A history of concussion is associated with minimal perturbations to heart rate variability in athletes

References

• Ellis M, Leddy J, Willer B. 2015. Physiological, vestibulo-ocular and cervicogenic post-concussion disorders: an evidence-based classification system with directions for treatment. Brain Inj. 29(2):238–48. doi:10.3109/02699052.2014.965207
   PubMed Web of Science ®Google Scholar
• Collins MW, Kontos AP, Reynolds E, Murawski CD, Fu FH. 2014. A comprehensive, targeted approach to the clinical care of athletes following sport-related concussion. Knee Surg Sports Traumatol Arthrosc. 22(2):235–46. doi:10.1007/s00167-013-2791-6
   PubMed Web of Science ®Google Scholar
• Barkhoudarian G, Hovda DA, Giza CC. 2016. The molecular pathophysiology of concussive brain injury - An update. Phys Med Rehabil Clin N Am. 27(2):373–93. doi:10.1016/j.pmr.2016.01.003
   PubMed Web of Science ®Google Scholar
• Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, Solomon GS. 2017. Predictors of clinical recovery from concussion: a systematic review. Br J Sports Med. 51(12):941–48. doi:10.1136/bjsports-2017-097729
   PubMed Web of Science ®Google Scholar
• McCrory P, Meeuwisse W, Dvorak J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, et al. Consensus statement on concussion in sport-the 5th international conference on concussion in sport held in Berlin, October 2016. Br J Sport Med. 2017;51(11):838–47. doi:10.1136/bjsports-2017-097699.
   PubMed Web of Science ®Google Scholar
• Churchill NW, Hutchison MG, Richards D, Leung G, Graham SJ, Schweizer TA. The first week after concussion: blood flow, brain function and white matter microstructure. Neuroimage Clin. 2017;14:480–89. doi:10.1016/j.nicl.2017.02.015.
   PubMed Web of Science ®Google Scholar
• Guskiewicz KM, Mihalik JP. 2011. Biomechanics of sport concussion: quest for the elusive injury threshold. Exerc Sport Sci Rev. 39(1):4–11. doi:10.1097/JES.0b013e318201f53e
   PubMed Web of Science ®Google Scholar
• Esterov D, Greenwald B. 2017. Autonomic dysfunction after mild traumatic brain injury. Brain Sci. 7(8):E100. doi:10.3390/brainsci7080100
   PubMed Web of Science ®Google Scholar
• Ropper AH, Gorson KC.Clinical practice. Concussion N Engl J Med. 2007;356(2):166–72.doi:10.1056/NEJMcp064645.
   PubMed Web of Science ®Google Scholar
• Churchill NW, Hutchison MG, Richards D, Leung G, Graham SJ, Schweizer TA. 2017. Neuroimaging of sport concussion: persistent alterations in brain structure and function at medical clearance. Sci Rep-UK. 7(1):8297. doi:10.1038/s41598-017-07742-3
   PubMed Web of Science ®Google Scholar
• Churchill NW, Caverzasi E, Graham SJ, Hutchison MG, Schweizer TA. 2017. White matter microstructure in athletes with a history of concussion: comparing diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Hum Brain Mapp. 38(8):4201–11. doi:10.1002/hbm.23658
   PubMed Web of Science ®Google Scholar
• Cubon VA, Putukian M, Boyer C, Dettwiler A. 2011. A diffusion tensor imaging study on the white matter skeleton in individuals with sports-related concussion. J Neurotrauma. 28(2):189–201. doi:10.1089/neu.2010.1430
   PubMed Web of Science ®Google Scholar
• Zhu DC, Covassion T, Nogle S, Doyle S, Russell D, Pearson RL, Monroe J, Liszewski CM, DeMarco JK, Kaufman DI. 2015. A potential biomarker in sports-related concussion: brain functional connectivity alteration of the default-mode network measure with longitudinal resting-state fMRI over thirty days. J Neurotrauma. 32(5):327–41. doi:10.1089/neu.2014.3413
   PubMed Web of Science ®Google Scholar
• Sasaki T, Pasternak O, Mayinger M, Muehlmann M, Savadiiev P, Bouix S, Kubicki M, Fredman E, Dahlben B, Helmer KG, et al. Changes in white matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study. J Neurosurg. 2014;120(4):882–90.doi:10.3171/2013.12.JNS132092.
   PubMedGoogle Scholar
• Hutchison M, Mainwaring L, Senthinathan A, Churchill N, Thomas S, Richards D. 2017. Psychological and physiological markers of stress in concussed athletes across recovery milestones. J Head Trauma Rehabil. 32(3):E38–E48. doi:10.1097/HTR.0000000000000252
   PubMed Web of Science ®Google Scholar
• Bishop S, Dech R, Baker T, Butz M, Aravinthan K, Neary JP. 2017. Parasympathetic baroreflexes and heart rate variability during acute stage of sport concussion recovery. Brain Inj. 31(2):247–59. doi:10.1080/02699052.2016.1226385
   PubMed Web of Science ®Google Scholar
• Abaji J, Curnier D, Moore R, Ellemberg D. 2016. Persisting effects of concussion on heart rate variability during physical exertion. J Neurotrauma. 33(9):811–17. doi:10.1089/neu.2015.3989
   PubMed Web of Science ®Google Scholar
• Bruce JM, Echemendia RJ, Meeuwisse W, Hutchison MG, Aubry M, Comper P. 2017. Measuring cognitive change with ImPACT: the aggregate baseline approach. Clin Neuropsychol. 31(8):1329–40. doi:10.1080/13854046.2017.1311375
   PubMed Web of Science ®Google Scholar
• Billman GE, Huikuri HV, Sacha J, Trimmel K. An introduction to heart rate variability: methodological considerations and clinical applications. Front Physiol. 2015;6:55. doi:10.3389/fphys.2015.00055.
   PubMed Web of Science ®Google Scholar
• Tsuji H, Larson M, Venditti FJ Jr., Manders ES, Evans JC, Feldman CL, Levy D.Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study Circulation. 1996;94(11):2850–55.doi:10.1161/01.CIR.94.11.2850.
   PubMed Web of Science ®Google Scholar
• Videira G, Castro P, Vieira B, Filipe JP, Santos R, Azevedo E, Sa MJ, Abreu P. Autonomic dysfunction in multiple sclerosis is better detected by heart rate variability and is not correlated with central autonomic network damage. J Neurol Sci. 2016;367:133–37. doi:10.1016/j.jns.2016.05.049.
   PubMed Web of Science ®Google Scholar
• Fyfe-Johnson AL, Muller CJ, Alonso A, Folsom AR, Gottesman RF, Rosamond WD, Whitsel EA, Agarwal SK, MacLehose RF. 2016. Heart rate variability and incident stroke: the Atherosclerosis Risk in Communities Study. Stroke. 47(6):1452–58. doi:10.1161/STROKEAHA.116.012662
   PubMed Web of Science ®Google Scholar
• Gall B, Parkhouse W, Goodman D.Heart rate variability of recently concussed athletes at rest and exercise. Med Sci Sports Exerc. 2004;36(8):1269–74.doi:10.1249/01.MSS.0000135787.73757.4D.
   PubMed Web of Science ®Google Scholar
• La Fountaine MF, Heffernan KS, Gossett JD, Bauman WA, De Meersman RE. 2009. Transient suppression of heart rate complexity in concussed athletes. Auton Neurosci. 148(1–2):101–03. doi:10.1016/j.autneu.2009.03.001
   PubMed Web of Science ®Google Scholar
• Giza CC, Hovda DA. 2014. The new neurometabolic cascade of concussion. Neurosurgery. 75(Suppl 4):S24–S33. doi:10.1227/NEU.0000000000000505
   PubMedGoogle Scholar
• Di Battista AP, Rhind SG, Baker AJ, Jetly R, Debad JD, Richards D, Hutchison MG. 2018. An investigation of neuroinjury biomarkers after sport-related concussion: from the subacute phase to clinical recovery. Brain Inj. 32(5):575–82. doi:10.1080/02699052.2018.1432892
   PubMed Web of Science ®Google Scholar
• Senthinathan A, Mainwaring LM, Hutchison M. 2017. Heart rate variability of athletes across concussion recovery milestones: A preliminary study. Clin J Sport Med. 27(3):288–95. doi:10.1097/JSM.0000000000000337
   PubMed Web of Science ®Google Scholar
• Dobney DM, Thomas SG, Taha T, Keightley M. 2018. Physiological and performance measures for baseline concussion assessment. J Sport Rehabil. 27(4):312–18. doi:10.1123/jsr.2017-0038
   PubMed Web of Science ®Google Scholar
• Paniccia M, Verweel L, Thomas S, Taha T, Keightley M, Wilson KE, Reed N. Heart rate variability in healthy non-concussed youth athletes: exploring the effect of age, sex, and concussion-like symptoms. Front Neurol. 2018;8:753. doi:10.3389/fneur.2017.00753.
   PubMed Web of Science ®Google Scholar
• Koenig J, Thayer JF. Sex differences in healthy human heart rate variability: A meta-analysis. Neurosci Biobehav Rev. 2016;64:288–310. doi:10.1016/j.neubiorev.2016.03.007.
   PubMed Web of Science ®Google Scholar
• Emery CF, Stoney CM, Thayer JF, Williams D, Bodine A. Sex and family history of cardiovascular disease influence heart rate variability during stress among healthy adults. J Psychosom Res. 2018;110:54–60. doi:10.1016/j.jpsychores.2018.04.011.
   PubMed Web of Science ®Google Scholar
• Umetani K, Singer DH, McCraty R, Atkinson M.Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol. 1998;31(3):593–601.doi:10.1016/S0735-1097(97)00554-8.
   PubMed Web of Science ®Google Scholar
• Estévez-Báez M, Carricarte-Naranjo C, Jas-García JD, Rodriguez-Rios E, Machado C, Montes-Brown J, Leisman G, Schiavi A, Machado-Garcia A, Luaces CS, et al. Influence of heart rate, age, and gender on heart rate variability in adolescents and young adults. Adv Exp Med Biol. 2019;1133:19–33.
   PubMed Web of Science ®Google Scholar
• Krishnan A, Williams LJ, McIntosh A, Abdi H. 2011. Partial Least Squares (PLS) methods for neuroimaging: a tutorial and review. Neuroimage. 56(2):455–75. doi:10.1016/j.neuroimage.2010.07.034
   PubMed Web of Science ®Google Scholar
• Monda M, Viggiano A, Vicidomini C, Iannaccone T, Tafuri D, De Luca B. Espresso coffee increases parasympathetic activity in young, healthy people. Nutr Neurosci. 2009;12:43–48. doi:10.1179/147683009X388841.
   PubMed Web of Science ®Google Scholar
• Rauh R, Burkert M, Siepmann M, Mueck-Weymann M. Acute effects of caffeine on heart rate variability in habitual caffeine consumers. Clin Physiol Funct Imaging. 2006;26:163–66. doi:10.1111/j.1475-097X.2006.00663.
   PubMed Web of Science ®Google Scholar
• Zimmermann-Viehoff F, Thayer J, Koenig J, Herrmann C, Weber CS, Deter HC. 2016. Short-term effects of espresso coffee on heart rate variability and blood pressure in habitual and non-habitual coffee consumers—A randomized crossover study. Nutr Neurosci. 19(4):169–75. doi:10.1179/1476830515Y.0000000018
   PubMed Web of Science ®Google Scholar