Enhancing autophagy leads to increased cell death in radiation-treated cervical cancer cells

References

• Baskar, R., et al., 2012. Cancer and radiation therapy: current advances and future directions. International Journal of Medical Sciences, 9 (3), 193–199.
   PubMed Web of Science ®Google Scholar
• Bogani, G., et al., 2022. Development of a nomogram predicting the risk of persistence/recurrence of cervical dysplasia. Vaccines, 10 (4), 579.
   Web of Science ®Google Scholar
• Briceno, E., Reyes, S. and Sotelo, J., 2003. Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine. Neurosurgical focus, 14 (2), e3.
   PubMedGoogle Scholar
• Cascardi, E., et al., 2022. Association between cervical microbiota and HPV: could this be the key to complete cervical cancer eradication? Biology, 11 (8), 1114.
   PubMed Web of Science ®Google Scholar
• Chang, L., et al., 2014. PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways. Cell death & Disease, 5 (10), e1437.
   PubMed Web of Science ®Google Scholar
• Dellino, M., et al., 2022. Lactobacillus crispatus M247 oral administration: is it really an effective strategy in the management of papillomavirus-infected women? Infectious Agents and Cancer, 17 (1), 53.
   PubMed Web of Science ®Google Scholar
• D'oria, O., et al., 2022. New advances in cervical cancer: from bench to bedside. International Journal of Environmental Research and Public Health, 19 (12), 7094.
   Web of Science ®Google Scholar
• Gewirtz, D.A., 2014a. An autophagic switch in the response of tumor cells to radiation and chemotherapy. Biochemical pharmacology, 90 (3), 208–211.
   PubMed Web of Science ®Google Scholar
• Gewirtz, D.A., 2014b. The four faces of autophagy: implications for cancer therapy. Cancer Research, 74 (3), 647–651.
   PubMed Web of Science ®Google Scholar
• Giannini, A., et al., 2022. Advances on prevention and screening of gynecologic tumors: Are We Stepping Forward? Healthcare, 10 (9), 1605.
   Web of Science ®Google Scholar
• Gozuacik, D. and Kimchi, A., 2004. Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 23 (16), 2891–2906.
   PubMed Web of Science ®Google Scholar
• Jackson, S.P. and Bartek, J., 2009. The DNA-damage response in human biology and disease. Nature, 461 (7267), 1071–1078.
   PubMed Web of Science ®Google Scholar
• Kumar, L. and Gupta, S., 2016. Integrating chemotherapy in the management of cervical cancer: a critical appraisal. Oncology, 91 (Suppl 1), 8–17.
   PubMed Web of Science ®Google Scholar
• Levine, B. and Kroemer, G., 2008. Autophagy in the pathogenesis of disease. Cell, 132 (1), 27–42.
   PubMed Web of Science ®Google Scholar
• Levy, J.M.M., Towers, C.G. and Thorburn, A., 2017. Targeting autophagy in cancer. Nature Reviews Cancer, 17 (9), 528–542.
   PubMed Web of Science ®Google Scholar
• Li, Q., et al., 2021. Role of borneol-induced autophagy in enhancing radiosensitivity of malignant Glioma. Frontiers in Oncology, 11, 749987.
   PubMed Web of Science ®Google Scholar
• Monk, B.J., et al., 2022. Proportions and incidence of locally advanced cervical cancer: a global systematic literature review. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer society, 32 (12), 1531–1539.
   PubMed Web of Science ®Google Scholar
• Ondrej, M., et al., 2016. To live or let die: unclear task of autophagy in the radiosensitization battle. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, 119 (2), 265–275.
   PubMed Web of Science ®Google Scholar
• Rabinowitz, J.D. and White, E., 2010. Autophagy and metabolism. Science, 330 (6009), 1344–1348.
   PubMed Web of Science ®Google Scholar
• Roy, A., et al., 2022. Role of autophagy in tumor response to radiation: Implications for improving radiotherapy. Frontiers in Oncology, 12, 957373.
   PubMed Web of Science ®Google Scholar
• Surova, O. and Zhivotovsky, B., 2013. Various modes of cell death induced by DNA damage. Oncogene, 32 (33), 3789–3797.
   PubMed Web of Science ®Google Scholar
• Tam, S.Y., Wu, V.W. and Law, H.K., 2017. Influence of autophagy on the efficacy of radiotherapy. Radiation Oncology, 12 (1), 57.
   PubMed Web of Science ®Google Scholar
• Wang, Y., Yin, W. and Zhu, X., 2014. Blocked autophagy enhances radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro. Acta oto-Laryngologica, 134 (1), 105–110.
   PubMed Web of Science ®Google Scholar
• White, E., 2012. Deconvoluting the context-dependent role for autophagy in cancer. Nature reviews. Cancer, 12 (6), 401–410.
   PubMed Web of Science ®Google Scholar
• Wilson, E.N., et al., 2011. A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Hormones & Cancer, 2 (5), 272–285.
   PubMedGoogle Scholar
• Xin, Y., et al., 2017. Role of autophagy in regulating the radiosensitivity of tumor cells. Journal of Cancer Research and Clinical Oncology, 143 (11), 2147–2157.
   PubMed Web of Science ®Google Scholar
• Yuh, W.T., et al., 2009. Predicting control of primary tumor and survival by DCE MRI during early therapy in cervical cancer. Investigative Radiology, 44 (6), 343–350.
   PubMed Web of Science ®Google Scholar