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Original Article

The pedunculopontine nucleus in Parkinson's disease: primate studies

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Pages S4-S8 | Published online: 06 Jul 2009

References

  • Geula C, Schatz C R, Mesulam M M. Differential localization of NADPH-diaphorase and calbindin-D28k within the cholinergic neurons of the basal forebrain, striatum and brainstem in the rat, monkey, baboon and human. Neuroscience 1993; 54: 461–476
  • Olszewski J, Baxter D. Cytoarchitecture of the human brain stem. Lippencott, Philadelphia 1954
  • Jones B E, Beaudet A. Distribution of acetylcholine and catecholamine neurons in the cat brainstem: a choline acetyltransferase and tyrosine hydroxylase immunohistochemical study. J Comp Neurol 1987; 15–32
  • Lavoie B, Parent A. Pedunculopontine nucleus in the squirrel monkey: distribution of cholinergic and monoaminergic neurons in the mesopontine tegmentum with evidence for the presence of glutamate in cholinergic neurons. J Comp Neurol 1994; 344: 190–209
  • Rye D B, Lee H J, Saper C B, Wainer B H. Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat. J Comp Neurol 1998; 315–341
  • Albin R L, Young A B, Penney J B. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989; 12(10)366–375
  • Alexander G E, Crutcher M D. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990; 13: 266–271
  • Jackson A, Crossman A R. Nucleus tegmenti pedunculopontinus: efferent connections with special reference to the basal ganglia, studied in the rat by anterograde and retrograde transport of horseradish peroxidase. Neuroscience 1983; 10: 725–765
  • Noda T, Oka H. Distribution and morphology of tegmental neurons receiving nigral inhibitory inputs in the cat: an intracellular HRP study. J Comp Neurol 1986; 254–266
  • Garcia-Rill E. The pedunculopontine nucleus. Prog Neurobiol 1991; 36: 363–389
  • Sofroniew M V, Priestley J V, Consolazione A, Eckenstein F, Cuello A C. Cholinergic projections from the midbrain and pons to the thalamus in the rat, identified by combined retrograde tracing and choline acetyltransferase immunohistochemistry. Brain Res 1985; 213–223
  • Lavoie B, Parent A. Pedunculopontine nucleus in the squirrel monkey: projections to the basal ganglia as revealed by anterograde tract-tracing methods. J Comp Neurol 1994; 344: 210–231
  • Pahapill P A, Lozano A M. The pedunculopontine nucleus and Parkinson's disease. Brain 2000; 123: 1767–1783
  • Garcia-Rill E, Skinner R D. The mesencephalic locomotor region. I. Activation of a medullary projection site. Brain Res 1987; 1–12
  • Garcia-Rill E, Houser C R, Skinner R D, Smith W, Woodward D J. Locomotion-inducing sites in the vicinity of the pedunculopontine nucleus. Brain Res Bull 1987; 18: 731–738
  • Eidelberg E, Walden J G, Nguyen L H. Locomotor control in macaque monkeys. Brain 1981; 647–663
  • Ogura M, Nakao N, Nakai E, Itakura T. Firing activity of the basal ganglia and pedunculpontine nucleus in rats with nigrostriatal lesions [abstract]. Stereotact Funct Neurosurg 1997; 67: 80–81
  • Hirsch E C, Graybiel A M, Duyckaerts C, Javoy-Agid F. Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy. Proc Natl Acad Sci USA 1987; 5976–5980
  • Jellinger K. The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease. J Neurol Neurosurg Psychiat 1988; 51: 540–543
  • Zweig R M, Whitehouse P J, Casanova M F, Walker L C, Jankel W R, Price D L. Loss of pedunculopontine neurons in progressive supranuclear palsy. Ann Neurol 1987; 22: 18–25
  • Zweig R M, Jankel W R, Hedreen J C, Mayeux R, Price D L. The pedunculopontine nucleus in Parkinson's disease. Annl Neurol 1989; 26: 41–46
  • Aziz T Z, Davies L, Stein J F, France S. The role of descending basal ganglia connections to the brain stem in parkinsonian akinesia. Br J Neurosurg 1998; 12: 245–249
  • Munro-Davies L, Winter J, Aziz T Z, Stein J F. The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia. Exp Brain Res 1999; 129: 511–517
  • Benabid A L, Pollak P, Gao D, et al. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg 1996; 84: 203–214
  • Laitenen L, Vikki J. Measurement of Parkinsonian hypokinesia with Purdue pegboard and motor reaction time tests. Parkinson's disease, J Siegfried. Huber, Berlin 1973; 2: 185–192
  • Bejjani B, Damier P, Arnulf I, et al. Pallidal stimulation for Parkinson's disease. Two targets?. Neurology 1997; 49: 1564–1569
  • Krack P, Pollak P, Limousin P, et al. Opposite motor effects of pallidal stimulation in Parkinson's disease. Ann Neurol 1998; 180–192
  • Aziz T Z, Peggs D, Sambrook M A, Crossman A R. Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. Mov Disord 1991; 6: 288–292
  • Benabid A L, Benazzouz A, Hoffmann D, Limousin P, Krack P, Pollak P. Long-term electrical inhibition of deep brain targets in movement disorders. Mov Disord 1998; 13: 119–125
  • Gill S S, Heywood P. Bilateral dorsolateral subthalamotomy for advanced Parkinson's disease. Lancet 1997; 350: 1224
  • Nandi D, Liu X, Winter J, Aziz T Z, Stein J F. Deep brain stimulation of the pedunculopontine region in the normal non-human primate. J Clin Neurosci 2002; 9: 170–174
  • Nandi D, Aziz T Z, Giladi N, Winter J, Stein J F. Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus. Brain 2002; 125: 2418–2430
  • Jenkinson N, Nandi D, Miall R C, Stein J F, Aziz T Z. Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey. Neuroreport 2004; 2621–2624
  • Jenkinson N, Nandi D, Oram R, Stein J F, Aziz T Z. Pedunculopontine nucleus electric stimulation alleviates akinesia independently of dopaminergic mechanisms. Neuroreport 2006; 639–641
  • Jenkinson N, Nandi D, Aziz T Z, Stein J F. Pedunculopontine nucleus: a new target for deep brain stimulation for akinesia. Neuroreport 2005; 1875–1876
  • Mazzone P, Lozano A, Stanzione P, et al. Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease. Neuroreport 2005; 1877–1881
  • Plaha P, Gill S S. Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease. Neuroreport 2005; 1883–1887
  • Stefani A, Lozano A M, Peppe A, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain 2007; 1596–1607

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