Stability determination of solid lipid nanoparticles (SLN TM) in aqueous dispersion after addition of electrolyte

References

• FREITAS, C., and MoLLER, R. H., 1997, Long-term stability of solid lipid nanoparticles (SLN), Influence of crystallinity of the lipid and shear forces. European Pharmaceutics, Biopharmaceutics (In press).
   Google Scholar
• FREITAS, C., and MoLLER, R. H., 1998, Effect of light and temperature on zeta potential and physical stability in Solid Lipid Nanoparticles (SLN) dispersions. International Journal of Pharmaceutics, 221–229.
   Google Scholar
• FREITAS, C., LUCKS, J. S., and MOLLER, R. H., 1995, Effect of storage conditions on long-term stability of solid lipid nanoparticles (SLN) in aqueous dispersion. Proceedings of the 1st world meeting APGIMPV, Budapest, 9–11 May, 493–494.
   Google Scholar
• GARTI N., 1988, Effects of surfactants on crystallization and polymorphic transformation of fats and fatty acids. In Crystallization and polymorphism of fats and fatty adds, edited by N.Garti and K Sato (New York, Basel: Marcel Dekker Inc.), pp. 267–304.
   Google Scholar
• HAGEMANN, J. W., 1988, Thermal behavior and polymorphism of acylglycerides. In Crystallization and polymorphism of fats and fatty adds, edited by N. Garti and K. Sato (New York, Basel: Marcel Dekker Inc.), pp. 9–96.
   Google Scholar
• LUCKS, J. S., 1993, Parenterale Fettemulsionen als Arzneistcfftrager, Herstellung, Charakterisierung und Stabilitat. Ph.D. thesis, Christian Albrechts University Kiel.
   Google Scholar
• MORI, H., 1988, Solidification problems in preparation of fats. In Crystallization and polymorphism of fats and fatty adds, edited by N. Garti and K Sato (New York, Basel: Marcel Dekker Inc.), pp. 423112.
   Google Scholar
• MÜLLER, R. H., 1996, Zetapotential und Part ikelladung in der Laborpraxis. APV Paperback, Vol. 37 (Stuttgart: Wissenschaftliche Veragsgesellschaft).
   Google Scholar
• MÜLLER, R. H., and HEINEMANN, S., 1992, Fat emulsions for parenteral nutrition. I. Evaluation of microscopic and laser light scattering methods for the determination of the physical stability. Clinical Nutrition, 11, 223–236.
   Google Scholar
• MÜLLER, R. H., and HEINEMANN, S., 1993, Fat emulsions for parenteral nutrition. II. Characterization and physical long-term stability of Lipofundin MCT/LCT. Clinical Nutrition, 12, 298–309.
   Google Scholar
• MÜLLER, R. H., and HEINEMANN, S., 19944 Fat emulsions for parenteral nutrition. III. Lipofundin MCT/LCT regimens for total arenteral nutrition (TPN) with low electrolyte load. International Journal of Pharmaceutics, 101, 175–189.
   Google Scholar
• MÜLLER,R R. H., and HEINEMANN, S., 1994b. Fat emulsions for parenteral nutrition. IV. Lipofundin MCT/LCT regimes for total parenteral nutrition (TPN) with high electrolyte load. International Journal of Pharmaceutics, 107, 121–132.
   Google Scholar
• MÜLLER, R. H., and LUCKS, J. S., 1996, Mediation vehicles made of solid lipid particles (solid lipid nanospheres—SLN). European Patent EP 0 605 497 Bl.
   Google Scholar
• MÜLLER, R. H., MEHNERT, W., LUCKS, J. S., SCHWARZ, C., ZUR MOHLEN, A., WEYHERS, H., FREITAS, C., and Runt, D., 1995, Solid lipid nanoparticles (SLN)—An alternative colloidal carrier system for controlled drug delivery. European Pharmaceutics, Biopharmaceutics, 41, 62–69.
   Google Scholar
• RIDDIcK, T. M., 1968, Zeta-Meter Manual (New York Zeta Inc.).
   Google Scholar
• SATO, K., 1988, Crystallization of fats and fatty acids. In Crystallization and polymorphism of fats and fatty adds, edited by N. Garti and K Sato (New York, Basel: Marcel Dekker Inc.), pp. 227–266.
   Google Scholar
• SCHUHMANN, R., 1995, Physikalische Stabilität parenteraler Fettemulsionen—Entwicklung eines Untersuchungsschemas unter besonderem Aspekt analytischer Möglichkeiten. Ph.D. thesis, Freie Universität Berlin.
   Google Scholar
• SCHHHMANN, R., MEHNERT, W., and MoLLER, R. H., 1993, Coulter counter based coalescence assay for the determination of emulsion stability after addition of electrolyte. Pharmaceutics Industry, 55, 701–704.
   Google Scholar
• SIEKMANN, B., 1994, Untersuchungen zur Herstellung und zum Rekristallisationsverhalten schmelzemulgierter intravenbs applizierbarer Glyceridnanopartikel. PhD. thesis, Technical University of Braunschweig
   Google Scholar
• SIEKMANN, B., and WESTESEN, K., 1992, Submicron-sized parenteral carrier systems based on solid lipids. Pharmaceutic and Pharmacology Letters, 1, 123–126.
   Google Scholar
• STAMPA, B., LUCKS, J. S., MOLLER, B. W., and MOLLER, R. H., 1991, Electrophoretic properties of emulsions for parenteral nutrition determined by laser light scattering and application of the amplitude-weighted phase structure function (AWS). Journal of Colloid Interface Science, 143, 188–194.
   Google Scholar
• TARDROS, T. F., and VINCENT, B., 1980, Influence of temperature and electrolytes on the adsorption of poly(ethylene oxide)-poly(propylenene oxide) block copolymer on polystyrene latex and on the stability of the polymer coated particles. Journal of Physical Chemistry, 84, 1575–1580.
   Google Scholar
• WEYHERS, H., EHLERS, S., MEHNERT, W., HAHN, H., and MOLLER, R. H., 1995, Solid lipid nanoparticlesdetermination of in vivo toxicity. Proceedings of the Lst world meetingAPGIMPV, Budapest, 9–11 May, 489–490.
   Google Scholar
• ZUR MOHLEN, A., 1996, Feste Lipid Nanopartikl mit prolongierter Wirkstoffliberation. Herstellung Langzeitstabilität, Charakterisierung Freisetzungsverhalten und -mechanismen. PhD. thesis, Freie Universität Berlin.
   Google Scholar
• ZUR MOHLEN, A., ZUR MOHLEN, E., NIEHUS, H., and MEHNERT W., 1996, Atomic force microscopy studies of solid lipid nanoparticles. Pharmaceutical Research, 13, 1411–1416.
   Google Scholar