Pathogenesis of epileptic seizures and epilepsy after stroke

References

• Maruyama N, Fukuma A, Ihara I, et al. Epilepsy and variation in the frontal lobe artery. Epilepsy Res. 2005;64(1–2):71–5.10.1016/j.eplepsyres.2005.02.005
   PubMed Web of Science ®Google Scholar
• Krakow K, Sitzer M, Rosenow F, et al. Predictors of acute poststroke seizures. Cerebrovasc Dis. 2010;30(6):584–9.10.1159/000319777
   PubMed Web of Science ®Google Scholar
• Huang CW, Saposnik G, Fang J, et al. Influence of seizures on stroke outcomes: a large multicenter study. Neurology. 2014;82(9):768–76.10.1212/WNL.0000000000000166
   PubMed Web of Science ®Google Scholar
• Haapaniemi E, Strbian D, Rossi C, et al. The CAVE score for predicting late seizures after intracerebral hemorrhage. Stroke. 2014;45(7):1971–6.10.1161/STROKEAHA.114.004686
   PubMed Web of Science ®Google Scholar
• Conrad J, Pawlowski M, Dogan M, et al. Seizures after cerebrovascular events: risk factors and clinical features. Seizure. 2013;22(4):275–82.10.1016/j.seizure.2013.01.014
   PubMed Web of Science ®Google Scholar
• Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475–82.10.1111/epi.12550
   PubMed Web of Science ®Google Scholar
• Zelano J, Lundberg RG, Baars L, et al. Clinical course of poststroke epilepsy: a retrospective nested case-control study. Brain Behav. 2015;5(9):e00366.
   PubMed Web of Science ®Google Scholar
• Pitkanen A, Roivainen R, Lukasiuk K. Development of epilepsy after ischaemic stroke. Lancet Neurol. 2016;15(2):185–197.10.1016/S1474-4422(15)00248-3
   PubMed Web of Science ®Google Scholar
• Hsu CJ, Weng WC, Peng SS, et al. Early-onset seizures are correlated with late-onset seizures in children with arterial ischemic stroke. Stroke. 2014;45(4):1161–3.10.1161/STROKEAHA.113.004015
   PubMed Web of Science ®Google Scholar
• Camilo O, Goldstein LB. Seizures and epilepsy after ischemic stroke. Stroke. 2004;35(7):1769–75.10.1161/01.STR.0000130989.17100.96
   PubMed Web of Science ®Google Scholar
• Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2006;113(24):e873–e923.
   PubMed Web of Science ®Google Scholar
• Gooshe M, Abdolghaffari AH, Aleyasin AR, et al. Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems. Eur J Pharmacol. 2015;746:6–13.10.1016/j.ejphar.2014.11.005
   PubMed Web of Science ®Google Scholar
• Hwang JY, Aromolaran KA, Zukin RS. Epigenetic mechanisms in stroke and epilepsy. Neuropsychopharmacology. 2013;38(1):167–82.10.1038/npp.2012.134
   PubMed Web of Science ®Google Scholar
• Rodan LH, Aviv RI, Sahlas DJ, et al. Seizures during stroke thrombolysis heralding dramatic neurologic recovery. Neurology. 2006;67(11):2048–9.10.1212/01.wnl.0000247231.25231.2e
   PubMed Web of Science ®Google Scholar
• Battaglia D, Pasca MG, Cesarini L, et al. Epilepsy in shunted posthemorrhagic infantile hydrocephalus owing to pre- or perinatal intra- or periventricular hemorrhage. J Child Neurol. 2005;20(3):219–25.10.1177/08830738050200030901
   PubMed Web of Science ®Google Scholar
• Sun DA, Sombati S, DeLorenzo RJ. Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced “epilepsy”. Stroke. 2001;32(10):2344–50.10.1161/hs1001.097242
   PubMed Web of Science ®Google Scholar
• Mizielinska SM, Greenwood SM, Tummala H, et al. Rapid dendritic and axonal responses to neuronal insults. Biochem Soc Trans. 2009;37(Pt 6):1389–93.10.1042/BST0371389
   PubMed Web of Science ®Google Scholar
• Kharlamov EA, Downey KL, Jukkola PI, et al. Expression of GABA A receptor alpha1 subunit mRNA and protein in rat neocortex following photothrombotic infarction. Brain Res. 2008;1210:29–38.10.1016/j.brainres.2008.02.070
   PubMed Web of Science ®Google Scholar
• Patel A. Temporal trends of post-stroke early seizures or epilepsy during acute ischemic stroke hospitalizations and its impact on clinical outcomes. Neurol Suppl. 2016;86(16):1–62.
   Google Scholar
• Yang H, Song Z, Yang GP, et al. The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels. PLoS One. 2014;9(10):e109634.10.1371/journal.pone.0109634
   PubMed Web of Science ®Google Scholar
• Zhang B, Chen M, Yang H, et al. Evidence for involvement of the CD40/CD40L system in post-stroke epilepsy. Neurosci Lett. 2014;567:6–10.10.1016/j.neulet.2014.03.003
   PubMed Web of Science ®Google Scholar
• Antoniades C, Bakogiannis C, Tousoulis D, et al. The CD40/CD40 ligand system: linking inflammation with atherothrombosis. J Am Coll Cardiol. 2009;54(8):669–77.10.1016/j.jacc.2009.03.076
   PubMed Web of Science ®Google Scholar
• Huang Z, Walker MC, Shah MM. Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis. J Neurosci. 2009;29(35):10979–88.10.1523/JNEUROSCI.1531-09.2009
   PubMed Web of Science ®Google Scholar
• Jung S, Jones TD, Lugo JN Jr, et al. Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy. J Neurosci. 2007;27(47):13012–21.10.1523/JNEUROSCI.3605-07.2007
   PubMed Web of Science ®Google Scholar
• Jung S, Warner LN, Pitsch J, et al. Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus. J Neurosci. 2011;31(40):14291–5.10.1523/JNEUROSCI.1148-11.2011
   PubMed Web of Science ®Google Scholar
• Gubern C, Camos S, Ballesteros I, et al. miRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis. FEBS J. 2013;280(23):6233–46.10.1111/febs.12546
   PubMed Web of Science ®Google Scholar
• Gibson LM, Allan SM, Parkes LM, et al. Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model? Cardiovasc Psychiatry Neurol. 2011;2011:130406.
   PubMedGoogle Scholar
• Gibson LM, Hanby MF, Al-Bachari SM, et al. Late-onset epilepsy and occult cerebrovascular disease. J Cereb Blood Flow Metab. 2014;34(4):564–70.10.1038/jcbfm.2014.25
   PubMed Web of Science ®Google Scholar
• Hawco CS, Bagshaw AP, Lu Y, et al. BOLD changes occur prior to epileptic spikes seen on scalp EEG. NeuroImage. 2007;35(4):1450–8.10.1016/j.neuroimage.2006.12.042
   PubMed Web of Science ®Google Scholar
• Valmier J, Touchon J, Baldy-Moulinier M. Interictal regional cerebral blood flow during non specific activation test in partial epilepsy. J Neurol Neurosurg Psychiatry. 1989;52(3):364–71.10.1136/jnnp.52.3.364
   PubMed Web of Science ®Google Scholar
• Wiest R, von Bredow F, Schindler K, et al. Detection of regional blood perfusion changes in epileptic seizures with dynamic brain perfusion CT – a pilot study. Epilepsy Res. 2006;72(2–3):102–10.10.1016/j.eplepsyres.2006.07.017
   PubMed Web of Science ®Google Scholar
• De Reuck J, Van Maele G. Acute ischemic stroke treatment and the occurrence of seizures. Clin Neurol Neurosurg. 2010;112(4):328–31.10.1016/j.clineuro.2010.01.004
   PubMed Web of Science ®Google Scholar
• Sun DA, Sombati S, Blair RE, et al. Long-lasting alterations in neuronal calcium homeostasis in an in vitro model of stroke-induced epilepsy. Cell Calcium. 2004;35(2):155–63.10.1016/j.ceca.2003.09.003
   PubMed Web of Science ®Google Scholar
• Seiffert E, Dreier JP, Ivens S, et al. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J Neurosci. 2004;24(36):7829–36.10.1523/JNEUROSCI.1751-04.2004
   PubMed Web of Science ®Google Scholar
• David Y, Cacheaux LP, Ivens S, et al. Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? J Neurosci. 2009;29(34):10588–99.10.1523/JNEUROSCI.2323-09.2009
   PubMed Web of Science ®Google Scholar
• Heinemann U, Gabriel S, Jauch R, et al. Alterations of glial cell function in temporal lobe epilepsy. Epilepsia. 2000;41(Suppl 6):S185–S189.10.1111/epi.2000.41.issue-s6
   PubMed Web of Science ®Google Scholar
• Armitage PA, Farrall AJ, Carpenter TK, et al. Use of dynamic contrast-enhanced MRI to measure subtle blood-brain barrier abnormalities. Magn Reson Imaging. 2011;29(3):305–14.10.1016/j.mri.2010.09.002
   PubMed Web of Science ®Google Scholar
• Vezzani A, Friedman A, Dingledine RJ. The role of inflammation in epileptogenesis. Neuropharmacology. 2013;69:16–24.10.1016/j.neuropharm.2012.04.004
   PubMed Web of Science ®Google Scholar
• Marchi N, Lerner-Natoli M. Cerebrovascular remodeling and epilepsy. Neuroscientist. 2013;19(3):304–12.10.1177/1073858412462747
   PubMed Web of Science ®Google Scholar
• Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005–2009. Epilepsia. 2010;51(4):676–85.10.1111/epi.2010.51.issue-4
   PubMed Web of Science ®Google Scholar
• Spencer SS. Neural networks in human epilepsy: evidence of and implications for treatment. Epilepsia. 2002;43(3):219–27.10.1046/j.1528-1157.2002.26901.x
   PubMed Web of Science ®Google Scholar
• Kadam SD, Smith-Hicks CL, Smith DR, et al. Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. Epilepsy Behav. 2010;18(4):344–57.10.1016/j.yebeh.2010.05.006
   PubMed Web of Science ®Google Scholar
• Wang X. L.Y., Seizure Generation via Aberrant Integration of New Neurons into the Dentate Circuits in Stroke. Evidence-Based Complement Alternat Med. 2014;2014:7.
   Google Scholar
• Saito T, Miyata K, Hosoda M, et al. Clinical, electrophysiological and histological analysis of adult onset chronic sensory neuropathy. Rinsho Shinkeigaku. 1989;29(7):859–865.
   PubMedGoogle Scholar
• Epsztein J, Milh M, Bihi RI, et al. Ongoing epileptiform activity in the post-ischemic hippocampus is associated with a permanent shift of the excitatory-inhibitory synaptic balance in CA3 pyramidal neurons. J Neurosci. 2006;26(26):7082–92.10.1523/JNEUROSCI.1666-06.2006
   PubMed Web of Science ®Google Scholar
• Heuser K, Szokol K, Tauboll E. The role of glial cells in epilepsy. Tidsskr Nor Laegeforen. 2014;134(1):37–41.10.4045/tidsskr.12.1344
   PubMedGoogle Scholar
• Kharlamov EA, Kharlamov A, Kelly KM. Changes in neuropeptide Y protein expression following photothrombotic brain infarction and epileptogenesis. Brain Res. 2007;1127(1):151–62.10.1016/j.brainres.2006.09.107
   PubMed Web of Science ®Google Scholar
• Hubbard JA, Hsu MS, Fiacco TA, et al. Glial cell changes in epilepsy: overview of the clinical problem and therapeutic opportunities. Neurochem Int. 2013;63(7):638–51.10.1016/j.neuint.2013.01.017
   PubMed Web of Science ®Google Scholar
• Aronica E, Zurolo E, Iyer A, et al. Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. Epilepsia. 2011;52(9):1645–55.10.1111/epi.2011.52.issue-9
   PubMed Web of Science ®Google Scholar
• Stefanits H, Czech T, Pataraia E, et al. Prominent oligodendroglial response in surgical specimens of patients with temporal lobe epilepsy. Clin Neuropathol. 2012;31(6):409–17.10.5414/NP300536
   PubMed Web of Science ®Google Scholar
• Ravizza T, Gagliardi B, Noe F, et al. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis. 2008;29(1):142–60.10.1016/j.nbd.2007.08.012
   PubMed Web of Science ®Google Scholar
• Huang YH, Chi NF, Kuan YC, et al. Efficacy of phenytoin, valproic acid, carbamazepine and new antiepileptic drugs on control of late-onset post-stroke epilepsy in Taiwan. Eur J Neurol. 2015;22(11):1459–68.10.1111/ene.2015.22.issue-11
   PubMed Web of Science ®Google Scholar
• Xuan A, Long D, Li J, et al. Neuroprotective effects of valproic acid following transient global ischemia in rats. Life Sci. 2012;90(11–12):463–8.10.1016/j.lfs.2012.01.001
   PubMed Web of Science ®Google Scholar
• Markowitz GJ, Kadam SD, Smith DR, et al. Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. Epilepsy Res. 2011;94(3):138–48.10.1016/j.eplepsyres.2011.01.002
   PubMed Web of Science ®Google Scholar
• Seker FB, Kilic U, Caglayan B, et al. HMG-CoA reductase inhibitor rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS. Neuroscience. 2015;284:349–59.10.1016/j.neuroscience.2014.10.014
   PubMed Web of Science ®Google Scholar
• Gouveia TL, Scorza FA, Iha HA, et al. Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy. Epilepsy Behav. 2014;36:68–73.10.1016/j.yebeh.2014.04.009
   PubMed Web of Science ®Google Scholar
• Guo J, Guo J, Li J, et al. Statin treatment reduces the risk of poststroke seizures. Neurology. 2015;85(8):701–7.10.1212/WNL.0000000000001814
   PubMed Web of Science ®Google Scholar
• Zhao RR, Xu XC, Xu F, et al. Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. Biochem Biophys Res Commun. 2014;448(4):414–7.10.1016/j.bbrc.2014.04.130
   PubMed Web of Science ®Google Scholar
• Rahn JJ, Bestman JE, Josey BJ, et al. Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy. Neuroscience. 2014;259:142–54.10.1016/j.neuroscience.2013.11.040
   PubMed Web of Science ®Google Scholar