Continuous tracking of startled Drosophila as an alternative to the negative geotaxis climbing assay

References

• Amaral, J. D., Xavier, J. M., Steer, C. J., & Rodrigues, C. M. (2010). The role of p53 in apoptosis. Discovery Medicine, 9, 145–152.
   PubMed Web of Science ®Google Scholar
• Beharry, C., Alaniz, M. E., & Alonso, A. d. C. (2013). Expression of Alzheimer-like pathological human tau induces a behavioral motor and olfactory learning deficit in Drosophila melanogaster. Journal of Alzheimer’s Disease, 37, 539–550. doi:10.3233/JAD-130617
   PubMed Web of Science ®Google Scholar
• Beucher, A., Birraux, J., Tchouandong, L., Barton, O., Shibata, A., Conrad, S., … Löbrich, M. (2009). ATM and artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2. The EMBO Journal, 28, 3413–3427. doi:10.1038/emboj.2009.276
   PubMed Web of Science ®Google Scholar
• Bouleau, S., & Tricoire, H. (2015). Drosophila models of Alzheimer’s disease: Advances, limits, and perspectives. Journal of Alzheimer’s Disease, 45, 1015–1038. doi:10.3233/JAD-142802
   PubMed Web of Science ®Google Scholar
• Caesar, I., Jonson, M., Nilsson, K. P. R., Thor, S., & Hammarström, P. (2012). Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. PLoS One, 7, e31424. doi:10.1371/journal.pone.0031424
   PubMed Web of Science ®Google Scholar
• Casci, I., & Pandey, U. B. (2015). A fruitful endeavor: Modeling ALS in the fruit fly. Brain Research, 1607, 47–74. doi:10.1016/j.brainres.2014.09.064
   PubMed Web of Science ®Google Scholar
• Cenini, G., Sultana, R., Memo, M., & Butterfield, D. A. (2008). Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer’s disease. Journal of Cellular and Molecular Medicine, 12, 987–994. doi:10.1111/j.1582-4934.2008.00163.x
   PubMed Web of Science ®Google Scholar
• Chang, J. R., Ghafouri, M., Mukerjee, R., Bagashev, A., Chabrashvili, T., & Sawaya, B. E. (2012). Role of p53 in neurodegenerative diseases. Neurodegenerative Diseases, 9, 68–80. doi:10.1159/000329999
   PubMed Web of Science ®Google Scholar
• Chatoo, W., Abdouh, M., & Bernier, G. (2010). p53 pro-oxidant activity in the central nervous system: Implication in aging and neurodegenerative diseases. Antioxidants & Redox Signaling, 15, 1729–1737. doi:10.1089/ars.2010.3610
   Web of Science ®Google Scholar
• Crowther, D. C., Kinghorn, K. J., Miranda, E., Page, R., Curry, J. A., Duthie, F. A. I., … Lomas, D. A. (2005). Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease. Neuroscience, 132, 123–135. doi:10.1016/j.neuroscience.2004.12.025
   PubMed Web of Science ®Google Scholar
• Culmsee, C., & Mattson, M. P. (2005). p53 in neuronal apoptosis. Biochemical and Biophysical Research Communications, 331, 761–777. doi:10.1016/j.bbrc.2005.03.149
   PubMed Web of Science ®Google Scholar
• Davenport, C. M., Sevastou, I. G., Hooper, C., & Pocock, J. M. (2010). Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of Neurochemistry, 112, 552–563. doi:10.1111/j.1471-4159.2009.06485.x
   PubMed Web of Science ®Google Scholar
• Faville, R., Kottler, B., Goodhill, G. J., Shaw, P. J., & van Swinderen, B. (2015). How deeply does your mutant sleep? Probing arousal to better understand sleep defects in Drosophila. Scientific Reports, 5, 8454. doi:10.1038/srep08454
   PubMed Web of Science ®Google Scholar
• Ganetzky, B., & Flanagan, J. R. (1978). On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster. Experimental Gerontology, 13, 189–196. doi:10.1016/0531-5565(78)90012-8
   PubMed Web of Science ®Google Scholar
• Gargano, J. W., Martin, I., Bhandari, P., & Grotewiel, M. S. (2005). Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila. Experimental Gerontology, 40, 386–395. doi:10.1016/j.exger.2005.02.005
   PubMed Web of Science ®Google Scholar
• Hewitt, V. L., & Whitworth, A. J. (2017). Mechanisms of Parkinson’s disease: lessons from Drosophila. Current Topics in Developmental Biology, 121, 173–200. doi:10.1016/bs.ctdb.2016.07.005
   PubMed Web of Science ®Google Scholar
• Hoege, C., Pfander, B., Moldovan, G.-L., Pyrowolakis, G., & Jentsch, S. (2002). RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature, 419, 135–141. doi:10.1038/nature00991
   PubMed Web of Science ®Google Scholar
• Jazvinšćak Jembrek, M., Slade, N., Hof, P. R., & Šimić, G. (2018). The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease. Progress in Neurobiology, 168, 104–127. doi:10.1016/j.pneurobio.2018.05.001
   PubMed Web of Science ®Google Scholar
• Jordán, J., Galindo, M. F., Prehn, J. H. M., Weichselbaum, R. R., Beckett, M., Ghadge, G. D., … Miller, R. J. (1997). p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. Journal of Neuroscience, 17, 1397–1405. Retrieved from Scopus. doi:10.1523/JNEUROSCI.17-04-01397.1997
   PubMed Web of Science ®Google Scholar
• Kerr, F., Augustin, H., Piper, M. D. W., Gandy, C., Allen, M. J., Lovestone, S., & Partridge, L. (2011). Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer’s disease. Neurobiology of Aging, 32, 1977–1989. doi:10.1016/j.neurobiolaging.2009.10.015
   PubMed Web of Science ®Google Scholar
• Kohlhoff, K. J., Jahn, T. R., Lomas, D. A., Dobson, C. M., Crowther, D. C., & Vendruscolo, M. (2011). The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. Integrative Biology: Quantitative Biosciences from Nano to Macro, 3, 755–760. doi:10.1039/c0ib00149j
   PubMed Web of Science ®Google Scholar
• Kramer, J. M., & Staveley, B. E. (2003). GAL4 causes developmental defects and apoptosis when expressed in the developing eye of Drosophila melanogaster. Genetics and Molecular Research, 2, 43–47.
   PubMedGoogle Scholar
• Liu, H., Han, M., Li, Q., Zhang, X., Wang, W.-A., & Huang, F.-D. (2015). Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifiers of Aβ42-induced locomotor decline in Drosophila. Neuroscience Bulletin, 31, 541–549. doi:10.1007/s12264-014-1526-0
   PubMed Web of Science ®Google Scholar
• Lorenzo, A., & Yankner, B. A. (1994). Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo Red. Proceedings of the National Academy of Sciences, 91, 12243–12247. doi:10.1073/pnas.91.25.12243
   PubMed Web of Science ®Google Scholar
• McGurk, L., Berson, A., & Bonini, N. M. (2015). Drosophila as an in vivo model for human neurodegenerative disease. Genetics, 201, 377–402. doi:10.1534/genetics.115.179457
   PubMed Web of Science ®Google Scholar
• Miquel, J., Lundgren, P. R., Bensch, K. G., & Atlan, H. (1976). Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster. Mechanisms of Ageing and Development, 5, 347–370. doi:10.1016/0047-6374(76)90034-8
   PubMed Web of Science ®Google Scholar
• Pannunzio, N. R., Watanabe, G., & Lieber, M. R. (2018). Nonhomologous DNA end-joining for repair of DNA double-strand breaks. Journal of Biological Chemistry, 293, 10512–10523. doi:10.1074/jbc.TM117.000374
   PubMed Web of Science ®Google Scholar
• Podratz, J. L., Staff, N. P., Boesche, J. B., Giorno, N. J., Hainy, M. E., Herring, S. A., … Windebank, A. J. (2013). An automated climbing apparatus to measure chemotherapy-induced neurotoxicity in Drosophila melanogaster. Fly, 7, 187–192. doi:10.4161/fly.24789
   PubMed Web of Science ®Google Scholar
• Rezával, C., Werbajh, S., & Ceriani, M. F. (2007). Neuronal death in Drosophila triggered by GAL4 accumulation. European Journal of Neuroscience, 25, 683–694. doi:10.1111/j.1460-9568.2007.05317.x
   PubMed Web of Science ®Google Scholar
• Romero, E., Cha, G.-H., Verstreken, P., Ly, C. V., Hughes, R. E., Bellen, H. J., & Botas, J. (2008). Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron, 57, 27–40. doi:10.1016/j.neuron.2007.11.025
   PubMed Web of Science ®Google Scholar
• Rosato, E., & Kyriacou, C. P. (2006). Analysis of locomotor activity rhythms in Drosophila. Nature Protocols, 1, 559–568. doi:10.1038/nprot.2006.79
   PubMed Web of Science ®Google Scholar
• Sachse, S., Rueckert, E., Keller, A., Okada, R., Tanaka, N. K., Ito, K., & Vosshall, L. B. (2007). Activity-dependent plasticity in an olfactory circuit. Neuron, 56, 838–850. doi:10.1016/j.neuron.2007.10.035
   PubMed Web of Science ®Google Scholar
• Saitoe, M., Horiuchi, J., Tamura, T., & Ito, N. (2011). Drosophila as a novel animal model for studying the genetics of age-related memory impairment. Reviews in the Neurosciences, 16, 137–150. doi:10.1515/REVNEURO.2005.16.2.137
   Google Scholar
• Speretta, E., Jahn, T. R., Tartaglia, G. G., Favrin, G., Barros, T. P., Imarisio, S., … Dobson, C. M. (2012). Expression in Drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity. The Journal of Biological Chemistry, 287, 20748–20754. doi:10.1074/jbc.M112.350124
   PubMed Web of Science ®Google Scholar
• Sugie, A., Marchetti, G., & Tavosanis, G. (2018). Structural aspects of plasticity in the nervous system of Drosophila. Neural Development, 13, 14. doi:10.1186/s13064-018-0111-z
   PubMed Web of Science ®Google Scholar
• Sung, P., & Klein, H. (2006). Mechanism of homologous recombination: Mediators and helicases take on regulatory functions. Nature Reviews: Molecular Cell Biology, 7, 739–750. doi:10.1038/nrm2008
   PubMed Web of Science ®Google Scholar
• Szybińska, A., & Leśniak, W. (2017). P53 dysfunction in neurodegenerative diseases: The cause or effect of pathological changes? Aging and Disease, 8, 506–518. doi:10.14336/AD.2016.1120
   PubMed Web of Science ®Google Scholar
• Voigt, A., Herholz, D., Fiesel, F. C., Kaur, K., Müller, D., Karsten, P., … Schulz, J. B. (2010). TDP-43-mediated neuron loss in vivo requires RNA-binding activity. PLoS One, 5, e12247. doi:10.1371/journal.pone.0012247
   PubMed Web of Science ®Google Scholar
• Willenbrink, A. M., Gronauer, M. K., Toebben, L. F., Kick, D. R., Wells, M., & Zhang, B. (2016). The Hillary Climber trumps manual testing: An automatic system for studying Drosophila climbing. Journal of Neurogenetics, 30, 205–211. doi:10.1080/01677063.2016.1255211
   PubMed Web of Science ®Google Scholar
• Wood, A., Krogan, N. J., Dover, J., Schneider, J., Heidt, J., Boateng, M. A., … Shilatifard, A. (2003). Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Molecular Cell, 11, 267–274. doi:10.1016/S1097-2765(02)00802-X
   PubMed Web of Science ®Google Scholar