References
- Alstchul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990): Basic local alignment search tool. J Mol Biol 215:403–410.
- Baumann N, Masson M, Carreau V, Lefebvre M, Herschkowitz N, Turpin JC (1991): Adult forms of metachromatic leukodystrophy: clinical and biochemical approach. Dev Neurosci 13:221–215.
- Bradova V, Smid F, Ulrich-Bott B, Roggendorf W, Paton BC, Harzer K (1993): Porsaposin defi-ciency: further characterization of the sphingolipid activator protein-deficient sibs. Hum Genet 92:143–152.
- Campana WM, Hiraiwa M, O'Brien JS (1998): Prosaptide activates the MAPK pathway by G-pro-tein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J 12:307–314.
- Christomanou H, Aignesberg A, Linke RP (1986): Immunochemical characterization of two activator proteins stimulating enzymic sphingomyelin degradation in vitro: absence of one of them in a human Gaucher's disease variant. Biol Chem Hoppe-Seyler 367:879–890.
- Coffey DS (1992): Prostate cancer: an overview of an increasing dilemma. Cancer 71:880–886.
- Collard MW, Sylvester SR, Tsuruta JK, Griswold MD (1988): Biosynthesis and molecular cloning of sulfated glycoprotein-1 secreted by rat Sertoli cells: sequence similarities with the 70-kilodalton pre-cursor to sulfatide/GM1 activator. Biochemistry 27:4557–4564.
- Conzelmann E, Sandhoff K (1991): Biochemical basis of late-onset neurolipidosis. Dev Neurosci 13:197–204.
- Conzelmann E, Sandhoff K (1978): AB variant of infantile GM2 gangliosidosis: deficiency of a factor necessary for stimulation of hexosaminidase A-catalyzed degradation of ganglioside GM2 and glycolipid GA2. Proc Natl Acad Sci USA 75:3979–3987.
- Cunha GR (1994): Role of mesenchymal-epithelial interactions in normal and abnormal development of male urogenital glands. In: Ultrastructure of Male Urogenital Glands: Prostate, Seminal Vesicle, Urethral and Bulbourethral Glands, Rival A, Testa-Riva F (Eds). New York: Kluwer Academic, pp 15–34.
- Dewji N, Wenger D, Fujibayashi S, Donoviei M, Esch F, Hill F, O'Brien JS (1986): Molecular cloning of the sphingolipid activator protein-1 (SAP-1), the sulfatide sulfatase activator. Biochem Biophys Res Commun 134:989–994.
- Fambrough DM, Takeyasu K, Lippincott-Schwartz J, Siegel NR (1988): Structure of LEP100, a glycoprotein that shuttles between lysosomes and the plasma membrane: reduced nucleotide sequence of the encoding cDNA. J Cell Biol 106:61–67.
- Fischer G, Jatzkewitz (1975): The activator of cerebroside sulfatase: purification from human liver and identification as a protein. Hoppe-Seyler's Physiol Chem 356:605–613.
- Fischer G, Jatzkewitz H (1977): The activator of cerebroside sulfatase: binding studies with enzymes and substrate demonstrating the detergent function of the activator protein. Biochem Biophys Acta 481:561–568.
- Fujibayashi S, Kao F, Jones C, Morse H, Law M, Wenger DA (1985): Assignment of the gene for human sphingolipid activator protein-2 (SAP-2) to chromosome 10. Am J Hum Genet 37:741–748.
- Fujita N, Suzuki K, Vanier M, Popko B, Maeda N, Klein A, Henseler M, Sandhoff K, Nakayasu H, Suzuki K (1996): Targeted disruption of the mouse sphingolipid activator gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids. Human Mol Gen 5:711–725.
- Furst W, Machleidt W, Sandhoff K (1988): The precursor of sulfatide activator protein is processed to three different proteins. Biol Chem Hoppe-Seyler 369:317–328.
- Futerman AH (1995): Inhibition of sphingolipid synthesis: effects on glycolipid-GPI anchored protein microdomains. Trends Cell Biol 5:377–379.
- Hermo L, Morales CR, Oko R (1992): Immunocytochemical localization of sulfated glycoprotein-1 (SGP-1) and identification of its transcripts in epithelial cells of the extratesticular duct system of the rat. Anat Rec 232:401–422.
- Hiesberger T, Haler S, Rohlmann, Schneider W, Sandhoff K, Herz J (1998): Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related pro-tein (LRP). EMBO J 17:4617–4625.
- Hiraiwa M, Soeda S, Kishimoto Y, O'Brien JS (1992): Binding and transport of gangliosides by prosaposin. Proc Natl Acad Sci USA 89:11254–11258.
- Hiramatsu M, Kashimita M, Minami N, Sato A, Murayama M, Minami N (1988): Androgenic regu-lation of epidermal growth factor in the mouse ventral prostate. Biochem Int 17:311–317.
- Ho MW, O'Brien JS (1971): Gaucher's disease: deficiency of acid f3-glucosidase and reconstitution of enzyme activity in vitro. Proc Natl Acad Sci USA 68:2810–2813.
- Igdoura SA, Hermo L, Rosenthal A, Morales CR (1993): Nonciliated cells of the rat efferent ducts endocytosed testicular sulfated glycoprotein-1 (SGP-1) and synthesize SOP-1 derived saposins. Anat Rec 235:411–424.
- Igdoura SA, Morales CR (1995): Role of sulfated glycoprotein-1 (SGP-1) in the disposal of residual bodies by Sertoli cells of the rat. Mol Reprod Dev 40:91–102.
- Igdoura SA, Rasky A, Morales CR (1996): Trafficking of sulfated glycoprotein-1 to lysosomes or to the extracellular space in rat Sertoli cells. Cell Tissue Res 283:385–394.
- Jatzkewitz H, Stinshoff K (1973): An activator of cerebroside sulfatase in human normal liver and in cases of congenital metachromatic leukodystrophy. FEBS Lett 32:129–137.
- Kappler J, Potter W, Gieselmann V, Kiessling W, Friedl W, Propping P (1991): Phenotypic conse-quences of low arylsulfatase A genotypes: does it exist an association with multiple sclerosis? Dev Neurosci 13:228–231.
- Klein A, Henseler M, Klein C, Suzuki K, Sandhoff K (1994): Sphingolipid activator protein D (Sap-D) stimulates the lysosomal degradation of ceramide in vivo. Biochem Biophys Res Commun 220:1440–1448.
- Kleinschmidt T, Christomanou M, Braunitzer G (1987): Complete content of the naturally occurring glucosylceramide activator protein (GMT activator) absent from a new human Gaucher disease vari-ant. Biol Chem Hoppe-Seyler 368:157–158.
- Kolesnick R (1992): Ceramide: a novel second messenger. TICB 2:232–236.
- Kondoh K, Hineno T, Sano A, Kakimoto Y (1991): Isolation and characterization of prosaposin from human milk. Biochem Biophys Res Commun 181:286–292.
- Kretz KA, Carson GS, Morimoto S, Kishimoto Y, Fluharty AL, O'Brien JS (1990): Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect. Proc Natl Acad Sci USA 87:2541–2544.
- Kyprianou N, Isaacs JT (1988): Identification of a cellular receptor for transforming growth factor-beta in rat ventral prostate and its negative regulation by androgens. Endocrinology 123:2124–2131.
- Kyprianou N, Isaacs IT (1989): Expression of transforming growth factor-beta in rat ventral prostate during castration-induced programmed cell death. Mol Endocrinol 3:1515–1522.
- Lefrancois S, Michaud L, Potier M, Igdoura S, Morales CR (1999): Role of sphingolipids in the transport of prosaposin to the lysosomes. J Lipid Res 40:1593–1603.
- Li SC, Li YT (1976): An activator stimulating the enzymatic hydrolysis of sphingolipids. J Biol Chem 251:1159–1163.
- Li SC, Li YT (1986): Activator proteins (protein cofactors) for the catabolism of glycosphingolipids. In: Enzymes of Lipid Metabolism II, Faysz L, Dreyfus H, Massarelli L, Gatt S (Eds). New York: Plenum, pp 307–314.
- Mahon-Haft H, Stone RK, Johnson R, Shah S (1981): Biochemical abnormalities of metachromatic leukodystrophy in an adult psychiatric population. Am J Psychiatr 138:1372–1374.
- Mays RW, Siemers KA, Fritz BA, Lowe AW, van Meer G, Nelson W (1995): Hierarchy of mechanism involved in generating Ne/KtATPase polarity in MDCK epithelial cells. J Cell Biol 130:1105–1115.
- McKeehan WL, Adams PS, Rosser MP (1984): Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not andro-gen, on normal rat prostate epithelial cells in serum free, primary cell culture. Cancer Res 44:1998–2010.
- Morales C (1988): Role of sialic acid in the endocytosis of prosaposin by the nonciliated cells of the rat efferent ducts. Mol Reprod Dev 51:156–166.
- Morales, CR, Zhao Q, El-Alfy M, Suzuki K (2000): Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs.
- Morales CR, El-Alfy M, Zhao Q, Igdoura S (1995): Molecular role of sulfated glycoprotein-1 (SGP-1/Prosaposin) in Sertoli cells. Histol Histopathol 10:1023–1034.
- Morales CR, El-Alfy M, Zhao Q, Igdoura S (1995): Expression and tissue distribution of rat sulfated glycoprotein-1 (prosaposin). J Histochem Cytochem 44:327–337.
- Morales CR, Hay N, El-Alfy M, Zhao Q (1998): Distribution of mouse sulfated glycoprotein-1 (prosaposin) in the testis and other tissues. J Androl 19:156–164.
- Morimoto S, Martin BM, Kishimoto Y, O'Brien JS (1988): Saposin D: a sphingomyelinase activator. Biochem Biophys Res Commun 156:503–510.
- Morimoto S, Martin BM, Yamamoto Y, Kretz KA, O'Brien JS (1989: Saposin A: second cerebroside activator protein. Proc Natl Acad Sci USA 86:3389–13393.
- Munford R, Sheppard PO, O'Hara PJ (1995): Saposin-like proteins (SALIP) carry out diverse func-tion on a common backbone structure. J Lipid Res 36:1653–1663.
- O'Brien JS, Carson GS, Seo HC, Hiraiwa M, Kishimoto Y (1994): Identification of prosaposin as a neurotrophic factor. Proc Natl Acad Sci USA 91:9593–9596.
- O'Brien JS, Carson GS, Seo HC, Hiraiwa M, Weiler S, Tonuch IM, Barranger JA, Khan M, Azuma N, Kishimoto Y (1995): Identification of the neurotrophic factor sequence of prosaposin. FASEB J 9:681–685.
- O'Brien JS, Kretz KA, Dewji N, Wenger DA, Esch F, Fluharty AL (1988): Coding of two sphin-golipid activator proteins (SAP-1 and SAP-2) by same genetic locus. Science 241:1098–1101.
- O'Brien JS, Kishimoto Y (1991): Saposin proteins: structure, function, and role in human lysosomal storage disorders. FASEB J 5:301–308.
- Ponting CP (1995): Swaposins: circular permutations within genes encoding saposin homologues. TIBS 20:179–180.
- Porter MT, Fluharty AL, Trammell J, Kihara H (1971): A correlation of intracellular cerebroside sulfatase activity in fibroblasts with latency in metachromatic leukodystrophy. Biochem Biophys Res Commun 44:660–666.
- Rinjboutt S, Aerts HMFG, Geuze HJ, Tager JM, Strous GJ (1991): Mannose 6-phosphate-indepen-dent membrane association of cathesin D, glucocerebroside, and sphingolipid activating protein in HepG2 cells. J Biol Chem 266:4862–4868.
- Rohrer J, Schweizer A, Russell D, Kornfeld S (1996): The targeting of LAMP-1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane. J Cell Biol 132:565–576.
- Sano A, Matsuda S, Wen TC, Kotani Y, Kondoh K (1994): Protection by prosaposin against ischemia-induced learning disability and neuronal loss. Biochem Biophys Res Commun 204:994–1000.
- Sandhoff K, Kolter T (1996): Topology of glycosphingolipid degradation. Trends Cell Biol 6:98–103.
- Sandhoff K, Kolter T, Van Echten G (1996): Sphingolipid metabolism. In: Sphingolipid as Signalling Modulators in the Nervous System, Ledeen RW, Hakomori Al, Yates AJ, Ccheider JS, Yu RK (Eds). New York: Ann NY Acad Sci, pp 139–151.
- Schnabel D, Schoder M, Fiirst W, Klein A, Hurwitz R, Zenk T, Weber J, Harzer K, Paton BC, Poulous A, Suzuki K, Sandhoff K (1992): Simultaneous deficiency of sphingolipid activator proteins 1 and 2 is caused by a mutation in the initiation codon of their common gene. J Biol Chem 267:3312–3315.
- Spiegel S, Foster R, Kolesnick R (1996): Signal transduction through lipid second messengers. Curr Opin Cell Biol 8:159–167.
- Sprecher-Levy H, Orr-Urtreger A, Lonai P, Horowitz M (1994): Murine prosaposin: expression in the reproductive system of a gene implicated in human genetic disease. Cell Mol Biol 39:287–299.
- Steiner MS (1995): Review of peptide growth factors in benign prostatic hyperplasia and urological malignancy. J Urol 153:1085–1096.
- Stevens RL, Fluharty AL, Kihara H, Kaback MM, Shapiro LJ, Marsh B, Sandhoff K, Fisher G (1981): Cerebroside sulfatase activator deficiency induced metachromatic leukodystrophy. Am J Hum Genet 33:255–265.
- Sylvester SR, Morales CR, Oko R, Griswold MD (1989): Sulfated glycoprotein-1 (saposin precursor) in the reproductive tract of the male rat. Biol Reprod 41:941–948.
- Tsuda M, Sakiyama T, Endo H, Kitagawa T (1992): The primary structure of mouse saposin. Biochem Biophys Res Commun 184:1266–1272.
- von Figura K, Hasilik A (1986): Lysosomal enzymes and their receptors. Annu Rev Biochem 55:167–193.
- Waheed A, Gottschalk S, Hille A, Kentler C, Pohlmann K, Braulke T, Hauser H, Geuze H, von Figura K (1988): Human lysosomal acid phosphatase is transported as a transmembrane protein to the lyso-somes in transfected baby hamster kidney cells. EMBO J 7:2351–2358.
- Wenger DA, Degala G, Williams C, Taylor HA, Stevenson RE, Pruitt JR, Miller J, Garen PD, Balentine JD (1989): Clinical, pathological, biochemical studies on an infantile case of sulfatide/GM1 activator protein deficiency. Am J Med Genet 33:255–265.
- Zhao Q, Hay N, Morales CR (1997): Structural analysis of the mouse prosaposin (SGP-1) gene reveals the presence of an exon that is alternatively spliced in transcribed mRNAs. Mol Reprod Dev 48:1–8.
- Zhao Q, Bell A, El-Alfy M, Morales CR (1998): Mouse testicular sulfated glycoprotein-1: sequence analysis of the common backbone structure of prosaposins. J Androl 19:165–174.