YAP/TAZ Signaling Enhances Angiogenesis of Retinal Microvascular Endothelial Cells in a High-Glucose Environment

References

• Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–136. doi:10.1016/s0140-6736(09)62124-3.
   PubMed Web of Science ®Google Scholar
• Vujosevic S, Aldington SJ, Silva P, Hernández C, Scanlon P, Peto T, Simó R. Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol. 2020;8(4):337–347. doi:10.1016/s2213-8587(19)30411-5.
   PubMed Web of Science ®Google Scholar
• Bandello F, Battaglia Parodi M, Lanzetta P, Loewenstein A, Massin P, Menchini F, Veritti D. Diabetic macular edema. Dev Ophthalmol. 2017;58:102–138. doi:10.1159/000455277.
   PubMedGoogle Scholar
• Wong TY, Cheung CMG, Larsen M, Sharma S, Simó R. Diabetic retinopathy. Nat Rev Dis Primers. 2016;2(1):16012. doi:10.1038/nrdp.2016.12.
   PubMedGoogle Scholar
• Apte RS, Chen DS, Ferrara N. VEGF in signaling and disease: beyond discovery and development. Cell. 2019;176(6):1248–1264. doi:10.1016/j.cell.2019.01.021.
   PubMed Web of Science ®Google Scholar
• Chung AS, Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol. 2011;27(1):563–584. doi:10.1146/annurev-cellbio-092910-154002.
   PubMedGoogle Scholar
• Piccolo S, Dupont S, Cordenonsi M. The biology of YAP/TAZ: hippo signaling and beyond. Physiol Rev. 2014;94(4):1287–1312. doi:10.1152/physrev.00005.2014.
   PubMed Web of Science ®Google Scholar
• Yu Y, Su X, Qin Q, Hou Y, Zhang X, Zhang H, Jia M, Chen Y. Yes-associated protein and transcriptional coactivator with PDZ-binding motif as new targets in cardiovascular diseases. Pharmacol Res. 2020;159:105009. doi:10.1016/j.phrs.2020.105009.
   PubMed Web of Science ®Google Scholar
• Zanconato F, Cordenonsi M, Piccolo S. YAP/TAZ at the roots of cancer. Cancer Cell. 2016;29(6):783–803. doi:10.1016/j.ccell.2016.05.005.
   PubMed Web of Science ®Google Scholar
• Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H. Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress. J Exp Clin Cancer Res. 2018;37(1):216. doi:10.1186/s13046-018-0892-2.
   PubMedGoogle Scholar
• Zhang Y, Xu H, Cui G, Liang B, Chen X, Ko S, Affo S, Song X, Liao Y, Feng J, et al. β-Catenin sustains and is required for YES-associated protein oncogenic activity in cholangiocarcinoma. Gastroenterology. 2022;163(2):481–494. doi:10.1053/j.gastro.2022.04.028.
   PubMed Web of Science ®Google Scholar
• Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, et al. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell. 2017;42(5):462–478. doi:10.1016/j.devcel.2017.08.002.
   PubMed Web of Science ®Google Scholar
• Shen Y, Wang X, Liu Y, Singhal M, Gürkaşlar C, Valls AF, Lei Y, Hu W, Schermann G, Adler H, et al. STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis. Sci Signal. 2021;14(712):eabj8393. doi:10.1126/scisignal.abj8393.
   PubMed Web of Science ®Google Scholar
• Boopathy GTK, Hong W. Role of hippo pathway-YAP/TAZ signaling in angiogenesis. Front Cell Dev Biol. 2019;7:49. doi:10.3389/fcell.2019.00049.
   PubMed Web of Science ®Google Scholar
• Hao GM, Lv TT, Wu Y, Wang HL, Xing W, Wang Y, Li C, Zhang ZJ, Wang ZL, Wang W, et al. The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy. BMC Complement Altern Med. 2017;17(1):187. doi:10.1186/s12906-017-1678-3.
   PubMedGoogle Scholar
• Kim J, Kim YH, Kim J, Park DY, Bae H, Lee D-H, Kim KH, Hong SP, Jang SP, Kubota Y, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127(9):3441–3461. doi:10.1172/JCI93825.
   PubMed Web of Science ®Google Scholar
• Choi H-J, Zhang H, Park H, Choi K-S, Lee H-W, Agrawal V, Kim Y-M, Kwon Y-G. Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nat Commun. 2015;6(1):6943. doi:10.1038/ncomms7943.
   PubMedGoogle Scholar
• Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HCA, Itoh N, Hirose T, Breier G, Vestweber D, et al. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol. 2013;15(3):249–260. doi:10.1038/ncb2679.
   PubMed Web of Science ®Google Scholar
• Ito M, Makino N, Matsuda A, Ikeda Y, Kakizaki Y, Saito Y, Ueno Y, Kawata S. High glucose accelerates cell proliferation and increases the secretion and mRNA expression of osteopontin in human pancreatic duct epithelial cells. Int J Mol Sci. 2017;18(4):807. doi:10.3390/ijms18040807.
   PubMed Web of Science ®Google Scholar
• Mugahid D, Kalocsay M, Liu X, Gruver JS, Peshkin L, Kirschner MW. YAP regulates cell size and growth dynamics via non-cell autonomous mediators. eLife. 2020;9:e53404. doi:10.7554/eLife.53404.
   PubMed Web of Science ®Google Scholar
• Nair PR, Wirtz D. Enabling migration by moderation: YAP/TAZ are essential for persistent migration. J Cell Biol. 2019;218(4):1092–1093. doi:10.1083/jcb.201902035.
   PubMed Web of Science ®Google Scholar
• Moens S, Goveia J, Stapor PC, Cantelmo AR, Carmeliet P. The multifaceted activity of VEGF in angiogenesis–Implications for therapy responses. Cytokine Growth Factor Rev. 2014;25(4):473–482. doi:10.1016/j.cytogfr.2014.07.009.
   PubMed Web of Science ®Google Scholar
• Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003;92(8):827–839. doi:10.1161/01.RES.0000070112.80711.3D.
   PubMed Web of Science ®Google Scholar
• Moss LAS, Jensen-Taubman S, Stetler-Stevenson WG. Matrix metalloproteinases: changing roles in tumor progression and metastasis. Am J Pathol. 2012;181(6):1895–1899. doi:10.1016/j.ajpath.2012.08.044.
   PubMed Web of Science ®Google Scholar
• Bischoff J. Endothelial-to-mesenchymal transition. Circ Res. 2019;124(8):1163–1165. doi:10.1161/CIRCRESAHA.119.314813.
   PubMed Web of Science ®Google Scholar
• Gorelova A, Berman M, Al Ghouleh I. Endothelial-to-mesenchymal transition in pulmonary arterial hypertension. Antioxid Redox Signal. 2021;34(12):891–914. doi:10.1089/ars.2020.8169.
   PubMed Web of Science ®Google Scholar
• Huang Q, Gan Y, Yu Z, Wu H, Zhong Z. Endothelial to mesenchymal transition: an insight in atherosclerosis. Front Cardiovasc Med. 2021;8:734550. doi:10.3389/fcvm.2021.734550.
   PubMed Web of Science ®Google Scholar
• Thounaojam MC, Jadeja RN, Warren M, Powell FL, Raju R, Gutsaeva D, Khurana S, Martin PM, Bartoli M. MicroRNA-34a (miR-34a) mediates retinal endothelial cell premature senescence through mitochondrial dysfunction and loss of antioxidant activities. Antioxidants (Basel). 2019;8(9):328. doi:10.3390/antiox8090328.
   PubMedGoogle Scholar
• Liu J, Chen S, Biswas S, Nagrani N, Chu Y, Chakrabarti S, Feng B. Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs. Physiol Rep. 2020;8(3):e14331. doi:10.14814/phy2.14331.
   PubMed Web of Science ®Google Scholar