Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis

References

• Battaglia, A.M., Chirillo, R., and Aversa, I., 2020. Ferroptosis and cancer: mitochondria meet the "Iron Maiden" cell death. Cells, 9 (6), 1.
   Web of Science ®Google Scholar
• Boreel, D.F., et al., 2021. Targeting oxidative phosphorylation to increase the efficacy of radio- and immune-combination therapy. Clinical Cancer Research, 27 (11), 2970–10.
   PubMed Web of Science ®Google Scholar
• Charoentong, P., et al., 2017. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Reports, 18 (1), 248–262.
   PubMed Web of Science ®Google Scholar
• Chen, M., Zhang, Y., and Zheng, P.S., 2017. Tafazzin (TAZ) promotes the tumorigenicity of cervical cancer cells and inhibits apoptosis. PLOS One, 12 (5), e0177171.
   PubMed Web of Science ®Google Scholar
• Chung, C.H., et al., 2023. Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer. Advanced Science, 10 (15), e2204514.
   Web of Science ®Google Scholar
• Datta, A., et al., 2021. Impact of hypoxia on cervical cancer outcomes. International Journal of Gynecological Cancer, 31 (11), 1459–1470.
   PubMed Web of Science ®Google Scholar
• Deng, Y., et al., 2021. Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer. Aging, 13 (22), 24768–24785.
   PubMedGoogle Scholar
• Federico, C., et al., 2021. Localized delivery of cisplatin to cervical cancer improves its therapeutic efficacy and minimizes its side effect profile. International Journal of Radiation Oncology, Biology, Physics, 109 (5), 1483–1494.
   PubMed Web of Science ®Google Scholar
• Jiao, Y. and Geng, R., 2023. A hypoxia molecular signature-based prognostic model for endometrial cancer patients. International Journal of Molecular Sciences, 24 (2), 1675.
   PubMed Web of Science ®Google Scholar
• Liang, J.Y., et al., 2020. A novel ferroptosis-related gene signature for overall survival prediction in patients with hepatocellular carcinoma. International Journal of Biological Sciences, 16 (13), 2430–2441.
   PubMed Web of Science ®Google Scholar
• Liu, C., et al., 2022. Prognostic modeling of lung adenocarcinoma based on hypoxia and ferroptosis-related genes. Journal of Oncology, 2022, 1022580.
   PubMed Web of Science ®Google Scholar
• Liu, J., et al., 2020. Histone demethylase KDM3A promotes cervical cancer malignancy through the ETS1/KIF14/Hedgehog axis. OncoTargets and Therapy, 13, 11957–11973.
   PubMed Web of Science ®Google Scholar
• Liu, L., et al., 2019. Combination of TMB and CNA stratifies prognostic and predictive responses to immunotherapy across metastatic cancer. Clinical Cancer Research, 25 (24), 7413–7423.
   PubMed Web of Science ®Google Scholar
• Liu, S., et al., 2022. HPV16 E6/E7 stabilize PGK1 protein by reducing its poly-ubiquitination in cervical cancer. Cell Biology International, 46 (3), 370–380.
   PubMed Web of Science ®Google Scholar
• Liu, Y., et al., 2023. A new ferroptosis-related signature model including messenger RNAs and long non-coding RNAs predicts the prognosis of gastric cancer patients. Journal of Translational Internal Medicine, 11 (2), 145–155.
   PubMed Web of Science ®Google Scholar
• López-Muñoz, H., et al., 2013. Cervical cancer cells induce apoptosis in TCD4+ lymphocytes through the secretion of TGF-β. Archives of Gynecology and Obstetrics, 287 (4), 755–763.
   PubMed Web of Science ®Google Scholar
• Mei, J., et al., 2020. Construction of an immune-related gene signature for prediction of prognosis in patients with cervical cancer. International Immunopharmacology, 88, 106882.
   PubMed Web of Science ®Google Scholar
• Nie, D., et al., 2016. Knockdown of angiopoietin-like protein 4 inhibits proliferation and promotes apoptosis in cervical cancer SiHa cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 32 (4), 488–492.
   PubMedGoogle Scholar
• Nie, D., et al., 2019. Up-regulated of angiopoietin-like protein 4 predicts poor prognosis in cervical cancer. Journal of Cancer, 10 (8), 1896–1901.
   PubMed Web of Science ®Google Scholar
• Ousingsawat, J., Schreiber, R., and Kunzelmann, K., 2019. TMEM16F/Anoctamin 6 in ferroptotic cell death. Cancers, 11 (5), 625.
   PubMed Web of Science ®Google Scholar
• Qi, X., et al., 2021. A novel ferroptosis-related gene signature for predicting outcomes in cervical cancer. Bioengineered, 12 (1), 1813–1825.
   PubMed Web of Science ®Google Scholar
• Ren, M., et al., 2023. A novel pancreatic cancer hypoxia status related gene signature for prognosis and therapeutic responses. Molecular Biotechnology,
   Google Scholar
• Stockwell, B.R. and Jiang, X., 2019. A physiological function for ferroptosis in tumor suppression by the immune system. Cell Metabolism, 30 (1), 14–15.
   PubMed Web of Science ®Google Scholar
• Sun, Y., et al., 2020. The emerging role of ferroptosis in inflammation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 127, 110108.
   PubMed Web of Science ®Google Scholar
• Tewari, K.S., et al., 2017. Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240). Lancet, 390 (10103), 1654–1663.
   PubMed Web of Science ®Google Scholar
• Uno, K., et al., 2011. Divergent expression of l-type amino acid transporter 1 during uterine cervical carcinogenesis. Human Pathology, 42 (11), 1660–1666.
   PubMed Web of Science ®Google Scholar
• Valli, A., et al., 2019. Adaptation to HIF1α deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism. Molecular Cancer Research, 17 (7), 1531–1544.
   PubMed Web of Science ®Google Scholar
• Wen, K., et al., 2021. Construction and validation of a combined ferroptosis and hypoxia prognostic signature for hepatocellular carcinoma. Frontiers in Molecular Biosciences, 8, 809672.
   PubMed Web of Science ®Google Scholar
• Westendorf, A.M., et al., 2017. Hypoxia enhances immunosuppression by inhibiting CD4+ effector T cell function and promoting Treg activity. Cellular Physiology and Biochemistry, 41 (4), 1271–1284.
   PubMedGoogle Scholar
• Wu, A., et al., 2021. Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis. Cancer Science, 112 (11), 4515–4525.
   PubMed Web of Science ®Google Scholar
• Wu, K., et al., 2018. Identification of key pathways and genes in the progression of cervical cancer using bioinformatics analysis. Oncology Letters, 16 (1), 1003–1009.
   PubMed Web of Science ®Google Scholar
• Wu, S., et al., 2022. Development and verification of a prognostic ferroptosis-related gene model in triple-negative breast cancer. Frontiers in Oncology, 12, 896927.
   PubMed Web of Science ®Google Scholar
• Yamamoto, N., et al., 2013. Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma. International Journal of Oncology, 42 (5), 1523–1532.
   PubMed Web of Science ®Google Scholar
• Yang, C.B., Feng, H.X., and Dai, C.L., 2022. Development and validation of an immune-related prognosis signature associated with hypoxia and ferroptosis in hepatocellular carcinoma. Cancer Medicine, 11 (11), 2329–2341.
   PubMed Web of Science ®Google Scholar
• Yang, L., et al., 2021. Identification of prognosis-related genes in the cervical cancer immune microenvironment. Gene, 766, 145119.
   PubMed Web of Science ®Google Scholar
• Yang, M., et al., 2019. Clockophagy is a novel selective autophagy process favoring ferroptosis. Science Advances, 5 (7), eaaw2238.
   PubMed Web of Science ®Google Scholar
• Yang, X., et al., 2022. Ferroptosis-related genes identify tumor immune microenvironment characterization for the prediction of prognosis in cervical cancer. Annals of Translational Medicine, 10 (2), 123.
   PubMed Web of Science ®Google Scholar
• Yang, Y., et al., 2021. Constructed a novel 5 hypoxia genes signature for cervical cancer. Cancer Cell International, 21 (1), 345.
   PubMed Web of Science ®Google Scholar
• Yarla, N.S., et al., 2016. Targeting arachidonic acid pathway by natural products for cancer prevention and therapy. Seminars in Cancer Biology, 40–41, 48–81.
   PubMed Web of Science ®Google Scholar
• Zhang, T., et al., 2022. A novel predictive model for adrenocortical carcinoma based on hypoxia- and ferroptosis-related gene expression. Frontiers in Medicine, 9, 856606.
   Web of Science ®Google Scholar
• Zhang, Y., et al., 2021. hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire, 99 (2), 203–213.
   PubMedGoogle Scholar
• Zheng, S., et al., 2020. Identification and validation of a combined hypoxia and immune index for triple-negative breast cancer. Molecular Oncology, 14 (11), 2814–2833.
   PubMed Web of Science ®Google Scholar
• Zhong, J., et al., 2023. Development and validation of a combined hypoxia and ferroptosis prognostic signature for breast cancer. Frontiers in Oncology, 13, 1077342.
   PubMed Web of Science ®Google Scholar
• Zou, Y., et al., 2019. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nature Communications, 10 (1), 1617.
   PubMed Web of Science ®Google Scholar