The bioinformatics analysis of the clinicopathological and prognostic significances of REG4 mRNA in gynecological cancers

References

• Aquil, A., et al., 2021. Predictors of mental health disorders in women with breast and gynecological cancer after radical surgery: a cross-sectional study. Annals of Medicine and Surgery (2012), 65, 102278.
   PubMed Web of Science ®Google Scholar
• Bishnupuri, K.S., et al., 2006. Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology, 130 (1), 137–149.
   PubMed Web of Science ®Google Scholar
• Bishnupuri, K.S., et al., 2010. Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. Gastroenterology, 138 (2), 616–626.
   PubMed Web of Science ®Google Scholar
• Bishnupuri, K.S., et al., 2014. Reg4-induced mitogenesis involves Akt- GSK3β-β-catenin-TCF-4 signaling in human colorectal cancer. Molecular Carcinogenesis, 53 Suppl 1 (0 1), E169–80.
   PubMed Web of Science ®Google Scholar
• Bishnupuri, K.S., et al., 2022. Reg4 interacts with CD44 to regulate proliferation and stemness of colorectal and pancreatic cancer cells. Molecular Cancer Research, 20 (3), 387–399.
   PubMed Web of Science ®Google Scholar
• Chen, S., et al., 2015. The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma. BMC Cancer, 15, 471.
   PubMed Web of Science ®Google Scholar
• Du, F., et al., 2013. The expression patterns of Reg IV gene in normal rat reproduction system. Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology, 319 (1), 32–38.
   PubMed Web of Science ®Google Scholar
• Duan, Y., et al., 2014. Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV. Molecular Cancer, 13, 127.
   PubMed Web of Science ®Google Scholar
• Gao, L., et al., 2021. REG4 is a potential biomarker for radiochemotherapy sensitivity in colorectal cancer. OncoTargets and Therapy, 14, 1605–1611.
   PubMed Web of Science ®Google Scholar
• Giannini, A., et al., 2022. Advances on prevention and screening of gynecologic tumors: are we stepping forward? Healthcare, 10 (9), 1605.
   Web of Science ®Google Scholar
• Golia, D. T., et al., 2023. Novel insights into molecular mechanisms of endometrial diseases. Biomolecules, 13 (3), 499.
   PubMed Web of Science ®Google Scholar
• He, X.J., et al., 2012. REG4 contributes to the invasiveness of pancreatic cancer by upregulating MMP-7 and MMP-9. Cancer Science, 103 (12), 2082–2091.
   PubMed Web of Science ®Google Scholar
• Ho, M.R., et al., 2010. Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. Journal of Molecular Biology, 402 (4), 682–695.
   PubMed Web of Science ®Google Scholar
• Jin, J., et al., 2017. Regenerating family member 4 (Reg4) enhances 5-fluorouracil resistance of gastric cancer through activating MAPK/Erk/Bim signaling pathway. Medical Science Monitor : international Medical Journal of Experimental and Clinical Research, 23, 3715–3721.
   PubMed Web of Science ®Google Scholar
• Kawasaki, Y., et al., 2015. REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis. Scientific Reports, 5, 14291.
   PubMed Web of Science ®Google Scholar
• Kobayashi, Y., et al., 2010. Serum tumor antigen REG4 as a useful diagnostic biomarker in gastric cancer. Hepato-gastroenterology, 57 (104), 1631–1634.
   PubMedGoogle Scholar
• Kuniyasu, H., et al., 2009. Reg IV enhances peritoneal metastasis in gastric carcinomas. Cell Proliferation, 42 (1), 110–121.
   PubMed Web of Science ®Google Scholar
• Li, Y.G., et al., 2011. Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma. International Journal of Biological Macromolecules, 48 (3), 511–517.
   PubMed Web of Science ®Google Scholar
• Little, J., et al., 2009. STrengthening the REporting of genetic association studies (STREGA)–an extension of the STROBE statement. Genetic Epidemiology, 33 (7), 581–598.
   PubMed Web of Science ®Google Scholar
• Lu, S., et al., 2013. Genetic variants in c-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome. International Journal of Cancer, 133 (10), 2325–2333.
   PubMed Web of Science ®Google Scholar
• Mitani, Y., et al., 2007. Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene, 26 (30), 4383–4393.
   PubMed Web of Science ®Google Scholar
• Naito, Y., et al., 2012. Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer. PloS One, 7 (11), e47545.
   PubMed Web of Science ®Google Scholar
• Oue, N., et al., 2005. Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. The Journal of Pathology, 207 (2), 185–198.
   PubMed Web of Science ®Google Scholar
• Paepke, D., et al., 2020. Prevalence and predictors for nonuse of complementary medicine among breast and gynecological cancer patients. Breast Care, 15 (4), 380–385.
   PubMed Web of Science ®Google Scholar
• Saukkonen, K., et al., 2018. Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma. Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 40 (3), 1010428318761494.
   Google Scholar
• Segev, Y., et al., 2021. Correlation between an integrative oncology treatment program and survival in patients with advanced gynecological cancer. Supportive Care in Cancer : official Journal of the Multinational Association of Supportive Care in Cancer, 29 (7), 4055–4064.
   PubMed Web of Science ®Google Scholar
• Seland, M., et al., 2022. Distress, problems and unmet rehabilitation needs after treatment for gynecological cancer. Acta Obstetricia et Gynecologica Scandinavica, 101 (3), 313–322.
   PubMed Web of Science ®Google Scholar
• Sentani, K., et al., 2008. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. The American Journal of Surgical Pathology, 32 (8), 1182–1189.
   PubMed Web of Science ®Google Scholar
• Takayama, R., et al., 2010. Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma. Journal of Gastroenterology, 45 (1), 52–59.
   PubMed Web of Science ®Google Scholar
• Takehara, A., et al., 2006. Tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. Cancer Science, 97 (11), 1191–1197.
   PubMed Web of Science ®Google Scholar
• Tamura, H., et al., 2009. Reg IV expression and clinicopathologic features of gallbladder carcinoma. Human Pathology, 40 (12), 1686–1692.
   PubMed Web of Science ®Google Scholar
• Tao, H.Q., et al., 2011. Evaluation of REG4 for early diagnosis and prognosis of gastric cancer. Human Pathology, 42 (10), 1401–1409.
   PubMed Web of Science ®Google Scholar
• Vargiu, V., et al., 2022. Impact of obesity on sentinel lymph node mapping in patients with apparent early-stage endometrial cancer: the ObeLyX study. Gynecologic Oncology, 165 (2), 215–222.
   PubMed Web of Science ®Google Scholar
• Wang, F., et al., 2011. Identification of RegIV as ael GLI1 target gene in human pancreatic cancer. PLOS One, 6 (4), e18434.
   PubMed Web of Science ®Google Scholar
• Wang, H., et al., 2016. REG4 promotes peritoneal metastasis of gastric cancer through GPR37. Oncotarget, 7 (19), 27874–27888.
   PubMedGoogle Scholar
• Wang, Q., et al., 2012. Oncogenic reg IV is a novel prognostic marker for glioma patient survival. Diagnostic Pathology, 7, 69.
   PubMed Web of Science ®Google Scholar
• Wang, X., et al., 2022. Zebrafish xenograft model for studying pancreatic cancer-instructed innate immune microenvironment. International Journal of Molecular Sciences, 23 (12), 6442.
   PubMed Web of Science ®Google Scholar
• Xiang, L.W., et al., 2022. The effects of REG4 expression on chemoresistance of ovarian cancer. Journal of Obstetrics and Gynaecology, 42 (7), 3149–3157.
   PubMed Web of Science ®Google Scholar
• Xiao, Y., et al., 2019. Deficiency in intestinal epithelial Reg4 ameliorates intestinal inflammation and alters the colonic bacterial composition. Mucosal Immunology, 12 (4), 919–929.
   PubMed Web of Science ®Google Scholar
• Zheng, H.C., et al., 2010. The role of Reg IV gene and its encoding product in gastric carcinogenesis. Human Pathology, 41 (1), 59–69.
   PubMed Web of Science ®Google Scholar
• Zheng, H.C., et al., 2011. Expression profile of the REG gene family in colorectal carcinoma. The Journal of Histochemistry and Cytochemistry : official Journal of the Histochemistry Society, 59 (1), 106–115.
   PubMed Web of Science ®Google Scholar
• Zheng, H.C., et al., 2022. REG4 promotes the proliferation and anti-apoptosis of cancer. Frontiers in Cell and Developmental Biology, 10, 1012193.
   PubMed Web of Science ®Google Scholar