457
Views
5
CrossRef citations to date
0
Altmetric
Lens/Glaucoma

Immunohistochemical Profiles of LOXL-1, FBN1, TGF-β1, and COX-2 in Pseudoexfoliation Syndrome

, , &
Pages 880-889 | Received 12 Nov 2015, Accepted 30 Oct 2016, Published online: 13 Jan 2017

References

  • Elhawy E, Kamthan G, Dong CQ, Danias J. PEX syndrome, a systemic disorder with ocular manifestations. Hum Genomics 2012;6:22.[ PMID: 23157966]
  • Schlötzer-Schrehardt U, Naumann GOH. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol 2006;141:921–37. [ PMID: 16678509]
  • Ghosh M, Speakman JS. The origin of senile lens exfoliation. Can J Ophthalmol 1983;18:340–343. [ PMID: 6671154]
  • Kurowska AK, Kamińska A, Izdebska J, Szaflik JP, Szaflik J. PEX syndrome -a systemic disorder. Klin Oczna 2009;111:160–164. [ PMID: 19673450]
  • Ringvold A. Epidemiology of glaucoma in northern Europe. Eur J Ophthalmol 1996;6:26–29. [ PMID: 8744847]
  • Jonasson F, Damji KF, Arnarsson A, Sverrisson T, Wang L, Sasaki H et al. Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study. Eye (Lond) 2003;17:747–753. [ PMID: 12928689]
  • Andrikopoulos GK, Mela EK, Georgakopoulos CD, Papadopoulos GE, Damelou AN, Gartaganis SP. et al. Pseudoexfoliation syndrome prevalence in Greek patients with cataract and its association to glaucoma and coronary artery disease. Eye (Lond) 2009;23:442–447. [ PMID: 17932505]
  • Kozobolis VP, Papatzanaki M, Vlachonikolis IG, Pallikaris IG, Tsambarlakis IG. Epidemiology of pseudoexfoliation in the island of Crete (Greece). Acta Ophthalmol Scand 1997;75:726–729. [ PMID: 9527341]
  • Topouzis F, Wilson MR, Harris A, Anastasopoulos E, Yu F, Mavroudis L et al. Prevalence of open-angle glaucoma in Greece: the Thessaloniki Eye Study. Am J Ophthalmol 2007;144:511–519. [ PMID: 17893012]
  • Bengtsson B, Heijl A. A long-term prospective study of risk factors for glaucomatous visual field loss in patients with ocular hypertension. J Glaucoma 2005;14:135–138. [ PMID: 15741815]
  • Schlötzer-Schrehardt U. Genetics and genomics of PEX syndrome/glaucoma. Middle East Afr J Ophthalmol 2011;18:30–36. [ PMID: 21572731]
  • Ritch R, Schlötzer-Schrehardt U. Exfoliation (pseudoexfoliation) syndrome: toward a new understanding. Proceedings of the First International Think Tank. Acta Ophthalmol Scand 200;79:213–217. [ PMID: 11284770]
  • Schlötzer-Schrehardt U, von der Mark K, Sakai LY, Naumann GO. Increased extracellular deposition of fibrillin-containing fibrils in pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci 1997;38:970–984. [ PMID: 9112993]
  • Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol 2001;45:265–315. [ PMID: 11166342]
  • Schlötzer-Schrehardt U, Lommatzsch J, Küchle M, Konstas AG, Naumann GO. Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma. Invest Ophthalmol Vis Sci 2003;44:1117–1125. [ PMID: 12601038]
  • Schlötzer-Schrehardt U, Zenkel M, Küchle M, Sakai LY, Naumann GO. Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome. Exp Eye Res 2001;73:765–780. [ PMID 11846508]
  • Seibert K, Masferrer JL. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor 1994;4:17–23. [ PMID: 8038702]
  • Radi ZA, Render JA. The pathophysiologic role of cyclo-oxygenases in the eye. J Ocul Pharmacol Ther 2008;24:141–151. [ PMID: 18355129].
  • Yildirim Z, Yildirim F, Uçgun NI, Sepici-Dinçel A. The role of the cytokines in the pathogenesis of pseudoexfoliation syndrome. Int J Ophthalmol 2013;6:50–53. [ PMID: 23550261]
  • Karadimas SK, Klironomos G, Papachristou DJ, Papanikolaou S, Papadaki E, Gatzounis G. Immunohistochemical profile of NF-κB/p50, NF-κB/p65, MMP-9, MMP-2, and u-PA inexperimental cervical spondylotic myelopathy. Spine 2013;38:4–10 [ PMID: 22673181]
  • Schlötzer-Schrehardt U, Pasutto F, Sommer P, Hornstra I, Kruse FE, Naumann GO et al. Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients. Am J Pathol 2008;173:1724–1735. [ PMID: 18974306]
  • Kagan HM, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem 2003;88:660–672. [ PMID: 12577300]
  • Giampuzzi M et al. Lysyl oxidase activates the transcription activity of human collagen III promoter. Possible involvement of Ku antigen. J Biol Chem 2000;275:36341–36349. [ PMID: 10942761]
  • Laczko R, Szauter KM, Csiszar K. LOXL-1-Associated candidate epithelial pathomechanisms in exfoliation glaucoma. J Glaucoma 2014;23:S43–S47. [ PMID:25275905]
  • Schlötzer-Schrehardt U. Molecular pathology of pseudoexfoliation syndrome/glaucoma-new insights from LOXL1 gene associations. Exp Eye Res 2009;88:776–785 [ PMID: 18809397]
  • Djordjević-Jocić J, Zlatanović G, Veselinović D, Jovanović P, Djordjević V, Zvezdanović L et al. Transforming growth factor beta1, matrix-metalloproteinase-2 and its tissue inhibitor in patients with pseudoexfoliation glaucoma/syndrome. Clin Ophthalmol 2014;8:305–309. [ PMID: 24511224]
  • Gartaganis SP, Patsoukis NE, Nikolopoulos DK, Georgiou CD. Evidence for oxidative stress in lens epithelial cells in pseudoexfoliation syndrome. Eye 2007;21:1406–1411. [ PMID: 17001325]
  • Bocca C. et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin Ther Targets. 2014;18:121–135 [ PMID:24325753]
  • Brookshire HL, English RV, Nadelstein B, Weigt AK, Gift BW, Gilger BC. Efficacy of COX-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal. Vet Ophthalmol 2015;18:175–185 [ PMID: 24636042]
  • Fujii R et al. Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. J Exp Clin Cancer Res 2014;33:40[ PMID:24887090]
  • Zenkel M, Krysta A, Pasutto F, Juenemann A, Kruse FE, Schlötzer-Schrehardt U. Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci 2011;52:8488–8495. [ PMID: 21948647]
  • Klingberg F, Hinz B, White ES. The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol 2013;229:298–309. [ PMID: 22996908]
  • Kaartinen V, Warburton D. Fibrillin controls TGF-beta activation. Nat Genet 2003;33:331–332. [ PMID: 12610545]
  • Wipff J, Allanore Y, Boileau C. Interactions between fibrillin-1 and tgf-beta: consequences and human pathology. Med Sci (Paris) 2009;25:161–167.[ PMID: 19239848]
  • Rodríguez-Barbero A, Dorado F, Velasco S, Pandiella A, Banas B, López-Novoa JM. TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells. Kidney Int 2006;70:901–909. [ PMID: 16820791]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.