Advanced search
Publication Cover
Journal of Neurogenetics Volume 21, 2007 - Issue 1-2
Submit an article Journal homepage
33
Views
0
CrossRef citations to date
0
Altmetric
SHORT COMMUNICATIONS

SCREEN FOR DOMINANT BEHAVIORAL MUTATIONS CAUSED BY GENOMIC INSERTION OF P-ELEMENT TRANSPOSONS IN DROSOPHILA: AN EXAMINATION OF THE INTEGRATION OF VIRAL VECTOR SEQUENCES

Lyle E. Fox Department of Biological Sciences, University of Iowa, Iowa City, IowaCorrespondence[email protected]
,
David Green Department of Biological Sciences, University of Iowa, Iowa City, Iowa
,
Ziying Yan Department of Anatomy and Cell Biology, and Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases, Carver College of Medicine, University of Iowa, Iowa City, Iowa
,
John F. Engelhardt Department of Anatomy and Cell Biology, and Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases, Carver College of Medicine, University of Iowa, Iowa City, Iowa
&
Chun-Fang Wu Department of Biological Sciences and Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases, Carver College of Medicine, University of Iowa, Iowa City, Iowa
Pages 31-43 | Received 01 Nov 2006, Accepted 04 Dec 2006, Published online: 11 Jul 2009

REFERENCES

  • Bellen, H.J., Levis, R.W., Liao, G., He, Y., Carlson, J.W., Tsang, G., Evans-Holm, M., Hiesinger, P.R., Schulze, K.L., Rubin, G.M., Hoskins, R.A., &. Spradling, A.C. (2004). The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167, 761–781.
  • Collier, L.S., Carlson, C.M., Ravimohan, S., Dupuy, A.J., &. Largaespada, D.A. (2005). Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436, 272–276.
  • Couzin, J. &. Kaiser, J. (2005). Gene therapy. As Gelsinger case ends, gene therapy suffers another blow. Science 307, 1028.
  • Duan, D., Yue, Y., Yan, Z., &. Engelhardt, J.F. (2000). A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation. Nat. Med. 6, 595–598.
  • Duffy, J.B. (2002). GAL4 system in Drosophila: a fly geneticist's Swiss army knife. Genesis 34, 1–15.
  • Dupuy, A.J., Akagi, K., Largaespada, D.A., Copeland, N.G., &. Jenkins, N.A. (2005). Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436, 221–226.
  • Ganetzky, B. &. Wu, C.F. (1982). Indirect suppression involving behavioral mutants with altered nerve excitability in Drosophila melanogaster. Genetics 100, 597–614.
  • Green, C.C., Sparrow, J.C., &. Ball. E. (1986). Flight testing columns. Drosophila Inform. Serv. 63, 141.
  • Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M.P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C.S., Pawliuk, R., Morillon, E., Sorensen, R., Forster, A., Fraser, P., Cohen, J.I., de Saint Basile, G., Alexander, I., Wintergerst, U., Frebourg, T., Aurias, A., Stoppa-Lyonnet, D., Romana, S., Radford-Weiss, I., Gross, F., Valensi, F., Delabesse, E., Macintyre, E., Sigaux, F., Soulier, J., Leiva, L. E., Wissler, M., Prinz, C., Rabbitts, T.H., Le Deist, F., Fischer, A., &. Cavazzana-Calvo, M. (2003). LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302, 415–419.
  • Janson, C.G., McPhee, S.W., Leone, P., Freese, A., &. During, M.J. (2001). Viral-based gene transfer to the mammalian CNS for functional genomic studies. Trends Neurosci. 24, 706–712.
  • Karess, R.E. &. Rubin, G.M. (1984). Analysis of P transposable element functions in Drosophila. Cell 38, 135–146.
  • Palmiter, R.D. &. Brinster, R.L. (1986). Germ-line transformation of mice. Annu. Rev. Genet. 20, 465–499.
  • Pirrotta, V. (1988). Vectors for P-mediated transformation in Drosophila. In (R.L. Rogregez & D.T. Dengardt (Eds.), Vectors: A Survey of Molecular Cloning Vectors and their Uses, pp. 437–456, Butterworths: Boston.
  • Robertson, H.M., Preston, C.R., Phillis, R.W., Johnson-Schlitz, D.M., Benz, W.K., &. Engels, W.R. (1988). A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118, 461–470.
  • Rubin, G.M. &. Spradling, A.C. (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348–353.
  • Sinclair, J.H. (1987). The human cytomegalovirus immediate early gene promoter is a strong promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res. 15, 2392.
  • Suzuki, D.T., Grigliatti, T., &. Williamson, R. (1971). Temperature-sensitive mutations in Drosophila melanogaster. VII. A mutation (para-ts) causing reversible adult paralysis. Proc. Natl. Acad. Sci. USA. 68, 890–893.
  • Thomas, C.E., Ehrhardt, A., &. Kay, M.A. (2003). Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. 4, 346–358.
  • Tower, J., Karpen, G.H., Craig, N., &. Spradling, A.C. (1993). Preferential transposition of Drosophila P-elements to nearby chromosomal sites. Genetics. 133, 347–359.
  • Verma, I.M. &. Weitzman, M.D. (2005). Gene therapy: twenty-first century medicine. Annu. Rev. Biochem. 74, 711–738.
  • Washbourne, P &. McAllister, A.K. (2002). Techniques for gene transfer into neurons. Curr. Opin. Neurobiol. 12, 566–573.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.