Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis

References

• Addisu, D., Melkie, A. and Biru, S., 2020. Prevalence of preterm premature rupture of membrane and its associated factors among pregnant women admitted in Debre Tabor General Hospital, North West Ethiopia: institutional-based cross-sectional study. Obstetrics and Gynecology International, 2020, 4034680–4034687.
   PubMed Web of Science ®Google Scholar
• Ahmed, S., et al., 2012. Pregnancy outcome in women with threatened miscarriage: a year study. Materia Socio-Medica, 24 (1), 26–28.
   PubMedGoogle Scholar
• Akhavan, S., 2004. Pregnancy outcomes in patients with subcoronary hemorrhage in the first trimester of gestation compared with the control group in patients referring to specialized clinics in the years 81 and 82. Journal of Kourdestan University Medical Science, 9 (33), 31–36.
   Google Scholar
• Alijahan, R., et al., 2014. Prevalence and risk factors associated with preterm birth in Ardabil, Iran. Iranian Journal of Reproductive Medicine, 12 (1), 47–56.
   PubMedGoogle Scholar
• Amirkhani, Z., et al., 2013. Maternal and perinatal outcomes in pregnant women with first trimester vaginal bleeding. Journal of Family and Reproductive Health, 7 (2), 57–61.
   PubMedGoogle Scholar
• Ananth, C.V., et al., 2006. Evidence of placental abruption as a chronic process: associations with vaginal bleeding early in pregnancy and placental lesions. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 128 (1–2), 15–21.
   PubMed Web of Science ®Google Scholar
• Arafa, M., et al., 2000. Outcomes of pregnancies complicated by early vaginal bleeding. Eastern Mediterranean Health Journal, 6 (2–3), 457–464.
   PubMedGoogle Scholar
• Awoleke, J., 2012. Maternal risk factors for low birth weight babies in Lagos, Nigeria. Archives of Gynecology and Obstetrics, 285 (1), 1–6.
   PubMed Web of Science ®Google Scholar
• Batzofin, J., Fielding, W. and Fridman, E., 1994. effect of vaginal bleeding in early pregnancy on outcom. Obstetrics & Gynecology, 63 (4), 515–518.
   Google Scholar
• Baumfeld, Y., et al., 2017. Placenta associated pregnancy complications in pregnancies complicated with placenta previa. Taiwanese Journal of Obstetrics & Gynecology, 56 (3), 331–335.
   PubMed Web of Science ®Google Scholar
• Begg, C.B. and Mazumdar, M., 1994. Operating characteristics of a rank correlation test for publication bias. Biometrics, 50 (4), 1088–1101.
   PubMed Web of Science ®Google Scholar
• Berkowitz, G.S., et al., 1983. Early gastational bleeding and pregnancy outcome: a multivariable analysis. International Journal of Epidemiology, 12 (2), 165–173.
   PubMed Web of Science ®Google Scholar
• Bever, A.M., et al., 2018. Fetal growth patterns in pregnancies with first-trimester bleeding. Obstetrics and Gynecology, 131 (6), 1021–1030.
   PubMed Web of Science ®Google Scholar
• Bushtyreva, I.O., et al., 2015. Pregnancy outcomes in pregnant women with subchorionic hematoma. International Journal of Biomedicine, 5 (3), 137–140.
   Google Scholar
• Cobo, T., et al., 2011. Clinical and inflammatory markers in amniotic fluid as predictors of adverse outcomes in preterm premature rupture of membranes. American Journal of Obstetrics and Gynecology, 205 (2), 126. e121-126–e128.
   Web of Science ®Google Scholar
• Dadkhah, F., Kashanian, M. and Eliasey, G., 2012. Pregnancy outcomes in pregnant women with history of vaginal bleeding in the first half of pregnancy. Urmia Medical Journal, 23 (3), 254–259.
   Google Scholar
• Dars, S., et al., 2014. Maternal morbidity and perinatal outcome in preterm premature rupture of membranes before 37 weeks gestation. Pakistan Journal of Medical Sciences, 30 (3), 626–629.
   PubMed Web of Science ®Google Scholar
• Davari-Tanha, F., et al., 2008. Threatened abortion: a risk factor for poor pregnancy outcome. Acta Medica Iranica, 46 (4), 314–320.
   Google Scholar
• De Sutter, P., et al., 2006. First-trimester bleeding and pregnancy outcome in singletons after assisted reproduction. Human Reproduction (Oxford, England), 21 (7), 1907–1911.
   PubMed Web of Science ®Google Scholar
• Dee Zhen, L., 2017. Effects of subchorionic haematoma on pregnancy outcomes. Australian Medical Student Journal, 8 (1), 41–45.
   Google Scholar
• Dolatian, M., et al., 2013. Preterm delivery and psycho–social determinants of health based on World Health Organization model in Iran: a narrative review. Global Journal of Health Science, 5 (1), 52.
   Google Scholar
• Dongol, A., Mool, S. and Tiwari, P., 2011. Outcome of pregnancy complicated by threatened abortion. Kathmandu University Medical Journal, 9 (33), 41–44.
   PubMedGoogle Scholar
• Edwards, D.V., et al., 2012. First-trimester bleeding characteristics associate with increased risk of preterm birth: data from a prospective pregnancy cohort. Human Reproduction, 27 (1), 54–60.
   PubMed Web of Science ®Google Scholar
• Egger, M., et al., 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ, 315 (7109), 629–634.
   PubMed Web of Science ®Google Scholar
• Enaruna, N., Anya, C. and Anyanwu, C., 2020. Early and late pregnancy complications in women who experience first trimester vaginal bleeding at a University Hospital, Benin City, Nigeria. Journal of Medicine and Biomedical Research, 19 (1), 23–32.
   Google Scholar
• Eskild, A. and Vatten, L., 2009. Abnormal bleeding associated with preeclampsia: a population study of 315,085 pregnancies. Acta Obstetricia et Gynecologica Scandinavica, 88 (2), 154–158.
   PubMed Web of Science ®Google Scholar
• Grawal, S., et al., 2014. A predicting adverse maternal and perinatal outcome after threatened miscarriage. Open Journal of Obstetrics and Gynecology, 04 (01), 1–7.
   Google Scholar
• Guruvare, S., et al., 2015. Factors influencing pregnancy outcome in women with vaginal bleeding before midpregnancy: a prospective case control study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 4 (3), 601–605.
   Google Scholar
• Hasan, R., et al., 2010. Patterns and predictors of vaginal bleeding in the firsttrimester of pregnancy. Annals of Epidemiology, 20 (7), 524–531.
   PubMed Web of Science ®Google Scholar
• Hasan, R., et al., 2009. Association between first-trimester vaginal bleeding and miscarriage. Obstetrics and Gynecology, 114 (4), 860–867.
   PubMed Web of Science ®Google Scholar
• Hoseini, M. and Yaghoubipour, S., 2012. The role of vaginal bleeding in the first trimester of pregnancy on late pregnancy outcomes. Scientific Journal of the Islamic Republic of Iran Medical Organization, 30 (3), 250–255.
   Google Scholar
• Hossain, R., et al., 2007. Risk of preterm delivery in relation to vaginal bleeding in early pregnancy. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 135 (2), 158–163.
   PubMed Web of Science ®Google Scholar
• Huedo-Medina, T.B., et al., 2006. Assessing heterogeneity in meta-analysis: q statistic or I2 index? Psychological Methods, 11 (2), 193–206.
   PubMed Web of Science ®Google Scholar
• Ishtiaq, S., Qadir, T., and SHarafali, H., 2014. Maternal and perinatal outcom in threatened miscarriage in first trimester. Isra Medical Journal, 6 (3), 169–172.
   Google Scholar
• Karim, S.A., 1998. Effects of first and second trimester vaginal bleeding on pregnancy outcome. Journal of the Pakistan Medical Association, 48 (2), 40–42.
   PubMedGoogle Scholar
• Karimi, A., Daliri, S., and SayehMiri, K., 2016. The relationship between violence during pregnancy and low birth weight: a meta-analysis study. Hayat, Journal of School of Nursing and Midwifery, Tehran University of Medical Sciences, 22 (3), 216–228.
   Google Scholar
• Kayode, G.A., et al., 2016. Predicting stillbirth in a low resource setting. BMC Pregnancy and Childbirth, 16 (1), 1–8.
   PubMedGoogle Scholar
• Khalajinia, Z. and Sadeghimoghadam, P., 2011. Incidence and maternal risk factors related to preterm delivery in qom province, 2007. Journal of Qom University of Medical Sciences, 5 (1), 30–36.
   Google Scholar
• Kim, Y., et al., 2005. Risk factors for preterm birth in Korea: a multicenter prospective study. Gynecologic and Obstetric Investigation, 60 (4), 206–212.
   PubMed Web of Science ®Google Scholar
• Liberati, A., et al., 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Medicine, 6 (7), e1000100.
   PubMed Web of Science ®Google Scholar
• Lykke, J., et al., 2010. First-trimester vaginal bleeding and complications later in pregnancy. Obstetrics and Gynecology, 115 (5), 935–944.
   PubMed Web of Science ®Google Scholar
• Madan, I., et al., 2010. The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: an unexpected observation. Journal of Perinatal Medicine, 38 (3), 275–279.
   PubMed Web of Science ®Google Scholar
• McPherson, J. A., et al., 2013. Adverse outcomes in twin pregnancies complicated by early vaginal bleeding. American Journal of Obstetrics and Gynecology, 208 (1), 56.e1–5.
   PubMed Web of Science ®Google Scholar
• Morisaki, N., et al., 2014. Risk factors for spontaneous and provider‐initiated preterm delivery in high and low Human Development Index countries: a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG: An International Journal of Obstetrics and Gynaecology, 121 (s1), 101–109.
   PubMedGoogle Scholar
• Mulik, V., Bethel, J. and Bhal, K., 2004. A Retrospective population-based study of primigravid women on the potential effect of threatened miscarriage on obstetric outcome. Journal of Obstetrics and Gynaecology: The Journal of the Institute of Obstetrics and Gynaecology, 24 (3), 249–253.
   PubMedGoogle Scholar
• Mustafa, G., et al., 2009. Pregnancy outcome of patients complicated by threatened abortion. The Internet Journal of Gynecology and Obstetrics, 14, 1–4.
   Google Scholar
• Nagy, S., et al., 2005. Clinical significance of subchorionic and retroplacental hematomas detected in the first trimester of pregnancy. Orvosi Hetilap, 146 (42), 2157–2161.
   PubMedGoogle Scholar
• Norman, S., et al., 2010. Ultrasound-detected subchorionic hemorrhage and the obstetric implications. Obstetrics and Gynecology, 116 (2 Pt 1), 311–315.
   PubMed Web of Science ®Google Scholar
• Nour, N.M., 2012. Premature delivery and the millennium development goal. Reviews in Obstetrics and Gynecology, 5 (2), 100.
   PubMedGoogle Scholar
• Oppenraaij, R. V., et al., 2009. Predicting adverse obstetric outcome after early pregnancy events and complications: a review. Human Reproduction Update, 15 (4), 409–421.
   PubMed Web of Science ®Google Scholar
• Oyelese, Y. and Ananth, C.V., 2006. Placental abruption. Obstetrics and Gynecology, 108 (4), 1005–1016.
   PubMed Web of Science ®Google Scholar
• Palatnik, A. and Grobman, W., 2015. The relationship between first-trimester subchorionic hematoma, cervical length, and preterm birth. American Journal of Obstetrics and Gynecology, 213 (3), 403.e1–4.
   PubMed Web of Science ®Google Scholar
• Peterson, J., et al., 2011. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute, 2 (1), 1–12.
   Google Scholar
• Pitaphrom, A. and Sukcharoen, N., 2006. Pregnancy outcomes in placental abruption. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 89 (10), 1572–1578.
   PubMedGoogle Scholar
• Ramaeker, D.M. and Simhan, H.N., 2012. Sonographic cervical length, vaginal bleeding, and the risk of preterm birth. American Journal of Obstetrics and Gynecology, 206 (3), 224. e221-224–e224.
   Web of Science ®Google Scholar
• Riahinejad, S., et al., 2011. Effect of vaginal bleeding in first trimester of pregnancy on pregnancy Outcomes. Journal of Isfahan Medical School, 29 (156), 1296–1302.
   Google Scholar
• Salim, S., Ravishankar, D., and Vg, V.K., 2020. A study on first trimester vaginal bleeding and outcome of pregnancy in Thiruvananthapuram, Kerala. Age (Years), 19 (4), 400.
   Google Scholar
• Saraswat, L., et al., 2010. Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review. BJOG: An International Journal of Obstetrics and Gynaecology, 117 (3), 245–257.
   PubMed Web of Science ®Google Scholar
• Sarmalkar, M.S., Singh, S., and Nayak, A.H., 2016. Maternal and perinatal outcome in women with threatened abortion in first trimester. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 5 (5), 1438–1445.
   Google Scholar
• Schuster, H.J., et al., 2022. Risk factors for spontaneous preterm birth among healthy nulliparous pregnant women in the Netherlands, a prospective cohort study. Health Science Reports, 5 (3), e585.
   PubMedGoogle Scholar
• Sengodan, S. S., Dhanapal, M. and Subramanian, V., 2016. Pregnancy Outcome in First Trimester Bleed. Indian Journal of Applied Research, 6 (7), 46–53.
   Google Scholar
• Sharami, S.H., et al., 2013. The relationship between vaginal bleeding in the first and second trimester of pregnancy and preterm labor. International Journal of Reproductive BioMedicine, 11 (5), 385–390.
   Google Scholar
• Shim, S. S., et al., 2004. Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. American Journal of Obstetrics and Gynecology, 191 (4), 1339–1345.
   PubMed Web of Science ®Google Scholar
• Sipilä, P., et al., 1992. Perinatal outcome of pregnancies complicated by vaginal bleeding. British Journal of Obstetrics and Gynaecology, 99 (12), 959–963.
   PubMedGoogle Scholar
• Smits, L.J., et al., 2012. Patterns of vaginal bleeding during the first 20 weeks of pregnancy and risk of pre-eclampsia in nulliparous women: results from the SCOPE study. Acta Obstetricia et Gynecologica Scandinavica, 91 (11), 1331–1338.
   PubMed Web of Science ®Google Scholar
• Sohrabi, D. and Ghanbarigorgani, M., 2010. Study of some risk factors of pregnancy on preterm delivery in mothers referred to Valiasr Hospital in Zanjan in 2007. Journal of Faculty of Nursing and Midwifery, Urmia, 9 (31), 84–89.
   Google Scholar
• Strobino, B. and Pantel-Silverman, J., 1989. Gestational vaginal bleeding and pregnancy outcome. American Journal of Epidemiology, 129 (4), 806–815.
   PubMed Web of Science ®Google Scholar
• Suganya, K. and Subbarayan, L.M., 2019. Maternal and perinatal outcomes in women with first trimester vaginal bleeding. Journal of Family and Reproductive Health, 8 (11), 4.
   Google Scholar
• Sun, L., et al., 2012. First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women: from a large cohort study in China. The Journal of Maternal-Fetal & Neonatal Medicine, 25 (8), 1297–1301.
   PubMed Web of Science ®Google Scholar
• Sutter, P.D., et al., 2006. First-trimester bleeding and pregnancy outcome in singletons after assisted reproduction. Human Reproduction, 21 (7), 1907–1911.
   PubMed Web of Science ®Google Scholar
• Szymusik, I., et al., 2015. The association of first trimester bleeding with preterm delivery. Journal of Perinatal Medicine, 43 (5), 525–529.
   PubMed Web of Science ®Google Scholar
• Tenny, S. and Hoffman, M., 2023. Odds ratio. StatPearls [Internet]. Tampa, FL: StatPearls Publishing. [Updated 2023 May 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK431098/
   Google Scholar
• Tuuli, M., et al., 2011. Perinatal outcomes in women with subchorionic hematoma: a systematic review and meta-analysis. Obstetrics and Gynecology, 117 (5), 1205–1212.
   PubMed Web of Science ®Google Scholar
• Williams, M.A., et al., 1991. Adverse infant outcomes associated with first-trimester vaginal bleeding. Obstetrics and Gynecology, 78 (1), 14–18.
   PubMed Web of Science ®Google Scholar
• Yakıştıran, B., Yüce, T. and Söylemez, F., 2015. First trimester bleeding and pregnancy outcomes: case-control study. International Journal of Women’s Health and Reproduction Sciences, 4 (1), 4–7.
   Google Scholar
• Yang, J., et al., 2004. Vaginal bleeding during pregnancy and preterm birth. American Journal of Epidemiology, 160 (2), 118–125.
   PubMed Web of Science ®Google Scholar
• Yazdani, S., et al., 2015. the comparition of the risk factors in the term and preterm delivery. j Babol Univ Med Sci, 16 (15), 7–12.
   Google Scholar