References
- Barone, M.C., & Bohmann, D. (2013). Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining. Journal of Visualized Experiments, 24(74), e50339. doi:https://doi.org/10.3791/50339
- Bianco, C.L., Ridet, J.L., Schneider, B.L., Déglon, N., & Aebischer, P. (2002). alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10813–10818. doi:https://doi.org/10.1073/pnas.152339799
- Botella, J.A., Bayersdorfer, F., & Schneuwly, S. (2008). Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson’s disease. Neurobiology of Disease, 30(1), 65–73. doi:https://doi.org/10.1016/j.nbd.2007.11.013
- Breda, C., Nugent, M.L., Estranero, J.G., Kyriacou, C.P., Outeiro, T.F., Steinert, J.R., & Giorgini, F. (2015). Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour. Human Molecular Genetics, 24(4), 1077–1091. doi:https://doi.org/10.1093/hmg/ddu521
- Burr, A.A., Tsou, W.L., Ristic, G., & Todi, S.V. (2014). Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration of Drosophila eyes. Journal of Neuroscience Research, 92(9), 1100–1109. doi:https://doi.org/10.1002/jnr.23395
- Cabin, D.E., Shimazu, K., Murphy, D., Cole, N.B., Gottschalk, W., McIlwain, K.L., … Nussbaum, R.L. (2002). Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-synuclein. The Journal of Neuroscience, 22(20), 8797–8807. doi:https://doi.org/10.1523/JNEUROSCI.22-20-08797.2002
- Chen, L., & Feany, M.B. (2005). Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nature Neuroscience, 8(5), 657–663. doi:https://doi.org/10.1038/nn1443
- Chesselet, M. F. (2008). In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson’s disease? Experimental Neurology, 209(1), 22–27. doi:https://doi.org/10.1016/j.expneurol.2007.08.006
- Conway, K.A., Harper, J.D., & Lansbury, P.T. (1998). Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nature Medicine, 4(11), 1318–1320. doi:https://doi.org/10.1038/3311
- Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., … Lindquist, S. (2006). Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson’s models. Science, 313(5785), 324–328. doi:https://doi.org/10.1126/science.1129462
- Dabool, L., Juravlev, L., Hakim-Mishnaevski, K., & Kurant, E. (2019). Modeling Parkinson’s disease in adult Drosophila. Journal of Neuroscience Methods, 311, 89–94. doi:https://doi.org/10.1016/j.jneumeth.2018.10.018
- Daher, J.P.L., Ying, M., Banerjee, R., McDonald, R.S., Hahn, M.D., Yang, L., … Moore, D.J. (2009). Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Molecular Neurodegeneration, 4(1), 34. doi:https://doi.org/10.1186/1750-1326-4-34
- Farrer, M., Kachergus, J., Forno, L., Lincoln, S., Wang, D.-S., Hulihan, M., Maraganore, D., Gwinn-Hardy, K., Wszolek, Z., Dickson, D., & Langston, J. W. (2004). Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications. Annals of Neurology, 55(2), 174–179. https://doi.org/https://doi.org/10.1002/ana.10846
- Feany, M.B., & Bender, W.W. (2000). A Drosophila model of Parkinson’s disease. Nature, 404(6776), 394–398. doi:https://doi.org/10.1038/35006074
- Feng, L.R., Federoff, H.J., Vicini, S., & Maguire-Zeiss, K.A. (2010). α-Synuclein mediates alterations in membrane conductance: A potential role for α-synuclein oligomers in cell vulnerability. European Journal of Neuroscience, 32(1), 10–17. doi:https://doi.org/10.1111/j.1460-9568.2010.07266.x
- Ip, C.W., Klaus, L.C., Karikari, A.A., Visanji, N.P., Brotchie, J.M., Lang, A.E., … Koprich, J.B. (2017). AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: A new mouse model for Parkinson’s disease. Acta Neuropathologica Communications, 5(1), 11. doi:https://doi.org/10.1186/s40478-017-0416-x
- Jensen, P.H., Nielsen, M.S., Jakes, R., Dotti, C.G., & Goedert, M. (1998). Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson’s disease mutation. The Journal of Biological Chemistry, 273(41), 26292–26294. doi:https://doi.org/10.1074/jbc.273.41.26292
- Karpinar, D.P., Balija, M.B.G., Kügler, S., Opazo, F., Rezaei-Ghaleh, N., Wender, N., … Zweckstetter, M. (2009). Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson’s disease models. The EMBO Journal, 28(20), 3256–3268. doi:https://doi.org/10.1038/emboj.2009.257
- Kirik, D., Rosenblad, C., Burger, C., Lundberg, C., Johansen, T.E., Muzyczka, N., … Björklund, A. (2002). Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system. The Journal of Neuroscience, 22(7), 2780–2791. doi:https://doi.org/10.1523/JNEUROSCI.22-07-02780.2002
- Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998). AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genetics, 18(2), 106–108. https://doi.org/https://doi.org/10.1038/ng0298-106
- Lashuel, H.A., Petre, B.M., Wall, J., Simon, M., Nowak, R.J., Walz, T., & Lansbury, P.T. (2002). α-Synuclein, especially the Parkinson’s disease-associated mutants, forms pore-like annular and tubular protofibrils. Journal of Molecular Biology, 322(5), 1089–1102. doi:https://doi.org/10.1016/S0022-2836(02)00735-0
- Li, J., Uversky, V.N., & Fink, A.L. (2001). Effect of Familial Parkinson’s disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry, 40(38), 11604–11613. doi:https://doi.org/10.1021/bi010616g
- Maitra, U., Scaglione, M.N., Chtarbanova, S., & O’Donnell, J.M. (2019). Innate immune responses to paraquat exposure in a Drosophila model of Parkinson’s disease. Scientific Reports, 9(1), 12714. doi:https://doi.org/10.1038/s41598-019-48977-6
- Maitra, U., Harding, T., Liang, Q., & Ciesla, L. (2021). GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson’s disease. Communications Biology, 4(1), 162. doi:https://doi.org/10.1038/s42003-021-01685-2
- Matsuoka, N. (2001). Direct observation of frost wedging in alpine bedrock. Earth Surface Processes and Landforms, 26(6), 601–614. https://doi.org/https://doi.org/10.1002/esp.208
- Mougenot, A. L., Nicot, S., Bencsik, A., Morignat, E., Verchère, J., Lakhdar, L., … Baron, T. (2012). Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiology of Aging, 33(9), 2225–2228. doi:https://doi.org/10.1016/j.neurobiolaging.2011.06.022
- Navarro, J.A., Heßner, S., Yenisetti, S.C., Bayersdorfer, F., Zhang, L., Voigt, A., … Botella, J.A. (2014). Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson’s disease in Drosophila. Journal of Neurochemistry, 131(3), 369–382. doi:https://doi.org/10.1111/jnc.12818
- Nevzglyadova, O.V., Mikhailova, E.V., Artemov, A.V., Ozerova, Y.E., Ivanova, P.A., Golomidov, I.M., … Sarantseva, S.V. (2018). Yeast red pigment modifies cloned human α-synuclein pathogenesis in Parkinson’s disease models in Saccharomyces cerevisiae and Drosophila melanogaster. Neurochemistry International, 120, 172–181. doi:https://doi.org/10.1016/j.neuint.2018.08.002
- Periquet, M., Fulga, T., Myllykangas, L., Schlossmacher, M.G., & Feany, M.B. (2007). Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo. The Journal of Neuroscience, 27(12), 3338–3346. doi:https://doi.org/10.1523/JNEUROSCI.0285-07.2007
- Pesah, Y., Burgess, H., Middlebrooks, B., Ronningen, K., Prosser, J., Tirunagaru, V., … Mardon, G. (2005). Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila. Genesis, 41(4), 154–159. doi:https://doi.org/10.1002/gene.20106
- Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., & Nussbaum, R. L. (1997). Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease. Science, 276(5321), 2045–2047. https://doi.org/https://doi.org/10.1126/science.276.5321.2045
- Song, L., He, Y., Ou, J., Zhao, Y., Li, R., Cheng, J., … Ho, M.S. (2017). Auxilin underlies progressive locomotor deficits and dopaminergic neuron loss in a drosophila model of Parkinson’s disease. Cell Reports, 18(5), 1132–1143. doi:https://doi.org/10.1016/j.celrep.2017.01.005
- Strausfeld, N.J., & Hirth, F. (2013). Homology versus convergence in resolving transphyletic correspondences of brain organization. Brain, Behavior and Evolution, 82(4), 215–219. doi:https://doi.org/10.1159/000356102
- Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., … Gwinn-Hardy, K. (2003). α-Synuclein Locus Triplication Causes Parkinson's Disease. Science, 302(5646), 841–841. https://doi.org/https://doi.org/10.1126/science.1090278
- Trinh, K., Moore, K., Wes, P.D., Muchowski, P.J., Dey, J., Andrews, L., & Pallanck, L.J. (2008). Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson’s disease. The Journal of Neuroscience, 28(2), 465–472. doi:https://doi.org/10.1523/JNEUROSCI.4778-07.2008
- Tofaris, G.K., & Spillantini, M.G. (2005). Alpha-synuclein dysfunction in Lewy body diseases. Movement Disorders, 20(S12), S37–S44. doi:https://doi.org/10.1002/mds.20538
- Vargas, R.H., Ornelas, L.F., González, I.L., Escovar, J.R., Zurita, M., & Reynaud, E. (2011). Synphilin suppresses α-synuclein neurotoxicity in a Parkinson’s disease Drosophila model. Genesis, 49(5), 392–402. doi:https://doi.org/10.1002/dvg.20740
- White, K.E., Humphrey, D.M., & Hirth, F. (2010). The dopaminergic system in the aging brain of Drosophila. Frontiers in Neuroscience, 4(205), 205. doi:https://doi.org/10.3389/fnins.2010.00205
- Yacoubian, T.A., & Standaert, D.G. (2014). Reaping what you sow: Cross-seeding between aggregation-prone proteins in neurodegeneration. Movement Disorders, 29(3), 306–306. doi:https://doi.org/10.1002/mds.25766
- Yin, G., Lopes da Fonseca, T., Eisbach, S.E., Anduaga, A.M., Breda, C., Orcellet, M.L., … Zweckstetter, M. (2014). α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease, 70, 149–161. doi:https://doi.org/10.1016/j.nbd.2014.06.018