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Editorial

The challenge of completing a randomised clinical trial

References

  • Briel M, Olu KK, von Elm E, et al. A systematic review of discontinued trials suggested that most reasons for recruitment failure were preventable. J Clin Epidemiol 2016;80:8–15.
  • Demetriades AK, Park JJ, Tiefenbach J. Is there resource wastage in the research for spinal diseases? An observational analysis of discontinuation and non-publication in randomised controlled trials. Brain Spine 2022;2:100922.
  • Thomson S, Ainsworth G, Selvanathan S, et al. Clinical and cost-effectiveness of PCF versus ACD in the treatment of cervical brachialgia (FORVAD trial). Br J Neurosurg 2023;1–8.
  • Freedman B. Equipoise and the ethics of clinical research. N Engl J Med 1987;317:141–5.
  • Thorlund K, Haggstrom J, Park JJ, et al. Key design considerations for adaptive clinical trials: a primer for clinicians. BMJ 2018;360:k698.

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