Sex Differences in the Prevalence of Meibomian Gland Dysfunction: A Mini Review

References

• Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, Liu Z, Nelson JD, Nichols JJ, Tsubota K, et al. TFOS DEWS II Definition and Classification Report. Ocul Surf. 2017;15(3):276–283. doi:10.1016/j.jtos.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Kim H, An Y, Hwang WJ. Gender differences in dry eye disease symptoms associated with psychological health indicators among adults using mobile mental health apps. PLoS One. 2023;18(1):e0278921. doi:10.1371/journal.pone.0278921.
   PubMed Web of Science ®Google Scholar
• Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol. 2000;118(9):1264–1268. doi:10.1001/archopht.118.9.1264.
   PubMed Web of Science ®Google Scholar
• Ahn JM, Lee SH, Rim TH, Park RJ, Yang HS, Kim TI, Yoon KC, Seo KY, Epidemiologic Survey Committee of the Korean Ophthalmological Society. Prevalence of and risk factors associated with dry eye: the Korea National Health and Nutrition Examination Survey 2010-2011. Am J Ophthalmol. 2014;158(6):1205–1214.e7. doi:10.1016/j.ajo.2014.08.021.
   PubMed Web of Science ®Google Scholar
• Castro JS, Selegatto IB, Castro RS, Miranda ECM, de Vasconcelos JPC, de Carvalho KM, Arieta CEL, Alves M. Prevalence and Risk Factors of self-reported dry eye in Brazil using a short symptom questionnaire. Sci Rep. 2018;8(1):2076. doi:10.1038/s41598-018-20273-9.
   PubMed Web of Science ®Google Scholar
• Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, Knop E, Markoulli M, Ogawa Y, Perez V, et al. TFOS DEWS II pathophysiology report. Ocul Surf. 2017;15(3):438–510. doi:10.1016/j.jtos.2017.05.011.
   PubMed Web of Science ®Google Scholar
• Hassanzadeh S, Varmaghani M, Zarei-Ghanavati S, Heravian Shandiz J, Azimi Khorasani A. Global Prevalence of Meibomian Gland Dysfunction: a Systematic Review and Meta-Analysis. Ocul Immunol Inflamm. 2021;29(1):66–75. doi:10.1080/09273948.2020.1755441.
   PubMed Web of Science ®Google Scholar
• Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, Na KS, Schaumberg D, Uchino M, Vehof J, et al. TFOS DEWS II Epidemiology Report. Ocul Surf. 2017;15(3):334–365. doi:10.1016/j.jtos.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Amano S, Inoue K. Clinic-Based Study on Meibomian Gland Dysfunction in Japan. Invest Ophthalmol Vis Sci. 2017;58(2):1283–1287. doi:10.1167/iovs.16-21374.
   PubMed Web of Science ®Google Scholar
• Amano S, Inoue K. Estimation of Prevalence of Meibomian Gland Dysfunction in Japan. Cornea. 2017;36(6):684–688. doi:10.1097/ICO.0000000000001208.
   PubMed Web of Science ®Google Scholar
• Arita R, Mizoguchi T, Kawashima M, Fukuoka S, Koh S, Shirakawa R, Suzuki T, Morishige N. Meibomian gland dysfunction and dry eye are similar but different based on a population-based study: the Hirado-Takushima Study in Japan. Am J Ophthalmol. 2019;207:410–418. doi:10.1016/j.ajo.2019.02.024.
   PubMed Web of Science ®Google Scholar
• Ban Y, Shimazaki-Den S, Tsubota K, Shimazaki J. Morphological evaluation of meibomian glands using noncontact infrared meibography. Ocul Surf. 2013;11(1):47–53. doi:10.1016/j.jtos.2012.09.005.
   PubMed Web of Science ®Google Scholar
• Arita R, Itoh K, Inoue K, Amano S. Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology. 2008;115(5):911–915. doi:10.1016/j.ophtha.2007.06.031.
   PubMed Web of Science ®Google Scholar
• Den S, Shimizu K, Ikeda T, Tsubota K, Shimmura S, Shimazaki J. Association between meibomian gland changes and aging, sex, or tear function. Cornea. 2006;25(6):651–655. doi:10.1097/01.ico.0000227889.11500.6f.
   PubMed Web of Science ®Google Scholar
• Singh J, Priya Y, Bhat V. Prevalence, severity, and treatment outcomes of meibomian gland dysfunction in patients with dry eye symptoms at a Tertiary Care Center in South India. Cureus. 2022;14(6):e25703. doi:10.7759/cureus.25703.
   PubMed Web of Science ®Google Scholar
• Yadav S, Gupta N, Makwana T, Vanathi M, Tandon R. Noninvasive ocular surface analyzer as an adjunct in diagnosis and estimating prevalence of meibomian gland dysfunction: hospital-based comparative study. Indian J Ophthalmol. 2022;70(5):1539–1545. doi:10.4103/ijo.IJO_2245_21.
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Agrawal D, Sharma A. Meibomian gland dysfunction in a hospital-based population in central India. Cornea. 2020;39(5):634–639. doi:10.1097/ICO.0000000000002217.
   PubMed Web of Science ®Google Scholar
• Rathnakumar K, Ramachandran K, Baba D, Ramesh V, Anebaracy V, Vidhya R, Vinothkumar R, Poovitha R, Geetha R. Prevalence of dry eye disease and its association with dyslipidemia. J Basic Clin Physiol Pharmacol. 2018;29(2):195–199. doi:10.1515/jbcpp-2017-0001.
   PubMedGoogle Scholar
• Abu EK, Ofori AO, Boadi-Kusi SB, Ocansey S, Yankah RK, Kyei S, Awuku AY. Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana. Afr Health Sci. 2022;22(1):293–302. doi:10.4314/ahs.v22i1.36.
   PubMed Web of Science ®Google Scholar
• Asiedu K, Kyei S, Dzasimatu SK, Morny EKA. Meibomian gland dysfunction in a youthful clinical sample in Ghana. Optom Vis Sci. 2018;95(4):349–353. doi:10.1097/OPX.0000000000001192.
   PubMed Web of Science ®Google Scholar
• Osae EA, Ablorddepey RK, Horstmann J, Kumah DB, Steven P. Assessment of meibomian glands using a custom-made meibographer in dry eye patients in Ghana. BMC Ophthalmol. 2018;18(1):201. doi:10.1186/s12886-018-0869-0.
   PubMedGoogle Scholar
• Mussi N, Haque W, Robertson DM. The association between risk factors for metabolic syndrome and meibomian gland disease in a dry eye cohort. Clin Ophthalmol. 2021;15:3821–3832. doi:10.2147/OPTH.S322461.
   PubMed Web of Science ®Google Scholar
• Brooks CC, Gupta PK. Meibomian gland morphology among patients presenting for refractive surgery evaluation. Clin Ophthalmol. 2021;15:315–321. doi:10.2147/OPTH.S292919.
   PubMed Web of Science ®Google Scholar
• Hom MM, Martinson JR, Knapp LL, Paugh JR. Prevalence of Meibomian gland dysfunction. Optom Vis Sci. 1990;67(9):710–712. doi:10.1097/00006324-199009000-00010.
   PubMed Web of Science ®Google Scholar
• Borrelli M, Frings A, Geerling G, Finis D. Gender-specific differences in signs and symptoms of dry eye disease. Curr Eye Res. 2021;46(3):294–301. doi:10.1080/02713683.2020.1801758.
   PubMed Web of Science ®Google Scholar
• Pult H. Relationships between meibomian gland loss and age, sex, and dry eye. Eye Contact Lens. 2018;44 Suppl 2: S318–S324. doi:10.1097/ICL.0000000000000467.
   PubMed Web of Science ®Google Scholar
• Pult H, Riede-Pult BH. Non-contact meibography: keep it simple but effective. Cont Lens Anterior Eye. 2012;35(2):77–80. doi:10.1016/j.clae.2011.08.003.
   PubMed Web of Science ®Google Scholar
• Nøland ST, Badian RA, Utheim TP, Utheim ØA, Stojanovic A, Tashbayev B, Raeder S, Dartt DA, Chen X. Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients. Ocul Surf. 2021;19:68–73. doi:10.1016/j.jtos.2020.11.009.
   PubMed Web of Science ®Google Scholar
• Badian RA, Utheim TP, Chen X, Utheim ØA, Ræder S, Ystenæs AE, Aakre BM, Sundling V. Meibomian gland dysfunction is highly prevalent among first-time visitors at a Norwegian dry eye specialist clinic. Sci Rep. 2021;11(1):23412. doi:10.1038/s41598-021-02738-6.
   PubMed Web of Science ®Google Scholar
• Martinez JD, Galor A, Ramos-Betancourt N, Lisker-Cervantes A, Beltrán F, Ozorno-Zárate J, Sánchez-Huerta V, Torres-Vera MA, Hernández-Quintela E. Frequency and risk factors associated with dry eye in patients attending a tertiary care ophthalmology center in Mexico City. Clin Ophthalmol. 2016;10:1335–1342. doi:10.2147/OPTH.S106451.
   PubMed Web of Science ®Google Scholar
• Crespo-Treviño RR, Salinas-Sánchez AK, Amparo F, Garza-Leon M. Comparative of meibomian gland morphology in patients with evaporative dry eye disease versus non-dry eye disease. Sci Rep. 2021;11(1):20729. doi:10.1038/s41598-021-00122-y.
   PubMed Web of Science ®Google Scholar
• Hashemi H, Asharlous A, Aghamirsalim M, Yekta A, Pourmatin R, Sajjadi M, Pakbin M, Asadollahi M, Khabazkhoob M. Meibomian gland dysfunction in geriatric population: tehran geriatric eye study. Int Ophthalmol. 2021;41(7):2539–2546. doi:10.1007/s10792-021-01812-2.
   PubMed Web of Science ®Google Scholar
• Hashemi H, Rastad H, Emamian MH, Fotouhi A. Meibomian gland dysfunction and its determinants in Iranian adults: a population-based study. Cont Lens Anterior Eye. 2017;40(4):213–216. doi:10.1016/j.clae.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Lin X, Wu Y, Chen Y, Zhao Y, Xiang L, Dai Q, Fu Y, Zhao Y, Zhao YE. Characterization of meibomian gland atrophy and the potential risk factors for middle aged to elderly patients with cataracts. Transl Vis Sci Technol. 2020;9(7):48. doi:10.1167/tvst.9.7.48.
   PubMed Web of Science ®Google Scholar
• Gao JG, Chen J, Tang Y, Chen DN. Prevalence of meibomian gland dysfunction in staffs and faculty members of a Chinese university. Int J Ophthalmol. 2020;13(10):1667–1670. doi:10.18240/ijo.2020.10.23.
   PubMed Web of Science ®Google Scholar
• Viso E, Gude F, Rodríguez-Ares MT. The association of meibomian gland dysfunction and other common ocular diseases with dry eye: a population-based study in Spain. Cornea. 2011;30(1):1–6. doi:10.1097/ICO.0b013e3181da5778.
   PubMed Web of Science ®Google Scholar
• Viso E, Rodríguez-Ares MT, Abelenda D, Oubiña B, Gude F. Prevalence of asymptomatic and symptomatic meibomian gland dysfunction in the general population of Spain. Invest Ophthalmol Vis Sci. 2012;53(6):2601–2606. doi:10.1167/iovs.11-9228.
   PubMed Web of Science ®Google Scholar
• Robin M, Liang H, Rabut G, Augstburger E, Baudouin C, Labbé A. The role of meibography in the diagnosis of meibomian gland dysfunction in ocular surface diseases. Transl Vis Sci Technol. 2019;8(6):6. doi:10.1167/tvst.8.6.6.
   PubMed Web of Science ®Google Scholar
• Rabensteiner DF, Aminfar H, Boldin I, Schwantzer G, Horwath-Winter J. The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population. Acta Ophthalmol. 2018;96(6):e707–e711. doi:10.1111/aos.13732.
   PubMed Web of Science ®Google Scholar
• Aapola U, Nättinen J, Suurkuukka I, Tuomilehto J, Keinänen-Kiukaanniemi S, Saramies J, Uusitalo H. Ocular surface health of the Finnish elderly population. Acta Ophthalmol. 2022;100(8):894–902. doi:10.1111/aos.15130.
   PubMed Web of Science ®Google Scholar
• Craig JP, Wang MTM, Ambler A, Cheyne K, Wilson GA. Characterising the ocular surface and tear film in a population-based birth cohort of 45-year old New Zealand men and women. Ocul Surf. 2020;18(4):808–813. doi:10.1016/j.jtos.2020.08.005.
   PubMed Web of Science ®Google Scholar
• Siak JJ, Tong L, Wong WL, Cajucom-Uy H, Rosman M, Saw SM, Wong TY. Prevalence and risk factors of meibomian gland dysfunction: the Singapore Malay eye study. Cornea. 2012;31(11):1223–1228. doi:10.1097/ICO.0b013e31823f0977.
   PubMed Web of Science ®Google Scholar
• Lin PY, Tsai SY, Cheng CY, Liu JH, Chou P, Hsu WM. Prevalence of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study. Ophthalmology. 2003;110(6):1096–1101. doi:10.1016/S0161-6420(03)00262-8.
   PubMed Web of Science ®Google Scholar
• Jeon YJ, Song MY, Kim KY, Hwang KY, Kwon YA, Koh K. Relationship between the partial blink rate and ocular surface parameters. Int Ophthalmol. 2021;41(7):2601–2608. doi:10.1007/s10792-021-01819-9.
   PubMed Web of Science ®Google Scholar
• Vehof J, Sillevis Smitt-Kamminga N, Nibourg SA, Hammond CJ. Sex differences in clinical characteristics of dry eye disease. Ocul Surf. 2018;16(2):242–248. doi:10.1016/j.jtos.2018.01.001.
   PubMed Web of Science ®Google Scholar
• Machalińska A, Zakrzewska A, Safranow K, Wiszniewska B, Machaliński B. Risk factors and symptoms of meibomian gland loss in a healthy population. J Ophthalmol. 2016;2016:7526120. doi:10.1155/2016/7526120.
   PubMed Web of Science ®Google Scholar
• Yeotikar NS, Zhu H, Markoulli M, Nichols KK, Naduvilath T, Papas EB. Functional and morphologic changes of meibomian glands in an asymptomatic adult population. Invest Ophthalmol Vis Sci. 2016;57(10):3996–4007. doi:10.1167/iovs.15-18467.
   PubMed Web of Science ®Google Scholar
• Subcommittee of the International Dry Eye WorkShop. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5(2):108–152. doi:10.1016/s1542-0124(12)70083-6.
   PubMed Web of Science ®Google Scholar
• Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 2012;31(5):472–478. doi:10.1097/ICO.0b013e318225415a.
   PubMed Web of Science ®Google Scholar
• Rapoport Y, Singer JM, Ling JD, Gregory A, Kohanim S. A comprehensive review of sex disparities in symptoms, pathophysiology, and epidemiology of dry eye syndrome. Semin Ophthalmol. 2016;31(4):325–336. doi:10.3109/08820538.2016.1154168.
   PubMed Web of Science ®Google Scholar
• Begley CG, Chalmers RL, Abetz L, Venkataraman K, Mertzanis P, Caffery BA, Snyder C, Edrington T, Nelson D, Simpson T. The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci. 2003;44(11):4753–4761. doi:10.1167/iovs.03-0270.
   PubMed Web of Science ®Google Scholar
• Hashmi JA, Davis KD. Deconstructing sex differences in pain sensitivity. Pain. 2014;155(1):10–13. doi:10.1016/j.pain.2013.07.039.
   PubMed Web of Science ®Google Scholar
• Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K, Lemp MA, Sullivan DA. The International Workshop on Meibomian Gland Dysfunction: executive Summary. Invest Ophthalmol Vis Sci. 2011;52(4):1922–1929. doi:10.1167/iovs.10-6997a.
   PubMed Web of Science ®Google Scholar
• Ladwig KH, Marten-Mittag B, Formanek B, Dammann G. Gender differences of symptom reporting and medical health care utilization in the German population. Eur J Epidemiol. 2000;16(6):511–518. doi:10.1023/a:1007629920752.
   PubMed Web of Science ®Google Scholar
• Almeida SA, Trone DW, Leone DM, Shaffer RA, Patheal SL, Long K. Gender differences in musculoskeletal injury rates: a function of symptom reporting? Med Sci Sports Exerc. 1999;31(12):1807–1812. doi:10.1097/00005768-199912000-00017.
   PubMed Web of Science ®Google Scholar
• Thompson AE, Anisimowicz Y, Miedema B, Hogg W, Wodchis WP, Aubrey-Bassler K. The influence of gender and other patient characteristics on health care-seeking behaviour: a QUALICOPC study. BMC Fam Pract. 2016;17(1):38. doi:10.1186/s12875-016-0440-0.
   PubMed Web of Science ®Google Scholar
• Sullivan DA, Rocha EM, Aragona P, Clayton JA, Ding J, Golebiowski B, Hampel U, McDermott AM, Schaumberg DA, Srinivasan S, et al. TFOS DEWS II Sex, Gender, and Hormones Report. Ocul Surf. 2017;15(3):284–333. doi:10.1016/j.jtos.2017.04.001.
   PubMed Web of Science ®Google Scholar
• Krenzer KL, Dana MR, Ullman MD, Cermak JM, Tolls DB, Evans JE, Sullivan DA. Effect of androgen deficiency on the human meibomian gland and ocular surface. J Clin Endocrinol Metab. 2000;85(12):4874–4882. doi:10.1210/jcem.85.12.7072.
   PubMed Web of Science ®Google Scholar
• Sullivan BD, Evans JE, Krenzer KL, Reza Dana M, Sullivan DA. Impact of antiandrogen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. J Clin Endocrinol Metab. 2000;85(12):4866–4873. doi:10.1210/jcem.85.12.7066.
   PubMed Web of Science ®Google Scholar
• Zeligs M, Gordon KB. Dehydroepiandrosterone therapy for the treatment of dry eye disorders. 1994. WO1994004155 A1. PCT/US1992/007096.
   Google Scholar
• Bolognia JL. Aging skin. Am J Med. 1995;98(1a):99s–103s. doi:10.1016/s0002-9343(99)80066-7.
   PubMedGoogle Scholar
• Labrie F, Bélanger A, Cusan L, Gomez JL, Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab. 1997;82(8):2396–2402. doi:10.1210/jcem.82.8.4160.
   PubMed Web of Science ®Google Scholar
• Labrie F, Bélanger A, Cusan L, Candas B. Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology. J Clin Endocrinol Metab. 1997;82(8):2403–2409. doi:10.1210/jcem.82.8.4161.
   PubMed Web of Science ®Google Scholar
• Sullivan DA, Jensen RV, Suzuki T, Richards SM. Do sex steroids exert sex-specific and/or opposite effects on gene expression in lacrimal and meibomian glands? Mol Vis. 2009; Aug 1015:1553–72.
   PubMed Web of Science ®Google Scholar
• Reneker LW, Lubahn DB, Huang AJW. The Cross-talk between Androgen and Estrogen Signaling in Meibomian Glands. IOVS. 2023;64(8):676–676.
   Web of Science ®Google Scholar
• Pochi PE, Strauss JS. Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol. 1974;62(3):191–201. doi:10.1111/1523-1747.ep12676783.
   PubMed Web of Science ®Google Scholar
• Sweeney TM, Szarnicki RJ, Strauss JS, Pochi PE. The effect of estrogen and androgen on the sebaceous gland turnover time. J Invest Dermatol. 1969;53(1):8–10. doi:10.1038/jid.1969.100.
   PubMed Web of Science ®Google Scholar
• Tomlinson A, Bron AJ, Korb DR, Amano S, Paugh JR, Pearce EI, Yee R, Yokoi N, Arita R, Dogru M. The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee. Invest Ophthalmol Vis Sci. 2011;52(4):2006–2049. doi:10.1167/iovs.10-6997f.
   PubMed Web of Science ®Google Scholar
• Yazdani M, Elgstøen KBP, Utheim TP. Eye Make-up Products and Dry Eye Disease: a Mini Review. Curr Eye Res. 2022;47(1):1–11. doi:10.1080/02713683.2021.1966476.
   PubMed Web of Science ®Google Scholar
• Fenga C, Aragona P, Cacciola A, Spinella R, Di Nola C, Ferreri F, Rania L. Meibomian gland dysfunction and ocular discomfort in video display terminal workers. Eye (Lond)). 2008;22(1):91–95. doi:10.1038/sj.eye.6703025.
   PubMed Web of Science ®Google Scholar
• Wang J, Liu Y, Kam WR, Li Y, Sullivan DA. Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells. Exp Eye Res. 2020;196:108057. doi:10.1016/j.exer.2020.108057.
   PubMed Web of Science ®Google Scholar
• Kritharis A, Al-Samkari H, Kuter DJ. Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist’s perspective. Haematologica. 2018;103(9):1433–1443. doi:10.3324/haematol.2018.193003.
   PubMed Web of Science ®Google Scholar
• Jain NP, Shao K, Stewart C, Grant-Kels JM. The effects of alcohol and illicit drug use on the skin. Clin Dermatol. 2021;39(5):772–783. doi:10.1016/j.clindermatol.2021.05.005.
   PubMed Web of Science ®Google Scholar