Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (w/o/w) emulsion solvent evaporation technique

References

• BANGA, A. K., and CHIEN, Y. W., 1988, Systemic delivery of therapeutic peptides and proteins. International Journal of Pharmacy, 48, 15–16.
   Google Scholar
• CORDT, S. D., HENDRICIOC, I. A. M., and TOBBACK, P., 1994, DSC and protein-based time-temperature integrators: case study of a-Amylase stabilized by polyols and/or sugar. Biotechnology ED' Bioengineering, 44, 859–865.
   PubMedGoogle Scholar
• DAVIS, S. S., and ILLum, L., 1988, Polymeric microspheres as drug carriers. Biomaterials, 9, 111–115.
   PubMedGoogle Scholar
• Du, X.-Y., WANG, J., XU, W.-X., Z0u, K. J., JIANG, H. L., and Liu, S.-F., 1996, The study on immunological response of long-term release system hCG microspheres in C57 black mouse. Reproduction and Contraception, 7, 81–88.
   Google Scholar
• ELDRIDGE, J. H., STAAS, J. K., MUELBROEK, J. A., TICE, T. R., and GILLEY, R. M., 1991, Biodegradable and biocompatable poly(m.-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infectional Immunology, 59, 2978.
   PubMedGoogle Scholar
• GILDING, D. K., and REED, A. M., 1979, Biodegradable polymers for use in surgery-polyglycolic/poly(lactic acid) homo- and copolymers: 1. Polymer, 20, 1459-1464. HAYASHI, T., 1994, Biodegradable polymers for biomedical uses. Progress in Polymer Science, 19, 663–702.
   Google Scholar
• HORA, M. S., RANA, R. S., NUNBERG, H., TICE, T. R., T. R., GILLEY, R. M., and HUDSON, M. E., 1990, Release of human Serum Albumin from poly(lactide-co-glycolide) microspheres. Pharmaceutical Research, 7, 1190–1194.
   Google Scholar
• JEFFERY, H., DAVIS, S. S., and O'HAGAN, D. T., 1993, The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharma-catical Research, 10, 363–368.
   Google Scholar
• LEO, E., PECQUETS, S., ROJAS, J., COUVREUR, P., and FATTAL, E., 1998, Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method. Journal of Microencapsulation, 15, 421–430.
   PubMedGoogle Scholar
• NIHANT, N., GRANDFILS, C., JEROME, R., and TEYSSIE, P., 1995, Microencapsulation by coacervation of poly(lactide-co-glycolide): 1. Physico-chemical characteristics of the phase separation process. Journal of Controlled Release, 35, 117–125.
   Google Scholar
• NIWA, T., TAKEUCHI, H., HINO, T., KUNOU, N., and KAWASHIMA, Y., 1993, Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D,L-lactide/ glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. Journal of Controlled Release, 25, 89–98.
   Web of Science ®Google Scholar
• O'HAGAN, D. T., JEFFERY, H., and DAVIS, S. S., 1993a, Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles. Vaccine, 11, 965–969.
   Google Scholar
• O'HAGAN, D. T., JEFFERY, H., ROBERTS, M. J. J., McGEE, J. P., and DAVIS, S. S., 1991, Controlled release microparticles for vaccine development. Vaccine, 9, 768–771.
   Google Scholar
• O'HAGAN, D. T., McGEE, D., HOLMGREN, J., MOWAT, A. M. C., DONACHIE, A. M., MILLS, K. H. G., GAISFORD, W., RAHMAN, D., and CHALLACOMBE, S. J., 1993b, Biodegradable microparticles for oral immunization. Vaccine, 11, 149–154.
   Google Scholar
• OGAWA, Y., YAMAMOTO, M., OKADA, H., YASHIKI, T., and SHIMAMOTO, T., 1988a, A new technique to efficiently entrap Leuprolide acetate into microcapsules of polylactide acid or copoly(lactic/glycolic) acid. Chemical and Pharmaceutical Bulletin, 36, 1095–1103.
   PubMed Web of Science ®Google Scholar
• OGAWA, Y., YAMAMOTO, M., TAKADA, S., OKADA, H., and SHIMAMOTO, T., 1988b, Controlled-release of leuprolide acetate from polylactic acid or copoly(lactic/ glycolic) acid microcapsules: influence of molecular weight and copolymer ratio of polymer. Chemical and Pharmaceutical Bulletin, 36, 1502–1507.
   PubMed Web of Science ®Google Scholar
• PIERRCE, G., and PATRICK, G., 1985, Polymeric nanoparticles and microspheres (Florida: CRC press), p. 450.
   Google Scholar
• Ruiz, J.-M., BRUSNEL, J.-P., and BENOIT, J.-P., 1990, Influence of average molecular weights of poly(D,L-lactic acid-co-glycolic acid) copolymers 50/50 on phase separation and in vitro drug release from microspheres. Pharmaceutical Research, 7, 928–934.
   Google Scholar
• SCHUGENS, C., LARUELLE, N., NIHANT, N., GRANDFILS, C., JEROME, R., and TEYSSIE, P., 1994, Effect of the emulsion stabiilty on the morphology and porosity of semicrystalline poly L-lactide microp articles prepared by w/o/w double emulsion-evaporation. Journal of Controlled Release, 32, 161–176.
   Web of Science ®Google Scholar
• STEVENS, V. C., 1993, Vaccine delivery system: potential methods for use in antifertility Vaccines. American Journal of Reproductive Immunology, 29, 176.
   PubMedGoogle Scholar
• WANG, H. T., SHMITT, E., FLANAGAN, D. R., and LINHARDT, R. J., 1991, Influence of formulation methods on the in vitro controlled release of protein from poly(ester) microspheres. Journal of Controlled Release, 17, 23–32.
   Google Scholar
• YAN, C. H., RESAU, J. H., HEWETSON, J., WEST, M., RILL, W. L., and KENDE, M., 1994, Characterization and morphological analysis of protein-loaded poly(lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique. Journal of Controlled Release, 32, 231–241.
   Google Scholar