Effects of MFG-E8 expression on the biological characteristics of ovarian cancer cells via the AKT/mTOR/S6K signalling pathway

References

• Blain, S.W., 2008. Switching cyclin D-Cdk4 kinase activity on and off. Cell Cycle, 7 (7), 892–898.
   PubMed Web of Science ®Google Scholar
• Butler, J.E., et al., 1980. Bovine-associated mucoprotein: I. Distribution among adult and fetal bovine tissues and body fluids. Differentiation; Research in Biological Diversity, 17 (1), 31–40.
   PubMed Web of Science ®Google Scholar
• Engeland, K., 2022. Cell cycle regulation: p53-p21-RB signaling. Cell Death and Differentiation, 29 (5), 946–960.
   PubMed Web of Science ®Google Scholar
• Feng, X., et al., 2015. Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis. Oncotarget, 6 (32), 32353–32367.
   PubMedGoogle Scholar
• Feng, X., et al., 2017. Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters, 385, 12–20.
   PubMed Web of Science ®Google Scholar
• Fujiwara, C., et al., 2019. The significance of tumor cells-derived MFG-E8 in tumor growth of angiosarcoma. Journal of Dermatological Science, 96 (1), 18–25.
   PubMed Web of Science ®Google Scholar
• Gurova, K.V. and Gudkov, A.V., 2003. Paradoxical role of apoptosis in tumor progression. Journal of Cellular Biochemistry, 88 (1), 128–137.
   PubMed Web of Science ®Google Scholar
• Haitel, A., et al., 2001. Bilharzial related, organ confined, muscle invasive bladder cancer: prognostic value of apoptosis markers, proliferation markers, p53, E-cadherin, epidermal growth factor receptor and c-erbB-2. The Journal of Urology, 165 (5), 1481–1487.
   PubMed Web of Science ®Google Scholar
• Hanayama, R., et al., 2002. Identification of a factor that links apoptotic cells to phagocytes. Nature, 417 (6885), 182–187.
   PubMed Web of Science ®Google Scholar
• Hanayama, R., et al., 2004. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science, 304 (5674), 1147–1150.
   PubMed Web of Science ®Google Scholar
• Huang, Q., et al., 2011. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nature Medicine, 17 (7), 860–866.
   PubMed Web of Science ®Google Scholar
• Jerzak, K.J., Mancuso, T., and Eisen, A., 2018. Ataxia-telangiectasia gene (ATM) mutation heterozygosity in breast cancer: a narrative review. Current Oncology, 25 (2), e176–e180. 10.3747/co.25.3707
   PubMed Web of Science ®Google Scholar
• Kanemura, T., et al., 2018. Immunoregulatory influence of abundant MFG-E8 expression by esophageal cancer treated with chemotherapy. Cancer Science, 109 (11), 3393–3402. 10.1111/cas.13785
   PubMed Web of Science ®Google Scholar
• Khan, M.W., et al., 2013. PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 19 (9), 2342–2354.
   PubMed Web of Science ®Google Scholar
• Ko, D.S., et al., 2020. Milk fat globule-EGF factor 8 contributes to progression of hepatocellular carcinoma. Cancers, 12 (2), 403.
   PubMed Web of Science ®Google Scholar
• Lee, Y., et al., 2019. G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment. PLoS Biology, 17 (4), e3000228.
   PubMed Web of Science ®Google Scholar
• Lheureux, S., et al., 2019. Epithelial ovarian cancer. Lancet, 393 (10177), 1240–1253.
   PubMed Web of Science ®Google Scholar
• Li, N., et al., 2020. The expression levels and clinical significance of MFG-E8 and CD133 in epithelial ovarian cancer. Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology, 36 (9), 803–807.
   PubMed Web of Science ®Google Scholar
• Li, Y., et al., 2017. TGF-beta1 enhances phagocytic removal of neuron debris and neuronal survival by olfactory ensheathing cells via integrin/MFG-E8 signaling pathway. Molecular and Cellular Neurosciences, 85, 45–56.
   PubMed Web of Science ®Google Scholar
• Li, Y.J., Wang, Y. and Wang, Y.Y., 2019. MicroRNA-99b suppresses human cervical cancer cell activity by inhibiting the PI3K/AKT/mTOR signaling pathway. Journal of Cellular Physiology, 234 (6), 9577–9591.
   PubMed Web of Science ®Google Scholar
• Liebl, M.C. and Hofmann, T.G., 2021. The role of p53 signaling in colorectal cancer. Cancers, 13 (9), 2125.
   PubMed Web of Science ®Google Scholar
• Liotta, L.A. and Stetler-Stevenson, W.G., 1991. Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Research, 51 (18 Suppl), 5054–5059.
   PubMed Web of Science ®Google Scholar
• Makale, M., 2007. Cellular mechanobiology and cancer metastasis. Birth Defects Research. Part C, Embryo Today: Reviews, 81 (4), 329–343.
   PubMedGoogle Scholar
• Manu, K.A., et al., 2019. p21cip/waf1 coordinate autophagy, proloferation and apoptosis in response to metabolic stress. Cancers, 11 (8), 1112.
   PubMed Web of Science ®Google Scholar
• Matulonis, U.A., 2011. Bevacizumab and its use in epithelial ovarian cancer. Future Oncology, 7 (3), 365–379.
   PubMed Web of Science ®Google Scholar
• Mustofa, M.K., et al., 2020. Roles of Chk2/CHEK2 in guarding against environmentally induced DNA damage and replication stress. Environmental and Molecular Mutagenesis, 61 (7), 730–735.
   PubMed Web of Science ®Google Scholar
• Oba, J., et al., 2011. Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma. The British Journal of Dermatology, 165 (3), 506–512.
   PubMed Web of Science ®Google Scholar
• Okamoto, A., et al., 2020. Immunological and clinicopathological significance of MFG-E8 expression in patients with oral squamous cell carcinoma. Pathology Oncology Research: POR, 26 (2), 1263–1268.
   PubMed Web of Science ®Google Scholar
• Siegel, R.L., Miller, K.D., and Jemal, A., 2015. Cancer statistics, 2015. CA: A Cancer Journal for Clinicians, 65 (1), 5–29.
   PubMed Web of Science ®Google Scholar
• Silvestre, J.S., et al., 2005. Lactadherin promotes VEGF-dependent neovascularization. Nature Medicine, 11 (5), 499–506.
   PubMed Web of Science ®Google Scholar
• Tibaldi, L., et al., 2013. New blocking antibodies impede adhesion, migration and survival of ovarian cancer cells, highlighting MFGE8 as a potential therapeutic target of human ovarian carcinoma. PLos One, 8 (8), e72708.
   PubMed Web of Science ®Google Scholar
• Wang, M., et al., 2012. MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling. AGING Cell, 11 (3), 500–508.
   PubMed Web of Science ®Google Scholar
• Wang, J., et al., 2021. Absence of the MFG-E8 gene prevents hypoxia-induced pulmonary hypertension in mice. Journal of Cellular Physiology, 236 (1), 587–600.
   PubMed Web of Science ®Google Scholar
• Wang, Y., et al., 2017. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating milk fat globule-EGF factor 8 (MFG-E8) expressions. Scientific Reports, 7, 42642.
   PubMed Web of Science ®Google Scholar
• Yamazaki, M., et al., 2014. MFG-E8 expression for progression of oral squamous cell carcinoma and for self-clearance of apoptotic cells. Laboratory Investigation; A Journal of Technical Methods and Pathology, 94 (11), 1260–1272.
   PubMed Web of Science ®Google Scholar
• Yang, C., et al., 2011. The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers. Cancer Research, 71 (3), 937–945.
   PubMed Web of Science ®Google Scholar
• Zhao, Q., et al., 2017. MFG-E8 overexpression promotes colorectal cancer progression via AKT/MMPs signaling. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine, 39 (6), 1010428317707881.
   Google Scholar