. B. Calpain: a death protein that mediated progression of death injury. Trends Pharmacol. Sci. 2005; 26: 232–236
  • Murohisa G., Kobayashi Y., Kawasaki T., Nakamura S., Nakamura H. Involvement of platelet-activating factor in hepatic apoptosis and necrosis in chronic ethanol-fed rats given endotoxin. Liver 2002; 22: 394–403
  • Nagy L. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp. Biol. Med. 2003; 228: 882–890
  • Nanji A. Alcoholic liver disease. Hepatology, A Text Book of Liver Disease, D. Zakim, T. D. Boyer. W. B. Saunders, Philadelphia 2002; 839–922
  • Nanji A. A., Zhao S., Lamb R. G., Dannenberg A. J., Sadrzadeh S. M., Waxman D. J. Changes in cytochromes P-450, 2E1, 2B1, and 4A and phospholipases A and C in the intragastric feeding rat model for alcoholic liver disease: relationship to dietary fats and pathologic liver injury. Alcohol Clin. Exp. Res. 1994; 18: 902–908
  • Napirei M., Basnakian A. G., Apostolov E. O., Mannherz H. G. Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. Hepatology 2006; 43: 297–305
  • Okaya T., Lentsch A. B. Cytokine cascades and the hepatic inflammatory response to ischemia and reperfusion. J. Invest. Surg. 2003; 16: 141–147
  • O'Regan A., Berman J. S. Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation. Int. J. Exp. Pathol. 2000; 81: 373–390
  • Pennington H. L., Wilce P. A., Worrall S. Chemokine and cell adhesion molecule mRNA expression and neutrophil infiltration in lipopolysaccharide-induced hepatitis in ethanol-fed rats. Alcohol Clin. Exp. Res. 1998; 22: 1713–1718
  • Pritchard M. T., Nagy L. E. Ethanol-induced liver injury: potential roles for Egr-1. Alcoholism Clin. Exper. Res. 2005; 29: 146S–150S
  • Ramaiah S. K., Jaeschke H. Role of neutrophils in the pathogenesis of acute inflammatory liver injury. Toxicol. Pathol. 2007; 35, in press
  • Ramaiah S. K., Rivera C., Arteel G. E. Early-phase alcoholic liver disease: an update on animal models, pathology and pathogenesis. Int. J. Toxicol. 2004; 23: 217–231
  • Rose R., Banerjee A., Ramaiah S. K. Calpain inhibition attenuates iNOS production and midzonal hepatic necrosis in a repeat dose model of endotoxemia in rats. Toxicol. Pathol. 2006; 34: 785–794
  • Rose R., Banerjee A., Ramaiah S. K. Characterization of a lipopolysaccharide mediated neutrophilic hepatitis model in Sprague Dawley rats. J. Appl. Toxicol. March 16, 2007; 27, [Epub ahead of print].
  • Scaffidi P., Misteli T., Bianchi M. E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191–195
  • Schlayer H. J., Laaff H., Peters T., Woort-Menker M., Estler H. C., Karck U., Schaefer H. E., Decker K. Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase. J. Hepatol. 1988; 7: 239–249
  • Sodek J., Zhu B., Huynh M. H., Brown T. J., Ringuette M. Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC. Connect. Tissue Res. 2002; 43: 308–319
  • Spahr L., Garcia I., Bresson-Hadni S., Rubbia-Brandt L., Guler R., Olleros M., Chvatcko Y., Hadenbue A. Circulating concentrations of interleukin-18, interleukin-18 binding protein, and g-interferon in patients with alcoholic hepatitis. Liver Int. 2004; 24: 582–587
  • Spitzer J. A., Zhang P., Mayer A. M. Functional characterization of peripheral circulating and liver recruited neutrophils in endotoxic rats. J. Leukoc. Biol. 1994; 56: 166–173
  • Stadlbauer V., Mookerjee R. P., Lidder S., Hodges S. J., Davies N. A., Williams R., Jalan R. Failure of neutrophil function in decompensated alcoholic cirrhosis predicts survival (Abstract). Hepatology 2006; 44: 369A
  • Sweet M. J., Hume D. A. Endotoxin signal transduction in macrophages. J. Leukoc. Biol. 1996; 60: 8–26
  • Taieb J., Mathurin P., Elbim C., Cluzel P., Arce-Vicioso M., Bernard B., Opolon P., Gougerot-Pocidalo M. A., Poynard T., Chollet-Martin S. Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids. J. Hepatol. 2000; 32: 579–586
  • Thurman R. G., Bradford B. U., Iimuro Y., Knecht K. T., Arteel G. E., Yin M., Connor H. D., Wall C., Raleigh J. A., Frankenberg M. V., Adachi Y., Forman D. T., Brenner D., Kaiiska M., Mason R. P. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J. Gastroenterol. Hepatol. 1998; 13: S39–50
  • Tsukamoto H., Horne W., Kamimura S., Niemela O., Parkkila S., Yla-Herttuala S., Brittenham G. M. Experimental liver cirrhosis induced by alcohol and iron. J. Clin. Invest. 1995; 96: 620–630
  • Tsukamoto H., Lin M., Ohata M., Giulivi C., French S. W., Brittenham G. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. Am. J. Physiol. 1999; 277: G1240–G1250
  • Uesugi T., Froh M., Arteel G. E., Bradford B. U., Wheeler M. D., Gabele E., Isayama F., Thurman R. G. Role of lipopolysaccharide-binding protein in early alcohol-induced injury in mice. J. Immunol. 2002; 168: 2963–2969
  • Uesugi T., Yin M., Bradford B. U., Wheeler M. D., Uesugi T., Froh M., Goyert S. M., Thurman R. G. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001; 34: 101–108
  • Witthaut R., Farhood A., Smith C. W., Jaeschke H. Complement and tumor necrosis factor-alpha contribute to Mac-1 (CD11b-CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo. J. Leukoc. Biol. 1994; 55: 105–111
  • Wong J., Johnston B., Lee S. S., Bullard D. C., Smith C. W., Beaudet A. L., Kubes P. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J. Clin. Invest. 1997; 99: 2782–2790
  • Xu J., Lee G., Wang H., Vierling J. M., Maher J. J. Limited role of CXC chemokines in the pathogenesis of a-naphthylisothiocyanate-induced liver injury. Am. J. Physiol. Gastrointest. Liver Physiol. 2004; 287: G734–G741
  • Yamaguchi Y., Ohshiro H., Nagao Y., Odawara K., Okabe K., Hidaka H., Ishihara K., Uchino S., Furuhashi T., Yamada S., Mori K., Ogawa M. Urinary trypsin inhibitor reduces C-X-C chemokine production in rat liver ischemia/reperfusion. J. Surg. Res. 2000; 94: 107–115
  • Ziol M., Tepper M., Lohez M., Arcangeli G., Ganne N., Christidis C., Trinchet J. C., Beaugrand M., Guillet J. G., Guettier C. Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis. J. Hepatol. 2001; 34: 254–260

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