Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila

References

• Aggarwal, A., Costa, M. J., Rivero-Gutierrez, B., Ji, L., Morgan, S. L., & Feldman, B. J. (2017). The circadian clock regulates adipogenesis by a Per3 crosstalk pathway to Klf15. Cell Reports, 21(9), 2367–2375. doi:10.1016/j.celrep.2017.11.004
   PubMed Web of Science ®Google Scholar
• Alvers, A. L., Fishwick, L. K., Wood, M. S., Hu, D., Chung, H. S., Dunn, W. A., Jr., & Aris, J. P. (2009). Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell, 8(4), 353–369. doi:10.1111/j.1474-9726.2009.00469.x
   PubMed Web of Science ®Google Scholar
• Aoyama, S., & Shibata, S. (2020). Time-of-day-dependent physiological responses to meal and exercise. Frontiers in Nutrition, 7, 18. doi:10.3389/fnut.2020.00018
   PubMed Web of Science ®Google Scholar
• Azevedo, R., Hansen, D., Chen, K. F., Rosato, E., & Kyriacou, C. P. (2020). Disrupted glutamate signaling in Drosophila generates locomotor rhythms in constant light. Frontiers in Physiology., 6(11), 145.
   Web of Science ®Google Scholar
• Bachleitner, W., Kempinger, L., Wulbeck, C., Rieger, D., & Helfrich-Forster, C. (2007). Moonlight shifts the endogenous clock of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, 104(9), 3538–3543. doi:10.1073/pnas.0606870104
   PubMed Web of Science ®Google Scholar
• Bae, K., Lee, C., Sidote, D., Chuang, K., & Edery, I. (1998). Circadian regulation of a Drosophila homolog of the mammalian clock gene: PER and TIM function as positive regulators. Molecular and Cellular Biology, 18(10), 6142–6151. doi:10.1128/MCB.18.10.6142
   PubMed Web of Science ®Google Scholar
• Bailey, S. M., Udoh, U. S., & Young, M. E. (2014). Circadian regulation of metabolism. The Journal of Endocrinology, 222(2), R75–96. doi:10.1530/JOE-14-0200
   PubMed Web of Science ®Google Scholar
• Bedrosian, T. A., & Nelson, R. J. (2017). Timing of light exposure affects mood and brain circuits. Translational Psychiatry, 7(1), e1017. doi:10.1038/tp.2016.262
   PubMed Web of Science ®Google Scholar
• Benito, J., Hoxha, V., Lama, C., Lazareva, A. A., Ferveur, J. F., Hardin, P. E., & Dauwalder, B. (2010). The circadian output gene takeout is regulated by Pdp1ε. Proceedings of the National Academy of Sciences of the United States of America, 107 (6), 2544–2549. doi:10.1073/pnas.0906422107
   PubMed Web of Science ®Google Scholar
• Burke, T. M., Markwald, R. R., McHill, A. W., Chinoy, E. D., Snider, J. A., Bessman, S. C., Jung, C. M., O’Neill, J. S., & Wright, K. P. (2015). Effects of caffeine on the human circadian clock in vivo and in vitro. Science Translational Medicine, 7(305), 305. doi:10.1126/scitranslmed.aac5125
   Web of Science ®Google Scholar
• Chiu, J. C., Low, K. H., Pike, D. H., Yildirim, E., & Edery, I. (2010). Assaying locomotor activity to study circadian rhythms and sleep parameters in Drosophila. Journal of Visualized Experiments, 43, 2157.
   Google Scholar
• Cho, E., Oh, J. H., Lee, E., Do, Y. R., & Kim, E. Y. (2016). Cycles of circadian illuminance are sufficient to entrain and maintain circadian locomotor rhythms in Drosophila. Scientific Reports, 6, 37784. doi:10.1038/srep37784
   PubMed Web of Science ®Google Scholar
• D’Antona, G., Ragni, M., Cardile, A., Tedesco, L., Dossena, M., Bruttini, F., Caliaro, F., Corsetti, G., Bottinelli, R., Carruba, M. O., Valerio, A., & Nisoli, E. (2010). Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metabolism, 12(4), 362–372. doi:10.1016/j.cmet.2010.08.016
   PubMed Web of Science ®Google Scholar
• DiAngelo, J. R., Erion, R., Crocker, A., & Sehgal, A. (2011). The central clock neurons regulate lipid storage in Drosophila. PLOS One, 6(5), e19921. doi:10.1371/journal.pone.0019921
   PubMed Web of Science ®Google Scholar
• Doi, R., Oishi, K., & Ishida, N. (2010). CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. The Journal of Biological Chemistry, 285(29), 22114–22121. doi:10.1074/jbc.M110.110361
   PubMed Web of Science ®Google Scholar
• Dyar, K. A., Lutter, D., Artati, A., Ceglia, N. J., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., Abbondante, S., Tognini, P., Orozco-Solis, R., Kinouchi, K., Wang, C., Swerdloff, R., Nadeef, S., Masri, S., Magistretti, P., … Sassone-Corsi, P. (2018). Atlas of circadian metabolism reveals system-wide coordination and communication between clocks. Cell, 174(6), 1571–1585.e11. doi:10.1016/j.cell.2018.08.042
   PubMed Web of Science ®Google Scholar
• Esslinger, S. M., Schwalb, B., Helfer, S., Michalik, K. M., Witte, H., Maier, K. C., Martin, D., Michalke, B., Tresch, A., Cramer, P., & Förstemann, K. (2013). Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. RNA Biology, 10(6), 1042–1056. doi:10.4161/rna.24810
   PubMed Web of Science ®Google Scholar
• Fan, L., Hsieh, P. N., Sweet, D. R., & Jain, M. K. (2018). Kruppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity. Pharmacological Research, 130, 123–126. doi:10.1016/j.phrs.2017.12.018
   PubMed Web of Science ®Google Scholar
• Fonken, L. K., Aubrecht, T. G., Melendez-Fernandez, O. H., Weil, Z. M., & Nelson, R. J. (2013). Dim LAN disrupts molecular circadian rhythms and increases body weight. Journal of Biological Rhythms, 28(4), 262–271. doi:10.1177/0748730413493862
   PubMed Web of Science ®Google Scholar
• Fonken, L. K., & Nelson, R. J. (2014). The effects of LAN on circadian clocks and metabolism. Endocrine Reviews, 35(4), 648–670. doi:10.1210/er.2013-1051
   PubMed Web of Science ®Google Scholar
• Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010). LAN increases body mass by shifting the time of food intake. Proceedings of the National Academy of Sciences of the United States of America, 107(43), 18664–18669. doi:10.1073/pnas.1008734107
   PubMed Web of Science ®Google Scholar
• Gooley, J. J. (2016). Circadian regulation of lipid metabolism. The Proceedings of the Nutrition Society, 75(4), 440–450. doi:10.1017/S0029665116000288
   PubMed Web of Science ®Google Scholar
• Gooley, J. J., Chamberlain, K., Smith, K. A., Khalsa, S. B., Rajaratnam, S. M., Van Reen, E., Zeitzer, J. M., Czeisler, C. A., & Lockley, S. W. (2011). Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. The Journal of Clinical Endocrinology and Metabolism, 96(3), E463–472.
   PubMed Web of Science ®Google Scholar
• Gray, S., Wang, B., Orihuela, Y., Hong, E.-G., Fisch, S., Haldar, S., Cline, G. W., Kim, J. K., Peroni, O. D., Kahn, B. B., & Jain, M. K. (2007). Regulation of gluconeogenesis by Kruppel-like factor 15. Cell Metabolism, 5(4), 305–312. doi:10.1016/j.cmet.2007.03.002
   PubMed Web of Science ®Google Scholar
• Grima, B., Chelot, E., Xia, R., & Rouyer, F. (2004). Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature, 431(7010), 869–873. doi:10.1038/nature02935
   PubMed Web of Science ®Google Scholar
• Helfrich-Förster, C. (2000). Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster–sex-specific differences suggest a different quality of activity. Journal of Biological Rhythms, 15(2), 135–154. doi:10.1177/074873040001500208
   PubMed Web of Science ®Google Scholar
• Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. (2011). Circadian rhythms, sleep, and metabolism. The Journal of Clinical Investigation, 121(6), 2133–2141. doi:10.1172/JCI46043
   PubMed Web of Science ®Google Scholar
• Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T., & Benzer, S. (2007). Prandiology of Drosophila and the CAFE assay. Proceedings of the National Academy of Sciences of the United States of America, 104(20), 8253–8256. doi:10.1073/pnas.0702726104
   PubMed Web of Science ®Google Scholar
• Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S., & Guan, K. L. (2015). Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science, 347(6218), 194–198. doi:10.1126/science.1259472
   PubMed Web of Science ®Google Scholar
• Jeyaraj, D., Scheer, F. A. J. L., Ripperger, J. A., Haldar, S. M., Lu, Y., Prosdocimo, D. A., Eapen, S. J., Eapen, B. L., Cui, Y., Mahabeleshwar, G. H., Lee, H-g., Smith, M. A., Casadesus, G., Mintz, E. M., Sun, H., Wang, Y., Ramsey, K. M., Bass, J., Shea, S. A., Albrecht, U., & Jain, M. K. (2012). Klf15 orchestrates circadian nitrogen homeostasis. Cell Metabolism, 15(3), 311–323. doi:10.1016/j.cmet.2012.01.020
   PubMed Web of Science ®Google Scholar
• Kempinger, L., Dittmann, R., Rieger, D., & Helfrich-Forster, C. (2009). The nocturnal activity of fruit flies exposed to artificial moonlight is partly caused by direct light effects on the activity level that bypass the endogenous clock. Chronobiology International, 26(2), 151–166. doi:10.1080/07420520902747124
   PubMed Web of Science ®Google Scholar
• Lee, E., & Kim, M. (2019). Light and life at night as circadian rhythm disruptors. Chronobiology in Medicine, 1(3), 95–102. doi:10.33069/cim.2019.0016
   Google Scholar
• LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014). Light as a central modulator of circadian rhythms, sleep and affect. Nature Reviews. Neuroscience, 15(7), 443–454. doi:10.1038/nrn3743
   PubMed Web of Science ®Google Scholar
• Liang, C., Curry, B. J., Brown, P. L., & Zemel, M. B. (2014). Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes. Journal of Nutrition and Metabolism, 2014, 239750. doi:10.1155/2014/239750
   PubMedGoogle Scholar
• Monirujjaman, M., & Ferdouse, A. (2014). Metabolic and physiological roles of branched-chain amino acids. Advances in Molecular Biology, 2014, 1–6. doi:10.1155/2014/364976
   Google Scholar
• Nie, C., He, T., Zhang, W., Zhang, G., & Ma, X. (2018). Branched chain amino acids: Beyond nutrition metabolism. International Journal of Molecular Sciences, 19(4), 954. doi:10.3390/ijms19040954
   PubMed Web of Science ®Google Scholar
• Oishi, K., Yamamoto, S., Itoh, N., Miyazaki, K., Nemoto, T., Nakakita, Y., & Kaneda, H. (2014). Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice. Biochemical and Biophysical Research Communications, 450(1), 880–884. doi:10.1016/j.bbrc.2014.06.083
   PubMed Web of Science ®Google Scholar
• Okuliarova, M., Rumanova, V. S., Stebelova, K., & Zeman, M. (2020). Dim LAN disturbs molecular pathways of lipid metabolism. International Journal of Molecular Sciences, 21(18), 6919. doi:10.3390/ijms21186919
   PubMed Web of Science ®Google Scholar
• Pagel, JF, Parnes, BN (2001). Medications for the treatment of sleep disorders: an overview. Primary Care Companion J Clin Psychiatry 3, 118–125.
   Google Scholar
• Rahman, S. A., Wright, K. P., Jr., Lockley, S. W., Czeisler, C. A., & Gronfier, C. (2019). Characterizing the temporal dynamics of melatonin and cortisol changes in response to nocturnal light exposure. Scientific Reports, 9(1), 19720. doi:10.1038/s41598-019-54806-7
   PubMed Web of Science ®Google Scholar
• Rodríguez RM, Cortés-Espinar AJ, Soliz-Rueda JR, Feillet-Coudray C, Casas F, Colom-Pellicer M, Aragonès G, Avila-Román J, Muguerza B, Mulero M, et al. (2022). Time-of-day circadian modulation of grape-seed procyanidin extract (GSPE) in hepatic mitochondrial dynamics in cafeteria-diet-induced obese rats. Nutrients, 14, 774 https://doi.org/10.3390/nu14040774
   Google Scholar
• Seay, D. J., & Thummel, C. S. (2011). The circadian clock, light, and cryptochrome regulate feeding and metabolism in Drosophila. Journal of Biological Rhythms, 26(6), 497–506. doi:10.1177/0748730411420080
   PubMed Web of Science ®Google Scholar
• Sitta, A., Ribas, G. S., Mescka, C. P., Barschak, A. G., Wajner, M., & Vargas, C. R. (2014). Neurological damage in MSUD: The role of oxidative stress. Cellular and Molecular Neurobiology, 34(2), 157–165. doi:10.1007/s10571-013-0002-0
   PubMed Web of Science ®Google Scholar
• Stoleru, D., Peng, Y., Agosto, J., & Rosbash, M. (2004). Coupled oscillators control morning and evening locomotor behaviour of Drosophila. Nature, 431(7010), 862–868. doi:10.1038/nature02926
   PubMed Web of Science ®Google Scholar
• Strauss, K. A., Carson, V. J., Soltys, K., Young, M. E., Bowser, L. E., Puffenberger, E. G., Brigatti, K. W., Williams, K. B., Robinson, D. L., Hendrickson, C., Beiler, K., Taylor, C. M., Haas-Givler, B., Chopko, S., Hailey, J., Muelly, E. R., Shellmer, D. A., Radcliff, Z., Rodrigues, A., … Morton, D. H. (2020). Branched-chain alpha-ketoacid dehydrogenase deficiency (maple syrup urine disease): Treatment, biomarkers, and outcomes. Molecular Genetics and Metabolism, 129(3), 193–206. doi:10.1016/j.ymgme.2020.01.006
   PubMed Web of Science ®Google Scholar
• Xia, X., Fu, X., Wu, B., Zhu, J., & Zhao, Z. (2019). Circadian regulation of microRNA-target chimeras in Drosophila. bioRxiv, doi:10.1101/622183
   Google Scholar
• Yao, Z., Bennett, A. J., Clem, A. L., & Shafer, O. T. (2016). The Drosophila clock neuron network features diverse coupling modes and requires network-wide coherence for robust circadian rhythms. Cell Reports, 17(11), 2873–2881. doi:10.1016/j.celrep.2016.11.053
   PubMed Web of Science ®Google Scholar