Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 46, 2024 - Issue 6
84
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Genetic variants of folate metabolism and the risk of multiple sclerosis

, &
Pages 544-552 | Received 09 May 2023, Accepted 26 Mar 2024, Published online: 02 Apr 2024

References

  • Browne P, Chandraratna D, Angood C, et al. Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology. 2014;83(11):1022–1024. [ View] [PubMed]. doi: 10.1212/WNL.0000000000000768
  • Bölük C, Börü ÜT, Taşdemir M, et al. Epidemiology of multiple sclerosis in Turkey; a Ten-year trend in rural cities. Turk J Neurol. 2021;27(1):41–45. [ View] [Google Scholar]. doi: 10.4274/tnd.2020.36418.
  • Mirza M. The etiology and the epidemiology of multiple sclerosis. Erciyes Medical J. 2002;24(1): 40–47. [ View] [Google Scholar].
  • Orhan G, Eruyar E, SÖ M, et al. The association of IL-18 gene promoter polymorphisms and the levels of serum IL-18 on the risk of multiple sclerosis. Clin Neurol Neurosur. 2016;146:96–101. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1016/j.clineuro.2016.04.027
  • Karahalil B, Orhan G, Ak F. The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis. Clin Neurol Neurosur. 2015;139:288–294. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1016/j.clineuro.2015.10.028
  • Levin M, Douglas J, Meyers L, et al. Neurodegeneration in multiple sclerosis involves multiple pathogenic mechanisms. Degener Neurol Neuromuscul Dis. 2014;4:49–63. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.2147/DNND.S54391
  • Coppedè F, Grossi E, Buscema M, et al. Application of artificial neural networks to investigate one-carbon metabolism in Alzheimer’s disease and healthy matched individuals. Artificial Neural Networks. 2013;8(8):1–11. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1371/journal.pone.0074012
  • McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50(1):121–127. [ View] [Google Scholar]. doi: 10.1002/ana.1032
  • Karahalil B, Kocabas NA, Ozçelik T. DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population. Anticancer Res. 2006;26(6C): 4955–4958. [ View] [PubMed] [Web of Science] [Google Scholar].
  • Sazci A, Ergul E, Kaya G, et al. Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey. Cell Biochem Funct. 2005;23(1):51–54. [View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1002/cbf.1132
  • İzmirli M, Tufan T, Alptekin D. DNA methylation. Archives Medical Review J. 2012;21(4): 274–282. [ View] [Google Scholar].
  • Lawson BR, Eleftheriadis T, Tardif V, et al. Theofilopoulos an transmethylation in immunity and autoimmunity. Clin Immunol. 2012;143:8–21. [View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1016/j.clim.2011.10.007
  • Finkelstein JD. The metabolism of homocysteine: pathways and regulation. European J Pediatry. 1998;157(2):40–44. [View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1007/pl00014300
  • Küçükaslan AŞ, Altıntaş R, Çetintaş VB, et al. Effect of methionine synthase A2756G and methionine synthase reductase A66G gene polymorphisms in male infertility. Turk J Urol. 2011;37(1):38–42. [ View] [Google Scholar] [Web of Science]. doi: 10.5152/tud.2011.008
  • Barbosa PR, Stabler SP, Machado AL, et al. Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. Eur J Clin Nutr. 2008;62(8):1010–1021. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1038/sj.ejcn.1602810
  • Li WX, Dai SX, Zheng JJ, et al. Homocysteine metabolism gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) jointly elevate the risk of folate deficiency. Nutrients. 2015;7(8):6670–6687. doi: 10.3390/nu7085303. [ View] [PubMed] [Web of Science] [Google Scholar].
  • Çevik B, Serbülent Y, Karakuş N, et al. Association of methylenetetra hydrofolate reductase gene C677T polymorphism with multiple sclerosis in Turkish patients. J Invest Med. 2014;62(8):980–984. doi: 10.1097/JIM.0000000000000107 [ View] [PubMed] [Google Scholar].
  • Naghibalhossain F, Ehyakonandeh H, Nikseresht A, et al. Association between mthfr genetic variants and multiple sclerosis in a southern Iranian population. Int J Mol Cell Med. 2015;4(2): 87–93. [ View] [PubMed] [Web of Science] [Google Scholar].
  • Lu M, Peng K, Song L, et al. Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of autoimmune diseases: a systematic review and meta-analysis. Meta-Analysis Dis Markers. 2022: 1–24.[ View] [PubMed] [Web of Science] [Google Scholar].10.1155/2022/4568145
  • Mrissa NF, Mrad M, Klai S, et al. Association of methylenetetra hydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients. Clin Neurol Neurosurg. 2013;115(9):1657–1660. doi: 10.1016/j.clineuro.2013.02.025 [ View] [PubMed] [Google Scholar].
  • Lotti T, Martin V, Gasparini C, et al. Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis. Brain Res Bull. 2006;69(3):327–331. doi: 10.1016/j.brainresbull.2006.01.005 [ View] [PubMed] [Web of Science] [Google Scholar].
  • Klotz L, Farkas M, Bain N, et al. The variant methylenetetrahydrofolate reductase c.1298A > C (p.E429A) is associated with multiple sclerosis in a German case-control study. Neurosci lett. 2010;468:183–185. doi: 10.1016/j.neulet.2009.10.057. [ View] [PubMed] [Web of Science] [Google Scholar].
  • Lee YH, Seo YH, Kim JH, et al. Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis. Neurol Sci. 2015;36(11):2089–2096. View] [PubMed] [Web of Science] [Google Scholar. doi: 10.1007/s10072-015-2318-7
  • Cakina S, Ocak O, Ozkan A, et al. Relationship between genetic polymorphisms MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes and multiple sclerosis: a case-control study. Folia Neuropathol. 2019;57(1):36–40. doi: 10.5114/fn.2019.83829 [ View] [PubMed] [Google Scholar].
  • William HD Development of a high-throughput genotyping assay for detection of functional polymorphisms involved in homocysteine metabolism and the methylation process implicated in multiple sclerosis. [ Thesis of Master of Medical Science]. Stellenbosch South Africa: Stellenbosch University; 2013 [ View] [Google Scholar]
  • Szvetko AL, Fowdar J, Nelson J, et al. No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort. J Neurolog Sci. 2007;252(1):49–52. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1016/j.jns.2006.10.006
  • Yazıcı T Association of blood homocysteine levels with cognitive impairment in patients with multiple sclerosis. [ Thesis of Master of Medical Science]. Samsun Turkey: Ondokuz Mayıs University; 2013 [ View]
  • Russo C, Morabito F, Luise F, et al. Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis. J Neurol. 2008;255(1):64–69. doi: 10.1007/s00415-007-0668-7 [ View] [PubMed] [Web of Science] [Google Scholar].
  • Kararizou E, Paraskevas G, Triantafyllou N, et al. Plasma homocysteine levels in patients with multiple sclerosis in the Greek population. J Chin Med Assoc. 2013;76(11):611–614. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1016/j.jcma.2013.07.002
  • Zhu Y, He YZ, Liu HN. Meta-analysis of the relationship between homocysteine, vitamin B12, folate, and multiple sc lerosis. J Clin Neurosci. 2011;18(7):933–938. doi: 10.1016/j.jocn.2010.12.022 [View] [PubMed] [Web of Science] [Google Scholar].
  • Besler HT, Lipoprotein Oxidation ÇS. Plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. [View] [PubMed] [Web of Science] [Google Scholar]. Nutr Neurosci. 2003;6(3):189–196. doi: 10.1080/1028415031000115945
  • Akpınar Z, Kurban S. Serum nitric oxide, Homocysteine, asymmetric dimethylarginine levels in patients with multiple sclerosis. Selcuk Medical J. 2013;29(4): 168–17. [ View] [Google Scholar].
  • Ramsaransing GSM, Fokkema MR, Teelken A, et al. Plasma homocysteine levels in multiple sclerosis. Neurol Neurosurg Psychiatry. 2006;77(2):189–192. doi: 10.1136/jnnp.2005.072199 [ View] [PubMed] [Web of Science] [Google Scholar].
  • Teunissen CE, Killestein J, Kragt JJ, et al. Serum homocysteine levels in relation to clinical progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008;79(12):1349–1353. doi: 10.1136/jnnp.2008.151555 [ View] [PubMed] [Web of Science] [Google Scholar].
  • Li X, Yuan J, Han J, et al. Serum levels of homocysteine, vitamin B12 and folate in patients with multiple sclerosis: an updated meta-analysis. Int J Med Sci. 2020;17(6):751–761. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.7150/ijms.42058
  • Bystricka Z, Laubertova L, Durfinova M, et al. Methionine metabolism and multiple sclerosis. Biomarkers. 2017;22:747–754. doi: 10.1080/1354750X.2017.1334153. [View] [PubMed] [Web of Science] [Google Scholar].
  • Ariel MT, Maya K, Ronit A.Yanina G.Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurolog Sci. 2005;233(1–2):93–97. doi: 10.1016/j.jns.2005.03.009 [ View] [PubMed] [Google Scholar].
  • Tokgöz E Investigation of the effects of the vitamin B12 levels on clinical and laboratory in multiple sclerosis. [ Thesis of Master of Medical Science]. Ankara Turkey: Gülhane Military Medical Academia; 2012 [ View]
  • Rensburg SJ, Kotze MJ, Hon D, et al. Iron and the folate-vitamin B12- methylation pathway in multiple sclerosis. Metab Brain Dis. 2006;21(2–3):121–137. doi: 10.1007/s11011-006-9019-0 [ View] [PubMed] [Web of Science] [Google Scholar].
  • Nijst TQ, Wevers RA, Schoonderwaldt HC, et al. Vitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia. J Neurology, Neurosurgery, And Psychiatr. 1990;53(11):951–954. doi: 10.1136/jnnp.53.11.951 [ View] [PubMed] [Web of Science] [Google Scholar].
  • Kira Jİ, Tobimatsu S, Goto I. Vitamin B12 metabolism and Massive-Dose Methyl vitamin B12 therapy in Japanese patients with multiple sclerosis.Int Med. 1994;33(2):82–86. [View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.2169/internalmedicine.33.82
  • Najafi MR, Shaygannajad V, Mirpourian M, et al. Vitamin B12 deficiency and multiple Sclerosis; is there any association? Int J Prev Med. 2012;3(4): 286–289. [View] [PubMed] [Web of Science] [Google Scholar].
  • Dardiotis E, Arseniou S, Sokratous M, et al. Vitamin B12, folate, and homocysteine levels and multiple sclerosis: a meta-analysis. Multi Sclerosis Relat Disord. 2017;17:190–197. [ View] [PubMed] [Web of Science] [Google Scholar]. doi: 10.1016/j.msard.2017.08.004.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.