Inter-organ regulation by the brain in Drosophila development and physiology

References

• Agrawal, N., Delanoue, R., Mauri, A., Basco, D., Pasco, M., Thorens, B., & Leopold, P. (2016). The Drosophila TNF Eiger is an adipokine that acts on insulin-producing cells to mediate nutrient response. Cell Metabolism, 23(4), 675–684. https://doi.org/10.1016/j.cmet.2016.03.003
   PubMed Web of Science ®Google Scholar
• Al-Anzi, B., Armand, E., Nagamei, P., Olszewski, M., Sapin, V., Waters, C., Zinn, K., Wyman, R. J., & Benzer, S. (2010). The leucokinin pathway and its neurons regulate meal size in Drosophila. Current Biology, 20(11), 969–978. https://doi.org/10.1016/j.cub.2010.04.039
   PubMed Web of Science ®Google Scholar
• Alfa, R. W., Park, S., Skelly, K.-R., Poffenberger, G., Jain, N., Gu, X., Kockel, L., Wang, J., Liu, Y., Powers, A. C., & Kim, S. K. (2015). Suppression of insulin production and secretion by a decretin hormone. Cell Metabolism, 21(2), 323–334. https://doi.org/10.1016/j.cmet.2015.01.006
   PubMed Web of Science ®Google Scholar
• Amcheslavsky, A., Jiang, J., & Ip, Y. T. (2009). Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell, 4(1), 49–61. https://doi.org/10.1016/j.stem.2008.10.016
   PubMed Web of Science ®Google Scholar
• Amrein, H., & Thorne, N. (2005). Gustatory perception and behavior in Drosophila melanogaster. Current Biology, 15(17), R673–R684. https://doi.org/10.1016/j.cub.2005.08.021
   PubMed Web of Science ®Google Scholar
• Bai, H., Kang, P., & Tatar, M. (2012). Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. Aging Cell, 11(6), 978–985. https://doi.org/10.1111/acel.12000
   PubMed Web of Science ®Google Scholar
• Banerjee, U., Girard, J. R., Goins, L. M., & Spratford, C. M. (2019). Drosophila as a genetic model for hematopoiesis. Genetics, 211(2), 367–417. https://doi.org/10.1534/genetics.118.300223
   PubMed Web of Science ®Google Scholar
• Bellmann, D., Richardt, A., Freyberger, R., Nuwal, N., Schwarzel, M., Fiala, A., & Stortkuhl, K. F. (2010). Optogenetically induced olfactory stimulation in drosophila larvae reveals the neuronal basis of odor-aversion behavior. Frontiers in Behavioral Neuroscience, 4, 27. https://doi.org/10.3389/fnbeh.2010.00027
   PubMed Web of Science ®Google Scholar
• Benmimoun, B., Polesello, C., Waltzer, L., & Haenlin, M. (2012). Dual role for insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development, 139(10), 1713–1717. https://doi.org/10.1242/dev.080259
   PubMed Web of Science ®Google Scholar
• Berger, M., Gray, J. A., & Roth, B. L. (2009). The expanded biology of serotonin. Annual Review of Medicine, 60, 355–366. https://doi.org/10.1146/annurev.med.60.042307.110802
   PubMed Web of Science ®Google Scholar
• Besedovsky, H., del Rey, A., Sorkin, E., Da Prada, M., Burri, R., & Honegger, C. (1983). The immune response evokes changes in brain noradrenergic neurons. Science, 221(4610), 564–566. https://doi.org/10.1126/science.6867729
   PubMed Web of Science ®Google Scholar
• Cameron, P., Hiroi, M., Ngai, J., & Scott, K. (2010). The molecular basis for water taste in Drosophila. Nature, 465(7294), 91–95. https://doi.org/10.1038/nature09011
   PubMed Web of Science ®Google Scholar
• Capo, F., Chaduli, D., Viallat-Lieutaud, A., Charroux, B., & Royet, J. (2017). Oligopeptide transporters of the SLC15 family are dispensable for peptidoglycan sensing and transport in Drosophila. Journal of Innate Immunity, 9(5), 483–492. https://doi.org/10.1159/000475771
   PubMed Web of Science ®Google Scholar
• Castillo-Armengol, J., Fajas, L., & Lopez-Mejia, I. C. (2019). Inter-organ communication: a gatekeeper for metabolic health. EMBO Reports, 20(9), e47903. https://doi.org/10.15252/embr.201947903
   PubMed Web of Science ®Google Scholar
• Cekanaviciute, E., Yoo, B. B., Runia, T. F., Debelius, J. W., Singh, S., Nelson, C. A., Kanner, R., Bencosme, Y., Lee, Y. K., Hauser, S. L., Crabtree-Hartman, E., Sand, I. K., Gacias, M., Zhu, Y., Casaccia, P., Cree, B. A. C., Knight, R., Mazmanian, S. K., & Baranzini, S. E. (2017). Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proceedings of the National Academy of Sciences of the United States of America, 114(40), 10713–10718. https://doi.org/10.1073/pnas.1711235114
   PubMed Web of Science ®Google Scholar
• Chinta, S. J., & Andersen, J. K. (2005). Dopaminergic neurons. The International Journal of Biochemistry & Cell Biology, 37(5), 942–946. https://doi.org/10.1016/j.biocel.2004.09.009
   PubMed Web of Science ®Google Scholar
• Cho, B., Spratford, C. M., Yoon, S., Cha, N., Banerjee, U., & Shim, J. (2018). Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila. Nature Communications, 9(1), 2679. https://doi.org/10.1038/s41467-018-04990-3
   PubMed Web of Science ®Google Scholar
• Choi, N. H., Lucchetta, E., & Ohlstein, B. (2011). Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway. Proceedings of the National Academy of Sciences of the United States of America, 108(46), 18702–18707. https://doi.org/10.1073/pnas.1109348108
   PubMed Web of Science ®Google Scholar
• Chu, C., Artis, D., & Chiu, I. M. (2020). Neuro-immune interactions in the tissues. Immunity, 52(3), 464–474. https://doi.org/10.1016/j.immuni.2020.02.017
   PubMed Web of Science ®Google Scholar
• Clarke, I. J. (2015). Hypothalamus as an endocrine organ. Comprehensive Physiology, 5(1), 217–253. https://doi.org/10.1002/cphy.c140019
   PubMed Web of Science ®Google Scholar
• Corcoran, S., Mase, A., Hashmi, Y., Ouyang, D., Augsburger, J., Jacobs, T., Kukar, K., & Brückner, K. (2020). Regulation of blood cell transdifferentiation by oxygen sensing neurons. bioRxiv, 2020.2004.2022.056622. https://doi.org/10.1101/2020.04.22.056622
   Google Scholar
• Cox, M. A., Duncan, G. S., Lin, G. H. Y., Steinberg, B. E., Yu, L. X., Brenner, D., Buckler, L. N., Elia, A. J., Wakeham, A. C., Nieman, B., Dominguez-Brauer, C., Elford, A. R., Gill, K. T., Kubli, S. P., Haight, J., Berger, T., Ohashi, P. S., Tracey, K. J., Olofsson, P. S., & Mak, T. W. (2019). Choline acetyltransferase-expressing T cells are required to control chronic viral infection. Science, 363(6427), 639–644. https://doi.org/10.1126/science.aau9072
   PubMed Web of Science ®Google Scholar
• Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., Guzzetta, K. E., Jaggar, M., Long-Smith, C. M., Lyte, J. M., Martin, J. A., Molinero-Perez, A., Moloney, G., Morelli, E., Morillas, E., … Dinan, T. G. (2019). The microbiota-gut-brain axis. Physiological Reviews, 99(4), 1877–2013. https://doi.org/10.1152/physrev.00018.2018
   PubMed Web of Science ®Google Scholar
• Dahanukar, A., Lei, Y. T., Kwon, J. Y., & Carlson, J. R. (2007). Two Gr genes underlie sugar reception in Drosophila. Neuron, 56(3), 503–516. https://doi.org/10.1016/j.neuron.2007.10.024
   PubMed Web of Science ®Google Scholar
• Demontis, F., & Perrimon, N. (2009). Integration of insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development, 136(6), 983–993. https://doi.org/10.1242/dev.027466
   PubMed Web of Science ®Google Scholar
• Droujinine, I. A., & Perrimon, N. (2016). Interorgan communication pathways in physiology: Focus on Drosophila. Annual Review of Genetics, 50, 539–570. https://doi.org/10.1146/annurev-genet-121415-122024
   PubMed Web of Science ®Google Scholar
• Dus, M., Lai, J. S.-Y., Gunapala, K. M., Min, S., Tayler, T. D., Hergarden, A. C., Geraud, E., Joseph, C. M., & Suh, G. S. B. (2015). Nutrient sensor in the brain directs the action of the brain-gut axis in Drosophila. Neuron, 87(1), 139–151. https://doi.org/10.1016/j.neuron.2015.05.032
   PubMed Web of Science ®Google Scholar
• Duvic, B., Hoffmann, J. A., Meister, M., & Royet, J. (2002). Notch signaling controls lineage specification during Drosophila larval hematopoiesis. Current Biology, 12(22), 1923–1927. https://doi.org/10.1016/S0960-9822(02)01297-6
   PubMed Web of Science ®Google Scholar
• Escher, S. A., & Rasmuson-Lestander, A. (1999). The Drosophila glucose transporter gene: cDNA sequence, phylogenetic comparisons, analysis of functional sites and secondary structures. Hereditas, 130(2), 95–103. https://doi.org/10.1111/j.1601-5223.1999.00095.x
   PubMed Web of Science ®Google Scholar
• Fujii, S., Yavuz, A., Slone, J., Jagge, C., Song, X., & Amrein, H. (2015). Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing. Current Biology, 25(5), 621–627. https://doi.org/10.1016/j.cub.2014.12.058
   PubMed Web of Science ®Google Scholar
• Gancheva, S., Jelenik, T., Alvarez-Hernandez, E., & Roden, M. (2018). Interorgan metabolic crosstalk in human insulin resistance. Physiological Reviews, 98(3), 1371–1415. https://doi.org/10.1152/physrev.00015.2017
   PubMed Web of Science ®Google Scholar
• Ganguly, A., Pang, L., Duong, V. K., Lee, A., Schoniger, H., Varady, E., & Dahanukar, A. (2017). A molecular and cellular context-dependent role for Ir76b in detection of amino acid taste. Cell Reports, 18(3), 737–750. https://doi.org/10.1016/j.celrep.2016.12.071
   PubMed Web of Science ®Google Scholar
• García-García, A., Korn, C., García-Fernández, M., Domingues, O., Villadiego, J., Martín-Pérez, D., Isern, J., Bejarano-García, J. A., Zimmer, J., Pérez-Simón, J. A., Toledo-Aral, J. J., Michel, T., Airaksinen, M. S., & Méndez-Ferrer, S. (2019). Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes. Blood, 133(3), 224–236. https://doi.org/10.1182/blood-2018-08-867648
   PubMed Web of Science ®Google Scholar
• Garrett, R. W., & Emerson, S. G. (2009). Bone and blood vessels: The hard and the soft of hematopoietic stem cell niches. Cell Stem Cell, 4(6), 503–506. https://doi.org/10.1016/j.stem.2009.05.011
   PubMed Web of Science ®Google Scholar
• Ge, X., Yang, H., Bednarek, M. A., Galon-Tilleman, H., Chen, P., Chen, M., Lichtman, J. S., Wang, Y., Dalmas, O., Yin, Y., Tian, H., Jermutus, L., Grimsby, J., Rondinone, C. M., Konkar, A., & Kaplan, D. D. (2018). LEAP2 is an endogenous antagonist of the ghrelin receptor. Cell Metabolism, 27(2), 461–469 e466. https://doi.org/10.1016/j.cmet.2017.10.016
   PubMed Web of Science ®Google Scholar
• Geminard, C., Rulifson, E. J., & Leopold, P. (2009). Remote control of insulin secretion by fat cells in Drosophila. Cell Metabolism, 10(3), 199–207. https://doi.org/10.1016/j.cmet.2009.08.002
   PubMed Web of Science ®Google Scholar
• Ghysen, A. (2003). The origin and evolution of the nervous system. The International Journal of Developmental Biology, 47(7–8), 555–562. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/14756331
   PubMed Web of Science ®Google Scholar
• Goberdhan, D. C., Meredith, D., Boyd, C. A., & Wilson, C. (2005). PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development, 132(10), 2365–2375. https://doi.org/10.1242/dev.01821
   PubMed Web of Science ®Google Scholar
• Gold, K. S., & Bruckner, K. (2014). Drosophila as a model for the two myeloid blood cell systems in vertebrates. Experimental Hematology, 42(8), 717–727. https://doi.org/10.1016/j.exphem.2014.06.002
   PubMed Web of Science ®Google Scholar
• Gold, K. S., & Bruckner, K. (2015). Macrophages and cellular immunity in Drosophila melanogaster. Seminars in Immunology, 27(6), 357–368. https://doi.org/10.1016/j.smim.2016.03.010
   PubMed Web of Science ®Google Scholar
• Gunn, I., O'Shea, D., Turton, M. D., Beak, S. A., & Bloom, S. R. (1996). Central glucagon-like peptide-I in the control of feeding. Biochemical Society Transactions, 24(2), 581–584. https://doi.org/10.1042/bst0240581
   PubMed Web of Science ®Google Scholar
• Hallem, E. A., & Carlson, J. R. (2006). Coding of odors by a receptor repertoire. Cell, 125(1), 143–160. https://doi.org/10.1016/j.cell.2006.01.050
   PubMed Web of Science ®Google Scholar
• Harris, D. T., Kallman, B. R., Mullaney, B. C., & Scott, K. (2015). Representations of taste modality in the Drosophila brain. Neuron, 86(6), 1449–1460. https://doi.org/10.1016/j.neuron.2015.05.026
   PubMed Web of Science ®Google Scholar
• Hergarden, A. C., Tayler, T. D., & Anderson, D. J. (2012). Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 109(10), 3967–3972. https://doi.org/10.1073/pnas.1200778109
   PubMed Web of Science ®Google Scholar
• Hsu, H. J., & Drummond-Barbosa, D. (2009). Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 106(4), 1117–1121. https://doi.org/10.1073/pnas.0809144106
   PubMed Web of Science ®Google Scholar
• Hsu, H. J., & Drummond-Barbosa, D. (2011). Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands. Developmental Biology, 350(2), 290–300. https://doi.org/10.1016/j.ydbio.2010.11.032
   PubMed Web of Science ®Google Scholar
• Hughson, B. N. (2021). The glucagon-like adipokinetic hormone in Drosophila melanogaster – Biosynthesis and Secretion. Frontiers in Physiology, 12, 710652. https://doi.org/10.3389/fphys.2021.710652
   PubMed Web of Science ®Google Scholar
• Huh, J. R., & Veiga-Fernandes, H. (2020). Neuroimmune circuits in inter-organ communication. Nature Reviews. Immunology, 20(4), 217–228. https://doi.org/10.1038/s41577-019-0247-z
   PubMed Web of Science ®Google Scholar
• Ikeya, T., Galic, M., Belawat, P., Nairz, K., & Hafen, E. (2002). Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Current Biology, 12(15), 1293–1300. https://doi.org/10.1016/S0960-9822(02)01043-6
   PubMed Web of Science ®Google Scholar
• Imai, J., & Katagiri, H. (2022). Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation. International Immunology, 34(2), 67–79. https://doi.org/10.1093/intimm/dxab023
   PubMed Web of Science ®Google Scholar
• Jang, S., Chen, J., Choi, J., Lim, S. Y., Song, H., Choi, H., Kwon, H. W., Choi, M. S., & Kwon, J. Y. (2021). Spatiotemporal organization of enteroendocrine peptide expression in Drosophila. Journal of Neurogenetics, 35(4), 387–398. https://doi.org/10.1080/01677063.2021.1989425
   PubMed Web of Science ®Google Scholar
• Jessen, K. R. (2004). Glial cells. The International Journal of Biochemistry & Cell Biology, 36(10), 1861–1867. https://doi.org/10.1016/j.biocel.2004.02.023
   PubMed Web of Science ®Google Scholar
• Jiang, H., Tian, A., & Jiang, J. (2016). Intestinal stem cell response to injury: Lessons from Drosophila. Cellular and Molecular Life Sciences, 73(17), 3337–3349. https://doi.org/10.1007/s00018-016-2235-9
   PubMed Web of Science ®Google Scholar
• Jiao, Y., Moon, S. J., & Montell, C. (2007). A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proceedings of the National Academy of Sciences of the United States of America, 104(35), 14110–14115. https://doi.org/10.1073/pnas.0702421104
   PubMed Web of Science ®Google Scholar
• Jiao, Y., Moon, S. J., Wang, X., Ren, Q., & Montell, C. (2008). Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Current Biology, 18(22), 1797–1801. https://doi.org/10.1016/j.cub.2008.10.009
   PubMed Web of Science ®Google Scholar
• Jung, S. H., Evans, C. J., Uemura, C., & Banerjee, U. (2005). The Drosophila lymph gland as a developmental model of hematopoiesis. Development, 132(11), 2521–2533. https://doi.org/10.1242/dev.01837
   PubMed Web of Science ®Google Scholar
• Kannangara, J. R., Mirth, C. K., & Warr, C. G. (2021). Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones. Open Biology, 11(2), 200373. https://doi.org/10.1098/rsob.200373
   PubMed Web of Science ®Google Scholar
• Kaplan, D. D., Zimmermann, G., Suyama, K., Meyer, T., & Scott, M. P. (2008). A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes & Development, 22(14), 1877–1893. https://doi.org/10.1101/gad.1670508
   PubMed Web of Science ®Google Scholar
• Katayama, Y., Battista, M., Kao, W. M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006). Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell, 124(2), 407–421. https://doi.org/10.1016/j.cell.2005.10.041
   PubMed Web of Science ®Google Scholar
• Kendroud, S., Bohra, A. A., Kuert, P. A., Nguyen, B., Guillermin, O., Sprecher, S. G., Reichert, H., VijayRaghavan, K., & Hartenstein, V. (2018). Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments. The Journal of Comparative Neurology, 526(1), 33–58. https://doi.org/10.1002/cne.24316
   PubMed Web of Science ®Google Scholar
• Kim, B., Kanai, M. I., Oh, Y., Kyung, M., Kim, E.-K., Jang, I.-H., Lee, J.-H., Kim, S.-G., Suh, G. S. B., & Lee, W.-J. (2021). Response of the microbiome-gut-brain axis in Drosophila to amino acid deficit. Nature, 593(7860), 570–574. https://doi.org/10.1038/s41586-021-03522-2
   PubMed Web of Science ®Google Scholar
• Kim, D. H., Shin, M., Jung, S. H., Kim, Y. J., & Jones, W. D. (2017). A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila. PLOS Biology, 15(3), e2000532. https://doi.org/10.1371/journal.pbio.2000532
   PubMed Web of Science ®Google Scholar
• Kim, J., & Neufeld, T. P. (2015). Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3. Nature Communications, 6, 6846. https://doi.org/10.1038/ncomms7846
   PubMed Web of Science ®Google Scholar
• Kim, M. J., & O'Connor, M. B. (2020). Drosophila activin signaling promotes muscle growth through InR/TORC1-dependent and -independent processes. Development, 148(1) https://doi.org/10.1242/dev.190868
   Web of Science ®Google Scholar
• Koivunen, P., Hirsila, M., Remes, A. M., Hassinen, I. E., Kivirikko, K. I., & Myllyharju, J. (2007). Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. The Journal of Biological Chemistry, 282(7), 4524–4532. https://doi.org/10.1074/jbc.M610415200
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk, A., Sun, X., Meinertzhagen, I. A., & Nassel, D. R. (2008). Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system. PLOS One, 3(5), e2110. https://doi.org/10.1371/journal.pone.0002110
   PubMed Web of Science ®Google Scholar
• Koranteng, F., Cho, B., & Shim, J. (2022). Intrinsic and extrinsic regulation of hematopoiesis in Drosophila. Molecules and Cells, 45(3), 101–108. https://doi.org/10.14348/molcells.2022.2039
   PubMed Web of Science ®Google Scholar
• Koyama, T., Rodrigues, M. A., Athanasiadis, A., Shingleton, A. W., & Mirth, C. K. (2014). Nutritional control of body size through FoxO-ultraspiracle mediated ecdysone biosynthesis. eLife, 3. https://doi.org/10.7554/eLife.03091
   PubMed Web of Science ®Google Scholar
• Koyama, T., Texada, M. J., Halberg, K. A., & Rewitz, K. (2020). Metabolism and growth adaptation to environmental conditions in Drosophila. Cellular and Molecular Life Sciences, 77(22), 4523–4551. https://doi.org/10.1007/s00018-020-03547-2
   PubMed Web of Science ®Google Scholar
• Krzemień, J., Dubois, L., Makki, R., Meister, M., Vincent, A., & Crozatier, M. (2007). Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature, 446(7133), 325–328. https://doi.org/10.1038/nature05650
   PubMed Web of Science ®Google Scholar
• Lacin, H., Chen, H. M., Long, X., Singer, R. H., Lee, T., & Truman, J. W. (2019). Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS. eLife, 8. https://doi.org/10.7554/eLife.43701
   PubMed Web of Science ®Google Scholar
• Lebestky, T., Jung, S. H., & Banerjee, U. (2003). A serrate-expressing signaling center controls Drosophila hematopoiesis. Genes & Development, 17(3), 348–353. https://doi.org/10.1101/gad.1052803
   PubMed Web of Science ®Google Scholar
• Lee, G., & Park, J. H. (2004). Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics, 167(1), 311–323. https://doi.org/10.1534/genetics.167.1.311
   PubMed Web of Science ®Google Scholar
• Lee, K.-S., Kwon, O.-Y., Lee, J. H., Kwon, K., Min, K.-J., Jung, S.-A., Kim, A.-K., You, K.-H., Tatar, M., & Yu, K. (2008). Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling. Nature Cell Biology, 10(4), 468–475. https://doi.org/10.1038/ncb1710
   PubMed Web of Science ®Google Scholar
• Leitao, A. B., & Sucena, E. (2015). Drosophila sessile hemocyte clusters are true hematopoietic tissues that regulate larval blood cell differentiation. eLife, 4. https://doi.org/10.7554/eLife.06166
   PubMed Web of Science ®Google Scholar
• Li, S., Torre-Muruzabal, T., Søgaard, K. C., Ren, G. R., Hauser, F., Engelsen, S. M., Pødenphanth, M. D., Desjardins, A., & Grimmelikhuijzen, C. J. P. (2013). Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain. PLOS One, 8(10), e76131. https://doi.org/10.1371/journal.pone.0076131
   PubMed Web of Science ®Google Scholar
• Lin, H.-H., Kuang, M. C., Hossain, I., Xuan, Y., Beebe, L., Shepherd, A. K., Rolandi, M., & Wang, J. W. (2022). A nutrient-specific gut hormone arbitrates between courtship and feeding. Nature, 602(7898), 632–638. https://doi.org/10.1038/s41586-022-04408-7
   PubMed Web of Science ®Google Scholar
• Long-Smith, C., O'Riordan, K. J., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020). Microbiota-gut-brain axis: New therapeutic opportunities. Annual Review of Pharmacology and Toxicology, 60, 477–502. https://doi.org/10.1146/annurev-pharmtox-010919-023628
   PubMed Web of Science ®Google Scholar
• Madhwal, S., Shin, M., Kapoor, A., Goyal, M., Joshi, M. K., Ur Rehman, P. M., Gor, K., Shim, J., & Mukherjee, T. (2020). Metabolic control of cellular immune-competency by odors in Drosophila. eLife, 9. https://doi.org/10.7554/eLife.60376
   PubMed Web of Science ®Google Scholar
• Makhijani, K., Alexander, B., Rao, D., Petraki, S., Herboso, L., Kukar, K., Batool, I., Wachner, S., Gold, K. S., Wong, C., O'Connor, M. B., & Brückner, K. (2017). Regulation of Drosophila hematopoietic sites by Activin-beta from active sensory neurons. Nature Communications, 8, 15990. https://doi.org/10.1038/ncomms15990
   PubMed Web of Science ®Google Scholar
• Makhijani, K., Alexander, B., Tanaka, T., Rulifson, E., & Bruckner, K. (2011). The peripheral nervous system supports blood cell homing and survival in the Drosophila larva. Development, 138(24), 5379–5391. https://doi.org/10.1242/dev.067322
   PubMed Web of Science ®Google Scholar
• Makhijani, K., & Bruckner, K. (2012). Of blood cells and the nervous system: hematopoiesis in the Drosophila larva. Fly, 6(4), 254–260. https://doi.org/10.4161/fly.22267
   PubMed Web of Science ®Google Scholar
• Mandal, L., Martinez-Agosto, J. A., Evans, C. J., Hartenstein, V., & Banerjee, U. (2007). A Hedgehog- and antennapedia-dependent niche maintains Drosophila haematopoietic precursors. Nature, 446(7133), 320–324. https://doi.org/10.1038/nature05585
   PubMed Web of Science ®Google Scholar
• Manning, S., & Batterham, R. L. (2014). The role of gut hormone peptide YY in energy and glucose homeostasis: Twelve years on. Annual Review of Physiology, 76, 585–608. https://doi.org/10.1146/annurev-physiol-021113-170404
   PubMed Web of Science ®Google Scholar
• Marianes, A., & Spradling, A. C. (2013). Physiological and stem cell compartmentalization within the Drosophila midgut. eLife, 2, e00886. https://doi.org/10.7554/eLife.00886
   PubMed Web of Science ®Google Scholar
• Marina, N., Turovsky, E., Christie, I. N., Hosford, P. S., Hadjihambi, A., Korsak, A., Ang, R., Mastitskaya, S., Sheikhbahaei, S., Theparambil, S. M., & Gourine, A. V. (2018). Brain metabolic sensing and metabolic signaling at the level of an astrocyte. Glia, 66(6), 1185–1199. https://doi.org/10.1002/glia.23283
   PubMed Web of Science ®Google Scholar
• Martelli, C., Pech, U., Kobbenbring, S., Pauls, D., Bahl, B., Sommer, M. V., Pooryasin, A., Barth, J., Arias, C. W. P., Vassiliou, C., Luna, A. J. F., Poppinga, H., Richter, F. G., Wegener, C., Fiala, A., & Riemensperger, T. (2017). SIFamide translates hunger signals into appetitive and feeding behavior in Drosophila. Cell Reports, 20(2), 464–478. https://doi.org/10.1016/j.celrep.2017.06.043
   PubMed Web of Science ®Google Scholar
• McBrayer, Z., Ono, H., Shimell, M., Parvy, J.-P., Beckstead, R. B., Warren, J. T., Thummel, C. S., Dauphin-Villemant, C., Gilbert, L. I., & O'Connor, M. B. (2007). Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Developmental Cell, 13(6), 857–871. https://doi.org/10.1016/j.devcel.2007.11.003
   PubMed Web of Science ®Google Scholar
• McGaughey, K. D., Yilmaz-Swenson, T., Elsayed, N. M., Cruz, D. A., Rodriguiz, R. M., Kritzer, M. D., Peterchev, A. V., Roach, J., Wetsel, W. C., & Williamson, D. E. (2019). Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice. Scientific Reports, 9(1), 3281. https://doi.org/10.1038/s41598-019-40140-5
   PubMed Web of Science ®Google Scholar
• McNulty, M., Puljung, M., Jefford, G., & Dubreuil, R. R. (2001). Evidence that a copper-metallothionein complex is responsible for fluorescence in acid-secreting cells of the Drosophila stomach. Cell and Tissue Research, 304(3), 383–389. https://doi.org/10.1007/s004410100371
   PubMed Web of Science ®Google Scholar
• Melcher, C., Bader, R., Walther, S., Simakov, O., & Pankratz, M. J. (2006). Neuromedin U and its putative Drosophila homolog hugin. PLOS Biology, 4(3), e68. https://doi.org/10.1371/journal.pbio.0040068
   PubMed Web of Science ®Google Scholar
• Melcher, C., & Pankratz, M. J. (2005). Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain. PLOS Biology, 3(9), e305. https://doi.org/10.1371/journal.pbio.0030305
   PubMed Web of Science ®Google Scholar
• Mendez-Ferrer, S., Lucas, D., Battista, M., & Frenette, P. S. (2008). Haematopoietic stem cell release is regulated by circadian oscillations. Nature, 452(7186), 442–447. https://doi.org/10.1038/nature06685
   PubMed Web of Science ®Google Scholar
• Meneses, A., & Liy-Salmeron, G. (2012). Serotonin and emotion, learning and memory. Reviews in the Neurosciences, 23(5–6), 543–553. https://doi.org/10.1515/revneuro-2012-0060
   PubMed Web of Science ®Google Scholar
• Mihm, M., Gangooly, S., & Muttukrishna, S. (2011). The normal menstrual cycle in women. Animal Reproduction Science, 124(3-4), 229–236. https://doi.org/10.1016/j.anireprosci.2010.08.030
   PubMed Web of Science ®Google Scholar
• Min, S., Oh, Y., Verma, P., Whitehead, S. C., Yapici, N., Van Vactor, D., Suh, G. S., & Liberles, S. (2021). Control of feeding by piezo-mediated gut mechanosensation in Drosophila. eLife, 10. https://doi.org/10.7554/eLife.63049
   Web of Science ®Google Scholar
• Mirth, C., Truman, J. W., & Riddiford, L. M. (2005). The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Current Biology, 15(20), 1796–1807. https://doi.org/10.1016/j.cub.2005.09.017
   PubMed Web of Science ®Google Scholar
• Missirlis, F., Kosmidis, S., Brody, T., Mavrakis, M., Holmberg, S., Odenwald, W. F., Skoulakis, E. M. C., & Rouault, T. A. (2007). Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin. Genetics, 177(1), 89–100. https://doi.org/10.1534/genetics.107.075150
   PubMed Web of Science ®Google Scholar
• Miyazaki, T., & Ito, K. (2010). Neural architecture of the primary gustatory center of Drosophila melanogaster visualized with GAL4 and LexA enhancer-trap systems. The Journal of Comparative Neurology, 518(20), 4147–4181. https://doi.org/10.1002/cne.22433
   PubMed Web of Science ®Google Scholar
• Mochanova, M., Tomcala, A., Svobodova, Z., & Kodrik, D. (2018). Role of adipokinetic hormone during starvation in Drosophila. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 226, 26–35. https://doi.org/10.1016/j.cbpb.2018.08.004
   PubMed Web of Science ®Google Scholar
• Mukherjee, T., Kim, W. S., Mandal, L., & Banerjee, U. (2011). Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells. Science, 332(6034), 1210–1213. https://doi.org/10.1126/science.1199643
   PubMed Web of Science ®Google Scholar
• Newsholme, P., Procopio, J., Lima, M. M., Pithon-Curi, T. C., & Curi, R. (2003). Glutamine and glutamate–their central role in cell metabolism and function. Cell Biochemistry and Function, 21(1), 1–9. https://doi.org/10.1002/cbf.1003
   PubMed Web of Science ®Google Scholar
• Oh, Y., Lai, J. S.-Y., Mills, H. J., Erdjument-Bromage, H., Giammarinaro, B., Saadipour, K., Wang, J. G., Abu, F., Neubert, T. A., & Suh, G. S. B. (2019). A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila. Nature, 574(7779), 559–564. https://doi.org/10.1038/s41586-019-1675-4
   PubMed Web of Science ®Google Scholar
• Oh, Y., Lai, J. S., Min, S., Huang, H. W., Liberles, S. D., Ryoo, H. D., & Suh, G. S. B. (2021). Periphery signals generated by piezo-mediated stomach stretch and neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor. Neuron, 109(12), 1979–1995 e1976. https://doi.org/10.1016/j.neuron.2021.04.028
   PubMed Web of Science ®Google Scholar
• Okamoto, N., & Nishimura, T. (2015). Signaling from glia and cholinergic neurons controls nutrient-dependent production of an insulin-like peptide for Drosophila body growth. Developmental Cell, 35(3), 295–310. https://doi.org/10.1016/j.devcel.2015.10.003
   PubMed Web of Science ®Google Scholar
• Okamoto, N., Viswanatha, R., Bittar, R., Li, Z., Haga-Yamanaka, S., Perrimon, N., & Yamanaka, N. (2018). A membrane transporter is required for steroid hormone uptake in Drosophila. Developmental Cell, 47(3), 294–305 e297. https://doi.org/10.1016/j.devcel.2018.09.012
   PubMed Web of Science ®Google Scholar
• Palm, W., Sampaio, J. L., Brankatschk, M., Carvalho, M., Mahmoud, A., Shevchenko, A., & Eaton, S. (2012). Lipoproteins in Drosophila melanogaster–assembly, function, and influence on tissue lipid composition. PLOS Genetics, 8(7), e1002828. https://doi.org/10.1371/journal.pgen.1002828
   PubMed Web of Science ®Google Scholar
• Python, F., & Stocker, R. F. (2002). Adult-like complexity of the larval antennal lobe of D. melanogaster despite markedly low numbers of odorant receptor neurons. The Journal of Comparative Neurology, 445(4), 374–387. https://doi.org/10.1002/cne.10188
   PubMed Web of Science ®Google Scholar
• Rajan, A., & Perrimon, N. (2012). Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell, 151(1), 123–137. https://doi.org/10.1016/j.cell.2012.08.019
   PubMed Web of Science ®Google Scholar
• Ramaekers, A., Magnenat, E., Marin, E. C., Gendre, N., Jefferis, G. S., Luo, L., & Stocker, R. F. (2005). Glomerular maps without cellular redundancy at successive levels of the Drosophila larval olfactory circuit. Current Biology, 15(11), 982–992. https://doi.org/10.1016/j.cub.2005.04.032
   PubMed Web of Science ®Google Scholar
• Ren, G. R., Hauser, F., Rewitz, K. F., Kondo, S., Engelbrecht, A. F., Didriksen, A. K., Schjøtt, S. R., Sembach, F. E., Li, S., Søgaard, K. C., Søndergaard, L., & Grimmelikhuijzen, C. J. P. (2015). CCHamide-2 is an orexigenic brain-gut peptide in Drosophila. PLOS One, 10(7), e0133017. https://doi.org/10.1371/journal.pone.0133017
   PubMed Web of Science ®Google Scholar
• Roh, E., Song, D. K., & Kim, M. S. (2016). Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. Experimental & Molecular Medicine, 48, e216. https://doi.org/10.1038/emm.2016.4
   PubMed Web of Science ®Google Scholar
• Roman, G., Meller, V., Wu, K. H., & Davis, R. L. (1998). The opt1 gene of Drosophila melanogaster encodes a proton-dependent dipeptide transporter. The American Journal of Physiology, 275(3), C857–C869. https://doi.org/10.1152/ajpcell.1998.275.3.C857
   PubMed Web of Science ®Google Scholar
• Ronveaux, C. C., Tome, D., & Raybould, H. E. (2015). Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling. The Journal of Nutrition, 145(4), 672–680. https://doi.org/10.3945/jn.114.206029
   PubMed Web of Science ®Google Scholar
• Root, C. M., Ko, K. I., Jafari, A., & Wang, J. W. (2011). Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search. Cell, 145(1), 133–144. https://doi.org/10.1016/j.cell.2011.02.008
   PubMed Web of Science ®Google Scholar
• Roth, T. M., Chiang, C. Y., Inaba, M., Yuan, H., Salzmann, V., Roth, C. E., & Yamashita, Y. M. (2012). Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells. Molecular Biology of the Cell, 23(8), 1524–1532. https://doi.org/10.1091/mbc.E11-12-0999
   PubMed Web of Science ®Google Scholar
• Sano, H. (2015). Coupling of growth to nutritional status: The role of novel periphery-to-brain signaling by the CCHa2 peptide in Drosophila melanogaster. Fly, 9(4), 183–187. https://doi.org/10.1080/19336934.2016.1162361
   PubMed Web of Science ®Google Scholar
• Schlegel, P., Texada, M. J., Miroschnikow, A., Schoofs, A., Hückesfeld, S., Peters, M., Schneider-Mizell, C. M., Lacin, H., Li, F., Fetter, R. D., Truman, J. W., Cardona, A., & Pankratz, M. J. (2016). Synaptic transmission parallels neuromodulation in a central food-intake circuit. eLife, 5. https://doi.org/10.7554/eLife.16799
   PubMed Web of Science ®Google Scholar
• Scott, K. (2011). Out of thin air: sensory detection of oxygen and carbon dioxide. Neuron, 69(2), 194–202. https://doi.org/10.1016/j.neuron.2010.12.018
   PubMed Web of Science ®Google Scholar
• Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005). Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell, 7(1), 77–85. https://doi.org/10.1016/j.ccr.2004.11.022
   PubMed Web of Science ®Google Scholar
• Selcho, M., Millán, C., Palacios-Muñoz, A., Ruf, F., Ubillo, L., Chen, J., Bergmann, G., Ito, C., Silva, V., Wegener, C., & Ewer, J. (2017). Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila. Nature Communications, 8, 15563. https://doi.org/10.1038/ncomms15563
   PubMed Web of Science ®Google Scholar
• Semmelhack, J. L., & Wang, J. W. (2009). Select Drosophila glomeruli mediate innate olfactory attraction and aversion. Nature, 459(7244), 218–223. https://doi.org/10.1038/nature07983
   PubMed Web of Science ®Google Scholar
• Serrats, J., Schiltz, J. C., Garcia-Bueno, B., van Rooijen, N., Reyes, T. M., & Sawchenko, P. E. (2010). Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron, 65(1), 94–106. https://doi.org/10.1016/j.neuron.2009.11.032
   PubMed Web of Science ®Google Scholar
• Shim, J., Mukherjee, T., & Banerjee, U. (2012). Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. Nature Cell Biology, 14(4), 394–400. https://doi.org/10.1038/ncb2453
   PubMed Web of Science ®Google Scholar
• Shim, J., Mukherjee, T., Mondal, B. C., Liu, T., Young, G. C., Wijewarnasuriya, D. P., & Banerjee, U. (2013). Olfactory control of blood progenitor maintenance. Cell, 155(5), 1141–1153. https://doi.org/10.1016/j.cell.2013.10.032
   PubMed Web of Science ®Google Scholar
• Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020). The role of short-chain fatty acids from gut microbiota in gut-brain communication. Frontiers in Endocrinology, 11, 25. https://doi.org/10.3389/fendo.2020.00025
   PubMed Web of Science ®Google Scholar
• Slaidina, M., Delanoue, R., Gronke, S., Partridge, L., & Leopold, P. (2009). A Drosophila insulin-like peptide promotes growth during nonfeeding states. Developmental Cell, 17(6), 874–884. https://doi.org/10.1016/j.devcel.2009.10.009
   PubMed Web of Science ®Google Scholar
• Slone, J., Daniels, J., & Amrein, H. (2007). Sugar receptors in Drosophila. Current Biology, 17(20), 1809–1816. https://doi.org/10.1016/j.cub.2007.09.027
   PubMed Web of Science ®Google Scholar
• Soliz, J. (2013). Erythropoietin and respiratory control at adulthood and during early postnatal life. Respiratory Physiology & Neurobiology, 185(1), 87–93. https://doi.org/10.1016/j.resp.2012.07.018
   PubMed Web of Science ®Google Scholar
• Song, Q., Sun, X., & Jin, X. Y. (2003). 20E-regulated USP expression and phosphorylation in Drosophila melanogaster. Insect Biochemistry and Molecular Biology, 33(12), 1211–1218. https://doi.org/10.1016/j.ibmb.2003.06.005
   PubMed Web of Science ®Google Scholar
• Sterne, G. R., Otsuna, H., Dickson, B. J., & Scott, K. (2021). Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain. eLife, 10. https://doi.org/10.7554/eLife.71679
   PubMed Web of Science ®Google Scholar
• Sun, J., Liu, C., Bai, X., Li, X., Li, J., Zhang, Z., Zhang, Y., Guo, J., & Li, Y. (2017). Drosophila FIT is a protein-specific satiety hormone essential for feeding control. Nature Communications, 8, 14161. https://doi.org/10.1038/ncomms14161
   PubMed Web of Science ®Google Scholar
• Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., Zheng, L., Gardet, A., Tong, Z., Jany, S. S., Corr, S. C., Haneklaus, M., Caffrey, B. E., Pierce, K., Walmsley, S., … O’Neill, L. A. J. (2013). Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature, 496(7444), 238–242. https://doi.org/10.1038/nature11986
   PubMed Web of Science ®Google Scholar
• Teleman, A. A. (2009). Molecular mechanisms of metabolic regulation by insulin in Drosophila. The Biochemical Journal, 425(1), 13–26. https://doi.org/10.1042/BJ20091181
   PubMed Web of Science ®Google Scholar
• Tissot, M., Gendre, N., Hawken, A., Störtkuhl, K. F., & Stocker, R. F. (1997). Larval chemosensory projections and invasion of adult afferents in the antennal lobe of Drosophila. Journal of Neurobiology, 32(3), 281–297. https://doi.org/10.1002/(sici)1097-4695(199703)32:3 < 281::aid-neu3 > 3.0.co;2-3
   PubMed Web of Science ®Google Scholar
• Tokusumi, Y., Tokusumi, T., Shoue, D. A., & Schulz, R. A. (2012). Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. PLOS One, 7(7), e41604. https://doi.org/10.1371/journal.pone.0041604
   PubMed Web of Science ®Google Scholar
• Tramezzani, J. H., Morita, E., & Chiocchio, S. R. (1971). The carotid body as a neuroendocrine organ involved in control of erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America, 68(1), 52–55. https://doi.org/10.1073/pnas.68.1.52
   PubMed Web of Science ®Google Scholar
• Tsodyks, M., & Gilbert, C. (2004). Neural networks and perceptual learning. Nature, 431(7010), 775–781. https://doi.org/10.1038/nature03013
   PubMed Web of Science ®Google Scholar
• Ueishi, S., Shimizu, H., & Inoue, Y. H. (2009). Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila. Cell Structure and Function, 34(1), 61–69. https://doi.org/10.1247/csf.08042
   PubMed Web of Science ®Google Scholar
• van der Hee, B., & Wells, J. M. (2021). Microbial regulation of host physiology by short-chain fatty acids. Trends in Microbiology, 29(8), 700–712. https://doi.org/10.1016/j.tim.2021.02.001
   PubMed Web of Science ®Google Scholar
• von Bartheld, C. S., Bahney, J., & Herculano-Houzel, S. (2016). The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. The Journal of Comparative Neurology, 524(18), 3865–3895. https://doi.org/10.1002/cne.24040
   PubMed Web of Science ®Google Scholar
• Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., Al-Abed, Y., Czura, C. J., & Tracey, K. J. (2003). Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature, 421(6921), 384–388. https://doi.org/10.1038/nature01339
   PubMed Web of Science ®Google Scholar
• Wang, P., Jia, Y., Liu, T., Jan, Y. N., & Zhang, W. (2020). Visceral mechano-sensing neurons control Drosophila feeding by using piezo as a sensor. Neuron, 108(4), 640–650 e644. https://doi.org/10.1016/j.neuron.2020.08.017
   PubMed Web of Science ®Google Scholar
• Wang, S., Tulina, N., Carlin, D. L., & Rulifson, E. J. (2007). The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proceedings of the National Academy of Sciences of the United States of America, 104(50), 19873–19878. https://doi.org/10.1073/pnas.0707465104
   PubMed Web of Science ®Google Scholar
• Warren, J. T., Yerushalmi, Y., Shimell, M. J., O'Connor, M. B., Restifo, L. L., & Gilbert, L. I. (2006). Discrete pulses of molting hormone, 20-hydroxyecdysone, during late larval development of Drosophila melanogaster: Correlations with changes in gene activity. Developmental Dynamics, 235(2), 315–326. https://doi.org/10.1002/dvdy.20626
   PubMed Web of Science ®Google Scholar
• Weiss, L. A., Dahanukar, A., Kwon, J. Y., Banerjee, D., & Carlson, J. R. (2011). The molecular and cellular basis of bitter taste in Drosophila. Neuron, 69(2), 258–272. https://doi.org/10.1016/j.neuron.2011.01.001
   PubMed Web of Science ®Google Scholar
• Werbner, M., Barsheshet, Y., Werbner, N., Zigdon, M., Averbuch, I., Ziv, O., Brant, B., Elliott, E., Gelberg, S., Titelbaum, M., Koren, O., & Avni, O. (2019). Social-stress-responsive microbiota induces stimulation of self-reactive effector T helper cells. mSystems, 4(4), e00292-18. https://doi.org/10.1128/mSystems.00292-18
   PubMed Web of Science ®Google Scholar
• Williams, M. J. (2007). Drosophila hemopoiesis and cellular immunity. Journal of Immunology, 178(8), 4711–4716. https://doi.org/10.4049/jimmunol.178.8.4711
   PubMed Web of Science ®Google Scholar
• Williams, M. J., Akram, M., Barkauskaite, D., Patil, S., Kotsidou, E., Kheder, S., Vitale, G., Filaferro, M., Blemings, S. W., Maestri, G., Hazim, N., Vergoni, A. V., & Schiöth, H. B. (2020). CCAP regulates feeding behavior via the NPF pathway in Drosophila adults. Proceedings of the National Academy of Sciences of the United States of America, 117(13), 7401–7408. https://doi.org/10.1073/pnas.1914037117
   PubMed Web of Science ®Google Scholar
• Wilson, R. I., & Laurent, G. (2005). Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe. The Journal of Neuroscience, 25(40), 9069–9079. https://doi.org/10.1523/JNEUROSCI.2070-05.2005
   PubMed Web of Science ®Google Scholar
• Wu, Q., Wen, T., Lee, G., Park, J. H., Cai, H. N., & Shen, P. (2003). Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system. Neuron, 39(1), 147–161. https://doi.org/10.1016/S0896-6273(03)00396-9
   PubMed Web of Science ®Google Scholar
• Zhang, Y. V., Ni, J., & Montell, C. (2013). The molecular basis for attractive salt-taste coding in Drosophila. Science, 340(6138), 1334–1338. https://doi.org/10.1126/science.1234133
   PubMed Web of Science ®Google Scholar