Comparison of intensive versus conventional insulin therapy in traumatic brain injury: a meta-analysis of randomized controlled trials

References

• Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–78. doi:10.1097/00001199-200609000-00001.
   PubMed Web of Science ®Google Scholar
• Thurman DJ, Alverson C, Dunn KA, Guerrero J, Sniezek JE. Traumatic brain injury in the United States: a public health perspective. J Head Trauma Rehabil. 1999;14:602–15. doi:10.1097/00001199-199912000-00009.
   PubMed Web of Science ®Google Scholar
• Mosenthal AC, Lavery RF, Addis M, Kaul S, Ross S, Marburger R, Deitch EA, Livingston DH. Isolated traumatic brain injury: age is an independent predictor of mortality and early outcome. J Trauma. 2002;52:907–11.
   PubMed Web of Science ®Google Scholar
• Susman M, DiRusso SM, Sullivan T, Risucci D, Nealon P, Cuff S, Haider A, Benzil D. Traumatic brain injury in the elderly: increased mortality and worse functional outcome at discharge despite lower injury severity. J Trauma. 2002;53:219–23. discussion 23-4. doi:10.1097/00005373-200208000-00004.
   PubMed Web of Science ®Google Scholar
• Rutland-Brown W, Langlois JA, Thomas KE, Xi YL. Incidence of traumatic brain injury in the United States, 2003. J Head Trauma Rehabil. 2006;21:544–48. doi:10.1097/00001199-200611000-00009.
   PubMed Web of Science ®Google Scholar
• van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359–67. doi:10.1056/NEJMoa011300.
   PubMed Web of Science ®Google Scholar
• van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology. 2005;64:1348–53. doi:10.1212/01.WNL.0000158442.08857.FC.
   PubMed Web of Science ®Google Scholar
• Liu-DeRyke X, Collingridge DS, Orme J, Roller D, Zurasky J, Rhoney DH. Clinical impact of early hyperglycemia during acute phase of traumatic brain injury. Neurocrit Care. 2009;11:151–57. doi:10.1007/s12028-009-9228-6.
   PubMed Web of Science ®Google Scholar
• Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma. 2003;55:33–38. doi:10.1097/01.TA.0000074434.39928.72.
   PubMedGoogle Scholar
• Lannoo E, Van Rietvelde F, Colardyn F, Lemmerling M, Vandekerckhove T, Jannes C, De Soete G. Early predictors of mortality and morbidity after severe closed head injury. J Neurotrauma. 2000;17:403–14. doi:10.1089/neu.2000.17.403.
   PubMed Web of Science ®Google Scholar
• Jeremitsky E, Omert LA, Dunham CM, Wilberger J, Rodriguez A. The impact of hyperglycemia on patients with severe brain injury. J Trauma. 2005;58:47–50. doi:10.1097/01.TA.0000135158.42242.B1.
   PubMed Web of Science ®Google Scholar
• Cochran A, Scaife ER, Hansen KW, Downey EC. Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma. 2003;55:1035–38. doi:10.1097/01.TA.0000031175.96507.48.
   PubMedGoogle Scholar
• Rovlias A, Kotsou S. The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery. 2000;46:335–42. discussion 42-3. doi:10.1097/00006123-200002000-00015.
   PubMed Web of Science ®Google Scholar
• Oddo M, Schmidt JM, Carrera E, Badjatia N, Connolly ES, Presciutti M, Ostapkovich ND, Levine JM, Le Roux P, Mayer SA. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med. 2008;36:3233–38. doi:10.1097/CCM.0b013e31818f4026.
   PubMed Web of Science ®Google Scholar
• Butler SO, Btaiche IF, Alaniz C. Relationship between hyperglycemia and infection in critically ill patients. Pharmacotherapy. 2005;25:963–76. doi:10.1592/phco.2005.25.7.963.
   PubMed Web of Science ®Google Scholar
• Perner A, Nielsen SE, Rask-Madsen J. High glucose impairs superoxide production from isolated blood neutrophils. Intensive Care Med. 2003;29:642–45. doi:10.1007/s00134-002-1628-4.
   PubMed Web of Science ®Google Scholar
• Bilotta F, Caramia R, Cernak I, Paoloni FP, Doronzio A, Cuzzone V, Santoro A, Rosa G. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care. 2008;9:159–66. doi:10.1007/s12028-008-9084-9.
   PubMed Web of Science ®Google Scholar
• Arabi YM, Dabbagh OC, Tamim HM, Al-Shimemeri AA, Memish ZA, Haddad SH, Syed SJ, Giridhar HR, Rishu AH, Al-Daker MO, et al. Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Crit Care Med. 2008;36:3190–97. doi:10.1097/CCM.0b013e31818f21aa.
   PubMed Web of Science ®Google Scholar
• Yang M, Guo Q, Zhang X, Sun S, Wang Y, Zhao L, Hu E, Li C. Intensive insulin therapy on infection rate, days in NICU, in-hospital mortality and neurological outcome in severe traumatic brain injury patients: a randomized controlled trial. Int J Nurs Stud. 2009;46:753–58. doi:10.1016/j.ijnurstu.2009.01.004.
   PubMed Web of Science ®Google Scholar
• Mowery NT, Gunter OL, Guillamondegui O, Dossett LA, Dortch MJ, Morris JA Jr., May AK. Stress insulin resistance is a marker for mortality in traumatic brain injury. J Trauma. 2009;66:145–51. discussion 51-3. doi:10.1097/TA.0b013e3181938c5e.
   PubMedGoogle Scholar
• Bilotta F, Spinelli A, Giovannini F, Doronzio A, Delfini R, Rosa G. The effect of intensive insulin therapy on infection rate, vasospasm, neurologic outcome, and mortality in neurointensive care unit after intracranial aneurysm clipping in patients with acute subarachnoid hemorrhage: a randomized prospective pilot trial. J Neurosurg Anesthesiol. 2007;19:156–60. doi:10.1097/ANA.0b013e3180338e69.
   PubMedGoogle Scholar
• Lam AM, Winn HR, Cullen BF, Sundling N. Hyperglycemia and neurological outcome in patients with head injury. J Neurosurg. 1991;75:545–51. doi:10.3171/jns.1991.75.4.0545.
   PubMed Web of Science ®Google Scholar
• Coester A, Neumann CR, Schmidt MI. Intensive insulin therapy in severe traumatic brain injury: a randomized trial. J Trauma. 2010;68:904–11.
   PubMedGoogle Scholar
• Green DM, O’Phelan KH, Bassin SL, Chang CW, Stern TS, Asai SM. Intensive versus conventional insulin therapy in critically ill neurologic patients. Neurocrit Care. 2010;13:299–306. doi:10.1007/s12028-010-9417-3.
   PubMed Web of Science ®Google Scholar
• Finfer S, Chittock D, Li Y, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Hebert P, Henderson W, et al. Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study. Intensive Care Med. 2015;41:1037–47. doi:10.1007/s00134-015-3757-6.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li JP, Song YL, Zhao QH. Intensive insulin therapy for preventing postoperative infection in patients with traumatic brain injury: a randomized controlled trial. Medicine (Baltimore). 2017;96:e6458. doi:10.1097/MD.0000000000006458.
   PubMedGoogle Scholar
• Meier R, Bechir M, Ludwig S, Sommerfeld J, Keel M, Steiger P, Stocker R, Stover JF. Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury. Crit Care. 2008;12:R98. doi:10.1186/cc6974.
   PubMed Web of Science ®Google Scholar
• Cryer PE. Hypoglycemia, functional brain failure, and brain death. J Clin Invest. 2007;117:868–70. doi:10.1172/JCI31669.
   PubMed Web of Science ®Google Scholar
• Azevedo JR, Lima ER, Cossetti RJ, Azevedo RP. Intensive insulin therapy versus conventional glycemic control in patients with acute neurological injury: a prospective controlled trial. Arq Neuropsiquiatr. 2007;65:733–38. doi:10.1590/S0004-282X2007000500001.
   PubMed Web of Science ®Google Scholar
• Cinotti R, Ichai C, Orban JC, Kalfon P, Feuillet F, Roquilly A, Riou B, Blanloeil Y, Asehnoune K, Rozec B. Effects of tight computerized glucose control on neurological outcome in severely brain injured patients: a multicenter sub-group analysis of the randomized-controlled open-label CGAO-REA study. Crit Care. 2014;18:498. doi:10.1186/s13054-014-0498-9.
   PubMed Web of Science ®Google Scholar
• Moghissi ES, Korytkowski MT, DiNardo M, Einhorn D, Hellman R, Hirsch IB, Inzucchi SE, Ismail-Beigi F, Kirkman MS, Umpierrez GE. American Association of Clinical Endocrinologists and American Diabetes Association Consensus statement on inpatient glycemic control. Diabetes Care. 2009;32:1119–31. doi:10.2337/dc09-9029.
   PubMed Web of Science ®Google Scholar
• McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, Ochoa JB, Napolitano L, Cresci G. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2009;33:277–316. doi:10.1177/0148607109335234.
   PubMed Web of Science ®Google Scholar
• Jacobi J, Bircher N, Krinsley J, Agus M, Braithwaite SS, Deutschman C, Freire AX, Geehan D, Kohl B, Nasraway SA, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012;40:3251–76. doi:10.1097/CCM.0b013e3182653269.
   PubMed Web of Science ®Google Scholar
• Bero L, Rennie D. The Cochrane collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care. Jama. 1995;274:1935–38. doi:10.1001/jama.1995.03530240045039.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097. doi:10.1371/journal.pmed.1000097.
   PubMed Web of Science ®Google Scholar
• DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials. 2007;28:105–14. doi:10.1016/j.cct.2006.04.004.
   PubMed Web of Science ®Google Scholar
• Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315:629–34. doi:10.1136/bmj.315.7109.629.
   PubMed Web of Science ®Google Scholar
• Zafar SN, Iqbal A, Farez MF, Kamatkar S, De Moya MA. Intensive insulin therapy in brain injury: a meta-analysis. J Neurotrauma. 2011;28:1307–17. doi:10.1089/neu.2010.1724.
   PubMed Web of Science ®Google Scholar
• Kramer AH, Roberts DJ, Zygun DA. Optimal glycemic control in neurocritical care patients: a systematic review and meta-analysis. Crit Care. 2012;16:R203. doi:10.1186/cc11812.
   PubMed Web of Science ®Google Scholar
• Godoy DA, Di Napoli M, Rabinstein AA. Treating hyperglycemia in neurocritical patients: benefits and perils. Neurocrit Care. 2010;13:425–38. doi:10.1007/s12028-010-9404-8.
   PubMed Web of Science ®Google Scholar
• Tomlinson DR, Gardiner NJ. Glucose neurotoxicity. Nat Rev Neurosci. 2008;9:36–45. doi:10.1038/nrn2294.
   PubMed Web of Science ®Google Scholar
• Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth. 2007;99:4–9. doi:10.1093/bja/aem131.
   PubMed Web of Science ®Google Scholar
• Vespa P, McArthur DL, Stein N, Huang SC, Shao W, Filippou M, Etchepare M, Glenn T, Hovda DA. Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial. Crit Care Med. 2012;40:1923–29. doi:10.1097/CCM.0b013e31824e0fcc.
   PubMed Web of Science ®Google Scholar
• Chourdakis M, Kraus MM, Tzellos T, Sardeli C, Peftoulidou M, Vassilakos D, Kouvelas D. Effect of early compared with delayed enteral nutrition on endocrine function in patients with traumatic brain injury: an open-labeled randomized trial. JPEN J Parenter Enteral Nutr. 2012;36:108–16. doi:10.1177/0148607110397878.
   PubMed Web of Science ®Google Scholar
• Carney N, Totten A, O’Reilly C, Ullman J, Hawryluk G, Bell M, Bratton S, Chesnut R, Harris O, Kissoon N, et al. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery. 2017;80:6–15. doi: 10.1227/NEU.0000000000001432.
   Google Scholar