Cognitive and neural effects of exercise following traumatic brain injury: A systematic review of randomized and controlled clinical trials

References

• Nguyen R, Fiest KM, McChesney J, Kwon C-S, Jette N, Frolkis AD, Atta C, Mah S, Dhaliwal H, Reid A, et al. The international incidence of traumatic brain injury: a systematic review and meta-analysis. Can J Neurol Sci. 2016;43(6):774–85.doi:10.1017/cjn.2016.290.
   PubMed Web of Science ®Google Scholar
• Lancet T. The changing landscape of traumatic brain injury research. Lancet Neurol. 2012;11(8):651. doi:10.1016/S1474-4422(12)70166-7.
   PubMed Web of Science ®Google Scholar
• McInnes K, Friesen CL, MacKenzie DE, Westwood DA, Boe SG. Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: a scoping review. PLoS One. 2017;12(4):e0174847. doi:10.1371/journal.pone.0174847.
   PubMed Web of Science ®Google Scholar
• Bigler ED. Traumatic brain injury, neuroimaging, and neurodegeneration. Front Hum Neurosci. 2013;7:395. doi:10.3389/fnhum.2013.00395.
   PubMed Web of Science ®Google Scholar
• Johnson VE, Stewart JE, Begbie FD, Trojanowski JQ, Smith DH, Stewart W. Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Brain. 2013;136(1):28–42. doi:10.1093/brain/aws322.
   PubMed Web of Science ®Google Scholar
• Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, Nowinski CJ, Cantu RC, McKee AC, Stern RA. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging and Behavior. 2012;6(2):244–54. doi:10.1007/s11682-012-9164-5.
   Google Scholar
• Bédard M, Felteau M, Marshall S, Cullen N, Gibbons C, Dubois S, Maxwell H, Mazmanian D, Weaver B, Rees L, et al. Mindfulness-based cognitive therapy reduces symptoms of depression in people with a traumatic brain injury: results from a randomized controlled trial. J Head Trauma Rehabil. 2014;29(4):E13–E22. doi:10.1097/HTR.0b013e3182a615a0.
   PubMed Web of Science ®Google Scholar
• Cicerone KD, Langenbahn DM, Braden C, Malec JF, Kalmar K, Fraas M, Felicetti T, Laatsch L, Harley JP, Bergquist T, et al. Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Arch Phys Med Rehabil. 2011;92(4):519–30. doi:10.1016/j.apmr.2010.11.015.
   PubMed Web of Science ®Google Scholar
• Fann JR, Bombardier CH, Vannoy S, Dyer J, Ludman E, Dikmen S, Marshall K, Barber J, Temkin N. Telephone and in-person cognitive behavioral therapy for major depression after traumatic brain injury: a randomized controlled trial. J Neurotrauma. 2015;32(1):45–57. doi:10.1089/neu.2014.3423.
   PubMed Web of Science ®Google Scholar
• Radomski MV, Anheluk M, Bartzen MP, Zola J. Effectiveness of interventions to address cognitive impairments and improve occupational performance after traumatic brain injury: a systematic review. Am J Occup Ther. 2016;70(3):7003180050p1–p9. doi:10.5014/ajot.2016.020776.
   PubMed Web of Science ®Google Scholar
• Hawryluk GW, Bullock MR. Past, present, and future of traumatic brain injury research. Neurosurg Clin N Am. 2016;27(4):375–96. doi:10.1016/j.nec.2016.05.002.
   PubMed Web of Science ®Google Scholar
• Stein DG. Embracing failure: what the phase III progesterone studies can teach about TBI clinical trials. Brain Inj. 2015;29(11):1259–72. doi:10.3109/02699052.2015.1065344.
   PubMed Web of Science ®Google Scholar
• Malina RM, Bouchard C, Bar-Or O. 2004. Growth, maturation, and physical activity. Windsor (ON) : Human Kinetics.
   Google Scholar
• Lal A, Kolakowsky-Hayner SA, Ghajar J, Balamane M. The effect of physical exercise after a concussion: a Systematic Review and Meta-analysis. Am J Sports Med. 2018;46(3):743–52. 0363546517706137.
   Web of Science ®Google Scholar
• Archer T, Svensson K, Alricsson M. Physical exercise ameliorates deficits induced by traumatic brain injury. Acta Neurol Scand. 2012;125(5):293–302. doi:10.1111/ane.2012.125.issue-5.
   PubMed Web of Science ®Google Scholar
• Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6):295–301. doi:10.1016/S0166-2236(02)02143-4.
   PubMed Web of Science ®Google Scholar
• Van Praag H. Neurogenesis and exercise: past and future directions. Neuromolecular Med. 2008;10(2):128–40. doi:10.1007/s12017-008-8028-z.
   PubMed Web of Science ®Google Scholar
• Griesbach GS, Hovda DA, Gomez-Pinilla F. Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res. 2009;1288:105–15. doi:10.1016/j.brainres.2009.06.045.
   PubMed Web of Science ®Google Scholar
• Van Praag H, Kempermann G, Gage FH. Neural consequences of environmental enrichment. Nature Rev Neurosci. 2000;1(3):191. doi:10.1038/35044558.
   PubMed Web of Science ®Google Scholar
• Griesbach GS, Hovda D, Molteni R, Wu A, Gomez-Pinilla F. Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience. 2004;125(1):129–39. doi:10.1016/j.neuroscience.2004.01.030.
   PubMed Web of Science ®Google Scholar
• Clemenson GD, Deng W, Gage FH. Environmental enrichment and neurogenesis: from mice to humans. Curr Opin Behav Sci. 2015;4:56–62. doi:10.1016/j.cobeha.2015.02.005.
   Web of Science ®Google Scholar
• Imhoff S, Fait P, Carrier-Toutant F, Boulard G. Efficiency of an active rehabilitation intervention in a slow-to-recover paediatric population following mild traumatic brain injury: a pilot study. J Sports Med. 2016;2016. doi:10.1155/2016/5127374.
   Google Scholar
• Manikas V, Babl FE, Hearps S, Dooley J, Anderson V. Impact of exercise on clinical symptom report and neurocognition after concussion in children and adolescents. J Neurotrauma. 2017;34(11):1932–38. doi:10.1089/neu.2016.4762.
   PubMed Web of Science ®Google Scholar
• Leddy JJ, Cox JL, Baker JG, Wack DS, Pendergast DR, Zivadinov R, Willer B. Exercise treatment for postconcussion syndrome: a pilot study of changes in functional magnetic resonance imaging activation, physiology, and symptoms. J Head Trauma Rehabil. 2013;28(4):241–49. doi:10.1097/HTR.0b013e31826da964.
   PubMed Web of Science ®Google Scholar
• Polak P, Leddy JJ, Dwyer MG, Willer B, Zivadinov R. Diffusion tensor imaging alterations in patients with postconcussion syndrome undergoing exercise treatment: a pilot longitudinal study. J Head Trauma Rehabil. 2015;30(2):E32–E42. doi:10.1097/HTR.0000000000000037.
   PubMed Web of Science ®Google Scholar
• Morris T, Gomes Osman J, Tormos Muñoz JM, Costa Miserachs D, Pascual Leone A. The role of physical exercise in cognitive recovery after traumatic brain injury: a systematic review. Restor Neurol Neurosci. 2016;34(6):977–88. doi:10.3233/RNN-160687.
   PubMed Web of Science ®Google Scholar
• Vanderbeken I, Kerckhofs E. A systematic review of the effect of physical exercise on cognition in stroke and traumatic brain injury patients. NeuroRehabilitation. 2017;40(1):33–48. doi:10.3233/NRE-161388.
   PubMed Web of Science ®Google Scholar
• Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews. 2015;4(1):1.
   Google Scholar
• Santos CM, Pimenta CA, Nobre MR. The PICO strategy for the research question construction and evidence search. Revista Latino-americana de Enfermagem. 2007;15(3):508–11.
   Google Scholar
• Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.
   PubMed Web of Science ®Google Scholar
• American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. Lippincott Williams & Wilkins; 2013.
   Google Scholar
• Yuan W, Wade SL, Quatman-Yates C, Hugentobler JA, Gubanich PJ, Kurowski BG. Structural connectivity related to persistent symptoms after mild TBI in adolescents and response to aerobic training: preliminary investigation. J Head Trauma Rehabil. 2017. doi:10.1097/HTR.0000000000000318.
   PubMed Web of Science ®Google Scholar
• Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001;13(4):534–46. doi:10.1002/jmri.1076.
   PubMed Web of Science ®Google Scholar
• Bassett DS, Brown JA, Deshpande V, Carlson JM, Grafton ST. Conserved and variable architecture of human white matter connectivity. Neuroimage. 2011;54(2):1262–79. doi:10.1016/j.neuroimage.2010.09.006.
   PubMed Web of Science ®Google Scholar
• Kurowski BG, Hugentobler J, Quatman-Yates C, Taylor J, Gubanich PJ, Altaye M, Wade SL. Aerobic exercise for adolescents with prolonged symptoms after mild traumatic brain injury: an exploratory randomized clinical trial. J Head Trauma Rehabil. 2017;32(2):79–89. doi:10.1097/HTR.0000000000000238.
   PubMed Web of Science ®Google Scholar
• Lee YSC, Ashman T, Shang A, Suzuki W. Brief report: effects of exercise and self-affirmation intervention after traumatic brain injury. NeuroRehabilitation. 2014;35(1):57–65. doi:10.3233/NRE-141100.
   PubMed Web of Science ®Google Scholar
• Maerlender A, Rieman W, Lichtenstein J, Condiracci C. Programmed physical exertion in recovery from sports-related concussion: a randomized pilot study. Dev Neuropsychol. 2015;40(5):273–78. doi:10.1080/87565641.2015.1067706.
   PubMed Web of Science ®Google Scholar
• McMillan T, Robertson IH, Brock D, Chorlton L. Brief mindfulness training for attentional problems after traumatic brain injury: A randomised control treatment trial. Neuropsychol Rehabil. 2002;12(2):117–25. doi:10.1080/09602010143000202.
   Web of Science ®Google Scholar
• Robertson IH, Ward T, Ridgeway V, Nimmo-Smith I. The test of everyday attention (TEA). San Antonio, TX: Psychological Corporation; 1994.
   Google Scholar
• Coughlan AK, Hollows SE. The adult memory and information processing battery (amipb): test manual. AK Coughlin, Psychology Department, St James’ Hospital; 1985.
   Google Scholar
• Lezak MD. Neuropsychological assessment. USA: Oxford University Press; 2004.
   Google Scholar
• Sunderland A, Harris JE, Gleave J. Memory failures in everyday life following severe head injury. J Clin Exp Neuropsychol. 1984;6(2):127–42. doi:10.1080/01688638408401204.
   Web of Science ®Google Scholar
• Broadbent DE, Cooper PF, FitzGerald P, Parkes KR. The cognitive failures questionnaire (CFQ) and its correlates. Br J Clin Psychol. 1982;21(1):1–16. doi:10.1111/bjc.1982.21.issue-1.
   PubMed Web of Science ®Google Scholar
• Golden CJ. Shawna MF. Stroop color and word test. 1978.
   Google Scholar
• Wechsler D. Wechsler adult intelligence scale–fourth Edition (WAIS–IV). Vol. 22. San Antonio, TX: NCS Pearson; 2008. 498 p.
   Google Scholar
• Reitan, Ralph M, Wolfson D. The halstead-reitan neuropsychological test battery; 1986.
   Google Scholar
• Curlik D, Shors T. Training your brain: do mental and physical (MAP) training enhance cognition through the process of neurogenesis in the hippocampus? Neuropharmacology. 2013;64:506–14. doi:10.1016/j.neuropharm.2012.07.027.
   PubMed Web of Science ®Google Scholar
• Van der Borght K, Kóbor‐Nyakas DÉ, Klauke K, Eggen BJ, Nyakas C, Van der Zee EA, Meerlo P. Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis. Hippocampus. 2009;19(10):928–36. doi:10.1002/hipo.20545.
   PubMed Web of Science ®Google Scholar
• Thomas AG, Dennis A, Bandettini PA, Johansen-Berg H. The effects of aerobic activity on brain structure. Front Psychol. 2012;23(3):86.
   Web of Science ®Google Scholar
• Brooks GA, Martin NA. Cerebral metabolism following traumatic brain injury: new discoveries with implications for treatment. Front Neurosci. 2015;9(8):408.
   Web of Science ®Google Scholar
• McCrory P, Meeuwisse W, Dvorak J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ. Consensus statement on concussion in sport—the 5th international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med. 2017;51(11):838–47.
   Web of Science ®Google Scholar
• Schneider KJ, Leddy JJ, Guskiewicz KM, Seifert T, McCrea M, Silverberg ND, Feddermann-Demont N, Iverson GL, Hayden A, Makdissi M. Rest and treatment/rehabilitation following sport-related concussion: a systematic review. Br J Sports Med. 2017;51(12):930–4.
   Web of Science ®Google Scholar
• Silverberg ND, Iverson GL, McCrea M, Apps JN, Hammeke TA, Thomas DG. Activity-related symptom exacerbations after pediatric concussion. JAMA Pediatr. 2016;170(10):946–53. doi:10.1001/jamapediatrics.2016.1187.
   PubMed Web of Science ®Google Scholar
• Grool AM, Aglipay M, Momoli F, Meehan WP, Freedman SB, Yeates KO, et al. Association between early participation in physical activity following acute concussion and persistent postconcussive symptoms in children and adolescents. JAMA. 2016;316(23):2504–14. doi:10.1001/jama.2016.17396.
   PubMed Web of Science ®Google Scholar
• Thomas DG, Apps JN, Hoffmann RG, McCrea M, Hammeke T. Benefits of strict rest after acute concussion: a randomized controlled trial. Pediatrics. 2015;135(2):213–23.
   Web of Science ®Google Scholar
• Worts PR, Burkhart SO, Kim J-SJ-SM. A physiologically based approach to prescribing exercise following a sport-related concussion. 2019;49(5):683–706.
   Google Scholar
• Bonne O, Gilboa A, Louzoun Y, Kempf-Sherf O, Katz M, Fishman Y, Ben-Nahum Z, Krausz Y, Bocher M, Lester H. Cerebral blood flow in chronic symptomatic mild traumatic brain injury. Psychiatry Res. 2003;124(3):141–52. doi:10.1016/S0925-4927(03)00109-4.
   PubMed Web of Science ®Google Scholar
• Len T, Neary J. Cerebrovascular pathophysiology following mild traumatic brain injury. Clin Physiol Funct Imaging. 2011;31(2):85–93. doi:10.1111/j.1475-097X.2010.00990.x.
   PubMed Web of Science ®Google Scholar
• Meier TB, Bellgowan PS, Singh R, Kuplicki R, Polanski DW, Mayer AR. Recovery of cerebral blood flow following sports-related concussion. JAMA Neurol. 2015;72(5):530–38. doi:10.1001/jamaneurol.2014.4778.
   PubMed Web of Science ®Google Scholar
• da Costa L, van Niftrik CB, Crane D, Fierstra J, Bethune A. Temporal profile of cerebrovascular reactivity impairment, gray matter volumes, and persistent symptoms after mild traumatic head injury. Frontiers in Neurology. 2016;7:70.
   Google Scholar
• Richard Jennings J, Allen B, Gianaros PJ, Thayer JF, Manuck SB. Focusing neurovisceral integration: cognition, heart rate variability, and cerebral blood flow. Psychophysiology. 2015;52(2):214–24. doi:10.1111/psyp.12319.
   PubMed Web of Science ®Google Scholar
• Fuchs E, Czéh B, Kole MH, Michaelis T, Lucassen PJ. Alterations of neuroplasticity in depression: the hippocampus and beyond. Eur Neuropsychopharmacol. 2004;14:S481–S90. doi:10.1016/j.euroneuro.2004.09.002.
   PubMed Web of Science ®Google Scholar
• Fumagalli F, Molteni R, Racagni G, Riva MA. Stress during development: impact on neuroplasticity and relevance to psychopathology. Prog Neurobiol. 2007;81(4):197–217. doi:10.1016/j.pneurobio.2007.01.002.
   PubMed Web of Science ®Google Scholar
• Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology. 2008;33(1):88. doi:10.1038/sj.npp.1301574.
   PubMed Web of Science ®Google Scholar
• Gomez-Pinilla F, Kostenkova K. The influence of diet and physical activity on brain repair and neurosurgical outcome. Surg Neurol. 2008;70(4):333. doi:10.1016/j.surneu.2008.05.023.
   PubMedGoogle Scholar
• Griesbach GS. Exercise after traumatic brain injury: is it a double-edged sword? PM&R. 2011;3(6):S64–S72. doi:10.1016/j.pmrj.2011.02.008.
   Web of Science ®Google Scholar
• Werner JK, Stevens RD. Traumatic brain injury: recent advances in plasticity and regeneration. Current Opinion in Neurology. 2015;28(6):565–73. doi:10.1097/WCO.0000000000000265.
   Google Scholar