306
Views
0
CrossRef citations to date
0
Altmetric
Research Article

The role of Ca2+ signalling and InsP3R in the pathogenesis of intrahepatic cholestasis of pregnancy

, , , , , & show all
Article: 2345276 | Received 20 Sep 2023, Accepted 14 Apr 2024, Published online: 29 Apr 2024

References

  • Alpini, G., et al., 2002. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology, 35 (5), 1–9.
  • Alzayady, K.J., et al., 2016. Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release. Science Signaling, 9 (422), ra35.
  • Amaya, M.J. and Nathanson, M.H., 2014. Calcium signaling and the secretory activity of bile duct epithelia. Cell Calcium, 55 (6), 317–324.
  • Amroudie, M.N. and Ataei, F., 2016. Experimental and theoretical study of IBC domain from human IP3R2; molecular cloning, bacterial expression and protein purification. International Journal of Biological Macromolecules, 124, 1321–1327.
  • Beuers, U., Boyer, J.L., and Paumgartner, G., 1998. Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications. Hepatology, 28 (6), 1449–1453.
  • Bird, G.S. and Putney, J.W., Jr. 2018. Pharmacology of store-operated calcium entry channels. In: Calcium entry channels in non-excitable cells. CRC Press/Taylor & Francis, Chapter 16.
  • Bonus, M., Häussinger, D., and Gohlke, H., 2021. Liver cell hydration and integrin signaling. Biological Chemistry, 402 (9), 1033–1045.
  • Çelik, S., et al., 2019. Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy. Ginekologia Polska, 90 (4), 217–222.
  • Chen, Y., et al., 2015. Estrogen and estrogen receptor-α-mediated transrepression of bile salt export pump. Molecular Endocrinology, 29 (4), 613–626.
  • Dranoff, J.A., et al., 2001. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. American Journal of Physiology. Gastrointestinal and Liver Physiology, 281 (4), G1059–G1067.
  • Dutta, A.K., et al., 2020. Signaling through the interleukin-4 and interleukin-13 receptor complexes regulates cholangiocyte TMEM16A expression and biliary secretion. American Journal of Physiology. Gastrointestinal and Liver Physiology, 318 (4), G763–G771.
  • Fanyin, M., et al., 2018. Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2−/− mice and human primary sclerosing cholangitis. Laboratory Investigation, 98, 1465–1477.
  • Franca, A., et al., 2019. Effects of endotoxin on type 3 inositol 1,4,5-trisphosphate receptor in human cholangiocytes. Hepatology, 69 (2), 817–830.
  • Fu, C. and Xu, Y., 2021. Value of serum glycocholic acid and total bile acids in predicting maternal and perinatal outcomes in intrahepatic cholestasis of pregnancy. Journal of Healthcare Engineering, 2021, 3911998.
  • Gao, X.X., et al., 2020. Prevalence and risk factors of intrahepatic cholestasis of pregnancy in a Chinese population. Scientific Reports, 10 (1), 16307.
  • Garrido, A., et al., 2022. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. Journal of Hepatology, 76 (4), 850–861.
  • Gupta, K., et al., 2020. Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials, 259, 120283.
  • Hagar, R.E. and Ehrlich, B.E., 2000. Regulation of the type III InsP(3) receptor by InsP(3) and ATP. Biophysical Journal, 79 (1), 271–278.
  • Herta, T., et al., 2022. Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection. Journal of Hepatology, 76 (2), 319–331.
  • Hodeify, R., et al., 2018. Regulation and role of store-operated Ca2+ entry in cellular proliferation. In: J.A. Kozak and J.W. Putney, Jr., eds. Calcium entry channels in non-excitable cells. Boca Raton (FL): CRC Press/Taylor & Francis, 215–240.
  • Iyer, R. and Franzini-Armstrong, C., 2021. The location of InsP3 receptors in Purkinje cells of murine cerebellum does not supports a direct interaction in the transfer of calcium ions between ER and mitochondria. European Journal of Translational Myology, 31 (3), 9935.
  • Kilkenny, C., et al., 2010. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biology, 8 (6), e1000412.
  • Kremer, A.E., et al., 2010. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology, 139 (3), 1008–1018, 1018.e1.
  • Krupa, Ł., et al., 2021. Importance of bile composition for diagnosis of biliary obstructions. Molecules, 26 (23), 7279.
  • Lei, Z., et al., 2016. Effects of taurochenodeoxycholic acid on Ca2+/CaM signalling mediated by the TGR5 signalling pathway. Die Pharmazie, 71 (7), 390–393.
  • Li, Y., et al., 2017. Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases. Autoimmunity Reviews, 16 (9), 885–896.
  • Li, Y., et al., 2023. The spatial expression of mTORC2–AKT–IP3R signal pathway in mitochondrial combination of endoplasmic reticulum of maternal fetal interface trophoblast in intrahepatic cholestasis of pregnancy. Journal of Perinatal Medicine, 51 (8), 1032–1039.
  • Mangla, A., Guerra, M.T., and Nathanson, M.H., 2020. Type 3 inositol 1,4,5-trisphosphate receptor: a calcium channel for all seasons. Cell Calcium, 85, 102132.
  • Marongiu, L., et al., 2021. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells. Science Signaling, 14 (676), eaaz2120.
  • Mayo, M.J., et al., 2018. NGM282 for treatment of patients with primary biliary cholangitis: a multicenter, randomized, double-blind, placebo-controlled trial. Hepatology Communications, 2 (9), 1037–1050.
  • Minagawa, N., et al., 2007. Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology, 133 (5), 1592–1602.
  • Miranda, M.C.D., et al., 2019. Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase C delta-4 (PLCδ4). Journal of Biological Chemistry, 294 (45), 16650–16662.
  • Nathanson, M.H., et al., 2001. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochemical Journal, 358 (Pt 1), 1–5.
  • Piechota, J. and Jelski, W., 2020. Intrahepatic cholestasis in pregnancy: review of the literature. Journal of Clinical Medicine, 9 (5), 1361.
  • Rodrigues, M.A., et al., 2022. Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4). Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 145, 112403.
  • Rodrigues, M.A., Gomes, D.A., and Nathanson, M.H., 2018. Calcium signaling in cholangiocytes: methods, mechanisms, and effects. International Journal of Molecular Sciences, 19 (12), 3913.
  • Roos, F.J.M., et al., 2021. Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids. American Journal of Physiology. Gastrointestinal and Liver Physiology, 320 (5), G741–G752.
  • Ueasilamongkol, P., et al., 2020. Type 3 inositol 1,4,5-trisphosphate receptor is increased and enhances malignant properties in cholangiocarcinoma. Hepatology, 71 (2), 583–599.
  • Vasavan, T., et al., 2021. Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations. Journal of Hepatology, 74 (5), 1087–1096.
  • Xiao, J., et al., 2021. Molecular pathogenesis of intrahepatic cholestasis of pregnancy. Canadian Journal of Gastroenterology & Hepatology, 2021, 6679322.
  • Yang, F., et al., 2021. Preservation of endoplasmic reticulum (ER) Ca2+ stores by deletion of inositol-1,4,5-trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide-gated channel-deficient cone photoreceptors. FASEB Journal, 35 (6), e21579.
  • Zhang, L., et al., 2021. Upregulated SOCC and IP3R calcium channels and subsequent elevated cytoplasmic calcium signaling promote nonalcoholic fatty liver disease by inhibiting autophagy. Molecular and Cellular Biochemistry, 476 (8), 3163–3175.
  • Zhou, Q., et al., 2019. Effect of 4-phenylbutyric acid and tauroursodeoxycholic acid on magnesium and calcium metabolism in streptozocin-induced type 1 diabetic mice. Biological Trace Element Research, 189 (2), 501–510.
  • Zhu, P., et al., 2019. Correlation of lipid peroxidation and ATP enzyme on erythrocyte membrane with fetal distress in the uterus in patients with intrahepatic cholestasis of pregnancy. European Review for Medical and Pharmacological Sciences, 23, 2318–2324.