104
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Artemisia vulgaris L., Artemisia alba Turra and their constituents reduce mitomycin C-induced genomic instability in human peripheral blood lymphocytes in vitro

, , &
Pages 156-165 | Received 08 Jun 2022, Accepted 27 Nov 2022, Published online: 08 Dec 2022

References

  • Abraham, S.K., et al., 2012. Analysis of in vitro chemoprevention of genotoxic damage by phytochemicals, as single agents or as combinations. Mutation Research, 744 (2), 117–124.
  • Ahmed, M.M., et al., 2009. In-vitro radio protective role of ferulic acid in cultured lymphocytes. Journal of Radiation Research and Applied Science, 3 (1), 19–30.
  • Akram, M., et al., 2020. Medicinal plants with anti-mutagenic potential. Biotechnology & Biotechnological Equipment, 34 (1), 309–318.
  • Alcaraz, M., et al., 2021. Genoprotective effect of some flavonoids against genotoxic damage induced by X-rays in vivo: relationship between structure and activity. Antioxidants, 11 (1), 94.
  • Anantharaju, P.G., et al., 2017. Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). Cancer Biology & Therapy, 18 (7), 492–504.
  • Andrade, A.F., et al., 2016. In vitro cytotoxicity, genotoxicity and antigenotoxicity assessment of Solanum lycocarpum hydroalcoholic extract. Pharmaceutical Biology, 54 (11), 2786–2790.
  • Araújo., et al., 2020. Polyphenols and their applications: an approach in food chemistry and innovation potential. Food and Chemistry, 338, 127535.
  • Azqueta, A., and Collins, A., 2016. Polyphenols and DNA damage: a mixed blessing. Nutrients, 8 (12), 785.
  • Bajić, V., et al., 2005. A negative adaptive response is expressed in peripheral blood lymphocytes that are exposed to mitomycin C and cycloheximide. Journal of B.U.ON., 10 (1), 111–117.
  • Cavalcante, F.M.L., et al., 2018. Cytotoxicity, mutagenicity, and antimutagenicity of the gentisic acid on HTC cells. Drug and Chemical Toxicology, 41 (2), 155–161.
  • Çelik, H., and Arinç, E., 2010. Evaluation of the protective effects of quercetin, rutin, resveratrol, naringenin and trolox against idarubicin-induced DNA damage. Journal of Pharmacy & Pharmaceutical Sciences, 13 (2), 231–241.
  • Cinkilic, N., et al., 2013. Radioprotection by two phenolic compounds: chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro. Food and Chemical Toxicology, 53, 359–363.
  • Chassagne, F., et al., 2020. A systematic review of plants with antibacterial activities: a taxonomic and phylogenetic perspective. Frontiers in Pharmacology, 11, 586548.
  • Chedea, V.S., et al., 2021. Antioxidant/Pro-oxidant actions of polyphenols from grapevine and wine by-products-base for complementary therapy in ischemic heart diseases. Frontiers in Cardiovascular Medicine, 8, 750508.
  • Daradka, H.M., and Alshibly, N.M.Y., 2012. Effect of Artemisia alba L. extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes. African Journal and Biotechnology, 11 (86), 15246–15250.
  • Danova, K., et al., 2020. Therapeutic potential and biotechnological utilization of the indigenous biosynthetic capacity of Artemisia alba Turra: a review. Ecologica Balcanica, 3, 257–273.
  • De Flora, S., and Ramel, C., 1988. Mechanisms of inhibitors of mutagenesis and carcinogénesis. classification and overview. Mutation Research, 202 (2), 285–306.
  • de Giffoni de Carvalho, J.T., et al., 2019. Medicinal plants from Brazilian Cerrado: antioxidant and anticancer potential and protection against chemotherapy toxicity. Oxidative Medicine and Cellular Longevity, 2019, 1–16.
  • De Marino, S., et al., 2014. Antioxidant activity and chemical components as potential anticancer agents in the olive leaf (Olea europaea L. cv Leccino.) decoction. Anti-Cancer Agents in Medicinal Chemistry, 14 (10), 1376–1385.
  • Dettweiler, M., et al., 2020. A clerodane diterpene from Callicarpa americana resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics. ACS Infectious Diseases, 6 (7), 1667–1673.
  • Dias, M.C., et al., 2021. Plant flavonoids: chemical characteristics and biological activity. Molecules, 26 (17), 5377.
  • Ding, S., et al., 2020. The protective effect of polyphenols for colorectal cancer. Frontier in Immunolgy, 11, 1407.
  • Dziedzinski, M., et al., 2020. Identification of polyphenols from coniferous shoots as natural antioxidants and antimicrobial compounds. Molecules, 25 (15), 3527.
  • Eghbaliferiz, S., and Iranshahi, M., 2016. Prooxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: an updated review of mechanisms and catalyzing metals. Phytotherapy Research, 30 (9), 1379–1391.
  • Ekiert, H., et al., 2020. Significance of Artemisia vulgaris L. (common Mugwort) in the history of medicine and its possible contemporary applications substantiated by phytochemical and pharmacological studies. Molecules, 25 (19), 4415.
  • Engen, A., et al., 2015. Induction of cytotoxic and genotoxic responses by natural and novel quercetin glycosides. Mutation Research, 784–785, 15–22.
  • Erdem, M.G., et al., 2012. Genotoxic and anti-genotoxic effects of vanillic acid against mitomycin C-induced genomic damage in human lymphocytes in vitro. Asian Pacific Journal of Cancer Prevention, 13 (10), 4993–4998.
  • Fenech, M., 2000. The in vitro micronucleus technique. Mutation Research, 455 (1–2), 81–95.
  • Fenech, M., 2007. Cytokinesis-block micronucleus cytome assay. Nature Protocols, 2 (5), 1084–1104.
  • Fenech, M., 2020. Cytokinesis-block micronucleus cytome assay evolution into a more comprehensive method to measure chromosomal instability. Genes, 11 (10), 1203.
  • Grujičić, D., et al., 2020. Genotoxic and cytotoxic properties of two medical plants (Teucrium arduini L. and Teucrium flavum L.) in relation to their polyphenolic contents. Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 852 (2), 503168.
  • Hobbs, C.A., et al., 2018. Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential. Food and Chemical Toxicology, 113, 218–227.
  • Hovhannisyan, G., et al., 2016. Comparative analysis of individual chromosome involvement in micronuclei induced by Mitomycin C and bleomycin in human leukocytes. Molecular Cytogenetics, 9, 49.
  • Ickovski, J.D., et al., 2020. Comparative analysis of HPLC profiles and antioxidant activity of Artemisia alba Turra from two habitats in Serbia. Chemia Naissensis, 3 (2), 89–99.
  • Kalinowska, M., et al., 2021. Plant-derived and dietary hydroxybenzoic acids- acomprehensive study of structural, anti-/pro-oxidant, lipophilic, antimicrobial, and cytotoxic activity in MDA-MB-231 and MCF-7 cell lines. Nutrients, 13 (9), 3107.
  • Kocaman, A.Y., and Guzelkokar, M., 2018. The genotoxic and antigenotoxic potential of the methanolic root extract of Glycyrrhiza glabra L. on human peripheral blood lymphocytes. Drug and Chemical Toxicology, 41 (3), 368–375.
  • Kitsati, N., et al., 2012. Lipophilic caffeic acid derivatives protect cells against H2O2-induced DNA damage by chelating intracellular labile iron. Journal of Agricultural and Food Chemistry, 60 (32), 7873–7879.
  • Lian, G., et al., 2018. Herbal extract of Artemisia vulgaris (mugwort) induces antitumor effects in HCT-15 human colon cancer cells via autophagy induction, cell migration suppression and loss of mitochondrial membrane potential. Journal of B.U.ON., 23 (1), 73–78.
  • Luo, M., et al., 2020. Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer. Signal Transduction and Targeted Therapy, 5 (1), 141–154.
  • Maeda, J., et al., 2014. Natural and glucosyl flavonoids inhibit poly(ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells. Oncology Reports, 31 (2), 551–556.
  • Marcelia, M., et al., 2018. In vitro cytotoxicity of the synthesized gallic acid derivatives (N-Alkyl Gallamide) against breast MCF-7 cancer cells. Oriental Journal of Chemistry, 34 (5), 2268–2272.
  • Marković, A., et al., 2022. Methanol extracts of Teucrium arduini L. and Teucrium flavum L. induce protective effect against mitomycin C in human lymphocytes in vitro. Drug and Chemical Toxicology, 45 (2), 940–946.
  • Matsuno, Y., et al., 2020. Resveratrol and its related polyphenols contribute to the maintenance of genome stability. Scientific Reports, 10 (1), 5388.
  • Melguizo-Melguizo, D., et al., 2014. The potential of Artemisia vulgaris leaves as a source of antioxidant phenolic compounds. Journal of Functional Foods, 10, 192–200.
  • Milošević-Djordjević, O., et al., 2018. Polyphenolic contents of Teucrium polium L. and Teucrium scordium L. associated with their protective effects against MMC-induced chromosomal damage in cultured human peripheral blood lymphocytes. Turkish Journal of Biology = Turk Biyoloji Dergisi, 42 (2), 152–162.
  • Moghtaderi, H., et al., 2018. Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231. BioImpacts, 8 (3), 185–194.
  • Nasr, S.B., et al., 2020. In-vitro antioxidant and anti-inflamatory activities of Pituranthos chloranthus and Artemisia vulgaris from Tunisia. International Journal of Pharmaceutical Sciences and Research, 11 (2), 605–614.
  • Nigam, M., et al., 2019. Bioactive compounds and health benefits of Artemisia species. Natural Product Communication, 2019, 1–17.
  • Pandey, A.K., and Singh, P., 2017. The Genus Artemisia: a 2012–2017 literature review on chemical composition, antimicrobial, insecticidal and antioxidant activities of essential oils. Medicines, 4 (3), 68.
  • Pandey, B.P., et al., 2017. Chemical composition, antioxidant and antibacterial activities of essential oil and methanol extract of Artemisia vulgaris and Gaultheria fragrantissima collected from Nepal. Asian Pacific Journal of Tropical Medicine, 10 (10), 952–959.
  • Pandey, J., et al., 2021. Anti-inflammatory activity of Artemisia vulgaris leaves, originating from three different altitudes of Nepal. TheScientificWorldJournal, 2021, 6678059.
  • Patil, S.L., et al., 2017. In vitro protective effect of rutin and quercetin against radiation-induced genetic damage in human lymphocytes. Indian Journal of Nuclear Medicine, 32 (4), 289–295.
  • Peron, G., et al., 2017. Phytochemical investigations on Artemisia alba Turra growing in the North-East of Italy. Natural Product Research, 31 (16), 1861–1868.
  • Proshkina, E., et al., 2020. Genome-protecting compounds as potential geroprotectors. International Journal of Molecular Sciences, 21 (12), 4484.
  • Radović Jakovljević, M., et al., 2019. Ethyl acetate extracts of two Artemisia species: analyses of phenolic profile and anticancer activities against SW-480 colon cancer cells. Natural Product Communications, 14 (5), 1934578X1984301.
  • Radović Jakovljević, M., et al., 2020. In vitro study of genotoxic and cytotoxic activities of methanol extracts of Artemisia vulgaris L. and Artemisia alba Turra. South African Journal of Botany, 132, 117–126.
  • Radović Jakovljević, M., et al., 2022. Comparative study of the genotoxic activity of Artemisia vulgaris L. and Artemisia alba Turra extracts in vitro. Drug and Chemical Toxicology, 45 (4), 1915–1922.
  • Rahman, M., et al., 2021. Role of phenolic compounds in human disease: current knowledge and future prospects. Molecules, 27 (1), 233.
  • Sherin, L., et al., 2019. Time-dependent AI-modeling of the anticancer efficacy of synthesized gallic acid analogues. Computational Biology and Chemistry, 79, 137–146.
  • Shinohara, K., et al., 2006. Antitumor activity of sequence-specific alkylating agents: pyrolle-imidazole CBI conjugates with indole linker. Cancer Science, 97 (3), 219–225.
  • Sommer, S., et al., 2020. Micronucleus assay: the state of art, and future directions. International Journal of Molecular Sciences, 21 (4), 1534.
  • Stanković, M., et al., 2011. Teucrium plant species as natural sources of novel anticancer compounds: antiproliferative, proapoptotic and antioxidant properties. International Journal of Molecular Sciences, 12 (7), 4190–4205.
  • Strzelecka, M., et al., 2005. Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants. Journal of Physiology and Pharmacology, 56 (1), 139–156.
  • Taleghani, A., et al., 2020. Artemisia: a promising plant for the treatment of cancer. Bioorganic & Medicinal Chemistry, 28 (1), 115180.
  • Taner, G., et al., 2017. Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of vanillic and cinnamic acid. Drug and Chemical Toxicology, 40 (2), 183–190.
  • Todorova, M., et al., 2015. Highly oxygenated sesquiterpenes in Artemisia alba Turra. Phytochemistry, 110, 140– 149.
  • Trendafilova, A., et al., 2018. Phenolic profile of Artemisia alba Turra. Chemistry & Biodiversity, 15 (7), e1800109.
  • Turkez, H., et al., 2012. Xanthoria elegans (Link) (lichen) extract counteracts DNA damage and oxidative stress of mitomycin C in human lymphocytes. Cytotechnology, 64 (6), 679–686.
  • van Valenberg, F.J.P., et al., 2018. Assessment of the efficacy of repeated instillations of mitomycin C mixed with a thermosensitive hydrogel in an orthotopic rat bladder cancer model. Therapeutic Advances in Urology, 10 (7), 213–221.
  • Weng, M.W., et al., 2010. Repair of mitomycin C mono- and inter-strand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acids Research, 38 (20), 6976–6984.
  • Zhang, Z., et al., 2015. Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Scientific Reports, 5, 14633.
  • Zhang, Y., et al., 2022. A brief review of phenolic compounds identified from plants: their extraction, analysis, and biological activity. Natural Product Communications, 17 (1), 1934578X2110697–14.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.