Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 46, 2024 - Issue 6
79
Views
0
CrossRef citations to date
0
Altmetric
Research Article

The level of cytokines in tears as a novel indicator of demyelinating diseases

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 487-494 | Received 28 Aug 2023, Accepted 26 Mar 2024, Published online: 11 Apr 2024

References

  • Wang K, Song F, Fernandez-Escobar A, et al. The properties of cytokines in multiple sclerosis: pros and cons. Am J Med Sci. 2018;356(6):552–560. doi: 10.1016/j.amjms.2018.08.018
  • Oh J, Vidal-Jordana A, Montalban X. Multiple sclerosis: clinical aspects. Curr Opin Neurol. 2018;31(6):752–759. doi: 10.1097/WCO.0000000000000622
  • Ozenci V, Kouwenhoven M, Link H. Cytokines in multiple sclerosis: methodological aspects and pathogenic implications. Mult Scler. 2002;8(5):396–404. doi: 10.1191/1352458502ms837rr
  • Graner M, Pointon T, Manton S, et al. Oligoclonal IgG antibodies in multiple sclerosis target patient specific peptides. PLOS ONE. 2020;15(2):e0228883. doi: 10.1371/journal.pone.0228883
  • Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol. 2015;14(4):406–419. doi: 10.1016/S1474-4422(14)70305-9
  • Bai Z, Chen D, Wang L, et al. Cerebrospinal fluid and blood cytokines as biomarkers for multiple sclerosis: a systematic review and meta-analysis of 226 studies with 13,526 multiple sclerosis patients. Front Neurosci. 2019;13:1026. doi: 10.3389/fnins.2019.01026
  • Lebrun C, Forzy G, Collongues N, et al. Club francophone de la SEP and RISConsortium. Tear analysis as a tool to detect oligoclonal bands in radiologically isolated syndrome. Rev Neurol (Paris). 2015;171(4):390–393. doi: 10.1016/j.neurol.2014.11.007
  • Calais G, Forzy G, Crinquette C, et al. Tear analysis in clinically isolated syndrome as new multiple sclerosis criterion. Mult Scler. 2010;16(1):87–92. doi: 10.1177/1352458509352195
  • Pieragostino D, Bucci S, Agnifili L, et al. Differential protein expression in tears of patients with primary open angle and pseudoexfoliative glaucoma. Mol Biosyst. 2012;8(4):1017–1028. doi: 10.1039/c1mb05357d
  • Salvisberg C, Tajouri N, Hainard A, et al. Exploring the human tear fluid: discovery of new biomarkers in multiple sclerosis. Proteomics Clin Appl. 2014;8(3–4):185–194. doi: 10.1002/prca.201300053
  • London A, Benhar I, Schwartz M. The retina as a window to the brain-from eye research to CNS disorders. Nat Rev Neurol. 2013;9(1):44–53. doi: 10.1038/nrneurol.2012.227
  • Masoudi S. Biochemistry of human tear film: a review. Exp Eye Res. 2022;220:109101. doi: 10.1016/j.exer.2022.109101
  • Azkargorta M, Soria J, Acera A, et al. Human tear proteomics and peptidomics in ophthalmology: toward the translation of proteomic biomarkers into clinical practice. J Proteomics. 2017;150:359–367. doi: 10.1016/j.jprot.2016.05.006
  • Ponzini E, Santambrogio C, De Palma A, et al. Mass spectrometry-based tear proteomics for noninvasive biomarker discovery. Mass Spectrom Rev. 2022;41(5):842–860. doi: 10.1002/mas.21691
  • Pieragostino D, Lanuti P, Cicalini I, et al. Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis. J Proteomics. 2019;204:103403. doi: 10.1016/j.jprot.2019.103403
  • Kajdaniuk D, Foltyn W, Morawiec-Szymonik E, et al. Th17 cytokines and factors modulating their activity in patients with pernicious anemia. Immunol Res. 2023;71(6):873–882. doi: 10.1007/s12026-023-09399-9
  • Kula A, Dawidowicz M, Mielcarska S, et al. Overexpression and role of HHLA2, a novel immune checkpoint, in colorectal cancer. Int J Mol Sci. 2023;24(6):5876. doi: 10.3390/ijms24065876
  • Roda M, Corazza I, Bacchi Reggiani ML, et al. Dry eye disease and tear cytokine levels-A Meta-Analysis. Int J Mol Sci. 2020;21(9):3111. doi: 10.3390/ijms21093111
  • Landsend ECS, Utheim ØA, Pedersen HR, et al. The level of inflammatory tear cytokines is elevated in congenital aniridia and associated with meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2018;59:2197–2204. doi: 10.1167/iovs.18-24027
  • Hagan S, Martin E, Enríquez-de-Salamanca A. Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine. Epma J. 2016;7(1):15. doi: 10.1186/s13167-016-0065-3
  • Örnek N, Dağ E, Örnek K. Corneal sensitivity and tear function in neurodegenerative diseases. Curr Eye Res. 2015;40(4):423–428. doi: 10.3109/02713683.2014.930154
  • Çomoğlu SS, Güven H, Acar M, et al. Tear levels of tumor necrosis factor-alpha in patients with Parkinson’s disease. Neurosci Lett. 2013;553:63–67. doi: 10.1016/j.neulet.2013.08.019
  • Costagliola C, Romano V, De TM, et al. TNF-alpha levels in tears: a novel biomarker to assess the degree of diabetic retinopathy. Mediators Inflamm. 2013;2013:629529. doi: 10.1155/2013/629529
  • Niedźwiedź A, Kawa M, Pius-Sadowska E, et al. Increased proinflammatory cytokines in tears correspond with conjunctival SARS-CoV-2 positivity in symptomatic COVID-19 patients. Sci Rep. 2022;12(1):7225. doi: 10.1038/s41598-022-11285-7
  • Burgos-Blasco B, Güemes-Villahoz N, Luis Santiago J, et al. Hypercytokinemia in COVID-19: tear cytokine profile in hospitalized COVID-19 patients. Exp Eye Res. 2020;200(108253):108253. doi: 10.1016/j.exer.2020.108253
  • Agnifili L, Pieragostino D, Mastropasqua A, et al. Molecular biomarkers in primary open-angle glaucoma: from noninvasive to invasive. Prog Brain Res. 2015;221:1–32. doi: 10.1016/bs.pbr.2015.05.006
  • Pieragostino D, Agnifili L, Cicalini I, et al. Tear film steroid profiling in dry eye disease by liquid chromatography tandem mass spectrometry. Int J Mol Sci. 2017;18(7):1349. doi: 10.3390/ijms18071349
  • Pieragostino D, D’Alessandro M, di Ioia M, et al. Unraveling the molecular repertoire of tears as a source of biomarkers: beyond ocular diseases. Proteomics Clin Appl. 2015;9(1–2):169–186. doi: 10.1002/prca.201400084
  • Link H, Huang YM. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol. 2006;180(1–2):17–28. doi: 10.1016/j.jneuroim.2006.07.006
  • Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292–302. doi: 10.1002/ana.22366
  • Lolli F, Franciotta D. Oligoclonal bands in tears. Mult Scler. 2010;16(6):760. doi: 10.1177/1352458510367663
  • Lam SM, Tong L, Duan X, et al. Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles. J Lipid Res. 2014;55(2):289–298. doi: 10.1194/jlr.M044826
  • Pieragostino D, Agnifili L, Fasanella V, et al. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst. 2013;9(6):1108–1116. doi: 10.1039/c3mb25463a
  • Lam SM, Tong L, Reux B, et al. Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. J Lipid Res. 2014;55(2):299–306. doi: 10.1194/jlr.P041780
  • Lam SM, Tong L, Duan X, et al. Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction. J Lipid Res. 2014;55(9):1959–1969. doi: 10.1194/jlr.P051185
  • Pescosolido N, Imperatrice B, Koverech A, et al. L-carnitine and short chain ester in tears from patients with dry eye. Optom Vis Sci. 2009;86(2):E132–8. doi: 10.1097/OPX.0b013e318194e767
  • Lemus HN, Warrington AE, Rodriguez M. multiple sclerosis: mechanisms of disease and strategies for myelin and axonal repair. Neurol Clinics. 2018;36(1):1–11. doi: 10.1016/j.ncl.2017.08.002
  • Cheng W, Chen G. Chemokines and chemokine receptors in multiple sclerosis. Mediators Inflamm. 2014;2014:659206. doi: 10.1155/2014/659206
  • Heesen C, Steinman L. Cytokine networks in multiple sclerosis. Nat Rev Immunol. 2016;16(1):21–33.
  • Zhang C, Chen J, Liu L. Cytokine dysregulation and its role in the pathogenesis of multiple sclerosis. J Neuroimmune Pharmacol. 2018;13(6):881–892.
  • Agius L, Selmaj K. Immunomodulatory therapies for multiple sclerosis: A review of current evidence and future directions. Nat Rev Neurol. 2017;13(3):184–203.
  • Huang R, Su C, Fang L, et al. Dry eye syndrome: comprehensive etiologies and recent clinical trials. Int Ophthalmol. 2022;42(10):3253–3272. doi: 10.1007/s10792-022-02320-7
  • Lundh RL, Liotet S, Pouliquen Y. Study of the human blood-tear barrier and the biochemical changes in the tears of 30 contact lens wearers (50 eyes). Ophthalmologica. 1984;188(2):100–105. doi: 10.1159/000309348

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.