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Research Article

Particle size design of PLGA microspheres for potential pulmonary drug delivery using response surface methodology

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Pages 1-8 | Received 28 Apr 2007, Accepted 27 Mar 2008, Published online: 20 Oct 2008

References

  • Agu RU, Ugwoke MI, Armand M, Kinget R, Verbeke N. The lung as a route for systemic delivery of therapeutic proteins and peptides. Respiratory Res 2001; 2: 198–209
  • Benita S, Benoit JP, Puisieux F, Thies C. Characterization of drug-loaded poly(D,L-lactide) microspheres. J Pharm Sci 1984; 73: 1721–1724
  • Blanco D, Alonso MJ. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: Effect of the protein and polymer properties and of the co-encapsulation of surfactants. Eur J Pharm Biopharm 1998; 45: 285–294
  • Chew NY, Chan HK. Effect of powder polydispersity on aerosol generation. J Pharm Pharm Sci 2002; 5: 162–168
  • Chorny M, Fishbein I, Danenberg HD, Golomb G. Lipophilic drug loaded nanospheres prepared by nanoprecipitation: Effect of formulating variables on size, drug recovery and release kinetics. J Contr Rel 2002; 83: 389–400
  • Edwards DA, Hanes J, Caponetti G, Hrkach J, Ben-Jebria A, Eskew ML, Mintzes J, Deaver D, Lotan N, Langer R. Large porous particles for pulmonary drug delivery. Science 1997; 276: 1868–1871
  • El-Baseir MM, Phipps MA, Kellaway IW. Preparation and subsequent degradation of poly(L-lactic acid) microspheres suitable for aerosolizatiion: A physico-chemical study. Int J Pharm 1997; 151: 145–153
  • Freitas S, Merkle HP, Gander B. Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology. J Contr Rel 2005; 102: 313–332
  • Gabor F, Ertl B, Wirth M, Mallinger R. Ketoprofen-poly(D,L-lactic-co-glycolic acid) microspheres: Influence of manufacturing parameters and type of polymer on the release characteristics. J Microencapsulation 1999; 16: 1–12
  • Ghaderi R, Sturesson C, Carlfors J. Effect of preparative parameters on the characteristics of poly (D,L-lactide-co-glycolide) microspheres made by the double emulsion method. Int J Pharm 1996; 141: 205–216
  • Gonda I. The ascent of pulmonary drug delivery. J Pharm Sci 2000; 89: 940–945
  • Herrman J, Bodmeier R. Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on w/o/w-multiple emulsions. Int J Pharm 1995; 126: 129–138
  • Heyder J, Gebhart J, Rudolf G, Schiller CF, Stahlhofen W. Deposition of particles in the human respiratory tract in the size range 0.005–15 µm. J Acerosol Sci 1986; 17: 811–825
  • Hinds WC. Uniform particle motion. Aerosol technology – properties, behavior and measurement of airborne particles, WC Hinds. Wiley & Sons, New York 1999; 42–74
  • Jain RA. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 2000; 21: 2475–2490
  • Julienne MC, Alonso MJ, Amoza JLG, Benoit JP. Preparation of poly (D,L-lactide/glycolide) nanoparticles of controlled particle size distribution: Application of experimental design. Drug Dev Ind Pharm 1992; 18: 1063–1077
  • Kawashima Y, Yamamoto H, Takeuchi H, Fujioka S, Hino T. Pulmonary delivery of insulin with nebulized DL-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect. J Contr Rel 1999; 62: 279–287
  • Khuri AI, Cornell JA. Response surfaces; Designs and analyses. Marcel Dekker, New York 1987
  • Kincl M, Turk S, Vrecer F. Application of experimental design methodology in development and optimization of drug release method. Int J Pharm 2005; 291: 39–49
  • Koushik K, Dhanda DS, Cheruvu NPS, Kompella UB. Pulmonary delivery of deslorelin: Large-porous PLGA particles and HPβCD complexes. Pharm Res 2004; 21: 1119–1126
  • Kwon HY, Lee JY, Choi SW, Jang Y, Kim JH. Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method. Colloids Surfaces A 2001; 182: 123–130
  • Mainardes RM, Evangelista RC. PLGA nanoparticles containing praziquantel: Effect of formulation variable on size distribution. Int J Pharm 2005; 290: 137–144
  • Marple VA, Olson BA, Santhanakrishnan K, Mitchell JP, Murray SC, Hudson-Curtis BL. Next generation pharmaceutical impactor. Part II: Calibration. J Aerosol Med 2003; 16: 301–324
  • Mateovic T, Kriznar B, Bogataj M, Mrhar A. The influence of stirring rate on biopharmaceutical properties of Eudragit RS microspheres. J Microencapsulation 2002; 19: 29–36
  • Montgomery DC. Design and analysis of experiments. 3rd ed. Wiley, New York 1991
  • McCarron PA, Woolfson AD, Keating SM. Response surface methodology as a predictive tool for determining the effects of preparation conditions on the physicochemical properties of poly(isobutylcyanoacrylate) nanoparticles. Int J Pharm 1999; 193: 37–47
  • Munguia O, Delgado A, Farina J, Evora C, Llabres M. Optimization of DL-PLA molecular weight via response surface method. Int J Pharm 1992; 86: 107–111
  • Murakami H, Kobayashi M, Takeuchi H, Kawashima Y. Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method. Int J Pharm 1999; 187: 143–152
  • Musante CJ, Schroeter JD, Rosati JA, Crowder TM, Hickey AJ, Martonen TB. Factors affecting the deposition of inhaled porous drug particles. J Pharm Sci 2002; 91: 1580–1590
  • O’Donnell PB, McGinity JW. Properties of multiphase microspheres of poly(DL-lactic acid) or poly(DL-lactic-co-glycolic acid) produced by mechanical agitation, sonication, or potentiometric dispersion. J Microncapsulation 1996; 13: 667–677
  • Quintanar-Guerrero D, Fessi H, Allémann E, Doelker E. Influence of stabilizing agents and preparative variables on the formation of poly(D,L-lactic acid) nanoparticles by an emulsification-diffusion technique. Int J Pharm 1996; 143: 133–141
  • Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Del Rev 1997; 28: 5–24
  • Singh SK, Dodge J, Durrani MJ, Khan MA. Optimization and characterization of controlled release pellets coated with an experimental latex: I. Anionic drug. Int J Pharm 1995; 125: 243–255
  • Takeuchi H, Yamamoto H, Kawashima Y. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Del Rev 2001; 47: 39–54
  • Telko MJ, Hickey AJ. Dry powder inhaler formulation. Respiratory Care 2005; 50: 1209–1227
  • Van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm Res 2000; 17: 1159–1167
  • Vandervoort J, Ludwig A. Biocompatible stabilizers in the preparation of PLGA nanoparticles: A factorial design study. Int J Pharm 2002; 238: 77–92
  • Varde NK, Pack DW. Microspheres for controlled release drug delivery. Expert Opin Biol Therapy 2004; 4: 35–51
  • Yang YY, Chung TS, Bai XL, Chan WK. Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method. Chem Eng Sci 2000; 55: 2223–2236
  • Yang YY, Chung TS, Ng NP. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion solvent extraction/evaporation method. Biomaterials 2001; 22: 231–241
  • Zhu KJ, Li Y, Jiang HL, Yasyda H, Ichimaru A, Yamamoto K, Lecomte P, Jerome R. Preparation, characterization and in vitro release properties of ibuprofen-loaded microspheres based on polylactide, poly(ε-caprolactone) and their copolymers. J Microencapsulation 2005; 22: 25–36

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