Regulatory systems that mediate the effects of temperature on the lifespan of Caenorhabditis elegans

References

• Alcedo, J., & Kenyon, C. (2004). Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron, 41(1), 45–55. doi:10.1016/S0896-6273(03)00816-X
   PubMed Web of Science ®Google Scholar
• Ali, M.M.U., Roe, S.M., Vaughan, C.K., Meyer, P., Panaretou, B., Piper, P.W., … Pearl, L.H. (2006). Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex. Nature, 440(7087), 1013–1017. doi:10.1038/nature04716
   PubMed Web of Science ®Google Scholar
• Altintas, O., Park, S., & Lee, S.J. (2016). The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster. BMB Reports, 49(2), 81–92. doi:10.5483/bmbrep.2016.49.2.261
   PubMed Web of Science ®Google Scholar
• Anderson, J.L., Albergotti, L., Ellebracht, B., Huey, R.B., & Phillips, P.C. (2011). Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans? BMC Evolutionary Biology, 11, 157. doi:10.1186/1471-2148-11-157
   PubMed Web of Science ®Google Scholar
• Antebi, A. (2013). Regulation of longevity by the reproductive system. Experimental Gerontology, 48(7), 596–602. doi:10.1016/j.exger.2012.09.009
   PubMed Web of Science ®Google Scholar
• Aparicio, R., Hansen, M., Walker, D.W., & Kumsta, C. (2020). The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. Autophagy, 16(4), 772–774. doi:10.1080/15548627.2020.1725404
   PubMed Web of Science ®Google Scholar
• Apfeld, J., & Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature, 402(6763), 804–809. doi:10.1038/45544
   PubMed Web of Science ®Google Scholar
• Artan, M., Jeong, D.-E., Lee, D., Kim, Y.-I., Son, H.G., Husain, Z., … Lee, S.-J.V. (2016). Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. Genes & Development, 30(9), 1047–1057. doi:10.1101/gad.279448.116
   PubMed Web of Science ®Google Scholar
• Barna, J., Csermely, P., & Vellai, T. (2018). Roles of heat shock factor 1 beyond the heat shock response. Cellular and Molecular Life Sciences, 75(16), 2897–2916. doi:10.1007/s00018-018-2836-6
   PubMed Web of Science ®Google Scholar
• Beverly, M., Anbil, S., & Sengupta, P. (2011). Degeneracy and neuromodulation among thermosensory neurons contribute to robust thermosensory behaviors in Caenorhabditis elegans. The Journal of Neuroscience, 31(32), 11718–11727. doi:10.1523/jneurosci.1098-11.2011
   PubMed Web of Science ®Google Scholar
• Biron, D., Wasserman, S., Thomas, J.H., Samuel, A.D., & Sengupta, P. (2008). An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior. Proceedings of the National Academy of Sciences of the United States of America, 105(31), 11002–11007. doi:10.1073/pnas.0805004105
   PubMed Web of Science ®Google Scholar
• Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics, 77(1), 71–94.
   PubMed Web of Science ®Google Scholar
• Chatzigeorgiou, M., Yoo, S., Watson, J.D., Lee, W.-H., Spencer, W.C., Kindt, K.S., … Schafer, W.R. (2010). Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nature Neuroscience, 13(7), 861–868. doi:10.1038/nn.2581
   PubMed Web of Science ®Google Scholar
• Chen, Y., & Klionsky, D.J. (2011). The regulation of autophagy – Unanswered questions. Journal of Cell Science, 124(Pt 2), 161–170. doi:10.1242/jcs.064576
   PubMed Web of Science ®Google Scholar
• Chen, Y.C., Chen, H.J., Tseng, W.C., Hsu, J.M., Huang, T.T., Chen, C.H., & Pan, C.L. (2016). A C. elegans thermosensory circuit regulates longevity through crh-1/CREB-dependent flp-6 neuropeptide signaling. Developmental Cell, 39(2), 209–223. doi:10.1016/j.devcel.2016.08.021
   PubMed Web of Science ®Google Scholar
• Chen, Y.L., Tao, J., Zhao, P.J., Tang, W., Xu, J.P., Zhang, K.Q., & Zou, C.G. (2019). Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy. Nature Communications, 10(1), 2602. doi:10.1038/s41467-019-10475-8
   PubMed Web of Science ®Google Scholar
• Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M.C., Lucero, J., Brownell, S., … Bartfai, T. (2006). Transgenic mice with a reduced core body temperature have an increased life span. Science (New York, N.Y.), 314(5800), 825–828. doi:10.1126/science.1132191
   PubMed Web of Science ®Google Scholar
• DiLoreto, R., & Murphy, C.T. (2015). The cell biology of aging. Molecular Biology of the Cell, 26(25), 4524–4531. doi:10.1091/mbc.E14-06-1084
   PubMed Web of Science ®Google Scholar
• Dupuy, D., Bertin, N., Hidalgo, C.A., Venkatesan, K., Tu, D., Lee, D., … Vidal, M. (2007). Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans. Nature Biotechnology, 25(6), 663–668. doi:10.1038/nbt1305
   PubMed Web of Science ®Google Scholar
• Echtenkamp, F.J., Zelin, E., Oxelmark, E., Woo, J.I., Andrews, B.J., Garabedian, M., & Freeman, B.C. (2011). Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Molecular Cell, 43(2), 229–241. doi:10.1016/j.molcel.2011.05.029
   PubMed Web of Science ®Google Scholar
• Flatt, T., Min, K.-J., D'Alterio, C., Villa-Cuesta, E., Cumbers, J., Lehmann, R., … Tatar, M. (2008). Drosophila germ-line modulation of insulin signaling and lifespan. Proceedings of the National Academy of Sciences of the United States of America, 105(17), 6368–6373. doi:10.1073/pnas.0709128105
   PubMed Web of Science ®Google Scholar
• Freeman, B.C., Felts, S.J., Toft, D.O., & Yamamoto, K.R. (2000). The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes & Development, 14(4), 422–434.
   PubMed Web of Science ®Google Scholar
• Freeman, B.C., & Yamamoto, K.R. (2002). Disassembly of transcriptional regulatory complexes by molecular chaperones. Science (New York, N.Y.), 296(5576), 2232–2235. doi:10.1126/science.1073051
   PubMed Web of Science ®Google Scholar
• Genest, O., Wickner, S., & Doyle, S.M. (2019). Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling. The Journal of Biological Chemistry, 294(6), 2109–2120. doi:10.1074/jbc.REV118.002806
   PubMed Web of Science ®Google Scholar
• Goodman, M.B., & Sengupta, P. (2019). How Caenorhabditis elegans senses mechanical stress, temperature, and other physical stimuli. Genetics, 212(1), 25–51. doi:10.1534/genetics.118.300241
   PubMed Web of Science ®Google Scholar
• Grad, I., McKee, T.A., Ludwig, S.M., Hoyle, G.W., Ruiz, P., Wurst, W., … Picard, D. (2006). The Hsp90 cochaperone p23 is essential for perinatal survival. Molecular and Cellular Biology, 26(23), 8976–8983. doi:10.1128/mcb.00734-06
   PubMed Web of Science ®Google Scholar
• Hansen, M., Rubinsztein, D.C., & Walker, D.W. (2018). Autophagy as a promoter of longevity: Insights from model organisms. Nature Reviews. Molecular Cell Biology, 19(9), 579–593. doi:10.1038/s41580-018-0033-y
   PubMed Web of Science ®Google Scholar
• Hedgecock, E.M., & Russell, R.L. (1975). Normal and mutant thermotaxis in the nematode Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 72(10), 4061–4065. doi:10.1073/pnas.72.10.4061
   PubMed Web of Science ®Google Scholar
• Holthuis, J.C., & Menon, A.K. (2014). Lipid landscapes and pipelines in membrane homeostasis. Nature, 510(7503), 48–57. doi:10.1038/nature13474
   PubMed Web of Science ®Google Scholar
• Horikawa, M., Sural, S., Hsu, A.L., & Antebi, A. (2015). Co-chaperone p23 regulates C. elegans lifespan in response to temperature. PLoS Genetics, 11(4), e1005023. doi:10.1371/journal.pgen.1005023
   PubMed Web of Science ®Google Scholar
• Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K., & Mori, I. (2006). Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Genetics, 172(4), 2239–2252. doi:10.1534/genetics.105.050013
   PubMed Web of Science ®Google Scholar
• Jeong, D.E., Artan, M., Seo, K., & Lee, S.J. (2012). Regulation of lifespan by chemosensory and thermosensory systems: Findings in invertebrates and their implications in mammalian aging. Frontiers in Genetics, 3, 218. doi:10.3389/fgene.2012.00218
   PubMedGoogle Scholar
• Johnson, J.L., & Toft, D.O. (1994). A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. The Journal of Biological Chemistry, 269(40), 24989–24993.
   PubMed Web of Science ®Google Scholar
• Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K.Y., Vennekens, R., … Voets, T. (2009). TRPA1 acts as a cold sensor in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America, 106(4), 1273–1278. doi:10.1073/pnas.0808487106
   PubMed Web of Science ®Google Scholar
• Kenyon, C.J. (2010a). The genetics of ageing. Nature, 464(7288), 504–512. doi:10.1038/nature08980
   PubMed Web of Science ®Google Scholar
• Kenyon, C.J. (2010b). A pathway that links reproductive status to lifespan in Caenorhabditis elegans. Annals of the New York Academy of Sciences, 1204, 156–162. doi:10.1111/j.1749-6632.2010.05640.x
   PubMed Web of Science ®Google Scholar
• Kindt, K.S., Viswanath, V., Macpherson, L., Quast, K., Hu, H., Patapoutian, A., & Schafer, W.R. (2007). Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nature Neuroscience, 10(5), 568–577. doi:10.1038/nn1886
   PubMed Web of Science ®Google Scholar
• Kuhara, A., Okumura, M., Kimata, T., Tanizawa, Y., Takano, R., Kimura, K.D., … Mori, I. (2008). Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans. Science (New York, N.Y.), 320(5877), 803–807. doi:10.1126/science.1148922
   PubMed Web of Science ®Google Scholar
• Lee, D., An, S.W.A., Jung, Y., Yamaoka, Y., Ryu, Y., Goh, G.Y.S., … Lee, S.-J.V. (2019). MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis. PLoS Biology, 17(8), e3000415. doi:10.1371/journal.pbio.3000415
   PubMed Web of Science ®Google Scholar
• Lee, H.J., Noormohammadi, A., Koyuncu, S., Calculli, G., Simic, M.S., Herholz, M., … Vilchez, D. (2019). Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans. Nature Metabolism, 1(8), 790–810. doi:10.1038/s42255-019-0097-9
   PubMedGoogle Scholar
• Lee, S.J., & Kenyon, C. (2009). Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Current Biology, 19(9), 715–722. doi:10.1016/j.cub.2009.03.041
   PubMed Web of Science ®Google Scholar
• Lee, Y., An, S.W.A., Artan, M., Seo, M., Hwang, A.B., Jeong, D.-E., … Lee, S.-J.V. (2015). Genes and pathways that influence longevity in Caenorhabditis elegans. In N. Mori & I. Mook-Jung (Eds.), Aging mechanisms: Longevity, metabolism, and brain aging (pp. 123–169). Tokyo: Springer.
   Google Scholar
• Lovgren, A.K., Kovarova, M., & Koller, B.H. (2007). cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Molecular and Cellular Biology, 27(12), 4416–4430. doi:10.1128/mcb.02314-06
   PubMed Web of Science ®Google Scholar
• Luo, L., Clark, D.A., Biron, D., Mahadevan, L., & Samuel, A.D. (2006). Sensorimotor control during isothermal tracking in Caenorhabditis elegans. The Journal of Experimental Biology, 209(Pt 23), 4652–4662. doi:10.1242/jeb.02590
   PubMed Web of Science ®Google Scholar
• Luo, L., Cook, N., Venkatachalam, V., Martinez-Velazquez, L.A., Zhang, X., Calvo, A.C., … Samuel, A.D.T. (2014). Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons. Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2776–2781. doi:10.1073/pnas.1315205111
   PubMed Web of Science ®Google Scholar
• Ma, D.K., Li, Z., Lu, A.Y., Sun, F., Chen, S., Rothe, M., … Horvitz, H.R. (2015). Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids. Cell, 161(5), 1152–1163. doi:10.1016/j.cell.2015.04.026
   PubMed Web of Science ®Google Scholar
• Min, K.J., Lee, C.K., & Park, H.N. (2012). The lifespan of Korean eunuchs. Current Biology: CB, 22(18), R792–R793. doi:10.1016/j.cub.2012.06.036
   PubMed Web of Science ®Google Scholar
• Minke, B., Wu, C., & Pak, W.L. (1975). Induction of photoreceptor voltage noise in the dark in Drosophila mutant. Nature, 258(5530), 84–87. doi:10.1038/258084a0
   PubMed Web of Science ®Google Scholar
• Montell, C. (2011). The history of TRP channels, a commentary and reflection. Pflugers Archiv: European Journal of Physiology, 461(5), 499–506. doi:10.1007/s00424-010-0920-3
   PubMed Web of Science ®Google Scholar
• Montell, C., & Rubin, G.M. (1989). Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction. Neuron, 2(4), 1313–1323. doi:10.1016/0896-6273(89)90069-X
   PubMed Web of Science ®Google Scholar
• Mori, I. (1999). Genetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans. Annual Review of Genetics, 33, 399–422. doi:10.1146/annurev.genet.33.1.399
   PubMed Web of Science ®Google Scholar
• Mori, I., & Ohshima, Y. (1995). Neural regulation of thermotaxis in Caenorhabditis elegans. Nature, 376(6538), 344–348. doi:10.1038/376344a0
   PubMed Web of Science ®Google Scholar
• Morimoto, R.I. (2011). The heat shock response: Systems biology of proteotoxic stress in aging and disease. Cold Spring Harbor Symposia on Quantitative Biology, 76, 91–99. doi:10.1101/sqb.2012.76.010637
   PubMedGoogle Scholar
• Murphy, C.T., Lee, S.J., & Kenyon, C. (2007). Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 104(48), 19046–19050. doi:10.1073/pnas.0709613104
   PubMed Web of Science ®Google Scholar
• Murphy, C.T., McCarroll, S.A., Bargmann, C.I., Fraser, A., Kamath, R.S., Ahringer, J., … Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature, 424(6946), 277–283. doi:10.1038/nature01789
   PubMed Web of Science ®Google Scholar
• Nakatani, Y., Hokonohara, Y., Kakuta, S., Sudo, K., Iwakura, Y., & Kudo, I. (2007). Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Biochemical and Biophysical Research Communications, 362(2), 387–392. doi:10.1016/j.bbrc.2007.07.180
   PubMed Web of Science ®Google Scholar
• Nishida, Y., Sugi, T., Nonomura, M., & Mori, I. (2011). Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis. EMBO Reports, 12(8), 855–862. doi:10.1038/embor.2011.120
   PubMed Web of Science ®Google Scholar
• Partridge, L., Gems, D., & Withers, D.J. (2005). Sex and death: What is the connection? Cell, 120(4), 461–472. doi:10.1016/j.cell.2005.01.026
   PubMed Web of Science ®Google Scholar
• Parzych, K.R., & Klionsky, D.J. (2014). An overview of autophagy: Morphology, mechanism, and regulation. Antioxidants & Redox Signaling, 20(3), 460–473. doi:10.1089/ars.2013.5371
   PubMed Web of Science ®Google Scholar
• Pearl, R. (1928). Experiments on Longevity. The Quarterly Review of Biology, 3(3), 391–407. doi:10.1086/394311
   Google Scholar
• Prahlad, V., & Morimoto, R.I. (2011). Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14204–14209. doi:10.1073/pnas.1106557108
   PubMed Web of Science ®Google Scholar
• Prahlad, V., Cornelius, T., & Morimoto, R.I. (2008). Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science (New York, N.Y.), 320(5877), 811–814. doi:10.1126/science.1156093
   PubMed Web of Science ®Google Scholar
• Protsiv, M., Ley, C., Lankester, J., Hastie, T., & Parsonnet, J. (2020). Decreasing human body temperature in the United States since the industrial revolution. eLife, 9, e49555. doi:10.7554/eLife.49555
   PubMed Web of Science ®Google Scholar
• Ramot, D., MacInnis, B.L., & Goodman, M.B. (2008). Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans. Nature Neuroscience, 11(8), 908–915. doi:10.1038/nn.2157
   PubMed Web of Science ®Google Scholar
• Roth, G.S., Lane, M.A., Ingram, D.K., Mattison, J.A., Elahi, D., Tobin, J.D., … Metter, E.J. (2002). Biomarkers of caloric restriction may predict longevity in humans. Science (New York, N.Y.), 297(5582), 811. doi:10.1126/science.1071851
   PubMed Web of Science ®Google Scholar
• Satterlee, J.S., Ryu, W.S., & Sengupta, P. (2004). The CMK-1 CaMKI and the TAX-4 cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Current Biology, 14(1), 62–68. doi:10.1016/j.cub.2003.12.030
   PubMed Web of Science ®Google Scholar
• Simonsick, E.M., Meier, H.C.S., Shaffer, N.C., Studenski, S.A., & Ferrucci, L. (2016). Basal body temperature as a biomarker of healthy aging. Age (Dordrecht, Netherlands), 38(5–6), 445–454. doi:10.1007/s11357-016-9952-8
   PubMedGoogle Scholar
• Son, H.G., Altintas, O., Kim, E.J.E., Kwon, S., & Lee, S.V. (2019). Age-dependent changes and biomarkers of aging in Caenorhabditis elegans. Aging Cell, 18(2), e12853. doi:10.1111/acel.12853
   PubMed Web of Science ®Google Scholar
• Story, G.M., Peier, A.M., Reeve, A.J., Eid, S.R., Mosbacher, J., Hricik, T.R., … Patapoutian, A. (2003). ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell, 112(6), 819–829. doi:10.1016/S0092-8674(03)00158-2
   PubMed Web of Science ®Google Scholar
• Sulston, J.E., Schierenberg, E., White, J.G., & Thomson, J.N. (1983). The embryonic cell lineage of the nematode Caenorhabditis elegans. Developmental Biology, 100(1), 64–119. doi:10.1016/0012-1606(83)90201-4
   PubMed Web of Science ®Google Scholar
• Svensk, E., Stahlman, M., Andersson, C.H., Johansson, M., Boren, J., & Pilon, M. (2013). PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. PLoS Genetics, 9(9), e1003801. doi:10.1371/journal.pgen.1003801
   PubMed Web of Science ®Google Scholar
• Tatum, M.C., Ooi, F.K., Chikka, M.R., Chauve, L., Martinez-Velazquez, L.A., Steinbusch, H.W.M., … Prahlad, V. (2015). Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase. Current Biology, 25(2), 163–174. doi:10.1016/j.cub.2014.11.040
   PubMed Web of Science ®Google Scholar
• Taubert, S., Van Gilst, M.R., Hansen, M., & Yamamoto, K.R. (2006). A mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes & Development, 20(9), 1137–1149. doi:10.1101/gad.1395406
   PubMed Web of Science ®Google Scholar
• Van Gilst, M.R., Hadjivassiliou, H., Jolly, A., & Yamamoto, K.R. (2005). Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biology, 3(2), e53. doi:10.1371/journal.pbio.0030053
   PubMed Web of Science ®Google Scholar
• Venkatachalam, K., & Montell, C. (2007). TRP channels. Annual Review of Biochemistry, 76, 387–417. doi:10.1146/annurev.biochem.75.103004.142819
   PubMed Web of Science ®Google Scholar
• Vozdek, R., Hnizda, A., Krijt, J., Kostrouchova, M., & Kozich, V. (2012). Novel structural arrangement of nematode cystathionine β-synthases: Characterization of Caenorhabditis elegans CBS-1. The Biochemical Journal, 443(2), 535–547. doi:10.1042/bj20111478
   PubMed Web of Science ®Google Scholar
• Ward, S., Thomson, N., White, J.G., & Brenner, S. (1975). Electron microscopical reconstruction of the anterior sensory anatomy of the nematode Caenorhabditis elegans.?2UU. The Journal of Comparative Neurology, 160(3), 313–337. doi:10.1002/cne.901600305
   PubMed Web of Science ®Google Scholar
• Wasserman, S.M., Beverly, M., Bell, H.W., & Sengupta, P. (2011). Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling. Current Biology: CB, 21(5), 353–362. doi:10.1016/j.cub.2011.01.053
   PubMed Web of Science ®Google Scholar
• White, J.G., Southgate, E., Thomson, J.N., & Brenner, S. (1986). The structure of the nervous system of the nematode Caenorhabditis elegans. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 314(1165), 1–340. doi:10.1098/rstb.1986.0056
   PubMed Web of Science ®Google Scholar
• Wong, S.Q., Kumar, A.V., Mills, J., & Lapierre, L.R. (2020). Autophagy in aging and longevity. Human Genetics, 139(3), 277–290. doi:10.1007/s00439-019-02031-7
   PubMed Web of Science ®Google Scholar
• Xiao, R., Liu, J., & Xu, X.Z. (2015). Thermosensation and longevity. Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology, 201(9), 857–867. doi:10.1007/s00359-015-1021-8
   PubMed Web of Science ®Google Scholar
• Xiao, R., & Xu, X.Z. (2011). C. elegans TRP channels. Advances in Experimental Medicine and Biology, 704, 323–339. doi:10.1007/978-94-007-0265-3_18
   PubMed Web of Science ®Google Scholar
• Xiao, R., Zhang, B., Dong, Y., Gong, J., Xu, T., Liu, J., & Xu, X.Z. (2013). A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell, 152(4), 806–817. doi:10.1016/j.cell.2013.01.020
   PubMed Web of Science ®Google Scholar
• Yang, F., Vought, B.W., Satterlee, J.S., Walker, A.K., Jim Sun, Z.-Y., Watts, J.L., … Näär, A.M. (2006). An ARC/mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature, 442(7103), 700–704. doi:10.1038/nature04942
   PubMed Web of Science ®Google Scholar
• Yang, Y., & Klionsky, D.J. (2020). Autophagy and disease: Unanswered questions. Cell Death and Differentiation, 27(3), 858–871. doi:10.1038/s41418-019-0480-9
   PubMed Web of Science ®Google Scholar
• Yu, Y.V., Bell, H.W., Glauser, D., Van Hooser, S.D., Goodman, M.B., & Sengupta, P. (2014). CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron. Neuron, 84(5), 919–926. doi:10.1016/j.neuron.2014.10.046
   PubMed Web of Science ®Google Scholar
• Zhang, B., Gong, J., Zhang, W., Xiao, R., Liu, J., & Xu, X.Z.S. (2018). Brain-gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans. Genes & Development, 32(3–4), 258–270. doi:10.1101/gad.309625.117
   PubMed Web of Science ®Google Scholar
• Zhang, B., Xiao, R., Ronan, E.A., He, Y., Hsu, A.L., Liu, J., & Xu, X.Z. (2015). Environmental temperature differentially modulates C. elegans longevity through a thermosensitive TRP channel. Cell Reports, 11(9), 1414–1424. doi:10.1016/j.celrep.2015.04.066
   PubMed Web of Science ®Google Scholar
• Zou, J., Guo, Y., Guettouche, T., Smith, D.F., & Voellmy, R. (1998). Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell, 94(4), 471–480. doi:10.1016/S0092-8674(00)81588-3
   PubMed Web of Science ®Google Scholar