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Journal of Microencapsulation
Micro and Nano Carriers
Volume 16, 1999 - Issue 1
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Research Article

Particle size and loading efficiency of poly(D,L-lactic-coglycolic acid) multiphase microspheres containing water soluble substances prepared by the hydrous and anhydrous solvent evaporation methods

M. IWATA College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712-1074, USA
Pages 49-58 | Published online: 29 Sep 2008

References

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  • EPPSTEIN, D. A., KuRAHARA, C. G., BRUNO, N. A., VAN DER PAS, M. A., MARSH, Y. V., and SCHRYVER, B. B., 1986, Pathways to increasing efficacy of the interferons: Drug synergy and sustained-release. In The biology of the interferon system 1985, edited by W. E. Stewart and Schellelens (Elsevier Science Publishers B. V.), pp. 401 109.
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  • IWATA, M., and MuGINITY, J. W./, 1992, Preparation of multi-phase microspheres of poly(D,L-lactic acid) and poly(D,L-lactic-co-glycolic acid) containing a W/O emulsion by a multiple emulsion solvent evaporation technique. Journal of Microencapsulation, 9, 201–214.
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  • O'DoNNEEE, P. B., and McGE.Trry, J. W 1996, Properties of multiphase microspheres of poly(m—lactic acid) or poly(D,L-lactic-co-glycolic acid) produced by mechanical agitation, sonication, or potentiometric dispersion. Journal of Microencapsulation, 13, 667–677.
  • O'DoNNEEE, P. B., IWATA, M., and McGE.Trry, J. W., 1995, Properties of multiphase mirospheres of poly(D,L-lactic-co-glycolic acid) prepared by a potentiametric dispersion technique. Journal of Microencapsulation, 12, 155–163.
  • O'HAGAN, D. T., RAHMAN, D., McGEE, J. p., JEFFREY, H., DAVIES, M. C., WILLIAMS, p., DAVIS, S. S., and CHALLACOMBE, S. J., 1991, Biodegradable microparticles as controlled release antigen delivery systems. Immunology, 73, 239–242.
  • UCHIDA, T., YAGI, A., and GoTo, S., 1996, Microencapsulation of ovalbumin poly(lactide-co-glycolide) by an oil-in-oil (0/0 solvent evaporation method. Journal of Microencapsulation, 13, 509–518.
  • YAMAKAWA, I., KAWAHARA, M., WATANABE, S., and MIYAKE, Y., 1990, Sustained release of insulin by double-layered implant using poly(D,L-lactic acid). Journal of Pharmaceutical Sciences, 79, 505–509.

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