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Experimental Lung Research Volume 28, 2002 - Issue 5
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Research Article

QUANTITATIVE ANALYSIS OF ENDOTHELIN AND NITRIC OXIDE SYNTHASE IN RAT MODEL OF POSTOBSTRUCTIVE PULMONARY VASCULOPATHY

Hojoong Kim Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
,
Hyun A. Park Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
,
Gee Young Suh Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
,
Man Pyo Chung Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
&
O. Jung Kwon Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Pages 351-359 | Published online: 02 Jul 2009

  • Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
  • Giaid AG, Yanagisawa M, Langleben D, Michel RP, et al: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med. 1993;328:1732-1739.
  • Stewart DJ, Levy RD, Cernacek P, Langleben D: Increased plasma endothelin-1 in pulmonary hypertension: marker or mediatir of disease? Ann Intern Med. 1991;114:464-469.
  • Yamakami T, Taguchi O, Gabazza EC, Yoshida M, et al: Arterial endothlin-1 level in pulmonary emphysema and interstitial lung disease. Relation with pulmonary hypertension during exercise. Eur Respir J. 1997;10:2055-2060.
  • Oparil S, Chen SJ, Meng QC, Elton TS, et al: Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat. Am J Physiol. 1995;268:L95-L100.
  • Eddahibi S, Raffestin B, Clozel M, Levame M, et al: Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats. Am J Physiol. 1995;268:H828-H835.
  • Okada M, Yamashita C, Okada K: Endothelin receptor antagonists in a beagle model of pulmonary hypertension: contribution to possible potential therapy? J Am Coll Cardiol. 1995;25:1213-1217.
  • Liebow AA, Hales MR, Bloomer WE, Harrison W, Lindskog G: Studies on the lung after ligation of the pulmonary artery. II. Anatomical changes. Am J Pathol. 1950;26:177-195.
  • Weibel ER: Early stages in the development of collateral circulation to the lung in the rat. Cir Res. 1960;8:353-376.
  • Michel RP, Hakim TS, Petsikas D: Segmental vascular resistance in postobstructive pulmonary vasculopathy. J Appl Physiol. 1990;69:1022-1032.
  • Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN: Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase. Exp Lung Res. 2000;26:287-301.
  • Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN: Endothelin mediates pulmonary vascular remodeling in a canine model of chronic embolic pulmonary hypertension. Eur Respir J. 2000;15:640-648.
  • Michel RP, Hakim TS: Increased resistance in postobstructive pulmonary vasculopathy: structure-function relationships. J Appl Physiol. 1991;71:601-610.
  • Giaid A, Stewart DJ, Michel RP: Endothelin-1-like immunoreactivity in postobstructive pulmonary vasculopathy. J Vasc Res. 1993;30:333-338.
  • Shi W, Cernacek P, Hu F, Michel RP: Endothelin reactivity and receptor profile of pulmonary vessels in postobstructive pulmonary vasculopathy. Am J Physiol. 1997;273:H2558-H2564.
  • Shi W, Giaid A, Hu F, Michel RP: Increased reactivity to endothelin of pulmonary arteries in long-term post-obstructive pulmonary vasculopathy in rats. Pulmonary Pharmacol Ther. 1998;11:189-196.
  • Shi W, Cernacek P, Hu F, Michel RP: Endothelin receptor density of pulmonary vessels in postobstructive pulmonary vasculopathy. Am J Respir Crit Care Med. 1998;157:A788.
  • Shi W, Hu F, Kassouf W, Michel RP: Altered reactivity of pulmonary vessels in postobstructive pulmonary vasculopathy. J Appl Physiol. 2000;88:17-25.
  • Hislop A, Reid L: Normal structure and dimensions of the pulmonary arteries in the rat. J Anat. 1978;125:71-83.

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