Advanced search
Publication Cover
Brain Injury Volume 36, 2022 - Issue 8
Submit an article Journal homepage
322
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Concussion severity and functional outcome using biomarkers in children and youth involved in organized sports, recreational activities and non-sport related incidents

Linda Papaa Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USA;b Department of Pediatric Emergency Medicine, Arnold Palmer Hospital for Children, Orlando, Florida, USACorrespondence[email protected]
View further author information
,
Kimberly Rosenthalc College of Medicine, University of Florida, Orlando, Florida, USAView further author information
,
Laura Cooka Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Michael Cairea Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Josef G. Thundiyila Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USA;b Department of Pediatric Emergency Medicine, Arnold Palmer Hospital for Children, Orlando, Florida, USAView further author information
,
Jay G. Laddea Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USA;b Department of Pediatric Emergency Medicine, Arnold Palmer Hospital for Children, Orlando, Florida, USAView further author information
,
Alec Garfinkeld College of Medicine, California North state University, Elk Grove, California, USAView further author information
,
Carolina F. Bragaa Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Ciara N. Tana Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Neema J. Amelia Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Marco A. Lopeza Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Crystal A. Haeusslera Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Diego Mendez Giordanoa Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USAView further author information
,
Philip A. Giordanoa Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USA;b Department of Pediatric Emergency Medicine, Arnold Palmer Hospital for Children, Orlando, Florida, USAView further author information
,
Jose Ramirezb Department of Pediatric Emergency Medicine, Arnold Palmer Hospital for Children, Orlando, Florida, USAView further author information
,
Manoj K. Mittale Division of Emergency Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;f Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USAView further author information
&
Mark R. Zonfrillog Department of Emergency Medicine, Alpert Medical School of Brown University and Hasbro Children’s Hospital, Providence, Rhode Island, USAORCID Iconhttps://orcid.org/0000-0002-0610-9563View further author information
ORCID Icon show all
Pages 939-947 | Received 23 Sep 2021, Accepted 22 Jul 2022, Published online: 29 Jul 2022

References

  • Herring S, Kibler WB, Putukian M, Solomon GS, Boyajian-O’Neill L, Dec KL, Franks RR, A. Indelicato P, R. Labella C, Leddy JJ, et al. Selected issues in sport-related concussion (SRC | mild Traumatic Brain Injury) for the team physician: a consensus statement. Curr Sports Med Rep. 2021;20(8):420–31. doi:10.1249/JSR.0000000000000871.
  • Herring SA, Cantu RC, Guskiewicz KM, Putukian M, Kibler WB, Bergfeld JA, Dec KL, Franks RR, Indelicato P, LaBella C, Leddy JJ, Matuszak J, McDonough EB, O‘Connor FG, and Sutton KM. Concussion (mild traumatic brain injury) and the team physician: a consensus statement–2011 update. Med Sci Sports Exerc. 2011;43:2412–22.
  • Rabinowitz AR, Li X, Levin HS. Sport and nonsport etiologies of mild traumatic brain injury: similarities and differences. Annu Rev Psychol. 2014;65:301–31. doi:10.1146/annurev-psych-010213-115103.
  • Sarmiento K, Daugherty J, DePadilla L, Breiding MJ. Examination of sports and recreation-related concussion among youth ages 12-17: results from the 2018 YouthStyles survey. Brain Inj. 2020;34(3):357–62. doi:10.1080/02699052.2020.1723165.
  • Bryan MA, Rowhani-Rahbar A, Comstock RD, Rivara F. Seattle sports concussion research C. Sports- and recreation-related concussions in US youth. Pediatrics. 2016;138(1). doi:10.1542/peds.2015-4635.
  • Government of Western Australia. Sport and recreation. Department of Local Government Sport and Cultural Industries. 2011. [accessed 2021 Sept 21]. https://www.dlgsc.wa.gov.au/sport-and-recreation
  • FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults. Silver Springs: US Food & Drug Administration; 2018. [accessed 2021 Sept 21]. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm596531.htm
  • Papa L, Zonfrillo MR, Welch RD, Lewis LM, Braga CF, Tan CN, Ameli NJ, Lopez MA, Haeussler CA, Mendez Giordano D, et al. Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study. BMJ Paediatr Open. 2019;3(1):e000473. doi:10.1136/bmjpo-2019-000473.
  • Papa L, Mittal MK, Ramirez J, Silvestri S, Giordano P, Braga CF, Tan CN, Ameli NJ, Lopez MA, Haeussler CA, et al. Neuronal biomarker ubiquitin C-Terminal hydrolase detects traumatic intracranial lesions on computed tomography in children and youth with mild traumatic brain injury. J Neurotrauma. 2017;34(13):2132–40. doi:10.1089/neu.2016.4806.
  • Papa L, Mittal MK, Ramirez J, Ramia M, Kirby S, Silvestri S, Giordano P, Weber K, Braga CF, Tan CN, et al. In children and youth with mild and moderate traumatic brain injury, glial fibrillary acidic protein out-performs S100beta in detecting traumatic intracranial lesions on computed tomography. J Neurotrauma. 2016;33(1):58–64. doi:10.1089/neu.2015.3869.
  • Papa L, Zonfrillo MR, Ramirez J, Silvestri S, Giordano P, Braga CF, Tan CN, Ameli NJ, Lopez M, Mittal MK, et al. Performance of glial fibrillary acidic protein in detecting traumatic intracranial lesions on computed tomography in children and youth with mild head trauma. Acad Emerg Med. 2015;22(11):1274–82. doi:10.1111/acem.12795.
  • Ruff RM, Iverson GL, Barth JT, Bush SS, Broshek DK. Recommendations for diagnosing a mild traumatic brain injury: a National Academy of Neuropsychology education paper. Arch Clin Neuropsychol. 2009;24(1):3–10. doi:10.1093/arclin/acp006.
  • Berger RP, Beers SR, Papa L, Bell M. Common data elements for pediatric traumatic brain injury: recommendations from the biospecimens and biomarkers workgroup. J Neurotrauma. 2012;29(4):672–77. doi:10.1089/neu.2011.1861.
  • Kuppermann N, Holmes JF, Dayan PS, Hoyle JD Jr., Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgialli DA, et al. Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet. 2009;374(9696):1160–70. doi:10.1016/S0140-6736(09)61558-0.
  • Beers SR, Wisniewski SR, Garcia-Filion P, Tian Y, Hahner T, Berger RP, Bell MJ, and Adelson PD. Validity of a pediatric version of the Glasgow Outcome Scale-Extended. J Neurotrauma. 2012;29(6):1126–39. doi:10.1089/neu.2011.2272.
  • Papa L, Ramia MM, Kelly JM, Burks SS, Pawlowicz A, Berger RP. Systematic review of clinical research on biomarkers for pediatric traumatic brain injury. J Neurotrauma. 2013;30(5):324–38. doi:10.1089/neu.2012.2545.
  • Giza C, Greco T, Prins ML. Concussion: pathophysiology and clinical translation. Handb Clin Neurol. 2018;158:51–61.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.