Human wharton-jelly mesenchymal stromal cells reversed apoptosis and prevented multi-organ damage in a newborn model of experimental asphyxia

References

• Abas, B.I., et al., 2022. Wharton jelly-derived mesenchymal stem cell exosomes induce apoptosis and suppress EMT signaling in cervical cancer cells as an effective drug carrier system of paclitaxel. PLOS One, 17 (9), e0274607.
   PubMed Web of Science ®Google Scholar
• Ahn, S.Y., et al., 2021. Stem cells for bronchopulmonary dysplasia in preterm infants: a randomized controlled phase II trial. Stem Cells Translational Medicine, 10 (8), 1129–1137.
   PubMed Web of Science ®Google Scholar
• Aly, H., et al., 2015. Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. Journal of Perinatology, 35 (3), 186–191.
   PubMed Web of Science ®Google Scholar
• Aridas, J.D., et al., 2014. Detecting brain injury in neonatal hypoxic ischemic encephalopathy: closing the gap between experimental and clinical research. Experimental Neurology, 261, 281–290.
   PubMed Web of Science ®Google Scholar
• Aridas, J.D.S., et al., 2018. Systemic and transdermal melatonin administration prevents neuropathology in response to perinatal asphyxia in newborn lambs. Journal of Pineal Research, 64 (4), e12479.
   PubMed Web of Science ®Google Scholar
• Aridas, J.D., et al., 2021. Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia. Journal of Pineal Research, 71 (1), e12744.
   PubMed Web of Science ®Google Scholar
• Bembea, M.M., et al., 2011. Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatric Critical Care Medicine, 12 (5), 572–579.
   PubMed Web of Science ®Google Scholar
• Chaparro-Huerta, V., et al., 2017. Proinflammatory cytokines, enolase and S-100 as early biochemical ındicators of hypoxic-ıschemic encephalopathy following perinatal asphyxia in newborns. Pediatrics and Neonatology, 58 (1), 70–76.
   PubMed Web of Science ®Google Scholar
• Cui, X., Song, H., and Su, J., 2017. Curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through induction of nuclear factor erythroid-2-related factor 2 and heme oxygenase-1. Experimental and Therapeutic Medicine, 14 (2), 1512–1518.
   PubMed Web of Science ®Google Scholar
• Czeh, M., Gressens, P., and Kaindl, A.M., 2011. The Yin and Yang of microglia. Developmental Neuroscience, 33 (3–4), 199–209.
   PubMed Web of Science ®Google Scholar
• Devito, L., et al., 2019. Comparison of human isogeneic wharton’s jelly MSCs and iPSC-derived MSCs reveals differentiation-dependent metabolic responses to IFNG stimulation. Cell Death & Disease, 10 (4), 277.
   PubMed Web of Science ®Google Scholar
• Du, T., et al., 2013. Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells. Stem Cell Research & Therapy, 4 (3), 59.
   PubMed Web of Science ®Google Scholar
• Ekdahl, C.T., Kokaia, Z., and Lindvall, O., 2009. Brain inflammation and adult neurogenesis: The dual role of microglia. Neuroscience, 158 (3), 1021–1029.
   PubMed Web of Science ®Google Scholar
• Eroglu, M., et al., 2013. Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients. The Kaohsiung Journal of Medical Sciences, 29 (7), 368–373.
   PubMed Web of Science ®Google Scholar
• Hakobyan, M., et al., 2019. Outcome of ınfants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis. Neonatology, 115 (2), 127–133.
   PubMed Web of Science ®Google Scholar
• Hawkins, K. E., et al., 2018. Embryonic stem cell-derived mesenchymal stem cells (MSCs) have a superior neuroprotective capacity over fetal MSCs in the hypoxic-ıschemic mouse brain. Stem Cells Translational Medicine, 7 (5), 439–449.
   PubMed Web of Science ®Google Scholar
• Herz, J., et al., 2018. Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury. Brain, Behavior, and İmmunity, 70, 118–130.
   PubMed Web of Science ®Google Scholar
• Jatana, M., et al., 2006. Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ıschemic brain ınjury in neonatal rats. Pediatric Research, 59 (5), 684–689.
   PubMed Web of Science ®Google Scholar
• Kecskes, Z., Dunster, K.R., and Colditz, P.B., 2005. NSE and S100 after hypoxia in the newborn pig. Pediatric Research, 58 (5), 953–957.
   PubMed Web of Science ®Google Scholar
• Lee, J.A., et al., 2010. Mesenchymal stem-cell transplantation for hypoxic-ıschemic brain ınjury in neonatal rat model. Pediatric Research, 67 (1), 42–46.
   PubMed Web of Science ®Google Scholar
• Looney, A.-M., et al., 2015. Glial fibrillary acidic protein ıs not an early marker of ınjury in perinatal asphyxia and hypoxic-ıschemic encephalopathy. Frontiers in Neurology, 6, 264.
   PubMed Web of Science ®Google Scholar
• Owen, J. and Butterfield, D., 2010. Measurement of oxidized/reduced glutathione ratio. Methods in Molecular Biology, 648, 269–277.
   PubMedGoogle Scholar
• Rattka, M., et al., 2013. The intrahippocampal kainate model of temporal lobe epilepsy revisited: epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats. Epilepsy Research, 103 (2–3), 135–152.
   PubMed Web of Science ®Google Scholar
• Robertson, N.J., et al., 2013. Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain, 136 (Pt 1), 90–105.
   PubMed Web of Science ®Google Scholar
• Robertson, N.J., et al., 2021. Human umbilical cord mesenchymal stromal cells as an adjunct therapy with therapeutic hypothermia in a piglet model of perinatal asphyxia. Cytotherapy, 23 (6), 521–535.
   PubMed Web of Science ®Google Scholar
• Rodríguez, M., et al., 2020. Hypoxic-ıschemic encephalopathy and mitochondrial dysfunction: facts, unknowns, and challenges. Antioxidants & Redox Signaling, 33 (4), 247–262.
   PubMed Web of Science ®Google Scholar
• Romner, B., et al., 2000. Traumatic brain damage: serum S-100 protein measurements related to neuroradiological findings. Journal of Neurotrauma, 17 (8), 641–647.
   PubMed Web of Science ®Google Scholar
• Sahin Ersoy, G., et al., 2016. N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model. Reproductive Biomedicine Online, 33 (1), 93–101.
   PubMed Web of Science ®Google Scholar
• Shivakumar, S.B., et al., 2016. DMSO- and serum-free cryopreservation of wharton’s jelly tissue ısolated from human umbilical cord. Journal of Cellular Biochemistry, 117 (10), 2397–2412.
   PubMed Web of Science ®Google Scholar
• Sugiura-Ogasawara, M., et al., 2019. Adverse pregnancy and perinatal outcome in patients with recurrent pregnancy loss: multiple imputation analyses with propensity score adjustment applied to a large-scale birth cohort of the Japan Environment and Children’s Study. American Journal of Reproductive İmmunology, 81 (1), e13072.
   PubMed Web of Science ®Google Scholar
• Summanen, M., et al., 2018. Surge of peripheral arginine vasopressin in a rat model of birth asphyxia. Frontiers in Cellular Neuroscience, 12, 2.
   Google Scholar
• Tamer, S., et al., 2020. Regular moderate exercise alleviates gastric oxidative damage in rats via the contribution of oxytocin receptors. The Journal of Physiology, 598 (12), 2355–2370.
   PubMed Web of Science ®Google Scholar
• Tsuji, M., et al., 2020. Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety. Scientific Reports, 10 (1), 4603.
   PubMed Web of Science ®Google Scholar
• van Velthoven, C.T.J., et al., 2010a. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain, Behavior, and İmmunity, 24 (3), 387–393.
   PubMed Web of Science ®Google Scholar
• van Velthoven, C. T. J., et al., 2010b. Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. The Journal of Neuroscience, 30 (28), 9603–9611.
   PubMed Web of Science ®Google Scholar
• Yasuhara, T., et al., 2006. Behavioral and histological characterization of ıntrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ıschemic ınjury. Cell Transplantation, 15 (3), 231–238.
   PubMed Web of Science ®Google Scholar
• Zhou, L., et al., 2022. Umbilical cord blood and cord tissue-derived cell therapies for neonatal morbidities: current status and future challenges. Stem Cells Translational Medicine, 11 (2), 135–145.
   PubMed Web of Science ®Google Scholar
• Zubrow, A.B., et al., 2002. Nitric oxide-mediated Ca2+/calmodulin-dependent protein kinase IV activity during hypoxia in neuronal nuclei from newborn piglets. Neuroscience Letters, 335 (1), 5–8.
   PubMed Web of Science ®Google Scholar