Development and Assessment of a Novel Canine Ex Vivo Corneal Model

References

• Deshpande P, Ortega Í, Sefat F, Sangwan VS, Green N, Claeyssens F, et al. Rocking media over ex vivo corneas improves this model and allows the study of the effect of proinflammatory cytokines on wound healing. Invest Ophthalmol Vis Sci 2015 Mar;56(3):1553–1561.
   PubMed Web of Science ®Google Scholar
• Qazi Y, Wong G, Monson B, Stringham J, Ambati BK. Corneal transparency: genesis, maintenance and dysfunction. Brain Res Bull 2010 Feb 15;81(2–3):198–210.
   PubMed Web of Science ®Google Scholar
• Carrier P, Deschambeault A, Talbot M, Giasson CJ, Auger FA, Guérin SL, et al. Characterization of wound reepithelialization using a new human tissue-engineered corneal wound healing model. Invest Ophthalmol Vis Sci 2008 Apr;49(4):1376–1385.
   PubMed Web of Science ®Google Scholar
• Werner A, Braun M, Reichl S, Kietzmann M. Establishing and functional testing of a canine corneal construct. Vet Ophthalmol 2008 Oct;11(5):280–289.
   PubMed Web of Science ®Google Scholar
• Gum G, MacKay E. Physiology of the eye. In Kirk N. Gelatt, Brian C. Gilger and Thomas J. Kern, editors. Veterinary Ophthalmology, 5th ed; Ames, IA: Wiley-Blackwell; 2013; pp. 171–190.
   Google Scholar
• Ofri R. Optics and physiology of vision. In Kirk N. Gelatt, Brian C. Gilger and Thomas J. Kern, editors. Veterinary Ophthalmology, 5th ed; Ames, IA: Wiley-Blackwell; 2013; pp. 212–217.
   Google Scholar
• Bohnsack RN, Warejcka DJ, Wang L, Gillespie SR, Bernstein AM, Twining SS, et al. Expression of insulin-like growth factor 2 receptor in corneal keratocytes during differentiation and in response to wound healing. Invest Ophthalmol Vis Sci 2014 Dec;55(12):7697–708.
   PubMed Web of Science ®Google Scholar
• Barequet IS, Harizman N, Ziv H, Rosner M. Healing rate of corneal erosions: comparison of the effect of chloramphenicol eye drops and ointment and high-concentration hyaluronic acid in an animal model. Cornea 2014 Oct;33(10):1080–1082.
   PubMed Web of Science ®Google Scholar
• Janin-Manificat H, Rovère M-R, Galiacy SD, Malecaze F, Hulmes DJS, Moali C, et al. Development of ex vivo organ culture models to mimic human corneal scarring. Mol Vis 2012;18:2896–2908.
   PubMed Web of Science ®Google Scholar
• Tsujita H, Brennan AB, Plummer CE, Nakajima N, Hyon S-H, Barrie KP, et al. An ex vivo model for suture-less amniotic membrane transplantation with a chemically defined bioadhesive. Curr Eye Res 2012 May;37(5):372–380.
   PubMed Web of Science ®Google Scholar
• Suzuki K, Tanaka T, Enoki M, Nishida T. Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing. Invest Ophthalmol Vis Sci 2000 Aug;41(9):2495–2500.
   PubMed Web of Science ®Google Scholar
• Foreman DM, Pancholi S, Jarvis-Evans J, McLeod D, Boulton ME. A simple organ culture model for assessing the effects of growth factors on corneal re-epithelialization. Exp Eye Res 1996 May;62(5):555–564.
   PubMed Web of Science ®Google Scholar
• Castro-Combs J, Noguera G, Cano M, Yew M, Gehlbach PL, Palmer J, et al. Corneal wound healing is modulated by topical application of amniotic fluid in an ex vivo organ culture model. Exp Eye Res 2008 Jul;87(1):56–63.
   PubMed Web of Science ®Google Scholar
• Ledbetter EB, Gilger B. Diseases and surgery of the canine cornea and sclera. In Kirk N. Gelatt, Brian C. Gilger and Thomas J. Kern, editors. Veterinary Ophthalmology, 5th ed; Ames, IA: Wiley-Blackwell; 2013; pp. 976–992.
   Google Scholar
• Harman RM, Bussche L, Ledbetter EC, Van de Walle GR. Establishment and characterization of an air-liquid canine corneal organ culture model to study acute herpes keratitis. J Virol 2014 Dec;88(23):13669–13677.
   PubMed Web of Science ®Google Scholar
• Chandler HL, Colitz CMH, Lu P, Saville WJA, Kusewitt DF. The role of the slug transcription factor in cell migration during corneal re-epithelialization in the dog. Exp Eye Res 2007 Mar;84(3):400–411.
   PubMed Web of Science ®Google Scholar
• Martin CL. Ophthalmic Disease in Veterinary Medicine; New York, NY: CRC Press; 2009; 515, pp. 241–245.
   Google Scholar
• Hutcheon AEK, Sippel KC, Zieske JD. Examination of the restoration of epithelial barrier function following superficial keratectomy. Exp Eye Res 2007 Jan;84(1):32–38.
   PubMed Web of Science ®Google Scholar
• Flueckiger F, Kodjikian L, Halberstadt M, Boehnke M, Garweg JG. An ex-vivo, whole-globe porcine model of corneoepithelial wound healing tested using immunomodulatory drugs. J Ocul Pharmacol Ther Off J Assoc Ocul Pharmacol Ther 2005 Oct;21(5):367–375.
   PubMed Web of Science ®Google Scholar
• Xu K, McDermott M, Villanueva L, Schiffman RM, Hollander DA. Ex vivo corneal epithelial wound healing following exposure to ophthalmic nonsteroidal anti-inflammatory drugs. Clin Ophthalmol Auckl NZ 2011;5:269–274.
   PubMedGoogle Scholar
• Xu KP, Li XF, Yu FS. Corneal organ culture model for assessing epithelial responses to surfactants. Toxicol Sci Off J Soc Toxicol 2000 Dec;58(2):306–314.
   PubMed Web of Science ®Google Scholar
• Sriram S, Gibson DJ, Robinson P, Pi L, Tuli S, Lewin AS, et al. Assessment of anti-scarring therapies in ex vivo organ cultured rabbit corneas. Exp Eye Res 2014 Aug;125:173–182.
   PubMed Web of Science ®Google Scholar
• Chuck RS, Behrens A, Wellik SR, Liaw LH, Sweet PM, Osann KE, et al. Simple organ cornea culture model for re-epithelialization after in vitro excimer laser ablation. Lasers Surg Med 2001;29(3):288–292.
   PubMed Web of Science ®Google Scholar
• Chan KY, Cho P, Boost M. Corneal epithelial cell viability of an ex vivo porcine eye model. Clin Exp Optom 2014 Jul;97(4):337–340.
   PubMed Web of Science ®Google Scholar
• Richard NR, Anderson JA, Weiss JL, Binder PS. Air/liquid corneal organ culture: a light microscopic study. Curr Eye Res 1991 Aug;10(8):739–749.
   PubMed Web of Science ®Google Scholar
• Mohammadi S, Postnikoff C, Wright AM, Gorbet M. Design and development of an in vitro tear replenishment system. Ann Biomed Eng 2014 Sep;42(9):1923–1931.
   PubMed Web of Science ®Google Scholar
• Hermel M, Salla S, Hamsley N, Steinfeld A, Walter P. Detection of contamination during organ culture of the human cornea. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Für Klin Exp Ophthalmol. 2010 Jan;248(1):117–126.
   PubMed Web of Science ®Google Scholar
• Chen JY, Jones MN, Srinivasan S, Neal TJ, Armitage WJ, Kaye SB, et al. Endophthalmitis after penetrating keratoplasty. Ophthalmology 2015 Jan;122(1):25–30.
   PubMed Web of Science ®Google Scholar
• Panda A, Satpathy G, Sethi HS. Survival of Pseudomonas aeruginosa in M-K preserved corneas. Br J Ophthalmol 2005 Jun;89(6):679–683.
   PubMed Web of Science ®Google Scholar
• Samuelson D. Ophthalmic anatomy. In Kirk N. Gelatt, Brian C. Gilger and Thomas J. Kern, editors. Veterinary Ophthalmology, 5th ed; Ames, IA: Wiley-Blackwell; 2013; pp. 62–76.
   Google Scholar
• Sriram S, Robinson P, Pi L, Lewin AS, Schultz G. Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts. Invest Ophthalmol Vis Sci 2013 Dec;54(13):8214–8223.
   PubMed Web of Science ®Google Scholar
• Hovakimyan M, Falke K, Stahnke T, Guthoff R, Witt M, Wree A, et al. Morphological analysis of quiescent and activated keratocytes: a review of ex vivo and in vivo findings. Curr Eye Res 2014 Dec;39(12):1129–1144.
   PubMed Web of Science ®Google Scholar
• Lim M, Goldstein MH, Tuli S, Schultz GS. Growth factor, cytokine and protease interactions during corneal wound healing. Ocul Surf 2003 Apr;1(2):53–65.
   PubMedGoogle Scholar
• Gibson DJ, Tuli SS, Schultz GS. The progression of haze formation in rabbit corneas following phototherapeutic keratectomy. Invest Ophthalmol Vis Sci 2013 Jul;54(7):4776–4781.
   PubMed Web of Science ®Google Scholar