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Research Articles

Preparation, characterization, and toxicity evaluation of microemulsion formulation containing prunetin for potential oral applications

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Pages 235-242 | Received 29 Sep 2022, Accepted 02 Nov 2023, Published online: 22 Nov 2023

References

  • Ahmad, R., Kochumon, S., Chandy, B., Shenouda, S., Koshy, M., Hasan, A., Arefanian, H., Al-Mulla, F., & Sindhu, S. (2019). TNF-α drives the CCL4 expression in human monocytic cells: Involvement of the SAPK/JNK and NF-κB signaling pathways. Cellular Physiology and Biochemistry., 52, 908–921.
  • Ahn, T. G., Yang, G., Lee, H. M., Kim, M. D., Choi, H. Y., Park, S. K., Lee, D. S., Kook, B. S., Kook, B. Y., & An, J. H. (2013). Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone. Biochemical Pharmacology, 85(10), 1525–1533.
  • Berkman, S. M., & Güleç, K. (2021). Pseudo ternary phase diagrams: A practical approach for the area and centroid calculation of stable microemulsion regions. İstanbul Journal of Pharmacy, 51(1), 42–49.
  • Chanput, W., Mes, J. J., Savelkoul, H. F., & Wichers, H. J. (2013). Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds. Food & Function, 4(2), 266–276.
  • Chen, C., Wang, Y., Chen, S., Ruan, X., Liao, H., Zhang, Y., Sun, J., Gao, J., & Deng, G. (2020). Genistein inhibits migration and invasion of cervical cancer HeLa cells by regulating FAK-paxillin and MAPK signaling pathways. Taiwanese Journal of Obstetrics & Gynecology, 59(3), 403–408.
  • Cilek, A., Çelebi, N., & Tirnaksiz, F. (2006). Lecithin-based microemulsion of a peptide for oral administration: Preparation, characterization, and physical stability of the formulation. Drug Delivery, 13(1), 19–24.
  • Constantinides, P. P. (1995). Lipid microemulsions for ımproving drug dissolution and oral absorption: Physical and biopharmaceutical aspects. Pharmaceutical Research, 12(11), 1561–1572.
  • Esmeeta, A., Adhikary, S., Dharshnaa, V., Swarnamughi, P., Maqsummiya, U. Z., Banerjee, A., Surajit, P., & Duttaroy, A. K. (2022). Plant-derived bioactive compounds in colon cancer treatment: An updated review. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 153, 113384.
  • Ezzat, M. I., Hassan, M., Abdelhalim, M. A., EL-Desoky, A. M., Mohamed, S. O., & Ezzat, S. M. (2021). Immunomodulatory effect of Noni fruit and its isolates: İnsights into cell-mediated immune response and inhibition of LPS-induced THP-1 macrophage inflammation. Food & Function, 12(7), 3170–3179.
  • Foster, R. J. (2001). The functions of cytokines and their uses in toxicology. International Journal of Experimental Pathology, 82(3), 171–192.
  • Hanhineva, K., Törrönen, R., Bondia-Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H., & Poutanen, K. (2010). Impact of dietary polyphenols on carbohydrate metabolism. International Journal of Molecular Sciences, 11(4), 1365–1402.
  • Hu, H., & Li, H. (2018). Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 106, 1469–1477.
  • Jangid, A. K., Solanki, R., Patel, S., Pooja, D., & Kulhari, H. (2022). Genistein encapsulated inulin-stearic acid bioconjugate nanoparticles: Formulation development, characterization and anticancer activity. International Journal of Biological Macromolecules, 206, 213–221.
  • Karayildirim, K. C., Nalbantsoy, A., & Yavasoglu, K. N. U. (2021). Prunetin ınhibits nitric oxide activity, proliferation and ınduces apoptosis in urinary bladder cancer cells (RT-4). Through the Enhancement of Apoptotic Pathway via CASP3 and TNF-α Genes That Are Involved, 48(11), 7251–7259.
  • Koli, R. A., Ranch, M. K., Patel, P. H., Parikh, K. R., Shah, O. D., & Maulvi, A. F. (2021). Oral bioavailability improvement of felodipine using tailored microemulsion: Surface science, ex vivo and in vivo studies. International Journal of Pharmaceutics, 596, 120202.
  • Liu, Y. Y., Wu, Q. J., Fan, Y. R., He, H. Z., Li, Y. C., & He, F. M. (2020). Isoliquiritin promote angiogenesis by recruiting macrophages to improve the healing of zebrafish wounds. Fish & Shellfish İmmunology, 100, 238–245.
  • Loeb, W. F., & Quimby, F. W. (1999). The clinical chemistry of laboratory animals (2nd ed.). Taylor & Francis USA.
  • Murray, J. S., Pfeiffer, C., Madri, J., & Bottomly, K. (1992). Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype. European Journal of İmmunology, 22(2), 559–565.
  • OECD Guidelines for the testing of chemicals No: 425. (2008). Acute Oral Toxicity Up-and-Down-Procedure (UDP), 1–27.
  • OECD Guidelines for the testing of chemicals No: 471. (1997). Bacterial Reverse Mutation Test, 1–11.
  • Oliveira-Garcia, p., Otero, P., Pereira, G. A., Chamorro, F., Carpena, M., Echave, J., Corral-Fraga, M., Gandara-Simal, J., & Prieto, Am. (2021). Status and challenges of plant-anticancer compounds in cancer treatment. Pharmaceuticals, 14(2), 157.
  • Parekh, H. S., Liu, G., & Wei, M. Q. (2009). A new dawn for the use of traditional Chinese medicine in cancer therapy. Molecular Cancer, 8 (8), 21.
  • Rajput, S. M., & Sarkar, D. P. (2017). Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice. Chemico-Biological İnteractions, 268, 93–102.
  • Rathod, S., Desai, H., Patil, R., & Sarolia, J. (2022). Non-ionic surfactants as a P-Glycoprotein(P-gp) efflux ınhibitor for optimal drug delivery – A Concise outlook. AAPS PharmSciTech, 23(1), 55.
  • Sarasquete, C., Úbeda-Manzanaro, M., & Ortiz-Delgado, J. B. (2018). Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Comparative Biochemistry and Physiology. Toxicology & Pharmacology, 211, 57–67.
  • Siafaka, P. I., Çağlar, E. Ş., Sipahi, H., Charehsaz, M., Aydın, A., & Üstündağ Okur, N. (2021). Ocular microemulsion of brinzolamide: Formulation, physicochemical characterization, and in vitro irritation studies based on EpiOcularTM eye irritation assay. Pharmaceutical Development and Technology, 26(7), 765–778.
  • Sindhu, S., Kochumon, S., Shenouda, S., Wilson, A., Al-Mulla, F., & Ahmad, R. (2019). The cooperative ınduction of CCL4 in human monocytic cells by TNF-α and palmitate requires MyD88 and ınvolves MAPK/NF-κB signaling pathways. International Journal of Molecular Sciences, 20(18), 4658
  • Singh, K. S., Rashid, M., Bhalala, K., Malik, Y., Chaturvedi, S., Raju, S. R. K., Sultana, N., Mitra, K., Gayen, R. J., & Wahajuddin, M. (2021). A novel nanosized phospholipid complex of Biochanin A for improving oral bioavailability: Preparation and in-vitro/in-vivo characterizations. Journal of Drug Delivery Science and Technology, 61, 102254.
  • Suen, A. A., Kenan, C. A., & Williams, J. C. (2022). Developmental exposure to phytoestrogens found in soy: New findings and clinical implications. Biochemical Pharmacology, 195, 114848.
  • Szumala, P. (2015). Structure of microemulsion formulated with monoacylglycerols in the presence of polyols and ethanol. Journal of Surfactants and Detergents, 18, 97–106.
  • Tarrant, J. M. (2010). Blood cytokines as biomarkers of in vivo toxicity in preclinical safety assessment: Considerations for their use. Toxicological Sciences, 117(1), 4–16.
  • Umetani, N., Kanayama, Y., Okamura, M., Negoro, N., & Takeda, T. (1996). Lova-statin inhibits gene expression of type-I scavenger receptor in THP-1human macrophages. Biochimica Et Biophysica Acta, 1303(3), 199–206.
  • Üstündağ Okur, N., Yavaşoğlu, A., & Karasulu, H. Y. (2014). Preparation and evaluation of microemulsion formulations of naproxen for dermal delivery. Chemical & Pharmaceutical Bulletin, 62(2), 135–143.
  • Üstündağ Okur, N., Çağlar, E. Ş., Arpa, M. D., & Karasulu, H. Y. (2017). Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine. Pharmaceutical Development and Technology, 22(4), 500–510.
  • Vetrivel, P., Nachimuthu, S., Abuyaseer, A., Bhosale, B. P., Ha, E. S., Kim, H. H., Park, Y. M., & Kim, S. G. (2022). Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer. Scientific Reports, 12(1), 11852
  • Wang, H., Xiao, Y., Wang, H., Sang, Z., Han, X., Ren, S., Du, R., Shi, X., & Xie, Y. (2019). Development of daidzein nanosuspensions: Preparation, characterization, in vitro evaluation, and pharmacokinetic analysis. International Journal of Pharmaceutics, 566, 67–76.
  • White, B., Banerjee, S., O’Brien, S., Turro, N. J., & Herman, I. P. (2007). Zeta-potential measurements of surfactant-wrapped ındividual single-walled carbon nanotubes. The Journal of Physical Chemistry C, 111(37), 13684–13690.
  • Wong, S. L., Chang, H. S., Wang, G. J., Chiang, M. Y., Huang, H. Y., Chen, C. H., Tsai, S. C., Lin, C. H., & Chen, I. S. (2011). Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity. Journal of Natural Products, 74(12), 2489–2496.
  • Yang, G., Ham, I., & Choi, H. Y. (2013). Anti-inflammatory effect of prunetin via the suppression of NF-κB pathway. Food and Chemical Toxicology, 58, 124–132.
  • Zhang, W. Z., Cui, W. M., Zhang, X., Wang, W., Jia, X. D., Zhang, X. P., & Li, N. (2009). Subchronic toxicity study on soy isoflavones in rats. Biomedical and Environmental Sciences, 22(3), 259–264.
  • Zhang, H., Yao, M., Morrison, A. R., & Chong, S. (2003). Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein ­substrate, digoxin, in rats. Archives of Pharmacal Research, 26(9), 768–772.
  • Zimmermann, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16(2), 109–110.

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